Learn about the recently updated cancer screening recommendations for patients with a pathogenic variant (also known as a mutation) in certain breast and ovarian cancer susceptibility genes.
Breast and Ovarian Cancer Genetics Program
55 Fruit Street, YAW 10B
Boston, MA 02114
If you are interested in a consultation with the Breast and Ovarian Cancer Genetics Program team, you can make an appointment at one of four locations:
- Mass General Cancer Center main campus (Yawkey Building, Suite 10B, 55 Fruit St., Boston); call 617-724-1971
- Mass General/North Shore Cancer Center (102 Endicott St., Danvers, MA); call 978-882-6370
- Mass General Cancer Center at Emerson Hospital – Bethke (133 Old Road to Nine Acre Corner, Concord, MA); call 978-371-4805
- Mass General Waltham (52 Second Ave., Suite 1110, Waltham, MA 02451); call 781-487-6100
Explore the Breast and Ovarian Cancer Genetics Program
The Breast and Ovarian Cancer Genetics Program helps to identify and provide comprehensive, coordinated medical care for families that have a hereditary breast and/or ovarian cancer syndrome. Under the direction of Leif W. Ellisen, MD, PhD, our program includes specialists in both breast oncology and genetics, and we also work closely with the gynecology/oncology group at Massachusetts General Hospital.
Patients with pathogenic variants in hereditary breast and ovarian cancer genes are managed comprehensively with our team of physicians and genetic counselors. We also provide risk assessment for patients interested in an evaluation for hereditary breast or ovarian cancer. During the initial genetics consultation, family history is carefully reviewed. If your personal or family history suggests a possible genetic risk, we will discuss the option of genetic testing.
Should You Consider Genetic Counseling?
Our program is appropriate for any individual that has a pathogenic variant in a breast and ovarian cancer predisposition gene. It may also be appropriate if you have a personal or family history of one or more of the following:
- Breast cancer diagnosed before age 45
- Breast cancer in three or more people on one side (maternal or paternal) of the family
- Bilateral breast cancer diagnosis
- Breast cancer in an individual of Ashkenazi Jewish descent
- Ovarian cancer
- Family history of:
- Breast and ovarian cancer
- Breast, thyroid and uterine cancer
- Breast, sarcoma, leukemia, adrenal cortical cancer and brain cancer
- Breast cancer and diffuse gastric cancer
- Breast and pancreatic cancer
Hereditary Breast/Ovarian Cancer Diseases
The conditions most commonly discussed with patients in our program include:
- Hereditary breast and ovarian cancer syndrome (BRCA1/2 genes)
- Li-Fraumeni syndrome (TP53 gene)
- Cowden syndrome, also known at PTEN-hamartoma tumor syndrome (PTEN gene)
- Hereditary diffuse gastric cancer syndrome (CDH1 gene)
View our library of fact sheets about inherited cancer risk and genetic testing.
Learn about the Mind Body Program for Individuals with Hereditary Cancer Syndromes.
Our program provides care to patients with all stages of TNBC.
Related News and Articles
- Jun | 16 | 2022
Blum Center Program: Cancer Center Genetic Series – What You Need to Know About Hereditary Ovarian Cancer
Ovarian cancer is rare, but did you know that it can run in families? Janette Lawrence, MS, CGC, gives an overview of hereditary ovarian cancer and what you can do if it's detected in your family.
- May | 28 | 2021
Recent research has provided more evidence linking BARD1 and breast cancer risk, particularly for triple-negative (ER, PR, and HER-2) breast cancer.
- Oct | 20 | 2020
Testing for the classic hereditary breast cancer genes, BRCA1 and BRCA2, has been available and widely offered since their discovery in the 1990s. However, new technologies in genetic testing have recently uncovered information about other genes linked to hereditary breast cancer.
- Patient Story
- Mar | 23 | 2018
Lauren Corduck and her father Bob Cooperstein speak about how their lives have been impacted by having tested positive for a BRCA gene mutation.