This is a partial list of publications related to clinical trial work at Mass General. See our individual radiologists' profiles for a complete list of publications.
  • Miller JC and Thrall, JH. Clinical molecular imaging. J Am Coll Radiology 2004, 1: 4-23)
  • Miller JC, Pien HH, Sahani D, Sorensen AG and Thrall JH. Imaging angiogenesis: applications and potential for drug development. J Natl Cancer Inst 2005; 9: 172-87
  • Miller JC, Sorensen AG. Imaging biomarkers predictive of disease/therapy outcome: ischemic stroke and drug development. In: Rudin M, ed. Imaging in Drug Discovery and Early Clinical Trials. Basel, Switzerland: Birkhäuser/Springer, 2005; p. 319-56.
  • Miller JC, Fischman AJ, Aquino SL, Blake MA, Thrall JH, Lee SI. FDG-PET CT for tumor imaging. J Am Coll Radiol. 2007;4(4):256-9)
  • Miller JC, Pien HH, Sorensen AG. Imaging Biomarker Applications in Oncology Drug Development. Drug Information Journal. 2007;41:557-68
  • Miller JC, Sorensen AG, Pien HH. Role of imaging biomarkers in drug development. In Hayat MA, ed. Cancer Imaging, Vol 1 . Elsevier Academic Press, Amsterdam, NL, 2008, p. 139-156
  • Pien HH, Fischman AJ, Thrall JH, Sorensen AG. Using imaging biomarkers to accelerate drug development and clinical trials. Drug Discov Today. 2005 Feb 15;10(4):259-66.
  • Smith JJ, Sorensen AG, Thrall JH. Biomarkers in imaging: realizing radiology's future. Radiology. 2003 Jun;227(3):633-8.
  • Stark DD, Weissleder R, Elizondo G, Hahn PF, Todd LE, Ferrucci JT. Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 1988;168:297-301.
  • Weissleder R, Hahn PF, Stark DD, Elizondo G, Saini S, Todd LE, Wittenberg J, Ferrucci JT. Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging. Radiology 1988;169:399-403.
  • Weissleder R, Elizondo G, Stark DD, Hahn PF, Marfil J, Gonzalez JF, Saini S, Todd LE, Wittenberg J, Ferrucci JT. Diagnosis of diffuse splenic lymphoma by MR imaging: value of superparamagnetic iron oxide. AJR Am J Roentgenol 1989;152:175-80.
  • Saini S, Stark DD, Rzedzian RR, Pykett IL, Rummeny E, Hahn PF, Wittenberg J, Ferrucci JT. Forty-millisecond MR imaging of the abdomen at 2.0 T. Radiology 1989;173:111-116.
  • Hahn PF, Stark DD, Weissleder R, Elizondo G, Saini S, Ferrucci J. Superparamagnetic iron oxide: clinical application to imaging tissue perfusion in vascular liver tumors. Radiology 1990;174:361-366.
  • Hahn PF, Stark DD, Lewis JM, Saini S, Elizondo G, Weissleder R, Fretz CJ, Ferrucci JT. First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal MR contrast agent. Radiology 1990;175:695-700.
  • Goldberg MA, Saini S, Hahn PF, Egglin TK, Mueller PR. Differentiation between hemangiomas and metastases of the liver with ultrafast MR imaging: preliminary results with T2 calculations. AJR Am J Roentgenol 1991;157:727-30.
  • Reimer P, Saini S, Hahn PF, Mueller PR, Brady TJ, Cohen MS. Techniques for high-resolution echo-planar MR imaging of the pancreas. Radiology 1992;182:175-9.
  • Hahn PF, Saini S, Cohen MS, Goldberg M, Reimer P, Mueller PR. An aqueous gastrointestinal contrast agent for use in echo-planar MR imaging. Magn Reson Med 1992;25:380-3.
  • Girard MJ, Hahn PF, Saini S, Dawson SL, Goldberg MA, Mueller PR. Wallstent metallic biliary endoprosthesis: MR imaging characteristics. Radiology 1992;184:874-6.
  • Goldberg MA, Yucel EK, Saini S, Hahn PF, Kaufman JA, Cohen MS. MR angiography of the portal and hepatic venous system: preliminary experience with echo planar imaging. AJR Am J Roentgenol 1993;160:35-40.
  • Goldberg MA, Hahn PF, Saini S, Cohen MS, Reimer P, Brady TJ, Mueller PR. Value of T1 and T2 relaxation times from echoplanar MR imaging in the characterization of focal hepatic lesions. AJR Am J Roentgenol 1993;160:1011-7.
  • Reimer P, Saini S, Hahn PF, Cohen MS, Brady TJ. [The clinical use of echoplanar MR tomography in the detection of focal liver lesions. The results of a quantitative study]. [German] Rofo. Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren 1993;159:16-21.
  • Saini S, Reimer P, Hahn PF, Cohen MS. Echoplanar MR imaging of the liver in patients with focal hepatic lesions: quantitative analysis of images made with various pulse sequences. AJR Am J Roentgenol 1994;163:1389-93.
  • Reimer P, Saini S, Hahn PF, Brady TJ, Cohen MS. Clinical application of abdominal echoplanar imaging (EPI): optimization using a retrofitted EPI system. J Computer Assisted Tomography 1994;18:673-9.
  • Mayo-Smith WW, Saini S, Slater G, Kaufman JA, Sharma P, Hahn PF. MR contrast material for vascular enhancement: value of superparamagnetic iron oxide. AJR Am J Roentgenol 1996;166:73-7.
  • Saini S, Edelman RR, Sharma P, Li W. Mayo-Smith W, Slater GJ, Eisenberg PJ, Hahn PF. Blood-pool MR contrast material for detection and characterization of focal hepatic lesions: initial clinical experience. with ultrasmall superparamagnetic iron oxide (AMI-227). AJR Am J Roentgenol 1995;164:1147-52.
  • Slater GJ, Saini S, Mayo-Smith WW, Sharma P, Eisenberg PJ, Hahn PF. Mn-DPDP enhanced MR imaging of the liver: analysis of pulse sequence performance. Clinical Radiology 1996;51:484-6.
  • Gervais DA, Saini S, Hahn PF, Reimer P, Goldberg MA, Weiskoff R. Gadolinium-DTPA enhanced echoplanar MR imaging of the liver: preliminary observations. Clinical Radiology 1996;51:545-9.
  • Saini S, Edelman RR, Li W, Petersein J, Hahn PF. Clinical evaluation of ultrasmall superparamagnetic iron oxide particles for liver imaging. Academic Radiology 1996;3 Suppl 2:S409-12.
  • Harisinghani MG, Saini S, Weissleder R, Halpern EF, Schima W, Rubin DL, Stillman AE, Sica GT, Small WC, Hahn PF. Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent Code-7227. Radiology 1997;202:687-91.
  • Schima W, Petersein J, Hahn PF, Harisinghani M, Halpern E, Saini S. Contrast-enhanced MR imaging of the liver: comparison between Gd-BOPTA and Mangafodipir. JMRI 1997;7:130-5.
  • Goldberg SN, Ryan TP, Hahn PF, Schima W, Dawson SL, Lawes KR, MuellerPR, Gazelle GS. Transluminal radiofrequency tissue ablation with use of metallic stents. J Vasc Interv Radiol 1997;8:835-43.
  • Goldberg SN, Gazelle GS, Solbiati L, Livraghi T, Tanabe KK, Hahn PF, Mueller PR. Ablation of liver tumors using percutaneous RF therapy. AJR Am J Roentgenol 1998;170:1023-8.
  • Goldberg SN, Solbiati L, Hahn PF, Cosman E, Conrad JE, Fogle R, Gazelle GS. Large-volume tissue ablation with radio frequency by using a clustered, internally cooled electrode technique: laboratory and clinical experience in liver metastases. Radiology 1998;209:371-9.
  • Goldberg SN, Hahn PF, Halpern EF, Fogle RM, Gazelle GS. Radio-frequency tissue ablation: effect of pharmacologic modulation of blood flow on coagulation diameter. Radiology 1998;209:761-7.
  • Sharma R, Saini S, Ros PR, Hahn PF, Small WC, de Lange EE, Stillman AE, Edelman RR, Runge VM, Outwater EK, Morris M., Lucas M. Safety profile of ultrasmall superparamagnetic iron oxide ferumoxtran-10: phase II clinical trial data. Magn Reson Imaging 1999;9:291-4.
  • Harisinghani MG, Saini S, Weissleder R, Hahn PF, Yantiss RK, Tempany C, Wood BJ, Mueller PR. MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation. AJR Am J Roentgenol 1999;172:1347-51.
  • Small WC, DeSimone-Macchi D, Parker JR, Sukerkar A, Hahn PF, Rubin DL, Zelch JV, Kuhlman JE, Outwater EK, Weinreb JC, Brown JJ, de Lange EE, Woodward PJ, Arildsen R, Foster GS, Runge VM, Aisen AM, Muroff LR, Thoeni RF, Parisky YR, Tanenbaum LN, Totterman S, Herfkens RJ, Knudsen J, Bernardino ME. A multisite phase III study of the safety and efficacy of a new manganese chloride-based gastrointestinal contrast agent for MRI of the abdomen and pelvis. J Magn Reson Imaging 1999;10:15-24.
  • Schima W, Saini S, Petersein J, Weissleder R, Harisinghani M, Mayo-Smith W, Hahn PF. MR imaging of the liver with Gd-BOPTA: quantitative analysis of T1-weighted images at two different doses. J Magn Reson Imaging 1999;10:80-3.
  • Bennett GL, Petersein A, Mayo-Smith WW, Hahn PF, Schima W, Saini S. Addition of gadolinium chelates to heavily T2-weighted MR imaging: limited role in differentiating hepatic hemangiomas from metastases. AJR Am J Roentgenol 2000;174:477-85.
  • Petersein J, Schima W, Saini S, Mayo-Smith W, Hahn PF, Tanabe KE, Warshaw AL, F del Castillo C, Hamm B, Mueller PR. Comparison of in-phase and out-of-phase gradient recalled echo T1-weighted pulse sequence for MR imaging of malignant liver masses following administration of paramagnetic gadolinium-chelate. Abdom Imaging 2000;25:159-63.
  • Saini S, Sharma R, Baron RL, Turner DA, Ros PR, Hahn PF, Small WC, Delange EE, Stillman AE, Edelman RR, Runge VM, Outwater EK. Multicentre dose-ranging study on the efficacy of USPIO ferumoxtran-10 for liver MR imaging. Clin Radiol 2000;55:690-5.
  • Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R. MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer. Acad Radiol 2002 Aug;9 Suppl 2:S312-3
  • Saini S, Jhaveri KS, Sahani DV, Varghese JC, Hahn PF. Evaluation of simethicone coated cellulose (SonoRx) as a negative oral contrast agent for abdominal-pelvic computed tomography. Acad Radiol 2002 Aug;9 Suppl 2:S357-8
  • Sahani DV, Saini S, Kalra MK, Michael M, Hahn PF. Liver lesion detection and characterization with sequential use of hepatobiliary contrast agent mangafodipir trisodium and gadolinium-DTPA in a single imaging protocol. Acad Radiol 2002 Aug;9 Suppl 2:S460-2
  • Gervais DA, Hahn PF, O'Neill MJ, Mueller PR. CT-Guided transgluteal drainage of deep pelvic abscesses in children: selective use as an alternative to transrectal drainage. AJR Am J Roentgenol 2000;175:1393-6.
  • Malcolm PN, Brown JJ, Hahn PF, Stillman AE, Li KC, Kawamura Y, Tanaka T, Noel JK, Molony BA, Johnson MF, Hildebolt CF. The clinical value of ferric ammonium citrate: a positive oral contrast agent for T1-weighted MR imaging of the upper abdomen. J Magn Reson Imaging 2000;12:702-7.
  • Kubaska S, Sahani DV, Saini S, Hahn PF, Halpern E. Dual contrast enhanced magnetic resonance imaging of the liver with superparamagnetic iron oxide followed by gadolinium for lesion detection and characterization. Clin Radiol 2001;56:410-5.
  • Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF. Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations. J Comput Assist Tomogr 2001;25:770-6.
  • Sahani D, Prasad SR, Maher M, Warshaw AL, Hahn PF, Saini S. Functioning acinar cell pancreatic carcinoma: diagnosis on mangafodipir trisodium (Mn-DPDP)-enhanced MRI. J Comput Assist Tomogr 2002;26:126-8.
  • Sahani D, Saini S, Sharma R, O'Malley M, Harisinghani M, Hahn PF, Mueller PR. Characterizing liver hemangiomas on ferumoxides-enhanced dynamic TI-weighted imaging: preliminary experience. Acad Radiol 2002;9 Suppl 1:S255-6.
  • Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R. MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer. Acad Radiol 2002;9 Suppl 2:S312-3.
  • Saini S, Jhaveri KS, Sahani DV, Varghese JC, Hahn PF. Evaluation of simethicone coated cellulose (SonoRx) as a negative oral contrast agent for abdominal-pelvic computed tomography. Acad Radiol 2002;9 Suppl 2:S357-8.
  • Sahani DV, Saini S, Kalra MK, Michael M, Hahn PF. Liver lesion detection and characterization with sequential use of hepatobiliary contrast agent mangafodipir trisodium and gadolinium-DTPA in a single imaging protocol. Acad Radiol 2002;9 Suppl 2:S460-2.
  • Sahani DV, Jhaveri KS, D'souza RV, Varghese JC, Halpern E, Harisinghani MG, Hahn PF, Saini S. Evaluation of simethicone-coated cellulose as a negative oral contrast agent for abdominal CT Acad Radiol 2003;10:491-6.
  • Sahani DV, Kalva SP, Fischman AJ, Kadavigere R, Blake M, Hahn PF, Saini S. Detection of liver metastases from adenocarcinoma of the colon and pancreas: comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET. AJR Am J Roentgenol 2005;185:239-46.
  • Kalva SP, Sahani DV, Ryan D, Fischman AJ, Hahn PF, Mueller P, Saini S. Detection of liver metastases from gastrointestinal cancer: comparison of high resolution MnDPDP enhanced MRI and FDG-PET. Acad Radiol 2005;12 Suppl 1:S17-20.
  • Li CS, Harisinghani MG, Lin WC, Braschi M, Hahn PF, Mueller PR. Enhancement characteristics of ultrasmall superparamagnetic iron oxide particle within the prostate gland in patients with primary prostate cancer. J Comput Assist Tomogr 2008;32:523-8.

 

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