Read the latest news featuring experts from the Metabolism Unit.

March 2021

Steven Grinspoon, MD, on the Importance of Studying Treatments for Steatosis in HIV

In this video, Steven Grinspoon, MD, talks about why treatments for steatosis in HIV are important to study, including some reasons why most studies in nonalcoholic fatty liver disease (NAFLD) do not include patients with HIV.

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September 10, 2020

Theratechnologies to Develop Tesamorelin for the Treatment of NASH in the General Population

Theratechnologies Inc.. (Theratechnologies) (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and commercialization of innovative therapies, is pleased to announce that it plans to pursue Phase 3 clinical development of tesamorelin for the treatment of Non-Alcoholic Steatohepatitis (NASH) in the general population.

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August 26, 2020

MGH researchers gain insight into mechanism of promising therapy to reduce liver fat and prevent fibrosis progression in common form of liver disease

A team led by researchers at Massachusetts General Hospital (MGH) has taken an important step forward in the goal of developing a potential treatment for non-alcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease. There are currently no approved medications for NAFLD, but in a study published in the journal JCI Insight on August 20, 2020, investigators conducted a genetic analysis that has identified how one promising therapy may work to improve the adverse effects of this increasingly prevalent health threat.

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August 17, 2020

Major Global Study of HIV’s Ties to Heart Disease Is a Data Goldmine

The global REPRIEVE trial, which has enrolled 7,700 people taking HIV treatment and seeks to determine a cholesterol-lowering statin’s effects on cardiovascular disease (CVD) outcomes, is shedding light on many other pressing questions about the health of people living, and aging, with the virus.

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August 14, 2020

Large NIH Clinical Trial Illuminates Long-Term Health Effects of HIV

Initial data from a large NIH-supported clinical trial offer a detailed look at the health status of people aging with HIV around the world. With 7,770 participants enrolled in 12 countries across five continents, the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) is evaluating the ability of a statin medication, pitavastatin, to reduce the risk of heart disease among people with HIV. By leveraging data collected from this diverse group of study participants, researchers also are learning more about the long-term health effects of HIV. They report their initial findings in an August supplement for The Journal of Infectious Diseases.

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July 29, 2020

Age-Related Comorbidities for Patients Living with HIV

Mitigating myocardial steatosis is a long-term care solution and consideration for health care providers, according to a series of analyses studying comorbidities in the aging population of people living with human immunodeficiency virus (HIV).

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July 23, 2020

Theratechnologies Reports That Tesamorelin Improves Liver Health

Theratechnologies Inc. (Theratechnologies) (TSX: TH) (NASDAQ: THTX), a commercial-stage biopharmaceutical company, is pleased to announce new data that further support the potential role of tesamorelin in the treatment of HIV-associated nonalcoholic steatohepatitis (NASH).

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July 20, 2020

Data Reveals Chronic Disease Burden Among Individuals with HIV

The first collection of important data from the world’s largest study of cardiovascular disease prevention in people with HIV has revealed the significant chronic disease burden of this patient population.

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July 10, 2020

Initial data from the landmark REPRIEVE study on HIV and heart disease highlights the multiple health risks among a population that’s living longer

The impact and prevalence of heart disease and other critical comorbidities on an aging global population with human immunodeficiency virus (HIV) have emerged from a suite of articles in The Journal of Infectious Diseases that contains the first swath of important data from the world’s largest study of cardiovascular disease (CVD) prevention in people with HIV. This information from the ongoing National Institutes of Health (NIH)-funded study known as REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV), in which Massachusetts General Hospital (MGH) is playing a key coordinating role, is giving the field of medicine an advance look at the disproportionate risk of comorbidities like CVD, chronic liver and kidney disease, physical function impairment and frailty, premature reproductive aging, cancer, and obesity in people with HIV from all regions of the world.

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