Trust in physicians and hospitals declined over the course of the COVID-19 pandemic
In surveys completed throughout the COVID-19 pandemic by U.S. adults, trust in physicians and hospitals decreased over time in every socioeconomic group.
The goal of the Massachusetts General Hospital Center for Genomic Medicine (CGM) is the promulgation of the Genomic Medicine Cycle.
The CGM is leading an effort to complete the genomic medicine cycle—from genetic discoveries to mechanism to the clinic—by assessing where genomic medicine will have the greatest impact on human health, and by driving efforts to implement genomic medicine in those areas, at Mass General and beyond.
The cycle is a paradigm for disease research that begins by comparing human phenotypes and genetic variation to identify genes of importance in human disease, then moves on to characterizing the mechanisms by which the underlying DNA differences lead to disease, and is completed when the knowledge gained delivers benefit back to patients in the forms of improved diagnosis, disease management and treatments.
Christopher D. Anderson, MD, MMSc
Assistant Professor of Neurology, Harvard Medical School
Associate Director, Acute Stroke Service, Massachusetts General Hospital
Susan L. Cotman, PhD
Assistant Professor of Neurology, Harvard Medical School
Assistant in Neuroscience, CGM & Department of Neurology, Massachusetts General Hospital
William Crowley, MD
Daniel K. Podolsky Professor of Medicine, Harvard Medical School
Chief of the Reproductive Endocrine Unit, Massachusetts General Hospital
Adjunct Faculty, Broad Institute, Medical Population Genetics Program
Director/Principal Investigator, NIH-funded Harvard-wide Reproductive Endocrine Sciences Translational Research Center
Mark Daly, PhD
Chief, Analytic and Translational Genetics Unit, Massachusetts General Hospital
Associate Professor of Medicine, Harvard Medical School
Senior Associate Member, Broad Institute
Alysa Doyle, PhD
Assistant Professor of Psychiatry, Harvard Medical School
Director of Research, Learning and Emotional Assessment Program, Massachusetts General Hospital
Associate Researcher, Stanley Center for Psychiatric Research
Erin Dunn, ScD, MPH
Assistant Professor of Psychiatry, Harvard Medical School
Florian Eichler, MD
Director, Center for Rare Neurological Diseases, Massachusetts General Hospital
Associate Professor of Neurology, Harvard Medical School
Jose C. Florez, MD, PhD
Professor of Medicine, Harvard Medical School
Chief, Diabetes Unit, Massachusetts General Hospital
Institute Member, Broad Institute
Yulia Grishchuk, PhD
Instructor in Neurology, Massachusetts General Hospital
Assistant in Neuroscience, Harvard Medical School
James Gusella, PhD
Bullard Professor of Neurogenetics, Harvard Medical School
Director, Center for Neurofibromatosis and Allied Disorders, Harvard Medical School
Stephen J. Haggarty, PhD
Associate Professor of Neurology, Harvard Medical School
Rakesh Karmacharya, MD, PhD
Associate Professor of Psychiatry, Harvard Medical School
Sekar Kathiresan, MD
Professor of Medicine on Leave of Absence
Raymond J. Kelleher III, MD, PhD
Assistant Professor of Neurology, Harvard Medical School
Amit V. Khera, MD, MSc
Associate Director, Precision Medicine Unit, CGM, Massachusetts General Hospital
Associate Director, Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard
Instructor of Medicine, Harvard Medical School
Cardiologist, Corrigan Minehan Heart Center, Massachusetts General Hospital
W. Taylor Kimberly, MD, PhD
Associate Professor of Neurology, Harvard Medical School
Associate Director, Neuroscience ICU, Massachusetts General Hospital
Associate Chief, Division of Neurocritical Care & Emergency Neurology, Massachusetts General Hospital
Ben Kleinstiver, PhD
Assistant Investigator, Pathology, Massachusetts General Hospital
Assistant Professor of Pathology, Harvard Medical School
Jong-Min Lee, PhD
Assistant Professor of Neurology, Harvard Medical School
Phil Hyoun Lee, PhD
Assistant Professor of Psychiatry, Harvard Medical School
Daniel MacArthur, PhD
Assistant Professor of Medicine, Harvard Medical School
Co-Director of Medical and Population Genetics at, Broad Institute
Marcy E. MacDonald, PhD
Professor of Neurology, Harvard Medical School
Faculty, Basic Biological Sciences, Harvard Medical School
Non-clinical Staff, Massachusetts General Hospital
Associate Member, Broad Institute
Vamsi K. Mootha, MDInvestigator, Howard Hughes Medical Institute (HHMI)
Professor of Systems Biology and Medicine, Harvard Medical School
Institute Member, Broad Institute
Ricardo Mouro Pinto, PhD
Instructor in Neurology, Harvard Medical School
Patricia Musolino, MD, PhD
Assistant Professor of Neurology, Harvard Medical School
Co-Director of the Pediatric Stroke & Cerebrovascular Service, Massachusetts General Hospital
Benjamin Neale, PhD
Associate Professor of Medicine, Harvard Medical School
ATGU, Massachusetts General Hospital
Director of Population Genetics, Stanley Center for Psychiatric Research, Broad Institute
Christopher Newton-Cheh, MD, MPH
Assistant Professor of Medicine, Harvard Medical School
Faculty, Cardiovascular Research Center, Massachusetts General Hospital
Associate Member, Broad Institute
Aarno Palotie, MD, PhD
Lecturer, Harvard Medical School
Roy H. Perlis, MD, MSc
Professor of Psychiatry, Harvard Medical School
Director, Center for Experimental Drugs and Diagnostics, Massachusetts General Hospital
Vijaya Ramesh, PhD
Professor of Neurology, Harvard Medical School
Heidi L. Rehm, PhD, FASMG
Chief Genomics Officer, Department of Medicine, Massachusetts General Hospital
Medical Director, Broad Institute Clinical Research Sequencing Platform
Professor of Pathology, Harvard Medical School
Jonathan Rosand, MD, MSc
Professor of Neurology, Harvard Medical School
J.P. Kistler Neurologist, Massachusetts General Hospital
Chief, Neurocritical Care & Emergency Neurology, Massachusetts General Hospital
Co-Director, Institute for Brain Health, Massachusetts General Hospital
Associate Member, Broad Institute
Richa Saxena, PhD
Associate Professor of Anaesthesia, Harvard Medical School
Phyllis and Jerome Lyle Rappaport MGH Research Scholar
Associate Member, Medical and Population Genetics, Broad Institute
Jeremiah Scharf, MD, PhD
Assistant Professor of Neurology, Harvard Medical School
Co-Director, Tourette Association of America Center of Excellence, Massachusetts General Hospital
Co-Chair, Tourette Syndrome Association International Consortium for Genetics
Ihn Sik Seong, PhD
Assistant Professor of Neurology, Harvard Medical School
Brian Skotko, MD, MPP
Assistant Professor of Pediatrics, Harvard Medical School
Co-Director, Down Syndrome Program, Massachusetts General Hospital
Susan A. Slaugenhaupt, PhD
Scientific Director, Mass General Research Institute
Interim Director, Center for Genomic Medicine, Massachusetts General Hospital
Professor of Neurology (Genetics), Harvard Medical School
Jordan W. Smoller, MD, ScD
Professor of Psychiatry, Harvard Medical School
Director, Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital
Alexander Soukas, MD, PhD
Assistant Professor of Medicine, Harvard Medical School
David Sweetser, MD, PhD
Assistant Professor of Pediatrics, Harvard Medical School
Chief of Medical Genetics and Metabolism, Massachusetts General Hospital
Co-Director Pitt Hopkins Syndrome Clinic, Massachusetts General Hospital
Mass General Site Director, Undiagnosed Diseases Network
Kathryn J. Swoboda, MD
The Katherine B. Sims M.D. Endowed Chair in Neurogenetics
Director of the Neurogenetics Program at Massachusetts General Hospital/Harvard Medical School
Michael Talkowski, PhD
Associate Professor of Neurology, Harvard Medical School
James Walker, PhD
Assistant Professor of Neurology, Harvard Medical School
Assistant in Genetics, Massachusetts General Hospital
Associate Member, Broad Institute
Vanessa Wheeler, PhD
Associate Professor of Neurology, Harvard Medical School
Mass General is recognized as a top hospital on the U.S. News Best Hospitals Honor Roll for 2024-2025.
In surveys completed throughout the COVID-19 pandemic by U.S. adults, trust in physicians and hospitals decreased over time in every socioeconomic group.
The team of researchers in the Kleinstiver laboratory sought to develop a new genome editing approach that could enable the easy and precise installation of nearly any genetic change into a chromosome.
Mucolipidosis IV (MLIV) is a rare neurologic disease of childhood with extremely high unmet need.
Researchers have identified numerous genetic clusters that may help explain why people with type 2 diabetes have different clinical presentations.
A team led by investigators at Massachusetts General Hospital (MGH) and the Broad Institute of MIT and Harvard recently developed a strategy for inferring which phases is present for rare variant pairs within genes.
In lab models, the Mass General-led research team used a CRISPR-based approach to edit a comparable gene (SMN2) to produce the protein missing in SMA patients, a strategy that may overcome limitations of current treatment.