Center for Quantitative Health

The Center for Quantitative Health (CQH) in the Division of Clinical Research and the Center for Genomic Medicine at Massachusetts General Hospital focuses on utilizing large data sets to develop strategies for precision medicine and quantitative health.

Focus Areas

1. Developing methods to better match patients with effective treatment
2. Developing tools to allow clinicians to quantify and interpret short- and long-term risks for individual patients
3. Identifying promising treatments already approved by the FDA that can be repurposed for other applications
4. Monitoring and quantifying treatment outcomes and identifying sources of variability in these outcomes
5. Integrating clinical features with biological measures and passive physiologic measures to monitor and predict outcomes

Our Philosophy

We believe that despite the incredible hype associated with big data, there is a real opportunity to better serve patients by developing tools for making clinically-actionable predictions.

By facilitating the interaction of clinical and basic scientists at Mass General and the broader community, and providing tools to do challenging but essential studies, CQH is intended to bridge the gap between large data sets and clinical application.

Research Projects

We are currently not recruiting patients for our research studies.

Please call the research coordinator at 617-643-6310 or email us at mghcqh@mgh.harvard.edu with questions about our research program.

Research Support

We are grateful for the support of grants from NHLBI, NICHD, NIMH, NCCIH, the National Science Foundation, AHRQ, the Blyth Family Fund, the American Philosophical Society, the Bowman Family Foundation, and the Sidney J. Baer, Jr. Foundation, among others.

Thomas H. McCoy Jr, MD
Director of Research, Center for Quantitative Health

Affiliated Faculty

Victor M. Castro, MS
Data Scientist, Mass General Brigham

Center for Experimental Drugs and Diagnostics

Steven D. Sheridan, PhD
Sr. Research Investigator
Director, Platform for Cellular Modeling of Neuropsychiatric Disease (cMiND)

Jennifer Wang, PhD
Senior Research Investigator

Ting Fu
Senior Research Technologist

Liam McCrea
Research Technologist

Joy Horng
Research Technologist

Publications

Dr. Perlis on PubMed

2021

McCoy TH Jr., Castro MV Hart KL, Perlis RH. Stratified delirium risk using prescription medication data in a state-wide cohort. General Hospital Psychiatry. 2021 71:114-120. 

Perlis RH, Santilla M, Ognyanova K, Green J, Druckman J, Lazer D, Baum M. Factors associated with self-reported symptoms of depression among adults with and without a previous COVID-19 diagnosis. JAMA Network Open. 2021 4(6) e2116612-e2116612.

Clapp MA, McCoy TH Jr., James KE, Kaimal AJ, Perlis RH. Derivation and external validation of risk stratification models for severe maternal morbidity using prenatal encounter diagnosis codes. Journal of Perinatology. 2021; DOI: 10.1038/s41372-021-01072-z.

Castro VM, Sacks CA, Perlis RH, McCoy TH Jr. Development and external validation of a delirium prediction model for hospitalized patients with coronavirus disease. Journal of the Academy of Consultation-liaison Psychiatry, 2021 62 (3): 298-308.

Clapp MA, James KE, McCoy TH Jr., Perlis RH, Kaimal AJ. The use of a validated obstetrical risk score for maternal morbidity to predict postpartum hemorrhage for women in labor. American Journal of Obstetrics and Gynecology. 2021 DOI: 10.1016/j.ajog.2021.04.243.

Castro VM, Gunning FM, McCoy TH Jr., Perlis RH. Mood disorders and outcomes of COVID-19 hospitalizations. American Journal of Psychiatry. 2021; DOI: 10.1176/appi.ajp.2020.20060842.

Hart KL, Perlis RH, McCoy TH Jr. Mapping of Transdiagnostic Neuropsychiatric Phenotypes Across Patients in Two General Hospitals. Journal of the Academy of Consultation-Liaison Psychiatry.  2021; DOI: 10.1016/j.jaclp.2021.01.002.

Perlis RH, Ognyanova K, Santillana M, Baum MA, Lazer D, Druckman J, Della Volpe J. Association of acute symptoms of COVID-19 and symptoms of depression in adults. JAMA Network Open. 2021 4(3): e213223-e213223.

Clapp MA, McCoy TH Jr., James KE, Kaimal AJ, Perlis RH. The utility of electronic health record data for identifying postpartum hemorrhage. American Journal of Obstretrics and Gynecology. 2021 3(2): 100305.

Jacobs M, Pradier MF, McCoy TH Jr., Perlis RH, Doshi-Velez F, Gajos KZ. How machine-learning recommendations influence clinician treatment selections: the example of antidepressant selection. Translational Psychiatry. 2021 11(1): 1-9.

Boag W, Kovaleva O, McCoy TH Jr., Rumshisky A, Szolovits P, Perlis RH. Hard for humans, hard for machines: predicting readmission after psychiatric hospitalization using narrative notes. Translational Psychiatry. 2021 11(1);1-6.

Hart KL, Perlis RH. Authorship inequality: a bibliometric study of the concentration of authorship among a diminishing number of individuals in high-impact medical journals, 2008-2019. BMJ Open. 2021 11(1); e046002.

Zhao WN, Garza JC, Perlis RH, Haggarty SJ. Induced pluripotent stem cells as tools to investigate the neurobiology of bipolar disorder and advance novel therapeutic discovery. Neurobiology of Bipolar Disorder. 2021 155-173.

Hart KH, Pellegrini AM, Forrester BP, Berretta S, Murphy SN, Perlis RH, McCoy TH Jr. Distribution of agitation and related symptoms among hospitalized patients using a scalable natural language processing method. General Hospital Psychiatry. 2021 68; 46-51.

Pradier MF Hughes MC, McCoy TH Jr., Barroilhet SA,  Doshi-Velez F, Perlis RH. Predicting change in diagnosis from major depression to bipolar disorder after antidepressant initiation. Neuropsychopharmacology. 2021 46(2): 455-461.

2020

Perlis RH. Essential Work: Psychiatric clinical investigation in the midst of a pandemic. American Journal of Psychiatry. 2020 177(12); 1117-1118.

Perlis RH, Fihn SD. Hard truths about suicide prevention. JAMA Network Open. 2020 3(10); e2022713-e2022713.

Castro VM, McCoy TH Jr., Perlis, RH. Laboratory findings associated with severe illness and mortality among hospitalized individuals with coronavirus disease 2019 in Eastern Massachusetts. JAMA Network Open. 2020 2(10); e2023934.

Barroilhet SA, Pellegrini AM, McCoy TH Jr., Perlis RH. Characterizing DSM-5 and ICD-11 personality disorder features in psychiatric inpatients at scale using electronic health record. Psychological Medicine. 2020 50(13);2221-2229.

Biederman J, Fried R, DiSalvo M, Woodworth KY, Biederman I, Driscoll H, Noyes E, Faraone S, Perlis RH. Further evidence of low adherence to stimulant treatment in adult ADHD: an electronic medical record study examining timely renewal of a stimulant prescription. Psychopharmacology. 2020 237; 2835–2843.

Perlis, RH, Dowd, D, Fava, M, Lencz, T, Krause, DS. Randomized, controlled, participant- and rater-blind trial of pharmacogenomic test-guided treatment versus treatment as usual for major depressive disorder. Depress Anxiety. 2020 37; 834– 841. 

McCoy TH Jr., Pellegrini AM, Perlis RH. Differences among Research Domain Criteria score trajectories by Diagnostic and Statistical Manual categorical diagnosis during inpatient hospitalization. PLOS One. 2020 15(8); e0237698

Vuijk PJ, Martin J, Braaten EB, Genovese G, Capawana MR, O’Keefe SM Lee BA, Lind HS, Smoller JW, Faraone SV, Perlis RH, Doyle AE. Translating Discoveries in Attention-Deficit/Hyperactivity Disorder Genomics to an Outpatient Child and Adolescent Psychiatric Cohort. Journal of the American Academy of Child & Adolescent Psychiatry. 2020 59(8); 964-977.

Tseng CEJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zurcher NR, Hooker JM. In vivo human brain expression of histone deacetylases in bipolar disorder. Transl Psychiatry 2020.  10; 224.

Kathuria A, Lopez-Lengowski K, Jagtap SS, McPhie D, Perlis RH, Cohen BM, Karmacharya R. Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell–Derived Cerebral Organoids in Schizophrenia. JAMA Psychiatry. 2020 77(7):745–754.

Hart KL, Boitano LT, Tanious A, Conrad MF, Eagleton MJ, Lillemoe KD, Perlis RH, Srivastava SD. Trends in Female Authorship in High Impact Surgical Journals Between 2008 and 2018. 2020 DOI: 10.1097/sla.0000000000004057 

Gordon D, Ford A, Triedman N, Hart K, Perlis R. Health Care Consumer Shopping Behaviors and Sentiment: Qualitative Study. J Particip Med. 2020 12(2); e13924

Yu JZ, Wang J, Sheridan SD, Perlis RH, Rasenick MM.  N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. Mol Psychiatry 2020. https://doi.org/10.1038/s41380-020-0786-5

Castro VM, Perlis RH. Electronic Health Record Documentation of Psychiatric Assessments in Massachusetts Emergency Department and Outpatient Settings During the Coronavirus Disease 2019 (COVID-19) Pandemic. JAMA Netw Open. 2020 3(6);e2011346.

Hughes MC, Pradier MF, Ross AS, McCoy TH, Perlis RH, Doshi-Velez F. Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models. JAMA Netw Open. 2020 3(5); e205308.

Barroilhet SA, Bieling AE, McCoy TH Jr., Perlis RH. Association between DSM-5 and ICD-11 personality dimensional traits in a general medical cohort and readmission and mortality. General Hospital Psychiatry. 2020 64; 63-67.

Sonabend A, Pellegrini AM, Chan S, Brown HE, Rosenquist JN, Vuijk PJ, Doyle AE, Perlis RH, Cai T. Integrating questionnaire measures for transdiagnostic psychiatric phenotyping using word2vec. PLOS One, 2020 15(4); e0230663.

Edwards A, Perlis RH, & Krause D. 128 Factors Associated with Cost Savings Following Use of a Pharmacogenetic Assay in Individuals with Mood and Anxiety Disorders. CNS Spectrums. 2020 25(2); 281-282.

Pradier MF, McCoy Jr, TH, Hughes M, Perlis RH, Doshi-Velez F. Predicting treatment dropout after antidepressant initiation. Transl Psychiatry. 2020 10; 60.

Hart KL, Perlis RH, McCoy Jr. TH. What do patients learn about psychotropic medications on the web? A natural language processing study. Journal of Affective Disorders. 2020 260; 366-371.

McCoy Jr TH, Han L, Pellegrini AM, Tanzi RE, Berretta S, Perlis RH. Stratifying risk for dementia onset using large-scale electronic health record data: A retrospective cohort study. Alzheimer’s Dement. 2020 16;531-540.

2019

Doshi-Velez F, Perlis RH. Evaluating Machine Learning Articles. JAMA. 2019 322(18);1777-1779.

Jagtap S, Thanos JM, Fu T, Wang J, Lalonde J, Dial TO, Feiglin A, Chen J, Kohane I, Lee JT, Sheridan SD, Perlis RH. Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome. Hum Mol Genet. 2019 28(21); 3625-3636.

Moran LV, Guvenek-Cokol PE, Perlis RH. Attention-Deficit/Hyperactivity Disorder, Hypomania, and Bipolar Disorder in Youth. JAMA Psychiatry. 2019 76(11);1119–1121.

Biederman J, Fried R, DiSalvo M, Storch B, Pulli A, Woodworth KY, Biederman I, Faraone SV, Perlis RH. Evidence of low adherence to stimulant medication among children and youths with ADHD. An electronic health records study. Psychiatric Services. 2019 70(10);874-880.

Hart KL, Perlis RH. Trends in Proportion of Women as Authors of Medical Journal Articles, 2008-2018. JAMA Intern Med. 2019;179(9):1285–1287.

Skaljic M, Patel IH, Pellegrini AM, Castro VM, Perlis RH, Gordon DD. Prevalence of Financial Considerations Documented in Primary Care Encounters as Identified by Natural Language Processing Methods. JAMA Netw Open. 2019;2(8):e1910399.

Moran LV, Ongur D, Hsu J, Castro VM, Perlis RH, Schneeweiss S. Risk of Psychosis with Amphetamine versus Methylphenidate in Attention Deficit Hyperactivity Disorder. Pharmacoepidemiology and Drug Safety. 2019 28;41.

Perlis RH, Fava M, McCoy Jr TH. Can electronic health records revive central nervous system clinical trials? Mol Psychiatry. 2019 24, 1096–1098.

Biederman J, Fried R, DiSalvo M, Woodworth KY, Biederman I, Noyes E, Faraone SV, Perlis RH. A novel text message intervention to improve adherence to stimulants in adults with attention deficit/hyperactivity disorder. Journal of Clinical Psychopharmacology. 2019 39(4);351-356.

 Moran L, Ongur D, Hsu J, Castro V, Perlis R, Schneeweiss S. Psychosis with methylphenidate or amphetamine in patients with ADHD. NEJM. 2019 380;1129-1138.

McCoy TH, Wiste AK, Doyle AE, Pellegrini AM, Perlis RH. Association between child psychiatric emergency room outcomes and dimensions of psychopathology. General Hospital Psychiatry, 2019 59; 1-6.

Brown HE, Freudenreich O, Fan X, Heard SO, Goff D, Petrides G, Harrington AL, Kane JM, Judge H, Hoeppner B, Fava M, Perlis RH. Efficacy and Tolerability of Adjunctive Intravenous Sodium Nitroprusside Treatment for Outpatients With Schizophrenia: A Randomized Clinical Trial. JAMA Psychiatry. 2019 76(7):691–699

McCoy TH Jr, Pellegrini AM, Perlis RH. Research Domain Criteria scores estimated through natural language processing are associated with risk for suicide and accidental death. Depress Anxiety. 2019 36(5); 392-399.

Moran L, Ongur D, Hsu J, Castro V, Perlis R, Schneeweiss S. Comparative risk of psychosis with amphetamine versus methlyhenidate in adolescents and young adults with attention deficit hyperactivity disorder. Schizophrenia Bulletin, 2019 45 (Supplement 2); S201.

Chen C, Lee P, Castro V, Minnier J, Murphy S, Gainer V, Cai T, Sklar P, Perlis R, Smoller J. Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. European Neuropsychopharmacology. 2019 29(3); S9868-S969.

Zwicker A, Fabbri C, Gaston D, Denovan-Wright EM, Aitchison K, Peter M, Lewis CM, Perlis R, Castro V, Uher R. Genetic determinants of weight change during antidepressant treatment with selective serotonin re-uptake inhibitors: genome-wide study and meta-analysis. European Neuropsychopharmacology. 2019 29(3);S1000.

Hart KL, Perlis RH, Perlis CS. Conflict of interest and citation impact among dermatology guideline authors. J Am Acad Dermatol. 2019 Mar;80(3):813-815.

Hart KL, Brown HE, Roffman JL, Perlis RH. Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders. Neuropsychology. 2019 Mar;33(3):417-424.

Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, Fu T, Worringer K, Brown HE, Wang J, Kaykas A, Karmacharya R, Goold CP, Sheridan SD, Perlis RH. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019 Mar;22(3):374-385.

Hart KL, Frangou S, Perlis RH. Gender trends in authorship in psychiatry journals from 2008-2018. Biol Psychiatry. 2019 Feb 19. [Epub ahead of print]

McCoy TH Jr, Pellegrini AM, Perlis RH. Research Domain Criteria scores estimated through natural language processing are associated with risk for suicide and accidental death. Depress Anxiety. 2019 Feb 2. [Epub ahead of print]

McCoy TH Jr, Pellegrini AM, Perlis RH. Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8. Transl Psychiatry. 2019 Jan 29;9(1):45.

Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019 Jan 2;129(1):364-372.

2018

Perlis RH, Fava M, McCoy TH Jr. Can Electronic Health Records Revive Central Nervous System Clinical Trials? Mol Psychiatry. 2018 Nov 14. [Epub ahead of print]

McCoy TH Jr, Pellegrini AM, Perlis RH. Assessment of Time-Series Machine Learning Methods for Forecasting Hospital Discharge Volume. JAMA Netw Open. 2018 Nov 2;1(7):e184087.

Gordon DD, Patel I, Pellegrini AM, Perlis RH. Prevalence and Nature of Financial Discussions Documented in Narrative Clinical Records in Intensive Care Units: A Machine Learning Assessment of the MIMIC-III Cohort. JAMA Netw Open. 2018 Nov 2;1(7):e184178.

Snapper LA, Hart KL, Venkatesh KK, Kaimal AJ, Perlis RH. Cohort study of the relationship between individual psychotherapy and pregnancy outcomes. J Affect Disord. 2018 Oct 15;239:253-257.

Perlis RH, Mehta R, Edwards AM, Tiwari A, Imbens GW. Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study. Depress Anxiety. 2018 Oct;35(10):946-952.

McCoy TH Jr, Perlis RH. Temporal trends and characteristics of reportable health data breaches, 2010-2017. JAMA. 2018 Sep 25;320(12):1282-1284.

McCoy TH Jr, Hart K, Pellegrini A, Perlis RH. Genome-wide association identifies a novel locus for delirium risk. Neurobiol Aging. 2018 Aug;68:160.e9-160.e14.

Freedman R, Brown AS, Cannon TD, Druss BG, Earls FJ, Escobar J, Hurd YL, Lewis DA, López-Jaramillo C, Luby J, Mayberg HS, Moffitt TE, Oquendo M, Perlis RH, Pine DS, Rush AJ, Tamminga CA, Tohen M, Vieta E, Wisner KL, Xin Y. Can a Framework Be Established for the Safe Use of Ketamine? Am J Psychiatry. 2018 Jul 1;175(7):587-589.

McCoy TH Jr, Yu S, Hart KL, Castro VM, Brown HE, Rosenquist JN, Doyle AE, Vuijk PJ, Cai T, Perlis RH. High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records. Biol Psychiatry. 2018 Jun 15;83(12):997-1004.

McCoy TH Jr, Castro VM, Hart KL, Pellegrini AM, Yu S, Cai T, Perlis RH. Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records. Biol Psychiatry. 2018 Jun 15;83(12):1005-1011.

Fabbri C, Lewis CM, Perlis RH, Uher R. No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis. Am J Psychiatry. 2018 Jun 1;175(6):575-576.

Perlis RH. Anxiety About Antidepressants. Am J Psychiatry. 2018 Jun 1;175(6):500-501.

McCoy TH Jr, Fragomen AT, Hart KL, Pellegrini AM, Raskin KA, Perlis RH. Genomewide Association Study of Fracture Nonunion Using Electronic Health Records. JBMR Plus. 2018 May 29.

Brown HE, Hart KL, Snapper LA, Roffman JL, Perlis RH. Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders. NPJ Schizophr. 2018 May 28;4(1):9.

Chen CY, Lee PH, Castro VM, Minnier J, Charney AW, Stahl EA, Ruderfer DM, Murphy SN, Gainer V, Cai T, Jones I, Pato CN, Pato MT, Landén M, Sklar P, Perlis RH, Smoller JW. Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. Transl Psychiatry. 2018 Apr 18;8(1):86.

McCoy TH, Castro VM, Cagan A, Snapper L, Roberson A, Perlis RH. Cytochrome P450 interactions are common and consequential in Massachusetts hospital discharges. Pharmacogenomics J. 2018 Apr;18(2):347-350.

Sagers JE, Brown AS, Vasilijic S, M Lewis R, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep. 2018 Apr 3;8(1):5437.

2017

Ravichandran C, Shinn AK, Öngür D, Perlis RH, Cohen B. Frequency of non-right-handedness in bipolar disorder and schizophrenia. Psychiatry Res. 2017 Jul;253:267-269.

Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ. Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study. J Perinatol. 2017, 37(9);1003-1009.

McCoy TH, Hart KL, Perlis RH. Characterizing and predicting rates of delirium across general hospital settings. Gen Hosp Psychiatry. 2017 May;46:1-6.

Venkatesh KK, Kaimal AJ, Castro VM, Perlis RH.Improving discrimination in antepartum depression screening using the Edinburgh Postnatal Depression Scale.J Affect Discord. 2017 May;214:1-7.

Pavlova B, Perlis RH, Mantere O, Sellgren CM, Isometsä E, Mitchell PB, Alda M, Uher R. Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis. Psychol Med. 2017 Apr;47(6):1107-1115.

García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K; Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium, Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C. Pharmacogenetics of antidepressant response: A polygenic approach. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:128-134.

McCoy TH Jr, Chaukos DC, Snapper LA, Hart KL, Stern TA, Perlis RH. Enhancing Delirium Case Definitions in Electronic Health Records Using Clinical Free Text. Psychosomatics. 2017 Mar - Apr;58(2):113-120.

Bigdeli TB, Ripke S, Peterson RE, Trzaskowski M, Bacanu SA, Abdellaoui A, Andlauer TF, Beekman AT, Berger K, Blackwood DH, Boomsma DI, Breen G, Buttenschøn HN, Byrne EM, Cichon S, Clarke TK, Couvy-Duchesne B, Craddock N, de Geus EJ, Degenhardt F, Dunn EC, Edwards AC, Fanous AH, Forstner AJ, Frank J, Gill M, Gordon SD, Grabe HJ, Hamilton SP, Hardiman O, Hayward C, Heath AC, Henders AK, Herms S, Hickie IB, Hoffmann P, Homuth G, Hottenga JJ, Ising M, Jansen R, Kloiber S, Knowles JA, Lang M, Li QS, Lucae S, MacIntyre DJ, Madden PA, Martin NG, McGrath PJ, McGuffin P, McIntosh AM, Medland SE, Mehta D, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nauck M, Nyholt DR, Nöthen MM, Owen MJ, Penninx BW, Pergadia ML, Perlis RH, Peyrot WJ, Porteous DJ, Potash JB, Rice JP, Rietschel M, Riley BP, Rivera M, Schoevers R, Schulze TG, Shi J, Shyn SI, Smit JH, Smoller JW, Streit F, Strohmaier J, Teumer A, Treutlein J, Van der Auwera S, van Grootheest G, van Hemert AM, Völzke H, Webb BT, Weissman MM, Wellmann J, Willemsen G, Witt SH, Levinson DF, Lewis CM, Wray NR, Flint J, Sullivan PF, Kendler KS. Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry. 2017 Mar 28;7(3):e1074.

Harper DG, Jensen JE, Ravichandran C, Perlis RH, Fava M, Renshaw PF, Iosifescu DV. Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression. Neuropsychopharmacology. 2017 Mar;42(4):876-885.

Sellgren CM, Sheridan SD, Gracias J, Xuan D, Fu T, Perlis RH. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol Psychiatry. 2017 Feb; 22(2): 170–177.

McCoy TH, Castro V, Cagan A, Roberson AM, Perlis RH. Validation of a risk stratification tool for fall-related injury in a state-wide cohort. Brit Med J Open. 2017 Feb 6;7(2):e012189.

Barak-Corren Y, Castro VM, Javitt S, Hoffnagle AG, Dai Y, Perlis RH, Nock MK, Smoller JW, Reis BY. Predicting Suicidal Behavior From Longitudinal Electronic Health Records. Am J Psychiatry. 2017 Feb 1;174(2):154-162.

Charney AW, Ruderfer DM, Stahl EA, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Di Florio A, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Green EK, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Roussos P, Knowles JA, Jones I, Jones LA, Hultman CM, Perlis RH, Purcell SM, McCarroll SA, Pato CN, Pato MT, Craddock N, Landén M, Smoller JW, Sklar P. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Transl Psychiatry. 2017 Jan 10;7(1):e993.

2016

Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, Amin N, Baune BT, Bennett DA, Blackwood DH, Boomsma D, Breen G, Buttenschøn HN, Byrne EM, Børglum AD, Castelao E, Cichon S, Clarke TK, Cornelis MC, Dannlowski U, De Jager PL, Demirkan A, Domenici E, van Duijn CM, Dunn EC, Eriksson JG, Esko T, Faul JD, Ferrucci L, Fornage M, de Geus E, Gill M, Gordon SD, Grabe HJ, van Grootheest G, Hamilton SP, Hartman CA, Heath AC, Hek K, Hofman A, Homuth G, Horn C, Jan Hottenga J, Kardia SL, Kloiber S, Koenen K, Kutalik Z, Ladwig KH, Lahti J, Levinson DF, Lewis CM, Lewis G, Li QS, Llewellyn DJ, Lucae S, Lunetta KL, MacIntyre DJ, Madden P, Martin NG, McIntosh AM, Metspalu A, Milaneschi Y, Montgomery GW, Mors O, Mosley TH Jr, Murabito JM, Müller-Myhsok B, Nöthen MM, Nyholt DR, O'Donovan MC, Penninx BW, Pergadia ML, Perlis R, Potash JB, Preisig M, Purcell SM, Quiroz JA, Räikkönen K, Rice JP, Rietschel M, Rivera M, Schulze TG, Shi J, Shyn S, Sinnamon GC, Smit JH, Smoller JW, Snieder H, Tanaka T, Tansey KE, Teumer A, Uher R, Umbricht D, Van der Auwera S, Ware EB, Weir DR, Weissman MM, Willemsen G, Yang J, Zhao W, Tiemeier H, Sullivan PF. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biol Psychiatry. 2016 Dec 8; S0006-3223(16)33068-2.

Bernhard RM, Chaponis J, Siburian R, Gallagher P, Ransohoff K, Wikler D, Perlis RH, Greene JD. Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Soc Cogn Affect Neurosci. 2016 Dec; 11(12):1872-1881.

Rumshisky A, Ghassemi M, Naumann T, Szolovits P, Castro VM, McCoy TH, Perlis RH. Predicting early psychiatric readmission with natural language processing of narrative discharge summaries. Transl Psychiatry. 2016 Oct 18;6(10):e921.

Perlis RH. Abandoning personalization to get to precision in the pharmacotherapy of depression. World Psychiatry. 2016 Oct; 15(3):228-235.

McCoy TH Jr, Castro VM, Roberson AM, Snapper LA, Perlis RH. Improving Prediction of Suicide and Accidental Death After Discharge From General Hospitals With Natural Language Processing. JAMA Psychiatry. 2016 Oct 1; 73(10):1064-1071.

McCoy TH Jr, Snapper L, Stern TA, Perlis RH. Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling. Psychosomatics. 2016 Sep-Oct; 57(5):480-8.

Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, Tung JY, Hinds DA, Perlis RH, Winslow AR. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet. 2016 Sep; 48(9):1031-6.

Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA; Members of the International Cohort Collection for Bipolar Disorder (ICCBD), Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016 Sep;21(9):1290-7.

Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F, Che Y, Shanmugasundaram V, Lefker BA, Enerson BE, Livni E, Wang L, Guehl NJ, Patnaik D, Wagner FF, Perlis R, Holson EB, Haggarty SJ, El Fakhri G, Kurumbail RG, Vasdev N. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016 Aug 8; 55(33):9601-5.

Perlis RH. Autism and antidepressant use in pregnancy. J Pediatr. 2016 Jul; 174:278.

Haggarty SJ, Silva MC, Cross A, Brandon NJ, Perlis RH. Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models. Mol Cell Neurosci. 2016 Jun;73:104-15.

Corral-Frías NS, Pizzagalli DA, Carré JM, Michalski LJ, Nikolova YS, Perlis RH, Fagerness J, Lee MR, Conley ED, Lancaster TM, Haddad S, Wolf A, Smoller JW, Hariri AR, Bogdan R. COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. Genes Brain Behav. 2016 Jun;15(5):503-13.

Balekian DS, Linnemann RW, Castro VM, Perlis R, Thadhani R, Camargo CA Jr. Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy. Pediatr Allergy Immunol. 2016 Jun; 27(4):413-8.

Perlis RH, Perlis CS. Physician Payments from Industry Are Associated with Greater Medicare Part D Prescribing Costs. PLoS One. 2016 May 16; 11(5):e0155474.

 Venkatesh KK, Riley L, Castro VM, Perlis RH, Kaimal AJ. Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth. Obstet Gynecol. 2016 May; 127(5):926-33.

McGrath LM, Braaten EB, Doty ND, Willoughby BL, Wilson HK, O'Donnell EH, Colvin MK, Ditmars HL, Blais JE, Hill EN, Metzger A, Perlis RH, Willcutt EG, Smoller JW, Waldman ID, Faraone SV, Seidman LJ, Doyle AE. Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth. J Child Psychol Psychiatry. 2016 Apr;57(4):462-71.

Sylvia LG, Gold AK, Stange JP, Peckham AD, Deckersbach T, Calabrese JR, Weiss RD, Perlis RH, Nierenberg AA, Ostacher MJ. A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder. Am J Addict. 2016 Mar; 25(2):94-8.

Vöhringer PA, Perlis RH. Discriminating Between Bipolar Disorder and Major Depressive Disorder. Psychiatr Clin North Am. 2016 Mar; 39(1):1-10.

Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet. 2016 Mar 12; 387(10023):1085-93.

Roberson AM, Castro VM, Cagan A, Perlis RH. Antidepressant nonadherence in routine clinical settings determined from discarded blood samples. J Clin Psychiatry. 2016 Mar;77(3):359-62.

Castro VM, Roberson AM, McCoy TH, Wiste A, Cagan A, Smoller JW, Rosenbaum JF, Ostacher M, Perlis RH. Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study. Neuropsychopharmacology. 2016 Mar;41(4):1138-43.

Castro VM, Kong SW, Clements CC, Brady R, Kaimal AJ, Doyle AE, Robinson EB, Churchill SE, Kohane IS, Perlis RH. Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study. Transl Psychiatry. 2016 Jan 5;6:e708.

2015

Perlis RH. Getting Past Proof of Concept For New Treatments. Am J Psychiatry. 2015 Oct;172(10):937-8.

McCoy TH, Castro VM, Cagan A, Roberson AM, Kohane IS, Perlis RH. Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study. PLoS One. 2015 Aug 24; 10(8):e0136341.

Pavlova B, Perlis RH, Alda M, Uher R. Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry. 2015 Aug;2(8):710-7.

Uchida M, Spencer AE, Biederman J, Castro VM, Kenworthy T, Chan J, Rosales AM, Newton-Cheh C, Perlis RH. A Systematic Evaluation of the QTc Interval and Antidepressants in Youth: An Electronic Health Record Study. J Dev Behav Pediatr. 2015 Jul-Aug;36(6):434-9.

Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Neuron. 2015 Jun 3;86(5):1189-202.

Ostacher MJ, Perlis RH, Geddes J. Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder. Am J Psychiatry. 2015 Jun;172(6):586.

Ramos EM, Gillis T, Mysore JS, Lee JM, Alonso I, Gusella JF, Smoller JW, Sklar P, MacDonald ME, Perlis RH. Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder. Bipolar Disord. 2015 Jun;17(4):403-8.

Rotstein BH, Liang SH, Belov VV, Livni E, Levine DB, Bonab AA, Papisov MI, Perlis RH, Vasdev N. Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist. Molecules. 2015 May 26;20(6):9550-9.

Brennan FX, Gardner KR, Lombard J, Perlis RH, Fava M, Harris HW, Scott R. A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders. Prim Care Companion CNS Discord. 2015 Apr 16; 17(2).

Uher R, Ripke S, Müller-Myhsok B, Lewis CM, Perlis RH. Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.Am J Psychiatry. 2015 Apr;172(4):395-7.

Castro VM, Minnier J, Murphy SN, Kohane I, Churchill SE, Gainer V, Cai T, Hoffnagle AG, Dai Y, Block S, Weill SR, Nadal-Vicens M, Pollastri AR, Rosenquist JN, Goryachev S, Ongur D, Sklar P, Perlis RH, Smoller JW; International Cohort Collection for Bipolar Disorder Consortium. Validation of electronic health record phenotyping of bipolar disorder cases and controls. Am J Psychiatry. 2015 Apr;172(4):363-72.

McCoy TH, Castro VM, Rosenfield HR, Cagan A, Kohane IS, Perlis RH. A clinical perspective on the relevance of research domain criteria in electronic health records. Am J Psychiatry. 2015 Apr;172(4):316-20.

McCoy TH Jr, Perlis RH. A tool to utilize adverse effect profiles to identify brain-active medications for repurposing. Int J Neuropsychopharmacol. 2015 Feb 11;18(3).