Explore This Core

Overview

The Massachusetts General Hospital Gordon PET Core is cGMP/FDA registered PET drug manufacturer. It provides investigators with required personnel, equipment and services to design and conduct research studies using positron emission tomography.

Services

  • Main services include:
    Synthesis of radiotracers and radiopharmaceuticals
  • PET and SPECT animal and human imaging
  • Experimental design and pharmacokinetic modeling
  • Validation and regulatory submission of compound for human use

Radiopharmaceuticals Available for Human and Animal Use

The Core has synthesized over 20 compounds for clinical evaluation and routine use for neurology, cardiology and oncology. In addition, it has pioneered the use of 18F Tau imaging agents for neurodegenerative diseases such as Alzheimer’s disease and traumatic brain injuries.
  • F-18 FDG* (tumour metabolism/hypometabolism)
  • Florbetaben** (amyloid imaging) Flutemetamol** (amyloid imaging)
  • Florbetapir** (amyloid imaging) Fluciclovine** (tumor metabolism/prostate cancer imaging)
  • Sodium Fluoride** (bone imaging)
  • FES (estrogen receptor)†
  • Flortaucipir [T807] (tau protein)†
  • FPEB (mGlur5)‡
  • BFPET (myocardial perfusion) †
  • GE180 (TSPO/PBR)†
  • FLT (cellular proliferation)†
  • THK 5351/GE-216 (tau protein)†
  • FMISO (hypoxia)†
  • MK-6240 (tau protein) †
  • GE179 (NMDA receptor)‡
  • C-11 PiB (amlyoid)†
  • Altropane (Dopamine transport)‡
  • Raclopride (D2/D3 receptor imaging) †
  • Methionine (amino acid uptake)†
  • Acetate (fatty acid synthase) ‡
  • CO (gas for labeling red blood cells in vivo) ‡
  • Rolipram (PDE-4 receptor imaging) ‡
  • P943 (5-HT1B) ‡
  • PBR-28 (TSPO/PBR)† (S,S)-[11C]Methylreboxetine (MeNR/MRB)‡ – targets norepinephrine transporter
  • N-13
  • Ammonia*
  • N2 in Saline (lung perfusion imaging) ‡
  • Ga-68
  • DOTATATE** (neuroendocrine tumor imaging)
  • O-15
  • C15O2 (blood flow imaging) ‡
*FDA approved, MGH PET Center holds FDA marketing authorization
**FDA approved, available through local commercial nuclear pharmacies
†Active IND held by MGH Gordon PET Core
‡Available under Radioactive Drug Research Committee (RDRC) oversight
The Mass General Gordon PET Core can validate a radiopharmaceutical for clinical research use.

Please send inquiries to:
Georges El Fakhri, Ph.D.
Director, MGH Gordon PET Core
Phone: (617) 726-9640
Fax: (617) 726-6165
Email: elfakhri@pet.mgh.harvard.edu

Equipment

  • GE Discovery PET/CT
  • Automated Radiochemical Synthesis systems
  • E.cam (Siemens) SPECT Systems and Planar Gamma Cameras
  • Exact HR+ Large Bore PET Scanner
  • NeuroPET/CT dedicated high sensitivity brain scanner
  • PC4096 Large Bore PET Scanner
  • Siemens PET/CT Scanner
  • Siemens Symbia SPECT/CT
  • VISTA small animal micro PET/CT
  • Tri-modality MicroPET-SPECT-CT

2022 Fee Schedule

Services

Internal User Fee for ​Non-Profit and Federal Sponsored Research (Direct Cost)

External User Fee for ​Non-Profit and Federal Sponsored Research (Inclusive of Institutional Indirect Cost)

External & Internal User Fee for Industry Sponsored Research

13N Ammonia

 $4,000.00  $5,760.00

Contact us for rate

13N2 PET GMP Production + Imaging

 $2,850.00

 $4,104.00

Contact us for rate

13N2 PET Production + Imaging

 $1,400.00

 $2,016.00

Contact us for rate

13 NH3 Cardiac Blood Flow

 $3,750.00

 $5,400.00

Contact us for rate

18F FDG + Imaging

 $2,400.00

 $3,456.00

Contact us for rate

Other PET GMP Production + Imaging

(includes: 11C Compounds and 18F Compounds; excludes: 18F FDG, 13NH3, 13N2 and 13N Ammonia )

 $3,400.00

 $4,896.00

Contact us for rate

Other PET Production + Imaging

(includes: 11C Compounds and 18F Compounds; excludes: 18F FDG, 13NH3, 13N2 and 13N Ammonia)

 $2,500.00

 $3,600.00

Contact us for rate

PET Imaging Only (no dose, up to two hours)

 $2,250.00

 $3,240.00

Contact us for rate

Additional Imaging Time  (per hour)

 $575.00

 $828.00

Contact us for rate

Phantom Imaging

 $1,650.00

 $2,376.00

Contact us for rate

PET Compound Dose (No Imaging)

 $2,250.00

 $3,240.00

Contact us for rate

Cyclotron Beam Time  Isotope Production (per hour)

 $1,050.00

 $1,512.00

Contact us for rate

Micro PET Imaging Only

 $500.00

 $720.00

Contact us for rate

Micro PET Additional Imaging Hour

 $175.00

 $252.00

Contact us for rate

Blood Processing

 $1,275.00

 $1,836.00

Contact us for rate

Consent Charge

 $115.00

 $165.60

Contact us for rate

CT

 $1,100.00

 $1,584.00

Contact us for rate

IRB Renewal

 $3,650.00

 $5,256.00

Contact us for rate

Kinetic Modeling

 $1,200.00

 $1,728.00

Contact us for rate

Radionuclidic Purity Testing

 $440.00

 $633.60

Contact us for rate

Regulatory Submission

 $11,000.00

 $15,840.00

Contact us for rate

SPECT

 $2,100.00

 $3,024.00

Contact us for rate

SPECT-CT

 $2,700.00

 $3,888.00

Contact us for rate

Start-up Fee

 $7,850.00

 $11,304.00

Contact us for rate

Technician Training / Site Qualification (per hour)

 $300.00

 $432.00

Contact us for rate

Validation of Radiotracer for Animal Use

 $15,600.00

 $22,464.00

Contact us for rate

Validation of Radiotracer for Human and NHP Use

 $28,500.00

 $41,040.00

Contact us for rate

18F FDG Dose (No Imaging)

 $130.00

 $187.20

Contact us for rate

GA68 PSMA 11 Production + Imaging

 $6,200.00

 $8,928.00

Contact us for rate

GA68 Chloride Production

 $1,500.00

 $2,160.00

Contact us for rate

IRB Protocol Review

 $2,000.00

 $2,880.00

Contact us for rate


The Core commits its best efforts to successfully complete scheduled studies. However, given the very nature of many PET studies that rely on manufacturing of the radiopharmaceutical and in vivo imaging, the Core cannot cover costs associated with uncompleted studies due to equipment failure or circumstances outside of our control.

A PET study that is cancelled or rescheduled within 48 business hours of the original imaging session may incur a fee up to the cost of the cancelled imaging session. A radiotracer production that is not cancelled 48 business hours prior to the production day may incur a fee up to the cost of the produced dose.

* A Mass General Brigham investigator using a Mass General Brigham fund is considered an internal user and will be subject to the institutional overhead rate applied by Mass General Brigham Research Management. The external user fee comprises a direct fee negotiated with the PET Core plus an overhead component. The overhead rate set by Mass General Brigham is 44% for external academic users and 59% for external industry users.

Please send inquiries to:
Georges El Fakhri, Ph.D.
Director, MGH Gordon PET Core
Phone: (617) 726-9640
Fax: (617) 726-6165
Email: elfakhri@pet.mgh.harvard.edu

Contact Information

For questions related to human and large animal imaging, please contact:
Nicole DaSilva, RT(R)(N)(CT)(ARRT), CNMT
Research Technical Manager
Email: nedasilva@mgh.harvard.edu
Phone: 617-726-8367


For questions related to small animal imaging, please contact:
Moses Wilks, PhD
Instructor in Radiology
Email: MWILKS@mgh.harvard.edu
Phone: 617-643-9429


For questions related to drug production, please contact:
Georges El Fakhri, Ph.D., DABR
Director, Gordon Center for Medical Imaging
Email: elfakhri@pet.mgh.harvard.edu
Phone: 617-726-9640


For questions related to study budgets, invoices and payments, please contact:
Leigh Nerka
Business Manager
Phone: 617-724-2782
Email: lnerka@mgh.harvard.edu


For other inquiries, please contact:
Georges El Fakhri, Ph.D., DABR
Director, MGH Gordon PET Core
Phone: (617) 726-9640
Fax: (617) 726-6165
Email: elfakhri@pet.mgh.harvard.edu