About the Research Thrust
Through cancer biology research, the Department of Surgery at Massachusetts General Hospital is developing breakthroughs on the underlying mechanisms of cancer—including the growth, spread and maintenance of cancer cells—to inform cutting-edge treatments.
Therapeutic Intralesional Program
The Therapeutic Intralesional Program is a multi-disciplinary team of clinicians and researchers working together to create infrastructure and a community of experts focused on direct-to-tumor therapies across multiple tumor types.
Center for Engineering in Medicine and Surgery
The Center for Engineering in Medicine & Surgery (CEMS) at Massachusetts General Hospital are the ambassadors of bioengineering, bringing technology to the forefront of biomedical research and the practice of medicine.
Laboratories and Researchers
Irit Adini, PhD
Irit Adini, PhD, is an investigator at the Mass General Center for Engineering in Medicine & Surgery. Dr. Adini's research focuses on the role of the melanocytic microenvironment in tissue neovascularization-dependent disorders and inflammatory skin disorders, such as age-related macular degeneration, cancer and connective tissue diseases.
The Laboratory of Hugh Auchincloss, MD, uses institutional data combined with large national and international databases to answer questions about the treatment and prognosis of lung cancer and other thoracic surgery diseases.
The Boland Laboratory, led by Genevieve Boland, MD, PhD, focuses on blood-based techniques for assessing changes in the tumor microenvironment through analysis of circulating exosomes.
Research in the Laboratory of Yolonda Colson, MD, PhD, focuses on surgical innovation and surgical oncology, with NIH funding to study several novel approaches to cancer therapy with prior expertise in transplantation immunology and immune recognition.
Research topics in the Cusack Laboratory, led by James Cusack, MD, include molecular targeted therapies for colorectal cancer, melanoma, Merkel cell cancer and carcinomatosis, and improving delivery of surgical cancer care in resource-limited settings.
Head and Neck Translational Immuno-Oncology Research Laboratory
The Head and Neck Translational Immuno-Oncology Research Laboratory, led by Sara Pai, MD, PhD, is to rapidly translate innovative, biomarker-driven immunotherapies that have the potential to improve treatment outcomes for patients with head and neck cancer.
The Laboratory of Michael Lanuti, MD, leads translational research with the goal of designing novel therapeutics to treat lung and esophageal cancer to bring to clinical trials.
N. Murat Karabacak, PhD
N. Murat Karabacak, PhD, is an investigator at the Center for Engineering in Medicine & Surgery. Dr. Karabacak’s work is at the interface of mass spectrometry, microfluidics and medicine.
The Liss Laboratory, led by Andrew Liss, PhD, is interested in understanding the molecular mechanisms that contribute to pancreatic cancer.
Research topics in the Maheswaran Laboratory, led by Shyamala Maheswaran, PhD, include tumorigenesis, breast cancer and cancer genetics.
Oncolytic Virus Research Laboratory
The Oncolytic Virus Research Laboratory, led by Howard Kaufman, MD, FACS, seeks to understand how oncolytic viruses, a new class of tumor immunotherapy or cancer treatment, mediate antitumor activity.
Pancreatic Biology Research Laboratory
The focus of the basic and translational laboratory efforts is the molecular mechanisms underlying the initiation, progression and maintenance of pancreatic disease and cancer, specifically the contribution of developmental genes.
The Laboratory of Uma Sachdeva, MD, PhD, uses 3D culture models of human and mouse-derived cells to study the pathogenesis of esophageal cancer.
The research focuses of Lana Schumacher-Beal, MD, center on robotic surgery to treat lung and esophageal cancer in women.
Research topics in the Tanabe Laboratory, led by Kenneth Tanabe, MD, include hepatobiliary cancer, epidermal growth factor and hepatocellular carcinoma.
Thyroid Cancer Research Laboratory
The main focus of the Thyroid Cancer Research Laboratory, led by Sareh Parangi, MD, is to study certain key genetic and epigenetic changes seen more frequently in those patients who do poorly, and find out how exactly these genetic changes lead to more aggressive cancer behavior in those patients.
The Wang Laboratory, led by Xinhui Wang, MD, PhD, is focused on two major research initiatives: targeting cancer stem cells and immunotherapy for cancers.
Dr. Wright is interested in thymic tumors (both thymomas and thymic cancers) and has published on the surgical and multimodality treatment of thymic neoplasms. Dr. Wright has published extensively on outcomes based upon this robust national database as well as developed risk-models to predict and compare results of lung cancer and esophageal cancer resection.
The clinical and translational research of Chi-Fu Jeffrey Yang, MD, aims to improve care for patients with lung cancer and other diseases of the chest.
#1 Research Hospital in America
Mass General is the #1 hospital in New England based on U.S. News & World Report Best Hospitals for 2022-2023.
Annual Research Funding
150+ staff members carry out basic science, outcomes and clinical research.
Research at the Mass General Department of Surgery
Research is a critical element of patient-care. When research advances are made, the lives of patients everywhere are directly impacted for the better.