Meet Our Investigators:
Yves Boucher, PhD
Learn more about how the Boucher Lab within the Edwin L. Steele Laboratories for Tumor Biology is studying the delivery of oncolytic viruses and large therapeutic agents in tumors as well as tumor cell migration and metastasis.
Annie Chan, MD
Dr. Chan’s research has exploited the superior dose distribution of proton beam to improve clinical outcome and decrease the treatment-related morbidity in patients with head and neck and skull base malignancies.
Andrew Elia, MD
The Elia Lab studies molecular mechanisms that maintain genomic stability after DNA damage. The lab is located in the Center for Cancer Research and utilizes quantitative proteomic approaches to elucidate DNA repair pathways regulated by ubiquitin signaling with the goal of understanding how disruption of these pathways influences cancer progression and can be exploited to target tumors with DNA repair defects.
Dai Fukumura, MD, PhD
Explore how the Fukumura Lab within the Edwin L. Steele Laboratories for Tumor Biology is working to uncover the fundamental nature of vascular biology in both physiological and pathophysiological settings, and to utilize this knowledge for detection and treatment of diseases.
Kathryn Held, PhD
Dr. Held’s team conducts research on molecular mechanisms for the induction of bystander effects by high-energy particles in cells and tissues, characterization of charged particle beam-induced DNA damage responses and cell killing, with interest in effects on neural tissues, and mechanisms for regulation of DNA damage response by cell–cell communication.
Peigen Huang, MD, MS
The Huang Lab within the Edwin L. Steele Laboratories for Tumor Biology focuses on the development of spontaneous tumors in mice and on how the age, genetic background, and immune status of the mice-as well as the presence or absence of specific genes-affect the histopathological characteristics of the tumors.
William Hwang, MD, PhD
Dr. Hwang’s research program is focused on elucidating the interactions between pancreatic cancer cells and their microenvironment at high resolution using single-cell omics and multiplexed imaging techniques.
Rakesh Jain, PhD
Learn more about the Jain Lab within the Edwin L. Steele Laboratories for Tumor Biology, is celebrated for a new hypothesis that antiangiogenic therapy can "normalize" the abnormal tumor vasculature and improve both the delivery and efficacy of therapeutics.
Sophia Kamran, MD
Dr. Kamran is investigating the genomic underpinnings of differential responses to radiation through clinical computational analyses with specific focus on mutations that disrupt DNA-damage response pathways for biomarker discovery.
Melin Khandekar, MD
Dr. Khandekar is interested in the effects of systemic physiology, including diabetes, obesity and hypertension and other co-morbidities on tumor and the tumor microenvironment, and is interested in repurposing commonly used drugs and identifying novel therapeutic agents to better treat lung cancer and other thoracic malignancies.
Li Lan, PhD
The Lan Lab focuses on understanding the cellular responses induced by radiation, the roles of RNA in DNA damage repair, and crosstalk between immune response and DNA damage response, for promoting the discovery and development of novel biomarkers and targeted treatments of breast and ovarian cancer.
David Miyamoto, MD
Learn more about the Miyamoto Lab’s research on novel biomarkers to guide the personalized treatment of patients with prostate and bladder cancer.
Timothy Padera, PhD
The Padera Lab within the Edwin L. Steele Laboratories for Tumor Biology looks to understand the mechanisms behind the growth, maturation and function of lymphatic vessels and how these mechanisms can contribute to the pathogenesis of lymphedema, chronic infections and cancer dissemination.
Jan Schuemann, PhD
Dr. Schuemann’s team works at the interface between Biology and Physics research, combining modeling with experiments. To learn more about their studies on the mechanisms of extremely high dose rate (FLASH) proton radiation therapy, modeling of DNA damage induction and repair, or nanodosimetry
Lei Xu, Md, PhD
Read how the Xu Lab, within the Edwin L. Steele Laboratories for Tumor Biology, is studying biology of tumor-host interaction with the goal of developing novel therapeutic targets for cancer.