Phase 3 clinical trial results lead to approval of oral drug for red blood cell disorder
ACTIVATE trial generated positive safety and efficacy data for mitapivat.
About Hanny Al-Samkari, MD
Dr. Hanny Al-Samkari is a hematologist and clinical investigator at the Massachusetts General Hospital and Harvard Medical School. He received his medical degree from Washington University in St. Louis, completed his residency in internal medicine at the Hospital of the University of Pennsylvania (where he also served as Chief Medical Resident), and completed his fellowship in hematology and medical oncology at the Dana-Farber Cancer Institute-Massachusetts General Hospital combined program. He specializes in disorders of bleeding and clotting as well as hemolytic anemias. This includes hereditary hemorrhagic telangiectasia, immune thrombocytopenia, chemotherapy-induced thrombocytopenia, pyruvate kinase deficiency, thalassemia, hemophilia, von Willebrand disease, and other blood diseases. As a clinical investigator, Dr. Al-Samkari serves as the principal investigator for several clinical trials at any given time for these diseases and is able to offer new treatment options to these patients.
Dr. Al-Samkari also serves as the Associate Director of the multidisciplinary Massachusetts General Hospital Hereditary Hemorrhagic Telangiectasia Center of Excellence. Patients with hereditary hemorrhagic telangiectasia seeking care at our internationally-recognized center are encouraged to schedule an appointment with Dr. Al-Samkari.
Clinical Interests:
- Cancer-associated venous thromboembolism
- Chemotherapy-induced thrombocytopenia
- Hemophilia
- Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease)
- Hereditary thrombocytopenias
- Immune thrombocytopenia
- Perioperative thrombocytopenia
- Pyruvate kinase deficiency
- Red cell enzyme disorders
- Thalassemia
- von Willebrand disease
Treats:
- Adult
Locations
Mass General Cancer Center
55 Fruit St.
Boston, MA 02114
Phone: 617-726-5130
Phone: 877-726-5130
Medical Education
- MD, Washington University School of Medicine in St. Louis
- Residency, Hospital of the University of Pennsylvania
- Fellowship, Dana Farber Cancer Institute
- Fellowship, Massachusetts General Hospital*****
American Board Certifications
- Hematology, American Board of Internal Medicine
- Internal Medicine, American Board of Internal Medicine
- Medical Oncology, American Board of Internal Medicine
Accepted Insurance Plans
- Aetna Health Inc.
- Beech Street
- Blue Cross Blue Shield - Blue Care 65
- Blue Cross Blue Shield - Indemnity
- Blue Cross Blue Shield - Managed Care
- Blue Cross Blue Shield - Partners Plus
- BMC HealthNet Mass Health MCO/ACO
- Cigna (PAL #'s)
- Commonwealth Care Alliance
- Fallon Community HealthCare
- Great-West Healthcare (formally One Health Plan)
- Harvard Pilgrim Health Plan - ACD
- Harvard Pilgrim Health Plan - PBO
- Health Care Value Management (HCVM)
- Humana/Choice Care PPO
- Maine Community Health Options (MCHO)
- Mass General Brigham Health Plan - ACD
- Mass General Brigham Health Plan - PBO
- MassHealth
- Medicare
- Medicare - ACD
- Medicare ACO - ACD
- Medicare ACO - PBO
- OSW - Connecticut
- OSW - Maine
- OSW - New Hampshire
- OSW - Rhode Island
- OSW - Vermont
- Private Health Care Systems (PHCS)
- Railroad Medicare
- Railroad Medicare - ACD
- Senior Whole Health
- TriCare
- Tufts Health Plan
- Unicare
- United Healthcare (non-HMO) - ACD
- United Healthcare (non-HMO) - PBO
- Well Sense
- Well Sense Pediatrics
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
Research
Dr. Al-Samkari specializes in conducting research on non-malignant hematologic diseases, with a focus on disorders of hemostasis, thrombosis, and hemolysis. He runs clinical trials of new medications primarily in hereditary hemorrhagic telangiectasia (HHT), thrombocytopenias (disorders of low platelet count, including immune thrombocytopenia or ITP and chemotherapy-induced thrombocytopenia or CIT), hemophilia, and hereditary red cell disorders (including pyruvate kinase deficiency and thalassemia). He has published over 50 scholarly manuscripts and research abstracts in these areas and has presented numerous oral research presentations at national and international scientific conferences. which have been selected for a number of research awards.
Publications
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- Al-Samkari H, Rodriguez-Lopez JM, Kuter DJ. Systemic Bevacizumab for the Treatment of Chronic Bleeding in Hereditary Hemorrhagic Telangiectasia. Journal of Internal Medicine 2019 Feb;285(2):223-231.
- Al-Samkari H, Shin K, Cardoni L, Pighetti EH, Rits S, McMahon L, Perkins R, Uluer A, Connors JM. Antifibrinolytic Agents for Hemoptysis Management in Adults with Cystic Fibrosis. Chest 2019 Jun;155(6):1226-1233.
- Al-Samkari H, Marshall AL, Goodarzi K, Kuter DJ. Romiplostim for the Management of Perioperative Thrombocytopenia. British Journal of Haematology 2018 Jul;182(1):106-113.
- Al-Samkari H, Marshall AL, Goodarzi K, Kuter DJ. The use of romiplostim in treating chemotherapy-induced thrombocytopenia in patients with solid tumors. Haematologica 2018 Apr;103(4):e169-e172.
- Al-Samkari H, Kuter DJ. Thrombopoietin Level Predicts Response to Treatment with Eltrombopag and Romiplostim in Immune Thrombocytopenia. American Journal of Hematology 2018 Dec;93(12):1501-1508.
- Al-Samkari H, Van Cott EM, Kuter DJ. Platelet aggregation response in immune thrombocytopenia patients treated with romiplostim. Annals of Hematology 2019 Mar;98(3):581-588.
- Al-Samkari H, Kuter DJ. An Alternative Intermittent Eltrombopag Dosing Protocol for Treatment of Chronic Immune Thrombocytopenia. British Journal of Clinical Pharmacology 2018 Nov;84(11):2673-2677.