Post-traumatic Stress Disorder Research Laboratory

The Post-traumatic Stress Disorder Research Laboratory at Massachusetts General Hospital performs state-of-the-art psychobiological research into the assessment, pathophysiology, prevention and treatment of post-traumatic stress disorder (PTSD).



The Post-traumatic Stress Disorder (PTSD) Research Laboratory at Massachusetts General Hospital conducts federally-funded psychophysiological and neuroimaging research into PTSD.

Our Research Focus

The research done at the Post-traumatic Stress Disorder (PTSD) Research Laboratory seeks to understand both the causes of PTSD and preventative measures that can be taken to prevent its occurrence. Our current research includes:

  • Investigating a new, potentially novel treatment for PTSD. We are focused on determining whether medications administered at the time of traumatic memory reactivation can weaken the distressing emotional element of these memories through reconsolidation blockade, or updating of the memories. This work is conducted both at Mass General and international subcontract sites.
  • An ongoing, large-scale, psychobiological investigation of a national sample of identical twins. Within each set of twins, one twin had combat exposure in Vietnam and the other did not
  • Maternal adaptation to the landmark event of childbirth. We are studying the psychological and biological mechanisms involved in mothers’ adaptation following a potentially traumatic childbirth experience. As a part of this, we are conducting a longitudinal and prospective study on pregnant women to gain insight into the various psychological reactions to childbirth, including postpartum depression, anxiety and the overlooked traumatic stress response
  • Examining the acute neurological soft signs following traumatic brain injury. These research seeks to determine whether these signs can predict the subsequent development of post-concussive, PTSD and other psychopathological symptoms

We welcome referrals for possible participants. Contact us to learn more.

Our Staff

Roger K. Pitman, MD
Laboratory Director
Professor of Psychiatry, Harvard Medical School
Email Dr. Pitman
Publications by Dr. Pitman

Scott P. Orr, PhD
Associate Director
Associate Professor of Psychiatry, Harvard Medical School
Email Dr. Orr

Sharon Dekel, PhD
Assistant Professor of Psychology, Harvard Medical School
Email Dr. Dekel
Publications by Dr. Dekel

Lisa Shin, PhD
Email Dr. Shin

Sonika Agarwal
Alyssa Ashenfarb, LCSW
Purva Atreay
Gabriella Dishy
Mark Greenberg, PhD
Elizabeth Hoge, MD
Amanda King
Natasha Lasko, PhD
Mohammed Milad, PhD
Christoph Mueller-Pfeiffer, MD
Allison Rodgers
Caren Stuebe
Kalayon Tanev, MD

Research Projects

Our researchers are engaged in an ongoing series of studies related to both causes and preventative measures for PTSD. The laboratory is currently conducting the following studies.

Testing the Efficacy of Intranasal Oxytocin for the Prevention of Postpartum Depression

This novel pilot study is testing a preventive intervention for women at risk for postpartum depression. It examines the effect of intranasal oxytocin in enhancing maternal bonding and reducing postpartum depression and post-traumatic stress symptoms in mothers at risk.

Prinicipal Investigator: Sharon Dekel

We are currently enrolling participants. To learn more about this study, contact Dr. Dekel at or 617-726-1352.

Incidence of and Risk Factors for Postpartum Post-traumatic Stress

This study examines how a woman’s experience of childbirth relates to her mental health and well-being. Women are monitored during pregnancy and through the postpartum period in order to learn about potential incidences of post-traumatic stress following childbirth.

Prinicipal Investigator: Sharon Dekel

To learn more about this study, contact Dr. Dekel at or 617-726-1352.

Positron Emission Tomographic Study of Cerebral Blood Flow During Traumatic Mental Imagery in PTSD

This study seeks to evaluate which regions of the brain are selectively activated during traumatic re-experiencing.

Prinicipal Investigator: Roger K. Pitman

Secondary Prevention of PTSD with Propranolol

The major goal of this project is to investigate the effectiveness of the beta-adrengergic blocker propranolol to prevent the development of PTSD in patients presenting to the Mass General Emergency Department after a traumatic experience.

Prinicipal Investigator: Roger K. Pitman

Prospective Psychophysiologic Study of Risk for PTSD

This project aims to examine a promising set of pre-trauma psychophysiologic, endocrinologic and psychometric measures for their ability to predict the occurrence of PTSD following exposure to traumatic events in firefighter, EMT and police recruits.

Prinicipal Investigator: Scott P. Orr

The laboratory also provides consultation to other Mass General faculty, residents, predoctoral fellows, postdoctoral fellows and students regarding PTSD research design and implementation.

Contact us to learn more.


Contact Us

Post-traumatic Stress Disorder Research Laboratory

Charlestown Navy Yard
120 2nd Avenue
Charlestown, MA 02129

Email Dr. Pitman, Lab Director


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