New CRISPR C-to-G DNA base editor expands the landscape of precision genome editing
The new base editing platform may help researchers understand and correct genetic diseases by selective editing of single DNA 'letters' across nucleobase classes.
Press ReleaseJun | 25 | 2020
Simple Bed-side Test Detects Bleeding Risk in Patients After Surgery or Major Injury
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- Press Release
- Jun | 27 | 2019
Mutational "hotspots" in cancer genomes may not necessarily drive cancer growth
A study by investigators from the Massachusetts General Hospital Cancer Center has found that, contrary to common assumptions, the fact that a specific genetic mutation is frequently found in particular tumors may not signify that mutation drives cancer development and progression.
- Press Release
- Apr | 17 | 2019
CRISPR base editors can induce wide-ranging off-target RNA edits
A Massachusetts General Hospital research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target effects in RNA, extending beyond the targeted DNA.
- Press Release
- Feb | 28 | 2019
Atlas of acute myeloid leukemia cell types may lead to improved, targeted therapies
A research team led by Massachusetts General Hospital investigators has assembled a detailed atlas of bone marrow cells from patients with acute myeloid leukemia, an aggressive blood cancer that usually leads to death within five years of diagnosis.
- Press Release
- Nov | 1 | 2018
Specific CD8 T cell states may indicate response to immune checkpoint therapy for melanoma
A multi-institutional research team, led by investigators at Massachusetts General Hospital and the Broad Institute of MIT and Harvard, has identified specific states of cytotoxic CD8 T cells that are associated with patient response to checkpoint immunotherapy for melanoma.
- Press Release
- Aug | 28 | 2018
Mass. General team finds how NF-2 gene mutations make cells hyper-responsive to growth factor signaling
A team of Massachusetts General Hospital Cancer Center researchers has determined one way that mutations in a gene involved in a rare, hereditary cancer syndrome lead to out-of-control cellular proliferation.
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