Research Spotlight: Innovative Nanovaccine Found to Trigger an Anti-Tumor Response for Rare Cancer
Researchers found that a nanovaccine can be used to treat a rare form of melanoma.
Researchers found that a nanovaccine can be used to treat a rare form of melanoma.
Researchers used a unique 3D microfluidic model of tumors to investigate the mechanisms of treatment resistance to CAR-T cells.
Shadmehr (Shawn) Demehri, MD, PhD, of the Department of Dermatology and Center for Cancer Immunology at Massachusetts General Hospital, is the corresponding author of a paper published in Cancer Cell, “Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.”
Dan G. Duda, DMD, PhD, of the Edwin L. Steele Laboratories for Tumor Biology and Department of Radiation Oncology at Massachusetts General Hospital, is the corresponding author of a paper published in Cancer Immunology Research, “Combination CXCR4 and PD1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma.”
Massachusetts General Hospital has received a transformational gift of $100 million from entrepreneur, philanthropist, and proud Bostonian, Herb Chambers in support of a new state-of-the-art building designed to meet the growing demand for world-class cancer care.
The 2024 class of awardees will receive more than $6 million in funding to accelerate groundbreaking cancer research.
The researchers found that damage to the heart is driven by a different immune response than the anti-tumor one, suggesting that this serious complication could one day be managed without halting cancer therapy.
Cesar M. Castro, MD, MSc, of the Department of Medicine and Center for Systems Biology at Massachusetts General Hospital, and Hakho Lee, PhD, of the Department of Radiology and Center for Systems Biology at Massachusetts General Hospital, are co-corresponding authors of a paper published in Nature Biotechnology, “Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE.”
The John and Ashley Ranelli Endowed Scholar in Cancer Innovation will activate funding of promising cancer research, helping to advance critical work in the fight against cancer.
Nabeel Bardeesy, PhD, an investigator in the Krantz Center for Cancer Research in the Mass General Cancer Center and a Professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Discovery, DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer Through Impaired SIK Signaling and CRTC2/p300-mediated Transcriptional Reprogramming, a collaboration with Taran Gujral at Fred Hutchinson Cancer Institute in Seattle.
An integral part of one of the world’s most distinguished academic medical centers, Mass General Brigham Cancer Institute is among the leading cancer care providers in the United States.