About the Research Thrust
Through cancer biology research, the Department of Surgery at Massachusetts General Hospital is developing breakthroughs on the underlying mechanisms of cancer—including the growth, spread and maintenance of cancer cells—to inform cutting-edge treatments.
Therapeutic Intralesional Program
The Therapeutic Intralesional Program is a multi-disciplinary team of clinicians and researchers working together to create infrastructure and a community of experts focused on direct-to-tumor therapies across multiple tumor types.
Center for Engineering in Medicine and Surgery
The Center for Engineering in Medicine & Surgery (CEMS) at Massachusetts General Hospital are the ambassadors of bioengineering, bringing technology to the forefront of biomedical research and the practice of medicine.
Laboratories and Researchers
Irit Adini, PhD
Irit Adini, PhD, is an investigator at the Mass General Center for Engineering in Medicine & Surgery. Dr. Adini's research focuses on the role of the melanocytic microenvironment in tissue neovascularization-dependent disorders and inflammatory skin disorders, such as age-related macular degeneration, cancer and connective tissue diseases.
Head and Neck Translational Immuno-Oncology Research Laboratory
The Laboratory of Michael Lanuti, MD, leads translational research with the goal of designing novel therapeutics to treat lung and esophageal cancer to bring to clinical trials.
N. Murat Karabacak, PhD
Oncolytic Virus Research Laboratory
Pancreatic Biology Research Laboratory
The focus of the basic and translational laboratory efforts is the molecular mechanisms underlying the initiation, progression and maintenance of pancreatic disease and cancer, specifically the contribution of developmental genes.
The Laboratory of Uma Sachdeva, MD, PhD, uses 3D culture models of human and mouse-derived cells to study the pathogenesis of esophageal cancer.
Thyroid Cancer Research Laboratory
The main focus of the Thyroid Cancer Research Laboratory, led by Sareh Parangi, MD, is to study certain key genetic and epigenetic changes seen more frequently in those patients who do poorly, and find out how exactly these genetic changes lead to more aggressive cancer behavior in those patients.
Dr. Wright is interested in thymic tumors (both thymomas and thymic cancers) and has published on the surgical and multimodality treatment of thymic neoplasms. Dr. Wright has published extensively on outcomes based upon this robust national database as well as developed risk-models to predict and compare results of lung cancer and esophageal cancer resection.
The clinical and translational research of Chi-Fu Jeffrey Yang, MD, aims to improve care for patients with lung cancer and other diseases of the chest.