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Research at Mass General
Articles about the scientists and research initiatives at Massachusetts General Hospital, home to the largest hospital-based research enterprise in the United States.
Endowed MGH Research Institute Chairs provide flexible and sustainable long-term support that our researchers can use to follow their science wherever it leads. Because of visionary donors who recognize the power of science to transform medicine, there have been four Endowed MGH Research Institute Chairs established since 2015.
Three researchers from Massachusetts General Hospital were included in the 2018 class of STAT Wunderkinds. The awards were founded to recognize up-and-coming doctors and researchers who are on the cusp of launching their careers.
As it turns out, there are two different types of e-cigarette systems, each carrying a different set of risks. And for parents who are worried about their kids using e-cigarettes, it’s important to know the difference between the two, say a Mass General research team led by Jonathan Winickoff, MD, MPH, director of Pediatric Research at the Tobacco Research and Treatment Center.
Clostridium perfringens is a common foodborne illness that causes nearly 1 million infections each year. The bacterium has many environmental sources, but is typically found on raw meat and poultry.
Despite progress, gender disparities still exist in science and medicine. Recent research has found that women are often offered lower pay and do not receive equal opportunities to advance to leadership positions. Mothers are also at a disadvantage in trying to balance their professional and personal lives. To help address this disparity, Mass General’s Claflin Distinguished Scholars Awards provide financial support to help maintain research productivity during child-rearing years for junior faculty.
A new research study from Rudolph Tanzi, PhD, and Robert Moir, PhD, researchers in the Department of Neurology at Massachusetts General Hospital, has uncovered a Jekyll and Hyde role for a naturally occurring protein in the brain most commonly associated with Alzheimer’s disease (AD).
New research from a team based at Massachusetts General Hospital, the Harvard Department of Stem Cell and Regenerative Biology (HSCRB), Harvard Medical School (HMS), and the Harvard Stem Cell Institute (HSCI) shows that exercise can increase the generation of new heart cells, which might be crucial to maintaining heart function as we age.
The Neurological Clinical Research Institute (NCRI) based at Mass General is a team of over 60 staff members dedicated to developing, facilitating, and conducting multicenter clinical trials in ALS and other neurological diseases.
A new study published in Journal of Alternative and Complementary Medicine from researchers at Massachusetts General Hospital, the Benson-Henry Institute for Mind Body Medicine at Mass General, and Beth Israel Deaconess Medical Center, has found a possible explanation for why performing activities such as yoga and meditation can help patients reduce their high blood pressure without medication.
A new initiative from the Department of Medicine, the Pathways Service provides a way for medical residents to discuss unusual patient cases and initiate new research projects based on the questions the cases raise.
Md “Nabi” Nurunnabi, PhD, is a postdoctoral research fellow at the Massachusetts General Hospital Center for Systems Biology (CSB) and the Cardiovascular Research Center (CVRC). He is working on the design and development of target-specific therapeutic approaches for various diseases such as cancer, diabetes, fibrosis, and cardiovascular (stroke and myocardial infarction) along with immunology.
A recent study from Massachusetts General Hospital suggests that following the Dietary Approaches to Stop Hypertension (DASH) diet may reduce the risk of gout.
To help ease concerns and keep food allergy sufferers safe, a team of researchers at Massachusetts General Hospital has developed a new device small enough to fit on a keyring that costs only $40 and can quickly and accurately test for food allergens.
Shiqian Shen, MD, and Jianren Mao, MD, PhD, are leading a research team in exploring why patients undergoing chemotherapy develop CIPN.
Fibromyalgia has traditionally been a challenge to diagnose and treat, because there is no test for it. Doctors make the diagnosis based on patient reported symptoms. Researchers at Mass General are hoping to change that by using imaging techniques to demonstrate brain changes in fibromyalgia patients and investigating potential causes for the disease.
They say that eyes are the windows to the soul, but for individuals with autism, a lack of eye contact can reveal much more. A team of investigators based at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital has shed light on why those with autism often avoid looking others in the eyes.
Researchers from the Center for Celiac Research and Treatment at Massachusetts General Hospital and the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children (MGHfC) recently came out with a study published in Molecular Autism. Here are five things to know.
Massachusetts General Hospital researcher Jennifer Gatchel, MD, PhD, is using brain imaging technology to learn more about the connections between mental illness and cognitive decline in aging populations.
Scott Plotkin, MD, PhD, and Vijaya Ramesh, PhD, are using their respective expertise in clinical and fundamental science to investigate new treatments for neurofibromatosis and two related disorders.
Like a pebble thrown into a still body of water, a new study from the Mass General Center for Systems Biology has found that white blood cells called macrophages create a ripple effect in the heart that can lead to development of a condition known as heart failure with preserved ejection fraction, or HFpEF.
While it may not have been called rare disease research by name, Massachusetts General Hospital has been identifying and tracking rare diseases for more than a century, says Florian Eichler, MD, Director of the Center for Rare Neurological Diseases in the Department of Neurology. By combining new genetic insights with new models of collaborative research, Eichler and other clinician-investigators at Mass General are working to develop much needed new treatments for rare disease patients.
Mass General researcher Bryan Hurley, PhD, is exploring how controlling the infection and inflammation associated with cystic fibrosis could be the key to developing improved therapies for patients.
Jacqueline Lane, PhD, a postdoctoral researcher at Massachusetts General Hospital, is studying genetic factors that impact our sleep.
Joel Salinas, MD, is using data from long-term research studies to gain insights into how strong social networks help to promote brain health in individuals as they age.
Caroline Mitchell, MD, MPH, a researcher at the Vincent Center for Reproductive Biology at Massachusetts General Hospital, is studying how microbial changes in the female reproductive tract impact health outcomes across the lifecycle of women.
Elsie Taveras, MD, MPH, uses a combination of clinical and community-based research approaches to address the causes of childhood health problems and reduce health disparities.
Massachusetts General Hospital researcher Casey Maguire, PhD, is developing new strategies to shield virus-based gene therapy treatments from the immune system to help patients with genetic disorders.
Kamryn Eddy, PhD, is part of a research team that recently published the results of a long-term study analyzing the recovery rates of patients with eating disorders. What the team found provides new reasons for hope for individuals with bulimia and anorexia.
Basak Uygun, PhD, a researcher at the Center of Engineering in Medicine at Massachusetts General Hospital, is working on ways to create bioengineered livers in the lab that could one day be used in patients with liver failure.
Peter Moschovis, MD, MPH, is helping to develop new digital technology that could provide an efficient and cost effective way to diagnose childhood respiratory illnesses across the globe.
A research team at Massachusetts General Hospital is hoping to create new treatments for shigellosis, a potentially fatal digestive disorder, by factoring in genetic changes that occur in Shigella bacteria during the journey through the human digestive system.
Dr. Brown, Director of the Massachusetts General Hospital Program in Membrane Biology, is looking at the body as a system of water transportation with the goal of generating treatments for life-threatening water balance disorders.
Dr. Stanford, an Obesity Medicine Physician at the Massachusetts General Hospital Weight Center, an Associate at the Mass General Disparities Solution Center, and Associated Faculty at the Mass General Mongan Institute for Health Policy, is taking a holistic approach to both treat and advocate for patients who have obesity.
Dr. Hyle is an infectious disease clinician investigator at Massachusetts General Hospital, is investigating ways to improve outcomes for patients with HIV and to measure the effectiveness of medical interventions to prevent disease transmission during international travel.
A dramatic video illustrating the consequences of letting HIV care lapse is being tested as a public health intervention in the Latino immigrant community.
Eve Valera, PhD, a researcher at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital, is working to learn more about the traumatic brain injuries suffered by women in abusive relationships.
Marcia Goldberg, MD, the new Director of the Postdoctoral Division at Massachusetts General Hospital, hopes to make a positive impact on the next generation of scientists by providing mentorship and career advice.
It has often been said that searching for genetic clues to rare disease is like looking for a needle in a haystack. It’s even more difficult when you’re not sure what makes the needle different from the hay.
That was essentially the challenge facing researchers in rare disease genetics up until two years ago, when a team led by Daniel MacArthur, PhD, launched the Exome Aggregation Consortium (ExAC) database.
Pediatric anesthesiologist Paul Firth, MBChB, has spent the past two decades studying the medical case histories of mountain climbers and other adventurers to create a more complete picture of how the body functions in extreme conditions.
Researchers Alik Widge, MD, PhD, and Husam Katnani, PhD, are part of a team that is working on a more nuanced approach to deep brain stimulation that could help patients with traumatic brain injuries, treatment resistant depression and post traumatic stress disorder.
Cammie Lesser, MD, PhD, has always been fascinated by the way bacterial pathogens manipulate cells inside the human body. She likens the push and pull between bacterial aggression and human response as a struggle similar to warfare on the microbiological level.
A new process that makes it possible to replicate adult human stem cells in the lab has the potential to provide researchers with game-changing insights into the progression of diseases in the lungs and other organs.
A conversation with Brad Bernstein, MD, PhD, the inaugural Bernard and Mildred Kayden Endowed MGH Research Institute Chair.
John Stone, MD, MPH, is developing a new clinical trial to investigate a treatment for IgG-4 related disease, a condition that causes the growth of excessive fibrous tissue in the organs and is often misdiagnosed as lymphoma.
The leaders of the Community Research Program at MGH Chelsea discuss the role that research can play in improving the health outcomes of the residents in their community.
Martinos Center researchers Nouchine Hadjikhani, MD, PhD and Daphne Holt, MD, PhD, are using brain imaging technology to learn more about how individuals with autism and schizophrenia view the world through different lenses.
As an elected ECOR representative, Sylvie Breton, PhD, has advocated for new programs and initiatives to support researchers at Massachusetts General Hospital. She has also made connections across the institution that have aided the research efforts in her lab.
Researchers in the Division of Infectious Disease at Massachusetts General Hospital say that the elimination of funding to the Fogarty International Center could result in significant setbacks to infectious disease research and treatment worldwide.
Farrah J. Mateen, MD, PhD, Director of the MGH Multiple Sclerosis Clinic at Massachusetts General Hospital, is investigating whether light therapy could improve symptoms of fatigue in patients with multiple sclerosis.
A large scale analysis of genetic information from individuals with Tourette syndrome led by researchers at Massachusetts General Hospital and UCLA has identified alterations in two genes that significantly increase the risk of developing the disorder.
A team of researchers from the Massachusetts General Hospital and MIT have developed an innovative new strategy for treating pancreatic cancer with an implantable mesh patch designed to deliver chemotherapy drugs directly to the cancer site.
Patrick Fortune, PhD, MBA, draws on his vast background in research and business development to identify research breakthroughs that have the potential for commercial use, and to connect our researchers with members of industry.
Researchers at the Health Decision Sciences Center at Massachusetts General Hospital are working on ways to better involve patients in decisions about their medical care.
One Massachusetts General Hospital researcher is looking for innovative approaches to address the many challenges of long distance space travel.
Motivated by the challenges she faced in establishing her career as a female mechanical engineer in the 1950s and 1960s, philanthropist Brit d'Arbeloff continues to be a positive force for gender equality in the sciences.
President Donald Trump's proposed budget for Fiscal 2018, which calls for a 20% reduction in funding for the National Institutes of Health, would have a devastating effect on research at Massachusetts General Hospital and across the country, says Harry W. Orf, PhD, senior vice president for research.
How do you stop a deadly case of arrested development? That’s the question that prompted a six-year pursuit into the mechanisms underlying acute myeloid leukemia (AML) for David Sykes, MD, PhD, David Scadden, MD, and a team of collaborators from Massachusetts General Hospital, the Broad Institute, Bayer Pharma and the University of New Mexico.
Recently, $3.6 million of the funds raised by The ALS Association through the Ice Bucket Challenge and the ALS Finding a Cure foundation came to Mass General in a grant to support NeuroBANK, an online platform that was created to address the challenges of compiling patient data for ALS research.
A team of researchers at Massachusetts General Hospital including Andrew Rennekamp, PhD, is using behavior changes in zebrafish larvae to learn more about the brain mechanisms behind psychosis and threat response.
The All of Us Research Program is a national initiative with a goal of building a cohort of one million or more volunteer participants who reflect the diversity of America.
The three-day event provided an opportunity for three Mass General specialists to collaborate an innovative plan for reversing overdoses before they cause lasting damage.
A research team from Massachusetts General Hospital has returned to Antarctica to continue their study of Weddell Seals, world-champion diving mammals with unique adaptations that allow them to spend more than an hour underwater without surfacing for air.
The Global Neurology Research Group has created a multilingual coloring book to explain epilepsy to children around the world and reduce myths and stigma surrounding seizures. My Thinking Cap, A Coloring Book About Epilepsy introduces us to Ella, Dot, and Jon-Jon, a young boy with epilepsy.
Farrah Mateen, MD, PhD, divides her time between seeing patients at Massachusetts General Hospital and traveling across the globe researching innovative solutions for global neurological care.
Researchers will convene at Massachusetts General Hospital this fall to race strains of cells against each other in an effort to learn more about the mechanisms of sepsis—a devastating, costly and often fatal condition.
Emery Brown, MD, PhD, and a team of collaborating investigators from Massachusetts General Hospital are hoping to make a fundamental change in the way anesthesiologists think about the process of sedation—one that changes the focus from the body to the brain.
Kira Grogg, PhD, a researcher at the Gordon Center for Medical Imaging at Massachusetts General Hospital, is working to develop a methodology that will allow for better tracking and more precise delivery of proton beam therapy treatments for cancer patients.
A team of investigators led by Laura Germine, PhD, is using web-based tests to gain valuable insights into the way we think and process information.
Sekar Kathiresan, MD, medical director for the Cardiology Division, and his team of investigators – led by cardiologist Pradeep Natarajan, MD, and research coordinator Erina Kii in the Center for Human Genetic Research – are looking for a needle in a haystack.
Sagar Nigwekar, MD, MMSc, is using patient samples from the Partners Biobank to gain a better understanding of a rare but painful and debilitating condition called calciphylaxis.
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