Despite recent scientific breakthroughs that have vastly improved our understanding of some drivers of disease, there's one part of the body that remains shrouded in mystery—the human brain.
This is due, in part, to the unparalleled complexity of the brain—a 3-pound organ with billions of nerve cells and fibers connected by trillions of synapses—as well as the difficulty in observing brain processes in living humans.
These unknowns make it challenging to identify changes that occur in the brains of individuals with disorders such as depression, bipolar disorder and schizophrenia. If we're still not sure how a healthy brain works, how can we figure out what goes wrong in disease?
Mass General researcher Jacob Hooker, PhD, Phyllis and Jerome Lyle Rappaport MGH Research Scholar 2016-2021, is working to answer some of these questions using creative brain imaging strategies. Learn more.