CREST-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
Summary: Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.
- Primary Investigator: Scott Silverman, MD*
- Study Population or Disease Focus: Patients with asymptomatic high-grade carotid stenosis
- Status: Enrolling
- Source: Industry-initiated
*While Dr. Silverman is a physician within the Mass General Department of Neurology, multiple Mass General interventional cardiologists take part in the carotid stenting (CAS) arm of the trial.