In a multi-hospital analysis of individuals who experienced an allergic reaction to their first mRNA COVID-19 vaccine dose, all patients who went on to receive a second dose tolerated it without complications.
Department of Medicine
100 Blossom Street
Boston, MA 02114
Hours: Monday, Tuesday, Thursday, 8:30 am-5:00 pm; Wednesday, Friday, 7:30 am-5:00 pm
Allergy Associates at Mass General Waltham
52 Second Avenue
Waltham, MA 02451
Hours: Monday, 8:30 am-5:00 pm; Tuesday, 8:00 am-4:30 pm; Wednesday, 7:30 am-4:30 pm; Thursday 8:00 am-4:30 pm; Friday 7:30 am-4:00 pm
Explore This Treatment Program
Treating Angioedema in All Its Forms
Angioedema refers to unexplained swelling of the soft tissues. It may involve any part of the body—most frequently, the lips, tongue and the soft tissues around the eyes. Patients may experience angioedema alone or a combination of angioedema and hives (chronic urticaria). Forms of angioedema include:
- Associated with allergic reactions (e.g. drug allergy, food allergy)
- Idiopathic (i.e. of unknown cause)
Every angioedema patient's case is unique, so we tailor our diagnostic and therapeutic approaches based on your symptoms and medical history. Our goal is to identify the underlying cause of your angioedema, including what triggers it (when possible), and help you avoid these triggers. Some forms of angioedema may require lifelong medical management.
What to Expect
Your first appointment will be with Aleena Banerji, MD (one of the few angioedema specialists in the Northeast) or one of our other expert allergists. Your doctor will conduct an in-depth consultation that includes an evaluation of your medical history, including exposure to potential irritants, and a physical examination.
If hereditary angioedema is suspected, we will recommend blood tests for further evaluation. If food allergies are a possible cause of your angioedema, we will schedule food-allergy skin testing.
In many patients who are diagnosed with angioedema, the exact cause may not ultimately be identified. Patients with mild symptoms may not need any treatment. Those with more severe symptoms may benefit from medications for symptom relief. Your doctor will review the results of your blood tests (if applicable) and work with you to determine the most appropriate treatment regimen at your follow-up visit.
A Focus on Treating Hereditary Angioedema
The traditional therapy for hereditary angioedema includes the use of androgenic steroids taken daily. For many years, Mass General has been extensively involved in the study of several important novel therapies for treating hereditary angioedema, including:
- A bradykinin receptor antagonist
- C1-inhibitor replacement therapy
- Kallikrein inhibitor therapy
Our group's experience with these new medications leaves us uniquely skilled in determining the best way to manage your symptoms.
Idiopathic Angioedema & Acquired Angioedema
Idiopathic angioedema represents a wide spectrum of disease with varying degrees of severity and chronicity. For patients suspected of having idiopathic angioedema, we also consider possible food and drug allergies and try different therapies in search of an effective solution. Antihistamines may provide symptom relief in some patients with idiopathic angioedema.
Acquired angioedema, which is diagnosed by clinical history and blood tests, can be associated with lymphoma or other autoimmune diseases. The main goal of therapy is to understand the cause of your symptoms. Several novel therapies are under study at this time.
About This Program
Expertise in Diagnosis & Treatment
The Angioedema Program, part of Mass General's Allergy and Clinical Immunology Unit, offers a full range of services at our downtown Boston campus and at Mass General Waltham.
Angioedema is an allergic condition that causes swelling beneath the skin and usually resolves within a few hours to a few days. Some patients may experience angioedema with hives (or chronic urticaria), an allergic condition that causes red, itchy and swollen areas on the skin's surface.
Hereditary angioedema, a rare and sometimes life-threatening condition, can be triggered by stress, trauma and certain medications. In many cases, however, the trigger is not clear. The condition does not occur with hives.
Hereditary angioedema is often misdiagnosed as appendicitis or another abdominal disorder. As a result, some patients are treated for the wrong condition—and sometimes undergo unnecessary medical procedures, such as an appendectomy or abdominal surgery.
Our clinical and research experience means we are skilled in:
- Recognizing hereditary angioedema and other forms of angioedema
- Recommending the appropriate treatment
In addition, as an academic medical center, Mass General can offer patients access to clinical trials of promising new drugs to treat hereditary angioedema.
Leadership in the Angioedema Field
Aleena Banerji, MD, an Associate Professor in our group specializing in angioedema, is known nationally for her clinical and research expertise in this disorder. She is one of the few angioedema specialists in the Northeast and has been treating angioedema patients since 2003.
In addition, Dr. Banerji has been regularly involved in developing and operating research studies of novel treatments for hereditary angioedema. Under her guidance, Mass General has completed clinical trials of C1-inhibitor replacement therapy. An ongoing clinical trial is exploring the efficacy and safety of a novel antibody inhibiting kallikrein.
Dr. Banerji continues to lead groundbreaking research efforts and to incorporate the latest advances into her clinical practice whenever possible.
Meet Our Allergists
- Associate Professor at Harvard Medical School
- Director, Drug Allergy Program
- Clinical Director, Allergy and Clinical Immunology
- Press Release
- Jun | 23 | 2021
Skin problems can occur in some individuals after receiving a COVID-19 vaccine. Research by led by allergists at Massachusetts General Hospital (MGH) now provides encouraging indications that the reactions are rare, and they seldom recur after receiving a second vaccine dose.
- Press Release
- Apr | 19 | 2021
At the end of 2020, allergists examined all information related to possible allergic reactions to COVID-19 vaccinations. Now the team has published updated insights based on their experience overseeing more than 65,000 employees who have become fully vaccinated since that time.
- Press Release
- Mar | 17 | 2021
A meta-analysis confirms that cefazolin can be given to most patients who self-report a penicillin allergy because dual allergy to both penicillin and cefazolin was just 0.7%.
- Press Release
- Mar | 9 | 2021
Data on mRNA COVID-19 vaccinations among employees at Mass General Brigham provide reassurances of the rarity of serious reactions, and the ability to recover from them.
- Press Release
- Mar | 3 | 2021
These reactions should not discourage patients from getting the vaccine, researchers say.
Educating the Next Generation
Our division is dedicated to preparing the next generation of great academic clinicians and basic scientists in allergy and immunology. Fellows in the Allergy and Immunology Training Program receive clinical and research training in angioedema and all other major conditions. Internal medicine residents also gain exposure to angioedema patients as part of their general training.