The Pediatric Translational Research Center (PTRC) was founded to develop effective new personalized and preventative strategies for disorders starting in childhood.


The research mission of Pediatric Translational Research Center (PTRC) is to advance translational fundamental, clinical and population science related to the health and development of infants, children and adolescents. Research at MassGeneral for Children recognizes the challenges and opportunities for child health research dictated by the changing social, economic and health care policy landscape in the US, including the shift toward Precision Medicine. Across the Department, our research integrates multidisciplinary clinical and scientific expertise with local, regional, national and international collaborations.


Our focus is to develop new effective strategies for personalized and preventive medicine. The advent of genomics, proteomics, and now microbiome analysis raised the expectation of therapeutic solutions that never materialized. It is now becoming clear that many diseases affecting humankind are final destinations, but the path to disease development can be different from patient to patient. Unfortunately, the complexity, the multi-factorial nature and, most importantly, the lack of information on the environmental factors triggering the disease process have hampered the progress in defining host-environmental interactions causing disease in genetically susceptible individuals.

Strategic Priority

With the appreciation that the biological events in childhood can strongly influence disease onset in both childhood and adulthood, we intend to expand our integrated models focused on pre-clinical/early and translational clinical studies to provide the rationale of possible therapeutic and/or preventive interventions. Our strategic priority is to increase PTRC visibility and branding to expand our current research portfolio in order to become a unique asset complementary to the overall mission of the DCR and the Mass General Research Institute as a whole.


Our overarching goal is to improve the lives of children and families through science. A current strategic priority is to develop new effective personalized and preventive strategies for disorders starting in childhood by integrating multi-level, multisystem data ranging from the molecular to the whole child in order to prevent or reverse development of disease.