Researchers identify a promising drug for treating serious COVID-19 complication in children
Study shows rapid improvement in children with MIS-C treated with drug first developed for celiac disease.
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Drenkard E*, Hibbler RM*, Gutu DA, Eaton AD, Silverio AL, Ausubel FM, Hurley BP**, Yonker LM**. Replication of the ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants. Journal of Visualized Experiments. Accepted, In-press.
Yonker LM, Pazos MA, Mou H, Chu KK, Eaton AD, Bonventre JV, Tearney GJ, Rajagopal J, Hurley BP. Neutrophil-derived cytosolic PLA2α contributes to bacterial-induced neutrophil trans-epithelial migration. Journal of Immunology. J Immunol. 2017 Oct 15;199(8):2873-2884. PMID: 28887431
Yonker LM*, Mou H*, Chu KK, Pazos MA, Leung H, Cu D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP. Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. Scientific Reports. 2017 Aug 15;7(1):8182. PMID: 28811631
Yonker LM, Cigana C, Hurley BP, Bragonzi A. Host-pathogen interplay in the respiratory environment of cystic fibrosis. J Cystic Fibrosis. 2015 Jul;14(4):431-9
Friedman D, Linnemann RW, Altstein LL, Islam S, Bach KT, Lamb C, Volpe J, Doolittle C, St John A, O'Malley PJ, Sawicki GS, Georgiopoulos AM, Yonker LM*, Moskowitz SM*. The CF-CARES primary palliative care model: A CF-specific structured assessment of symptoms, distress, and coping. J Cyst Fibros. 2017 Mar 14. pii: S1569-1993(17)30077-2. PMID: 28302366
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Mass General is the #1 Research Hospital in America and recognized in 14 specialties assessed by U.S. News & World Report.
Study shows rapid improvement in children with MIS-C treated with drug first developed for celiac disease.
Viral load had no correlation to disease severity in kids, but kids are potential spreaders of current and emerging variants.
Researchers have determined that viral particles remaining in the gut long after an initial COVID-19 infection can travel into the bloodstream, instigating the condition called Multisystem Inflammatory Syndrome in Children (MIS-C).
Researchers at the Ragon Institute of MGH, MIT and Harvard and Massachusetts General Hospital show that levels of specific antibodies developed in the immune response may influence COVID-19 outcomes in both children and adults.
En las primeras etapas de la pandemia del COVID-19, se informó en gran medida que los niños y los jóvenes no corrían tanto riesgo de contraer o propagar el virus del COVID-19. Pero ahora que las pruebas están más disponibles, los números revelan una verdad muy diferente.
This past May marked the 11th anniversary of MGHfC Research Day, an annual event that recognizes the pioneering research of investigators throughout the hospital whose discoveries help to better understand childhood health and disease.