About Anthony Iafrate, MD

Dr. Iafrate is the director of the Center for Integrated Diagnostics, a clinical laboratory for molecular diagnostics at Massachusetts General Hospital. He oversees the Translational Research Laboratory (TRL), a shared effort of the Pathology Department and Mass General Cancer Center. The TRL provides rapid personalized genomic testing to help inform cancer treatment decisions for patients. Dr. Iafrate received his MD, PhD degrees from the State University of New York at Stony Brook in 2000, and was trained in anatomic and molecular genetic pathology at Brigham and Women's Hospital. He joined the Massachusetts General Hospital staff in 2005. His post-doctoral work involved the discovery and description of a novel source of human genetic diversity, termed "copy number variation" (CNV). He established a cancer diagnostics lab focusing on genetic fingerprints that help guide novel, targeted therapies. His laboratory launched SNaPshot several years ago, an assay that tests over 100 of the most common mutations in tumors. His research is focused on lung and brain tumors, and he has been closely involved in the clinical development of crizotinib and companion diagnostics in ALK-positive lung cancers.

Clinical Interests:

Treats:

Locations

Pathology Associates
55 Fruit Street
Boston, MA 02114-2696
Fax: 617-726-7474

Medical Education

  • MD, PhD, SUNY at Stony Brook School of Medicine
  • Residency, Brigham and Women's Hospital
  • Fellowship, Brigham and Women's Hospital

American Board Certifications

  • Anatomic Pathology, American Board of Pathology
  • Molecular Genetic Pathology, American Board of Medical Genetics

Accepted Insurance Plans

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Research

Research in the Iafrate laboratory focuses on bringing new genetic technologies to cancer diagnostics and their application to the practice of pathology. Initially research focused on lung cancer, but our approach is expanding to all malignancies. See details at the Iafrate Lab. For more information about research concepts, co-authors, and to see a timeline, visit  Dr. Iafrate's profile at the Harvard Clinical and Translational Science Center.

Publications