MGH Research Scholars Program
The MGH Research Scholars Program was established to support early career researchers with innovative yet unproven ideas that have the potential to transform the future of medicine. Funded 100% through philanthropy, this program gives researchers the freedom and flexibility they need to follow the science wherever it leads. History has shown that brilliant scientists who are given free rein to explore new frontiers make the greatest, often unexpected, advances.
MGH Research Scholar Nicholas Dyson, PhD, is studying the role of the retinoblastoma tumor suppressor, which is expressed in most cell types and enables them to stop dividing.
Understanding the Function of the Retinoblastoma Protein—A Key Tumor Suppressor
The Dyson laboratory studies the role of the retinoblastoma tumor suppressor (pRB). pRB is expressed in most cell types and its functions enable cells to stop dividing.
pRB is inactivated in many types of cancer; a change that is thought to be an important step in tumor progression.
The Dyson lab has three main goals:
- To understand the molecular details how how pRB acts
- To know how the inactivation of pRB changes the cell
- To use these insights to target tumor cells