Explore the Soft Tissue Sarcoma Treatment Program


Our multidisciplinary team of cancer specialists provides comprehensive, individually tailored treatment for children and adults with soft tissue sarcoma – cancers arising in tissue such as muscle, tendon, cartilage, fat, blood vessels, and nerves. Because sarcoma is so rare, it is important to seek treatment from experts with extensive experience in diagnosing and managing these rare cancers. Our program is one of the oldest, largest, and most experienced sarcoma treatment programs in the world.

Among the types of soft tissue sarcomas treated here are:

  • Alveolar Soft Parts Sarcoma
  • Angiosarcoma
  • Clear Cell Sarcoma
  • Dermatofibrosarcoma Protruberans (DFSP)
  • Desmoid tumor (Fibromatosis)
  • Desmoplastic Small Round Cell Tumor (DSRCT)
  • Epithelioid Hemangioendothelioma (EHE)
  • Epithelioid Sarcoma
  • Extraskeletal Myxoid Chondrosarcoma
  • Fibrosarcoma
  • Gastrointestinal Stromal Tumor (GIST)
  • Kaposi’s sarcoma (KS)
  • Leiomyosarcoma
  • Liposarcoma
  • Malignant Hemangiopericytoma
  • Malignant Peripheral Nerve Sheath Tumor (MPNST)
  • Pigmented Villonodular Synovitis (PVNS)
  • Pleomorphic Spindle Cell Sarcoma, including Fibroblastic and/or Myofibroblastic
  • Primitive Neuroectodermal Tumor (PNET)
  • Radiation associated sarcoma
  • Rhabdomyosarcoma
  • Soft Tissue Osteosarcoma
  • Synovial Sarcoma
  • Tenosynovial Giant Cell Tumor (TGCT)
  • Undifferentiated pleomorphic sarcoma (UPS)

Innovative Approaches

At the Center for Sarcoma and Connective Tissue Oncology, we offer cutting edge care and innovative surgical, medical oncology, and radiation oncology treatments designed to eradicate the tumor, prevent local recurrence, improve survival and optimize limb function.

Our surgeons are experienced in resecting tumors and reconstructing defects. We are active participants in a national clinical trials network that allows us to bring new treatments to our patients as quickly as possible. We are one of only a few centers in the United States that include proton beam therapy among our therapeutic offerings in addition to state-of-the-art surgery and targeted chemotherapy.

Multidisciplinary Patient Care

Our team approach ensures that every patient benefits from an individualized, coordinated and compassionate treatment plan, with care provided by leading experts from many specialties. We consider patients and their family and friends involved in their care to be part of this team. Your care team may include:

  • Pathologists evaluate all tumor samples to provide precise diagnostic information, including any biomarkers that can help your team design the best treatment plan for you
  • Musculoskeletal radiologists offer advanced imaging to evaluate tumors, assist in surgical planning, and monitor the results of treatment
  • Orthopaedic oncology surgeons and surgical oncologists provide the most advanced surgical techniques to maximize tumor removal and maintain extremity function
  • Spine surgeons assist in spinal reconstruction procedures
  • Microvascular surgeons aid in reconstruction procedures to enhance limb function
  • Medical and/or pediatric oncologists design the most appropriate combination of chemotherapy, immunotherapy, and/or targeted therapy for your particular cancer
  • Radiation oncologists offer innovative radiation therapy techniques customized to your individual needs and designed to deliver the most therapeutic radiation to the cancer while preserving adjacent normal tissue
  • Oncology nurses and nurse practitioners bring special expertise in cancer care
  • Oncology psychiatrists, social workers, and chaplains provide family, spiritual, and emotional, and mental health support
  • Oncology nutritionists help with dietary issues to enhance your health and well-being during treatment
  • Palliative care providers work with your team to address pain and quality-of-life concerns

Your team will develop and implement an integrated personalized care plan for you. Depending on the stage and other characteristics of your cancer, the treatment may include surgery, chemotherapy, radiation therapy, or a combination of these therapies. The team meets weekly in Sarcoma Conference to monitor treatment and ensure seamless communication and coordination of care.

Mass General Cancer Center's Adolescent and Young Adult (AYA) Cancer Program provides specialized resources and support for our AYA patients. Patients can access supportive care resources including social work, psychology, psychiatry, sexual health and fertility, lifestyle medicine, integrative therapies, and parenting guidance. Dedicated AYA clinicians and program manager are available to connect patients to these resources and answer any questions.

Expertise in Diagnosing and Staging Cancer

Our musculoskeletal pathologists sub-specialize in soft tissue tumors. They use state-of-the-art morphologic and molecular techniques to provide diagnostic information that helps the treatment team develop the most effective therapeutic strategies for each patient’s unique cancer. This includes precise diagnosis, tumor characterization, and staging (a determination of whether the cancer has spread). Molecular analysis techniques help to identify biologic markers that further guide therapy.

During surgery, pathologists carefully analyze the tumor to help ensure that the surgeons completely remove the tumor with negative margins (no surrounding cancer).

Our radiologists use advanced imaging technologies to provide diagnostic and staging information. Technologies include:

  • CT
  • MRI to pinpoint the location, size and shape of the tumor
  • Nuclear medicine including bone and PET scans, as well as PET/CT to gain integrated anatomic and functional information

Medical Oncology

We offer the full range of chemotherapeutic agents, including angiogenesis inhibitors and molecularly targeted agents to treat patients with the over 50 sub-types of sarcoma. Through our clinical trials program, we are able to offer many new investigational medications for appropriately selected patients. Research conducted at our Cancer Center and elsewhere is leading to better understanding of the genetic basis of soft tissue sarcomas and pointing the way to new treatment strategies. Additional research is focused on the problem of reverse drug resistance in sarcoma.

Excellence in Surgical Care

Our orthopaedic oncology and spine surgeons are expert in the most advanced techniques, including computer-navigated surgery. They are leaders in the resection of small to massive tumors and in the development of limb preservation techniques, including the use of modern prostheses for reconstruction. Today, 90 to 95 percent of patients who would have required an amputation 30 years ago can be safely treated with limb-sparing techniques, with the goal of moving about free of pain or assistive devices.

Pioneering Radiation Therapies

Our radiation oncologists offer a range of therapies designed to shrink and destroy tumors while protecting normal tissue. Advanced technologies include:

  • Brachytherapy uses radiotherapy implants at tumor margins to enhance tumor destruction
  • Intraoperative radiation therapy (IORT), a novel technique to deliver additional radiation during surgery to sites where the proximity of critical normal tissue prevents surgeons from removing as much tissue around the tumor as they would like
  • Proton beam therapy, a highly focused form of radiation, primarily used for sarcomas in the skull base and spine, which delivers precise radiation to the tumor while helping to spare surrounding healthy tissue
  • MAID protocol. This integrated chemoradiation program may improve disease-free and overall survival for patients with high-risk soft tissue sarcomas

Learn more about radiation therapy for sarcoma.

Developing Better Therapies through Research

Research conducted at Massachusetts General Hospital Cancer Center and other cancer centers is leading to better understanding of the genetic basis of soft tissue sarcomas. Our investigators are focused on identifying genetic mutations associated with sarcoma and biologic markers that predict tumor behavior. Findings will help shape new treatment strategies. Our laboratory researchers are also developing novel strategies to reverse drug resistance in sarcoma, supported in part by the Cancer Center's world-renowned archive of sarcoma tissue and associated clinical information. Results are being used to design new clinical trials.

The Sarcoma/Oncology Computational Biology Laboratory conducts cancer genomic/bioinformatics studies in order to detect molecular patterns relevant to tumor outcome and response to conventional or novel treatments.

Clinical Trials

Through our clinical trials program, we are able to offer many new, investigational medications for appropriately selected patients. We participate in the Massachusetts General Hospital Phase I program, which offers additional Phase I trials for patients with advanced solid tumors.

Find clinical trials for sarcoma.

Sarcoma and Chordoma: Compassionate, Team-Based & Personalized Care

The Center for Sarcoma and Connective Tissue Oncology is one of the largest and most experienced sarcoma and chordoma treatment groups in the country. Our team specializes in the diagnosis and treatment of bone and soft tissue tumors, and provides the latest and most innovative treatments matched with compassionate care. Learn more from our team in this video.

Patient Resources

Adolescent and Young Adult Cancer Program

Adolescent and Young Adult Cancer Program

This program addresses the unique needs of patients with cancer ages 15-39.

Sarcoma Surgery Program

Sarcoma Surgery Program

Learn about Mass General's Sarcoma Surgery Program.

Supportive Care

Supportive Care

We offer a variety of education and support resources to help you and your family.

Select Publications

View select publications from the Center for Sarcoma and Connective Tissue Oncology team.

View publications