Update on COVID-19 in Transplantation: from Travel to Treatment
On May 24, 2022, the Massachusetts General Hospital Transplant Center held a virtual, fireside chat to share the latest updates on COVID-19 and transplantation.
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The peripheral vascular system consists of the network of arteries and veins that carry blood throughout the body. Cholesterol plaques, blood clots and inflammation can injury and create blockages within the peripheral vascular system. Depending on the location of the blockages, symptoms can range from arm and leg pain, dizziness or even high blood pressure. The innovative research being conducted at Massachusetts General Hospital seeks to improve the clinical diagnosis and management of patients living with peripheral vascular disease. Specifically, our Mass General investigators are investigating techniques to ablate nerves within arteries supplying the kidneys in order to treat high blood pressure. Additionally, researchers at Mass General are studying innovative catheter-based techniques to treat blood clots in the lung arteries.
CREST-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
Summary: Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.
The RADIANCE-HTN Clinical Study: A Study of the ReCor Medical PARADISE® System in Clinical Hypertension
Summary: The objective of the RADIANCE-HTN study is to test the efficacy of the Paradise renal denervation system as a means to decrease the resting blood pressure in hypertensive patients.
The RADIANCE II Pivotal Study: A Study of the ReCor Medical PARADISE® System in Stage II Hypertension
Summary: The objective of the RADIANCE II study is to test the effectiveness and safety of the Paradise renal denervation system as a means to decrease the resting blood pressure in patients with stage 2 hypertension on 0-2 medications.
TARGET BP I: Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System™ Kit, in Subjects with Hypertension
Summary: This trial compares renal denervation performed with the Peregrine System Kit to a control group receiving no renal denervation in order to determine the safety and effectiveness of the Peregrine Catheter on relieving hypertension in patients who are adequately managed with oral antihypertensive medications.
C2R: The CREST-2 Registry
Summary: TThe objective of C2R is to promote the rapid initiation and completion of enrollment in the CREST-2 randomized clinical trial (clinicaltrials.gov ID NCT02089217). Patients with severe symptomatic and asymptomatic carotid artery occlusive disease will be treated with carotid artery stenting (CAS) performed by experienced and skilled interventionists.
CTEPH-BPA Registry: A retrospective study of adults who have CTEPH and underwent a balloon pulmonary angioplasty (BPA)
Summary: This is a registry to gather data on patients who undergo balloon pulmonary angioplasty (BPA) procedures at Mass General.
IVUS/PAD: Impact of Intravascular Ultrasound on Decision-Making in Lower Extremity Revascularization
Summary: This study is to evaluate how a special imaging catheter known as intravascular ultrasound (IVUS) may help guide procedures to open blocked or narrowed leg arteries in patients with peripheral artery disease (PAD).
Metabolomic and Circulating MicroRNA Profile of Lower Extremity Revascularization in Peripheral Artery Disease
Summary: This research to understand how opening blocked arteries (also known as revascularization) in the leg of people with peripheral artery disease (PAD) affects the muscles of these patients. We hope to better understand how revascularization improves symptoms and quality of life in people with PAD. People with PAD may or may not have an improvement in the severity of their symptoms with revascularization. However, it is not clear how revascularization exerts its beneficial effects, and we currently do not have a clear understanding of the effect of revascularization on the muscles of patients with PAD. We ultimately hope to develop new tools for predicting whether patients with PAD will improve with revascularization.
On May 24, 2022, the Massachusetts General Hospital Transplant Center held a virtual, fireside chat to share the latest updates on COVID-19 and transplantation.
Women who had experienced infertility had a 16% increased risk of heart failure compared with women who did not have an infertility history.
Advanced consumer technology has produced small electrocardiogram devices that could be efficiently deployed in point-of-care screening for atrial fibrillation, though the proportion of cases detected among all patients 65 and older is small.
Mutations in genes that direct the production of fibrillar collagens, essential components of blood vessel walls, appear to predispose individuals to SCAD.
Heart disease is the leading cause of death in men and women alike. In this presentation, Dr. Emily Lau reviews the epidemiology of heart disease in women, differences in heart disease between women and men, and special considerations for promoting female heart health.
“Thank you for your service” is a phrase shared with U.S. service members. But Mass General’s Shannon Stuart, RN, a commissioned officer with the Air National Guard, says she is the one who feels the need to share her appreciation.
Learn more about our research opportunities and open clinical trials.