Research labs at the Center for Immunology and Inflammatory Diseases at Massachusetts General Hospital.

Principal Investigators

      • Robert Anthony, PhD

        The Anthony Laboratory investigates the role and regulation of immunoglobulin glycosylation.

      • Donald Bloch, MD

        The Bloch Laboratory investigates the role of the bone morphogenetic protein signal transduction pathway in a broad spectrum of human diseases.

      • Shannon Bromley, PhD

        The Bromley Laboratory investigates lymphocyte migration, with an emphasis on the mechanisms that regulate the accumulation of T cells within normal and inflamed non-lymphoid tissues.

      • Joseph El Khoury, MD

        The El Khoury Laboratory investigates the role of the innate immune system in neurodegeneration, inflammation and host defense against infectious pathogens.

      • Sabina Islam, MD

        The Islam Laboratory investigates mechanisms regulating skin immunity and inflammation, and chemokine and associated pathways in chronic skin inflammation and host immunity.

      • David Lagares, PhD

        The Lagares Laboratory investigates the fundamental mechanisms that balance tissue regeneration and fibrosis following injury.

      • Bo Li, PhD

        The Li Laboratory focuses on developing standard operating procedures for single-cell genomics data analysis, building on state-of-the-art big data, machine learning and graphics processing unit computing technologies, and application of single-cell genomics to immunology questions.

      • Andrew D. Luster, MD, PhD

        The Luster Laboratory investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.

      • Benjamin Medoff, MD

        The Medoff Laboratory studies the pathogenesis of pulmonary inflammation in a number of important lung diseases such as asthma, COPD, lung transplant rejection and viral infections.

      • Thorsten R. Mempel, MD, PhD

        The Mempel Laboratory investigates cell migration and intercellular communction in the adaptive immune system through direct dynamic in vivo visualization of immune cell behavior using multiphoton intravital microscopy in mice.

      • James Moon, PhD

        The Moon Laboratory focuses on basic issues of CD4+ T cell tolerance studied by directly tracking antigen-specific populations in mouse and human models.

      • Sarita Patil, MD

        The Patil Laboratory is focused on the study of allergen-specific antibodies in allergic diseases.

      • Wayne Shreffler, MD, PhD

        The Shreffler Laboratory is interested in the mechanisms regulating both primary sensitization and the subsequent balance between immune progression or regulation that determines either clinical sensitivity or tolerance to mucosal allergens.

      • Caroline Sokol, MD, PhD

        The Sokol Laboratory investigates the innate and adaptive immune interactions that initiate the allergic immune response.

      • Allen Steere, MD

        The Steere Laboratory does translational studies using samples from patients with Lyme arthritis or rheumatoid arthritis to delineate mechanisms involved in the pathogenesis of these diseases, to identify biomarkers of disease activity and to develop diagnostic tests.

      • Alexandra-Chloe Villani, PhD

        The Villani Laboratory is developing and implementing single-cell 'omics' strategies and systems immunology approaches to further unravel the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.

Associate Members

    • Nir Hacohen, PhD

      The Hacohen Laboratory develops new and unbiased strategies to understand basic immune processes and immune-mediated diseases.

    • Shiv Pillai, MD, PhD

      The Pillai Laboratory investigates the biology of the immune system and human genetics.