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Research at Mass General
The research enterprise at Massachusetts General Hospital includes clinical departments, multidisciplinary thematic centers and research programs.
The Analytic and Translational Genetics Unit at Massachusetts General Hospital focuses on the interpretation of genome data to aide in the discovery of human disease.
The Andrew L. Warshaw, MD, Institute for Pancreatic Cancer Research at Massachusetts General Hospital is a collaborative of scientists, oncologists, surgeons, radiation oncologists and interventional endoscopists whose mission is to extend and improve the lives of patients with pancreatic cancer.
The Cardiovascular Research Center (CVRC) at Massachusetts General Hospital was founded in 1990 to bridge the gap between the science of heart disease and the practice of cardiovascular medicine.
CATCH is discovering new health measurements and tools to better diagnose and treat diseases within a patient’s daily life.
Massachusetts General Hospital Cancer Center is committed to eradicating cancer and is fueled by scientific investigation conducted as part of the largest hospital-based research program in the United States.
The Center for Computational and Integrative Biology is an affiliation of faculty drawn together by a common interest in the study of biology through a broader scale of inquiry than the existing standard.
We are the ambassadors of bioengineering, bringing the cutting edge of technology to the forefront of biomedical research and the practice of medicine.
The goal of the Massachusetts General Hospital Center for Genomic Medicine (CGM) is the promulgation of the Genomic Medicine Cycle.
The Center for Neurointestinal Health at Massachusetts General Hospital is an international leader in neurointestinal research and a premier provider of state-of-the-art clinical care.
The Center for Regenerative Medicine is dedicated to understanding how tissues are formed and may be repaired in settings of injury and disease.
The goal of the Massachusetts General Hospital Center for Systems Biology is to analyze, at a systems level, how biological molecules, proteins and cells interact in both healthy and diseased states.
CSIBD is a Research Center focused on IBD-oriented research at Massachusetts General Hospital and affiliated institutions sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.
The MGH Center for Translational Pain Research strives to improve the clinical management of patients experiencing acute, chronic, and cancer pain conditions.
The Center for Transplantation Sciences is a multidisciplinary research center working at the interface between basic science and clinical applications in transplantation immunology at Mass General.
The mission of the CTEU is to advance epidemiologic investigation for the translation of discoveries into effective clinical interventions.
Clinical Research Center conducts clinical research, including the use of specialized analyses and procedures for approved studies.
The Codman Center for Clinical Effectiveness in Surgery is is an academic and service program established by the Department of Surgery to encourage and support surgical outcomes research at Mass General.
An international consortium of scientists, physicians and advocates working to advance research and clinical care for people with X-linked Dystonia Parkinsonism
A network of world-class academic and medical institutions partnering with industry and government to foster collaboration and accelerate innovative healthcare technologies.
To achieve that goal the CBRC maintains an environment conducive to collaboration with industrial partners to disseminate the fruits of fundamental research from the CBRC.
Our unit conducts research to improve health care service delivery for multicultural populations.
The mission of the Division of Clinical Research is to increase the quality, quantity and efficiency of translating basic science advances into improved care for our patients.
The Division of Research in Emergency Medicine conducts research into cardiovascular, neurologic, pulmonary, infectious, mental health and traumatic emergencies.
The core activities of the Gordon Center for Medical Imaging include: research, training and education, and the translation of innovative research into clinical applications.
The Health Decision Sciences Center (HDSC) is a multidisciplinary research group that seeks to foster shared decision making and implement sustainable decision aid delivery.
Mass General’s CIID is a multidisciplinary research center focused on basic mechanisms of immune-mediated inflammatory diseases.
An interdivisional center dedicated to improving clinical outcomes—particularly in HIV/AIDS ad tuberculosis—increasing value in health policy and informing global health through research and education.
The MassGeneral Institute for Neurodegenerative Disease (MIND) is poised to change the future for people living with neurodegenerative disease.
The Mongan Institute connects centers and individual researchers to strengthen health care and populations science research at Mass General.
Our center aims to catalyze beneficial changes in health policy, the health care delivery system, and in the health and health care of disadvantaged populations.
The Mongan Institute Health Policy Center provides solutions to critical challenges in health policy, access, and health care delivery through innovation and research.
The MIBRC conduct basic research in mucosal immunology topics ranging from Salmonella food poisoning to intestinal inflammatory diseases such as celiac disease.
The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.
OMNI is a multidisciplinary research and education center focused on obesity and its related disorders.
The Tobacco Research and Treatment Center at Massachusetts General Hospital combines clinical care and scientific investigation to reduce the health consequences of tobacco use.
The Translational Medicine Group at Massachusetts General Hospital connects academia and industry to accelerate the development of novel therapeutics. We focus on efficient resource utilization and tightly coordinated timelines that distinguish us from traditional academic collaborations.
The Translational Research Center at Massachusetts General Hospital provides a unique infrastructure for industry-sponsored, patient-oriented clinical research.
The Vaccine & Immunotherapy Center (VIC) at Massachusetts General Hospital was established to speed the translation of laboratory discoveries into new, cost-effective therapies and treatments to prevent and cure various forms of cancer and infectious diseases.
The Vincent Center for Reproductive Biology consists of basic and clinical scientists whose primary research emphasis includes infertility, aging and cancer as they pertain to the ovary and uterus. The center provides an optimal environment for individuals who are interested in integrating clinical and basic sciences and have a strong desire to pursue a career in academic research.
The Wellman Center for Photomedicine at Massachusetts General Hospital investigates the effects of light on human biology and develops light-mediated, minimally invasive diagnostic and therapeutic technologies.
The 3D Imaging Lab at Massachusetts General Hospital produces 3D images that provide precise, anatomical visualizations to enhance patient care.
The Advanced Tissue Resource Center in the Department of Neurology at Massachusetts General Hospital serves as a molecular and anatomic neuropathology resource for the Boston neuroscience community. Our research incorporates advanced micro-molecular profiling technologies into studies of human neurodegenerative and psychiatric diseases.
Our laboratory has been involved in uncovering the mechanisms by which hepatitis viruses, particularly hepatitis C, persist in the liver and cause liver damage.
Our research group is focused on risk estimation, treatment and prevention of age-related brain deterioration.
Akito Nakagawa researches the identification of small molecules that modulate gas binding properties of human hemoglobin at Massachusetts General Hospital.
The Albers’s Laboratory uses the olfactory system of mice and humans to elucidate early pathologic events of neurodegeneration.
The Alessandrini Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital studies regulatory T cells and plasmacytoid dendritic cells, and the roles they play in the induction of transplantation tolerance.
Alexander G. Marneros, MD/PhD
Associate Professor, Department of Dermatology, Harvard Medical School
Dermatology Attending, Massachusetts General Hospital
My laboratory is interested in the development of the enteric nervous system (ENS), a complex neuronal network whose principal function is to maintain normal intestinal motility.
The Steere Laboratory at Massachusetts General Hospital does translational studies using samples from patients with Lyme arthritis or rheumatoid arthritis to delineate mechanisms involved in the pathogenesis of these diseases, to identify biomarkers of disease activity, and to develop diagnostic tests.
The Allergy Clinical Research Unit conducts clinical "translational" research and drug trials of allergic and immunologic diseases, including asthma, chronic rhinosinusitis, nasal polyopsis, drug allergy, hereditary angioedema (HAE) and food allergy.
The Luster Laboratory at Massachusetts General Hospital investigates chemokines, lipid chemoattractants and their receptors in normal physiology and disease.
Dr. Andrew J. Cole’s interests as a research investigator include clinical trials, clinical neurology, epilepsy, and basic neuroscience research.
The Anesthesia Center for Critical Care Research (ACCCR) at Massachusetts General Hospital aims to develop novel, paradigm-changing therapeutic strategies to improve outcomes in critically ill patients.
Anna Mandinova, M.D., Ph.D.
Principal Investigator Biologist (Dermatology) Massachusetts General Hospital
The Acute Respiratory Distress Syndrome (ARDS) Network Clinical Coordinating Center coordinates randomized controlled trials for patients with ARDS.
Research Interests: Investigating patient-reported outcomes, developing interventions to enhance patient-centered decision-making, and designing supportive and palliative care interventions to improve the care of patients with hematologic malignancies and their families.
The M. Amin Arnaout laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.
Computational methods for genomics and epigenomics...
The Martinos Center is committed to developing novel techniques for imaging biological systems and biologically relevant materials, toward a more comprehensive understanding and better care of the human mind and body.
Integrative systems biology of microbial sensing, autophagy, innate immune regulation and programming.
The Jodie L. Babitt Lab is focused on elucidating the molecular and cellular mechanisms involved in iron homeostasis
Brian Bacskai's laboratory uses sophisticated optical techniques to address fundamental questions in Alzheimer's disease research.
The BADR lab is focused on studying the genetic drivers of malignancy and treatment resistance as well as developing targeted and experimental therapeutics for brain tumors.
Research topics include: pancreatic ductal adenocarcinoma
The basic and translational research in the Diabetes Unit at Massachusetts General Hospital focuses on studies relating to insulin resistance and developing novel prevention strategies and treatments.
Research topics include: the response to cancer therapeutics, the molecular basis of sensitivity to specific drugs and how to identify the genetic variations affecting the response to targeted therapies
The Benichou Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital studies the immune mechanisms underlying the allorecognition and alloresponse by T and B cells in transplant rejection and tolerance.
The Medoff Laboratory at Massachusetts General Hospital studies the pathogenesis of pulmonary inflammation in a number of important lung diseases such as asthma, COPD, lung transplant rejection, and viral infections.
The research goal of Dr. Berezovska's lab is to study the cellular and molecular mechanisms of Alzheimer's disease pathology.
Research topics include: Neurofibromatosis-1 (NF1)
The Bradley Bernstein pathology research lab at Massachusetts General Hospital applies high-throughput, sequencing-based technologies to characterize chromatin structure genome-wide in human and mouse.
“Researching mucosal immunology and inflammatory bowel disease...”
Associate Professor of Dermatology, Harvard Medical School; Assistant Biologist, Massachusetts General Hospital.
Binglan Yu researches blood transfusion and blood substitutes with the goal of making transfusion of human blood stored for prolonged periods a safer clinical process.
The Hooker Research Group, part of the Athinoula A. Martinos Center for Biomedical Imaging, focuses on the development and application of in vivo molecular imaging tools.
The Bioengineering Laboratory continues its tradition of innovation and translational research in the area of joint arthroplasty engineering and in vivo biomechanics.
The Massachusetts General Hospital Biorepository for Neurological Injury advances research in brain health and recovery by providing data to help researchers understand how genes and other factors contribute to risk of brain disease, recovery from brain injuries and the maintenance of a healthy brain.
The Division of Biostatistics & Biomathematics supports research-oriented databases and data management needs for Radiation Oncology.
Research topics include: molecular biology of gynecologic cancer; novel therapeutics; genomics of ovarian cancer; clinical trial design; early detection technologies.
The Research Unit currently focuses on studies regarding the treatment of BDD as well as the factors that contribute to the development and maintenance of BDD.
The Boland Lab focuses on blood-based techniques for assessing changes in the tumor microenvironment through analysis of circulating exosomes.
The clinical mission of the Bone Marrow Transplant Clinical Research Lab is to provide a comprehensive range of transplant-related services to patients with hematologic malignancies and other potentially life-threatening blood dyscrasias. Its research mission is to develop novel methods of allogeneic stem cell transplantation to maximize the separation of graft versus host disease (GVHD) and graft versus tumor (GVT) effect in both the HLA-matched and mismatched settings.
As part of the Edwin L. Steele Laboratory for Tumor Biology, the Boucher Laboratory analyzes delivery of oncolytic viruses and large therapeutic agents in tumors and tumor cell migration and metastasis.
The Richard Bouley Laboratory is studying the role of vasopressin receptor type 2 in the pathophysiology of diseases associated with water reabsorption dysregulation.
The laboratory combines gene expression profiling and chemical screening of novel cellular models to understand the pathogenesis of hereditary dystonias.
The Brain Trauma Lab is aimed at learning how to better treat the millions of children with brain trauma and similar problems, now and in the future.
The Brain Tumor Stem Cell Lab develops novel therapeutic strategies for glioblastoma through a better understanding of the biological and molecular characteristics of glioblastoma stem cells
The Brainstem Imaging Lab has the goal of developing an in vivo neuroimaging-based atlas and connectome of brainstem nuclei by high- and ultra-high field MRI to enhance our knowledge and the quality of patient care in a vast array of brainstem-related disorders.
The Brastianos laboratory studies genomic drivers of human brain tumors.
The Breakefield laboratory uses molecular genetic techniques to elucidate the etiology of inherited neurological diseases and to develop vectors which can deliver genes to the nervous system for therapeutic purposes.
Our program is on the forefront of investigation to find better therapies, improve diagnostics, and develop less invasive, breast-sparing surgical techniques for the treatment of breast cancer.
The Breast Imaging Research program is dedicated to improving breast cancer detection and diagnosis in order to reduce the death rate of breast cancer.
The Sylvie Breton laboratory studies the regulation of epithelial cells in the urogenital tract with an emphasis on the kidney and epididymis. Our main areas of interest include: acute kidney injury, chronic kidney disease, male infertility, cystic fibrosis, acid/base homeostasis.
The Dennis Brown Laboratory uses cell biological and imaging techniques to understand mechanisms and physiological signals that regulate the distribution of important proteins in the kidney that regulate urine concentration and systemic acid base balance. We are especially interested in the pathophysiology of vasopressin activated water channels (aquaporins), and in proton pump (V-ATPase) function.
Associate Professor of Dermatology
Harvard Medical School
Associate Biologist (Dermatology)
Massachusetts General Hospital
Dr. Brugge is an active clinical consultant in gastroenterology and gastrointestinal endoscopy, focusing on patients with complex pancreatic diseases. His research has focused on the early diagnosis of pancreatic cancer, developing a variety of endoscopic techniques to aspirate malignant and pre-malignant lesions of the pancreas.
Research within the Cardiac Anesthesia Lab at Massachusetts General Hospital advances the evolving field of cardiac anesthesiology and improves outcomes for both adult and pediatric patients.
The Cardiac MR PET CT Program at Massachusetts General Hospital and Harvard Medical School is dedicated to developing and leveraging novel imaging techniques to address important cardiovascular issues.
The Cardiac Psychiatry Research Program (CPRP) aims to improve the mental health and medical outcomes of patients with heart disease.
Cardiac surgery research at the Massachusetts General Hospital Corrigan Minehan Heart Center offers patients the most promising therapies based on the latest scientific evidence.
The Cardiothoracic Transplantation Laboratory at Massachusetts General Hospital uses state-of-the-art molecular and cellular techniques to study transplantation tolerance, acute/chronic rejection, innate immunity, xenotransplantation and whole organ bioengineering for heart and lung transplantation models.
The Massachusetts General Hospital Cardiovascular Biorepository (CVBio) advances cardiovascular research by providing patient data and blood samples to help researchers understand how genes and other factors contribute to heart disease.
The Cardiovascular Clinical Research Lab seeks to improve clinical diagnosis and treatment of cardiovascular diseases.
The Sokol Laboratory at Massachusetts General Hospital investigates the innate and adaptive immune interactions that initiate the allergic immune response.
Working at the cellular and molecular levels, our studies cover a range of topics, including mechanisms of cell death, DNA damage induction and repair processes, bystander effects, and cancer genetics.
The Center for Addiction Medicine's research program offers the best in personally tailored behavioral and medication treatment for smoking cessation, prevention of relapse to smoking, and other substance use issues.
The Center for Anxiety and Traumatic Stress Disorders and Complicated Grief at Massachusetts General Hospital conducts state-of-the-art research aimed at improving the standard of care for people suffering from anxiety disorders.
Learn more about the Center for Applied Clinical Investigation (CACI) Research Lab and our current projects.
The Center for Computational and Integrative Biology provides support for investigators at the hospital and across Boston through a variety of autonomous cores that provide services in DNA sequencing, oligonucleotide synthesis, microarray analysis, and research laboratory automation.
We are scientists, engineers and physicians who are bringing the cutting edge of technology to the forefront of biomedical research and the practice of medicine.
The Center for Law, Brain & Behavior at Massachusetts General Hospital brings together experts in neurology, psychiatry, neuroimaging and the law to make well-grounded translations of medical concepts in the legal realm.
The Center for Molecular Imaging Research (CMIR) at Massachusetts General Hospital and Harvard Medical School researches molecular phenomena to develop novel sensing technologies and, ultimately, clinical applications that can save lives.
The MGH Psychiatry Center for Quantitative Health (CQH) focuses on utilizing large data sets to develop strategies for probabilistic medicine and quantitative health
The Mass General Center for Rare Neurological Diseases (CRND) aims to eradicate rare disorders of the nervous system by leveraging the power of biological insights towards design and implementation of clinical trials.
The Center for Surgery, Innovation & Bioengineering at Massachusetts General Hospital comprises physicians, surgeons, engineers and biologists who create novel, engineering-based biomedical approaches to improve the delivery of health care to patients worldwide.
Our research is focused on traditional, molecular, and genetic epidemiology of digestive diseases, including colorectal cancer, inflammatory bowel disease, and gastrointestinal bleeding.
The Chemical Genomics Laboratory (CGL) is unraveling the molecular mechanisms underlying neuroplasticity to develop novel, targeted therapeutics for the treatment of neuropsychiatric and neurological diseases.
The research of the Leo L. Cheng lab focuses on human prostate cancer, breast cancer, and lung cancer. The National Cancer Institute sponsors his research.
The overall goal of the Chung Laboratory is to better elucidate the genetic events in gastrointestinal tumorigenesis.
The main research interest of the Chung Laboratory has been studies of the biology of hepatitis C virus infection, the leading cause of chronic viral liver disease in the U.S.
Research topics include: the role of the pRB pathway and the pRB family of proteins (pRB, p107 and p130) in tumorigenesis
Our mission is to advance epidemiologic investigation for the translation of discoveries into effective clinical interventions in chronic disease.
Our research focuses on understanding the pathogenesis of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH), the interaction between obstructive sleep apnea (OSA) and NASH, and the influence of NASH on lipid metabolism and cardiovascular risk factors.
Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.
The Cobbold laboratory focuses on understanding how the healthy human immune response is able to recognize and target cancerous cells, and when it fails, how it could be strengthened to recognize this endogenous threat.
The Cognitive Neuroscience Lab probes the mechanisms by which individual neurons communicate locally and across cortical areas, and investigate new approaches for reconstituting the line of communication across areas disrupted within the CNS.
“Pathogenesis of rejection and tolerance of organ transplants...”
The mission of the Community Psychiatry Program for Research in Implementation and Dissemination of Evidence-Based Treatments is to reduce the disproportionate mental health burden in under-served, resource-constricted communities.
The Corcoran laboratory focuses on developing new and effective therapies for gastrointestinal cancers, such as colorectal and pancreatic cancers, by targeting the specific survival signals that are active in a given patient’s cancer.
The Cosimi/Kawai Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital focuses on allograft tolerance induction in nonhuman primates and humans, with the goal of developing safe and reliable tolerance-inducing regimens for clinical transplantation.
Modeling Cardiovascular and Metabolic Disease with Human Pluripotent Stem Cells
Advances in clinical treatment of congenital craniofacial malformations require improved understanding of the developmental genetic basis of facial morphogenesis. Our goal in the Craniofacial Developmental Biology Laboratory is to investigate fundamental genetic regulation of facial development, with a focus on translating basic science discoveries to clinical advances. We perform research on palate development and neural crest cell biology.
The Critical Care Translational Medicine Group designs, oversees and coordinates international trials in acute respiratory distress syndrome (ARDS) and sepsis.
Research topics in the Cusack Laboratory include: molecular targeted therapies for colorectal cancer, melanoma, Merkel cell cancer and carcinomatosis, and improving delivery of surgical cancer care in resource-limited settings.
The Nicolas Da Silva Laboratory focuses on interactions between the immune system and the male reproductive tract, specifically on the importance of macrophages and dendritic cells during sperm maturation and storage.
Molecular Epidemiology of ARDS:
Under the direction of David Christiani, MD, MPH, our laboratory examines genetic and environmental factors that may impact the development and progression of acute respiratory distress syndrome (ARDS).
The Lagares Laboratory at Massachusetts General Hospital investigates the fundamental mechanisms that balance tissue regeneration and fibrosis following injury.
Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.
Research Interests: Palliative and supportive care for patients with brain and spinal cord tumors.
The focus of the Demehri laboratory is to determine the role of the immune system in regulating the early stages of cancer development in order to harness its anti-tumor potential for cancer treatment and prevention.
Demet S. Sulemanji researches the use ventilation strategies in critically ill patients with a variety of lung diseases.
Research topics include: vaascular physiology of neurofibromatosis type 2 tumors
The Alshuler lab focuses on studies of human genome sequence variation as a route to understanding the inherited basis of common human diseases, with a major focus on type 2 diabetes.
The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.
For over two decades, the Massachusetts General Hospital Diabetes Clinical Research Center has developed and evaluated innovative therapies for type 1 and type 2 diabetes.
Researchers in Brad Dickerson's Laboratory seek to understand the relationships between brain anatomy, physiology, and behavior in humans across the lifespan and in those with neurodegenerative diseases.
The Manstein lab conducts basic and clinical research related to novel, energy-based procedures in dermatology.
Marian M. DiFiglia, PhD, is investigating the role of the HD mutation in the molecular and cellular events leading to neurodegeneration.
Dr. Dighe is engaged in research and development of expert system software for pathology interpretations.
The Division of Global Health (DGH) at MassGeneral Hospital for Children includes energetic faculty members and senior research fellows. The Division's primary mission is to build and foster international partnerships for interdisciplinary research, education and service to reduce health disparities and achieve optimal health for children and adolescents in resource-limited settings of the developing world. Our multidisciplinary team of faculty has significant experience working in the global arena, and in mentoring and teaching future leaders in global health.
Our lab focuses on translating neurobiological research into novel treatments for psychiatric disorders such as post traumatic stress disorder, major depressive disorder, eating disorders and obsessive compulsive disorder.
The Bloch Laboratory at Massachusetts General Hospital investigates the role of the bone morphogenetic protein signal transduction pathway in a broad spectrum of human diseases
The Dou laboratory studies the biology of aging and aims to develop new strategies to suppress aging and age-associated diseases.
We provide innovative opportunities for people with Down syndrome to participate in research.
We are interested in studying the role of actin regulation in the pathogenesis of inflammatory bowel disease.
The Plastic Surgery Clinical Research Program at Massachusetts General Hospital leverages surgical innovations, clinical practices and technological developments to improve diagnosis and treatment in plastic surgery. Our research in craniofacial surgery and breast reduction address the most common problems in plastic surgery involving pediatric and adult patients.
Epigenetics is a general term encompassing any and all mechanisms that govern gene expression patterns without modifying the underlying DNA sequence. We are interested in how “epigenetic” mechanisms such as histone modifying enzymes and non-coding RNA regulate inflammation and antiviral immunity.
The Iain Drummond Laboratory studies kidney organogenesis using the zebrafish to explore conserved molecular mechanisms underlying vertebrate kidney cell differentiation, morphogenesis, ciliogenesis, and regeneration.
Dr. Dryja is a principal investigator researching ophthalmic pathology, hereditary diseases of the eye, and new therapies for eye disease.
Research topics include: tumor microenvironment, metastatic progression, resistance to targeted therapy, radiation and immunotherapy, and biomarkers of response.
Research topics include: E2F - and pRB-; tumorigenesis
The Edwin L. Steele Laboratory is committed to improving the prevention, detection and treatment of cancer in patients through a better understanding of tumor pathophysiology and host-tumor interactions.
Dr. Florian Eichler's lab studies monogenetic lipid metabolism disorders of the nervous system at the Massachusetts General Hospital and Harvard Medical School.
The Elia laboratory studies pathways in the DNA damage response.
Research topics include: P53 and human tumorigenesis; breast cancer
Research Interests: Development and integration of motivational and behavioral intervention treatments, particularly for chronic stress and smoking cessation, into cancer and survivorship care.
The Emergency Medicine Network's (EMNet) mission is to advance public health objectives through diverse projects in emergency care, particularly through multicenter clinical research.
The MGH Department of Emergency Medicine is home to many ongoing research projects which include studies on cardiovascular, neurologic, pulmonary, infectious, mental health and traumatic emergencies.
Emmanuel Buys investigates the role that soluble guanylate cyclase (sGC) plays in the development of both cardiovascular disease and open angle glaucoma, testing sGC-targeted strategies for disease prevention, detection and treatment.
The Program in Endocrine Malignancies is dedicated to the diagnosis and therapy of benign and malignant tumors of the endocrine glands. The physicians affiliated with this center have expertise in the diagnosis and treatment of benign and malignant tumors of the thyroid, parathyroid, and adrenal glands as well as the tumors of the endocrine pancreas.
Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.
The Bastepe Lab strives to improve clinical management of endocrine and musculoskeletal disorders through fundamental research that involves genetics and molecular and cell biology.
The Demay Laboratory at Massachusetts General Hospital is focused on understanding the role of the vitamin D receptor (VDR) in skeletal maturation and in cutaneous homeostasis.
The Kobayashi Laboratory at Massachusetts General Hospital investigates the genetics of skeletal development.
The Kronenberg Laboratory at Massachusetts General Hospital uses genetically altered mice to study signaling by the PTH/PTHrP receptor in bone, bone development more generally and the relationships between cells of the osteoblast lineage and hematopoiesis.
Research in the Mannstadt Laboratory at Massachusetts General Hospital focuses on diseases of the parathyroid glands and mineral metabolism.
Thomas Gardella, PhD, is an Assistant Professor in Medicine and Biochemistry in the Massachusetts General Hospital Endocrine Unit, and conducts basic research on parathyroid hormone (PTH) and the PTH receptor.
The Wein laboratory studies molecular mechanisms controlling osteocyte differentiation and function. Our research focuses on transcriptional control of sclerostin, an osteocyte-specific secreted protein that happens to be a drug target for osteoporosis. We are interested in understanding how osteocytes turn on sclerostin, and how signals that boost bone formation (parathyroid hormone, mechanical loading) regulate its expression.
The Eugene Rhee Laboratory is interested in several aspects of renal metabolism, with the goal to understand how alterations in energy metabolism contribute to kidney disease pathogenesis and its complications and to discover metabolite markers of CKD and its progression.
Associate Professor of Dermatology
Harvard Medical School
Associate Biologist (Dermatology)
Massachusetts General Hospital
The Delirium Lab at Massachusetts General Hospital is committed to determining the causes and treatments of delirium through a combination of translational and clinical research.
The main focus of my laboratory centers on the bacterial pathogen Shigella flexneri, which causes millions of infections in children each year.
The Familial Dementia Neuroimaging Lab is focused on the study of age-related cognitive and brain changes that may predispose individuals to develop dementia later in life
The Fasano Lab is investigating the composition and changes in the gastrointestinal microbiota to determine why some individuals with an inherited predisposition to celiac disease develop clinical disease, while others do not.
The principal focus of our research is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic cancer, specifically the contribution of developmental genes.
The Fiorentino lab is interested in elucidating the molecular mechanisms of host-microbial interaction and understanding the impact of changes in the gut environment on brain function and behavior.
The First 1,000 Days aims to improve the health of families from pregnancy through age 2 by engaging providers from both clinical and community health services. It is being piloted at the MGH Chelsea and Revere HealthCare Centers and DotHouse Health.
Our group studies cell death/proliferation signals in relation to development and disease, particularly in cancer of pigment cells (melanoma) and tumors of childhood. We attempt to understand critical modes of cell homeostasis with a goal of molecular targeted therapy as well as prevention of melanoma and other human cancers
The Fitzgerald Laboratory explores the molecular mechanisms that cells use to export cholesterol and phospholipid to extracellular acceptor proteins, a process termed lipid efflux. We study how this process generates HDL and how HDL can modulate the innate immune system.
Alice W. Flaherty, MD, PhD has a dual appointment as associate professor of neurology, and of psychiatry at Harvard Medical School.
“Development and characterization of animal models of human neurodegenerative diseases...”
The Fuchs Lab researches prevention and treatment strategies for liver fibrosis and liver cancer as well as development of noninvasive techniques for imaging liver fibrosis.
Research topics include: nitric oxide; angiogenesis; tumor microcirculation; intravital microscopy; tumor microenvironment
The Functional Neurology Research Group at Massachusetts General Hospital, led by David Perez, MD, aims to identify biomarkers of disease, prognosis and treatment response for Functional Neurological Disorders.
Our laboratory is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.
Research topics include: mechanisms governing the development of brain tumors
The Tucker Gosnell Center for Gastrointestinal Cancers is the first center of excellence in the Harvard system that focuses on integrated multidisciplinary care and research for hepatic and biliary malignancies.
My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.
The Division of General Academic Pediatrics is an internationally-known academic research division dedicated to improving the health of children and adolescents.
The Schizophrenia Program is involved in a wide range of genetic research projects in collaboration with genetic laboratories at Harvard Medical School and other institutions.
The clinical research program of the Claire and John Bertucci Center for Genitourinary Cancers is a multidisciplinary effort to understand cancer biology, discover novel agents and improve treatment outcomes for patients with genitourinary malignancies including cancers of the prostate, bladder and kidney.
The Geriatric Neurobehavioral Clinic at Massachusetts General Hospital offers a multidisciplinary and individualized approach to the diagnosis of persons with memory disorders.
Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.
Functions of RNA Chemical Modifications (Epitranscriptomes) in Health and Disease
G. Paolo, Dotto, MD, PhD
Massachusetts General Hospital
Cutaneous Biology Research Center
Building 149, 13th Street
Charlestown, MA 02129
Tel: (617) 724-9538
Fax: (617) 726-9572
Research Interests: Development of integrative mind-body and behavioral interventions to promote health behavior change, treatment adherence, and treatment outcomes for patients throughout the cancer spectrum.
The Global Neurology Research Group, part of the Department of Neurology and the Neurological Clinical Research Institute, finds innovative solutions to improve the quality of neurological care in low- and middle-income countries.
The Mass General Global Outreach for Radiation Protection Program promotes the safer use of ionizing radiation around the world within the broader context of medical applications.
Dr. Glykys studies how seizures are generated in the pediatric brain and how we can enhance the brain’s inhibition system to treat seizures.
The Gobel Laboratory studies polarity, epithelial morphogenesis and growth regulation in Caenorhabditis elegans.
Research within the Marcia B. Goldberg, MD, Laboratory at Mass General focuses on the molecular nature of interactions between microbial pathogens and the host and the development of rapid diagnostics for infectious diseases.
Dr. Gomez-Isla investigates the neurobiology of normal aging, Alzheimers, and other dementias.
The Gomperts lab investigates Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease
Research topics include: endothelial cell function; imaging platelet thrombosis; blood rheology and thrombosis; hemolytic uremic syndrome
The Graubert laboratory focuses on the molecular basis of human blood cancers, including acute myeloid leukemia and myelodysplastic syndromes.
Research on the pathogenesis, diagnosis and treatment of cerebral amyloid angiopathy (CAA), a cause of cerebral hemorrhage in the elderly.
Grewo Lim researches the effect of gene expression on the behavioral interaction between pain and opioid tolerance, exploring the potential use of opioid therapy in chronic pain management.
The Center for Gynecologic Oncology has become one of the nation's outstanding centers for clinical research in gynecologic malignancy. The center has had a strong leadership role at every level of development of therapies for women's cancers, from preclinical drug development, to Phase I and II trials, to Phase III cooperative clinical trials.
The Haas laboratory uses quantitative mass spectrometry-based proteomics to study the cellular pathways that characterize cancer cells in a comprehensive proteome-wide manner.
Research topics include: genetics of cancer; breast cancer; Wilms tumor; somatic mutations linked to drug susceptibility in lung cancer
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists and computational biologists working together to develop new and unbiased strategies to understand basic immune processes and immune-mediated diseases, with an emphasis on the innate immune system.
Our unit conducts clinical research related to hair loss.
One of the most productive clinical research units in hand surgery, we address all aspects of recovery from hand and arm injury and illness.
The Jason Harris, MD, MPH and Regina LaRocque, MD, MPH Laboratory is focused on host-pathogen interactions and the innate and adaptive immune response to Vibrio cholerae, cholera vaccines, and in the area of susceptibility to cholera.
The Harris Orthopaedics Laboratory comprises preclinical biomechanical research and biomaterials testing along with clinical research involving in vivo follow-up of implant performance.
Research topics include: modeling neurodegenerative disease in C. elegans; notch signaling in the adult nervous system; osmotic stress response and aging; quiescence and sensory signaling; lipid homeostasis
The Harvard Orthopedic Trauma Research Division is an inter-institutional, multi-disciplinary team dedicated to understanding the human biological and clinical processes associated with traumatic orthopedic injuries.
The Harvard Program in Refugee Trauma has spent 25 years caring for the health and mental needs of survivors of mass violence and torture through a combined practice of clinical experience and medical research.
The Hata laboratory focuses on understanding the biological underpinnings of sensitivity and resistance to kinase inhibitor targeted therapies in lung cancers with specific genetic abnormalities (EGFR mutations, ALK translocations, KRAS mutations).
The Center for Head and Neck Cancers is a longstanding multidisciplinary clinical and scientific program that arose from a foundation established by world-renowned clinicians at Massachusetts General Hospital (MGH) and the Massachusetts Eye & Ear Infirmary (MEEI).
At the Healthy Lifestyles Program, people with schizophrenia receive state-of-the-art intervention for weight loss, diabetes prevention, cardiovascular fitness, and improved overall health.
Research topics include: apoptosis; DNA damage and repair; oxidative stress; radiation-induced bystander effects; heavy ion radiation biology
The Hematologic Malignancies Program encompasses research regarding leukemia, lymphoma and multiple myeloma, incorporating a substantial commitment to the understanding and use of stem cells in these diseases. It is closely integrated with the Bone Marrow Transplant Program, sharing commitment, faculty and research efforts.
The Hematopoietic Cell Transplantation Laboratory in the Center for Transplantation Sciences (CTS) studies the immunology of hematopoietic cell transplantation with the goal of eliminating immunological barriers in patients with cancers and other diseases that affect the blood, bone marrow and lymph nodes.
Led by Dr. Hersch, the Laboratory investigates Huntington’s disease using transgenic mouse models and human brain tissue. Research also includes HD clinical trials.
“Developing mathematical descriptions of complex human disease phenotypes and how they change over time...”
Our lab tries to understand the role stem cells play in normal development and disease.
Research topics include: pluripotency and nuclear reprogramming
Research topics include: transcription factors in blood development and leukemia
Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.
The Hoggatt Laboratory is broadly interested in the stem cell niche regulatory mechanisms that govern tissue regeneration, particularly regulation by macrophages, and that have a specific interest in translational science for bone marrow transplantation and other treatments.
The Hoggatt Laboratory focuses on stem cell biology and the development of novel therapies for cancer and tissue regeneration.
The Hooker Research Group, led by Jacob Hooker, PhD, aims to accelerate the study of the living human brain through development and application of molecular imaging tools. The group is located at the Martinos Center for Biomedical Imaging.
The Feng Laboratory at Mass General studies the modulation of ion channels by general anesthetics using molecular biology, biochemistry andelectrophysiology techniques. The laboratory also researches the mechanism and treatment of epilepsy and seizures as well as their related complications.
Research topics include: spontaneous tumors and their isograft models; histopathology; pathophysiology
The Hughes Lab develops a cancer risk assessment software (Hughes riskApps™) that focuses on increasing the quality and efficiency of care while decreasing cost.
The Hurley Laboratory at Massachusetts General Hospital investigates infectious and inflammatory diseases that disrupt mucosal surfaces of the lung and digestive tract.
The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.
“To identify actionable genetic alterations in cancer”
The Iliopoulos laboratory works on understanding the biochemical mechanisms of cancer angiogenesis and cancer metabolism in order to identify and validate new targets for treatment of Renal Cell Carcinoma (RCC).
The Massachusetts General Hospital Immunobiology Laboratory conducts basic and translational research focused on discovering novel treatments for autoimmune diseases, with a specific focus on type 1 diabetes.
Our research focuses on applying outcomes methodologies to the clinical field of gastroenterology. Specific examples include the use of decision-analytic modeling to perform comparative effectiveness research regarding the screening and management of various gastrointestinal cancers and diseases.
Research Interests: Outcomes related to supportive care of cancer patients and measuring the quality of oncology care.
The mission of the Institute is to accelerate the clinical translation of novel diagnostic tools for early disease detection and monitoring of emergent treatments.
The Institute conducts health outcomes research to guide the development, evaluation and utilization of medical technologies that improve the quality and cost-effectiveness of medical care.
We take an integrated translational approach to designing patient-oriented experimental and clinical trials for aging and dementia that involves advanced neuroimaging and assessment techniques, ultra-sensitive biomarker detection technologies, and high throughput proteomic and lipidomic assessment of tissue and biofluids.
The Intervention Clinical Trials Program research team seeks better medication options to treat schizophrenia symptoms and mitigate the medical problems associated with existing medications.
Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.
Experiments carried out by our group are directed at understanding the mechanisms that regulate intestinal innate immune responses to pathogenic and commensal bacteria.
The Kistler Stroke Research Center provides office space for Stroke Service research groups. It is named in honor of Dr. J. P. Kistler, Director of the MGH Stroke Service from 1978 to 2004, to recognize Dr. Kistler's contributions to the MGH Neurology Service, and the field of Stroke neurology.
The Jaffer Lab at Massachusetts General Hospital is developing new approaches to image high-risk plaques (narrowings, blockages) that cause myocardial infarction (heart attacks), which could ultimately help prevent heart attacks from occurring.
Research topics include: tumor microenvironment; angiogenesis and lymphangiogenesis; metastasis; in
vivo imaging; translational research; drug delivery, nanotechnology, mathematical
The Jain Lab is working to understand how the immune system develops and operates in newborns in order to develop new approaches to improving infant health.
The Perrin group studies chronic health conditions in children and adolescents, with particular focus on autism spectrum disorders (ASD). Recent work has examined care improvement for children with ASD and racial and ethnic disparities in autism diagnosis and care. The team also provides evidence to support decision-making regarding newborn genetic screening and has examined recent policy and changes regarding public programs supporting children with disabilities (the Supplemental Security Income [SSI] program).
The Moon Laboratory at Massachusetts General Hospital investigates basic issues of CD4+ T cell tolerance by directly tracking endogenous antigen-specific populations in mice and humans.
Research Interests: Psychosocial adaptation to cancer diagnosis and treatment, and evidence-based interventions to improve physical and emotional outcomes and symptom management for patients with cancer and cancer survivors.
The Center for Medical Simulation for Medical Simulation advances patient safety by teaching and study of the actions of healthcare providers and educators using simulation. The provider focus is on crises management and teamwork; instructor training focuses on debriefing and development of a learner-centered approach. Research generally studies provider behavior and instructional methods.
Research Interests: Issues related to quality of care and survivorship for patients with breast cancer as well as health policy and bioethics issues related to oncology.
Research Interests: Palliative care, symptom management, and patient-clinician communication.
The Center for Medical Simulation is a lab that uses highly realistic mannequin simulation to examine communication and cognition in the OR, ER, and ICU. We also examine the dilemmas clinicians face in providing effective feedback, conducting interprofessional negotiations in high-stakes clinical decisions, handling disclosure and apology, and learning to debrief clinical simulations.
The Roberts Laboratory is devoted to investigating novel mechanisms and developing new therapies for important pediatric lung diseases.
Associate Professor of Dermatology
Harvard Medical School
Associate Biologist (Dermatology)
Massachusetts General Hospital
The El Khoury Laboratory at Massachusetts General Hospital investigates the role of the innate immune system in neurodegeneration, inflammation and host defense against infectious pathogens.
Research Interests: Development and testing of supportive care interventions for patients with cancer.
“Genome-editing nuclease technologies have important applications in
biological research and gene therapy…”
At the MGH Weight Center, we believe that treatments for obesity that are safe and effective will be discovered only through ongoing research to find the answers to these and other questions.
Katia Georgopoulos, Ph.D.
Professor of Dermatology
Harvard Medical School
Massachusetts General Hospital
The Miller laboratory focuses on elucidating the molecular mechanisms by which general anesthetics act to produce anesthesia and its side effects.
Research Interests: Understanding health disparities for individuals with severe mental illness.
Molecular research of neurodegeneration in Alzheimer’s disease (AD) focused on identifying cellular pathways regulating the generation of the toxic beta-amyloid protein (Abeta).
Associate Professor of Dermatology
Harvard Medical School
Associate Biologist (Dermatology)
Massachusetts General Hospital
Research topics include: thrombopoietin; thrombocythemia
Our mission is to drive the development of new mechanism-driven therapies through a richer understanding of how neurologic disease affects behavior.
The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.
Dr. Brian Edlow’s Laboratory for NeuroImaging of Coma and Consciousness (NICC) aims to improve acute care and long-term outcomes for patients with coma and other disorders of consciousness caused by traumatic brain injury.
The Laboratory Of Adult Development studies adults and the ways their emotional well-being, physical health and interpersonal functioning are affected by earlier life experiences.
The Laboratory of Computer Science at Massachusetts General Hospital—the Clinical and Research Informatics Division of the Department of Medicine—explores innovative applications of clinical technology in health care.
The Laboratory of Gastrointestinal Epithelial Biology works to unravel the molecular mechanisms that underlie the processes of growth and differentiation within intestinal epithelia, focusing on gut mucosal defense and how the host interacts with the intestinal microbiota.
The Laboratory of Molecular Endocrinology conducts basic research to discover the causes of diabetes and potential cures for the disease.
The mission of the Sahay Laboratory is to generate fundamental insights into the functions of the dentate gyrus and the role of adult hippocampal neurogenesis in cognition and mood
Research topics include: clinical epidemiology and health services research in cancer
“Identifying molecular pathways that drive progression and relapse in pediatric cancer…”
Research Interests: Behavioral aspects of symptom management and quality of life among adults with cancer.
Understanding the human immune response against viruses, with a focus on T-cell responses targeting human hepatotropic viruses (Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), HCV/HIV co-infection). Establishing the groundwork for rational design of antiviral vaccines and immunotherapies.
The Lawrence Laboratory focuses on using computation as a powerful microscope to study the processes of DNA damage and repair, gene expression and genome replication, and cancer driver genes.
The Lazar Lab for Meditation Research at Massachusetts General Hospital studies the impact of yoga and meditation on cognitive and behavioral functions using scientifically validated brain imaging technologies.
The Herbert Lin Laboratory studies the role of the TGF-beta/BMP signaling pathways in health and disease.
Lipid Metabolism research activities center on cholesterol trafficking in and out of cells and the proteins that control this movement.
The Liss Laboratory at Massachusetts General Hospital is interested in understanding the molecular mechanisms that contribute to pancreatic cancer.
Understanding how long noncoding RNAs regulate embryonic stem cell differentiation and liver fibrosis
“Elucidating the molecular basis of glioma formation impacts both diagnostic and therapeutic aspects of clinical neuro-oncology…”
The main focus in the Hua Lu Laboratory is to study the mechanism of the trafficking of a water channel protein, AQP2.
The Lubitz Lab focuses on improving the quality of care for patients with thyroid, parathyroid and adrenal disorders.
The Misra group studies neuroendocrine and bone alterations in conditions spanning the nutritional spectrum.
Research topics in the Maheswaran Lab include: tumorigenesis, breast cancer and cancer genetics.
The Michael K. Mansour, MD, PhD Laboratory at Massachusetts General Hospital focuses on developing novel cellular diagnostics and therapies for invasive fungal infections.
The Markmann Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital examines the hypothesis that a small subset of B cells plays a beneficial or regulatory role in transplant tolerance within the elderly population.
Masao Kaneki, MD, PhD investigates clinical data to help develop new strategies to improve the clinical outcome of critically ill patients with conditions such as sepsis or burn injuries, and chronic inflammation-mediated human diseases such as diabetes.
Mass General Imaging's Global Health Programs are dedicated to addressing unmet medical imaging needs and healthcare disparities for vulnerable and crisis-affected populations.
The MassGeneral Institute for Neurodegenerative Disease (MIND) is a research center for Alzheimer’s, ALS (Lou Gehrig’s), Huntington’s, Parkinson’s and other neurodegenerative diseases. The Institute's mission is to accelerate research discoveries that will lead to treatment and cures.
The goal of the Maus lab is to design and evaluate next generation genetically-modified (CAR) T cells as immunotherapy in patients with cancer.
“The role of the membrane: cytoskeleton interface in receptor tyrosine kinase
signaling, tissue morphogenesis and tumorigenesis...”
The research in the Medoff Laboratory is dedicated to understanding the molecular basis of immune-mediated lung injury.
The Center for Melanoma draws upon the specialized expertise of physicians and researchers from the Departments of Dermatology and Radiation Oncology, and the Divisions of Surgical Oncology, Transplant Surgery, Hematology and Oncology, and Dermatopathology.
Membrane proteins play critical roles in the brain. The Membrane Biology Lab studies ATP-hydrolyzing enzymes that control sodium, potassium and calcium movements. Molecular, cellular and biochemical approaches are used to study structure, function and physiology. Mutations found in human diseases, such as dystonia, are being studied in mutant mice.
The mission of the Center for Mental Health and Media is to destigmatize mental illness, comfort and educate families about optimal development, and to change the public's outdated and inaccurate perceptions of the nature, causes and treatment of mental illness.
A collaboration by Mass General and Brigham and Women’s Hospital, the CCDS aims to transform healthcare by applying the latest advances in artificial intelligence.
Research areas are organized into three Centers of excellence: PET Radiochemistry Discovery (CPRD); Advanced Radiological Sciences (CARS); and Translational Nuclear Medicine and Molecular Imaging (CTNMI).
The Center for Ultrasound Research & Translation (CURT) is a joint MGH-MIT Center dedicated to clinical translational research and engineering innovation in the field of medical ultrasound.
Research in the Michaelson Lab focuses on development of databases on several cancers, testing systems and various analyses.
MIND Informatics develops and applies integrative computational methods in biomedical and brain research, working with leading clinicians and researchers to understand and cure neurological disorders.
The Clinical Proteomics Research Center explores neurovascular pathophysiology using a translational approach - with the goal of developing prognostic tools to guide clinical decision-making.
The goal of the Mitchell Lab is to understand how vaginal microbes influence reproductive health and disease. We approach this in two ways: basic science experiments in the lab, and translational studies using patient samples.
The Miyamoto laboratory focuses on the discovery and development of novel biomarkers to guide the personalized treatment of patients with prostate cancer.
Dr. Robert Moir's research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.
The Molecular Biology Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital focuses on deciphering the role of major histocompatibility class II molecules in the modulation of T cell responses to self and foreign antigens.
Research in the Molecular Neurosurgery Lab focuses on the use of herpes simplex virus (HSV) vectors for cancer therapy and gene delivery in the nervous system, with the long-term goal being the therapeutic application of these vectors to patients.
The goal of this laboratory is to investigate the role of immunological events in the pathogenesis of orthopedic malignancies and to develop combinatorial immunotherapeutic strategies for the treatment of orthopedic malignancies with special emphasis on translational research.
Research topics include: sirtuins in aging and metabolism; chromatin structure and DNA repair
Research topics include: RNA-mediated epigenetic gene silencing.
The Mou Laboratory in the Mucosal Immunology and Biology Research Center at Massachusetts General Hospital applies stem cell technologies to investigate personalized medicine approaches for lung and airway diseases including cystic fibrosis, asthma, bronchopulmonary dysplasia (BPD) and chronic obstructive pulmonary disorder (COPD).
We use established health services research methods to identify and compare alternative delivery models for achieving desired outcomes. We have a particular interest in strategies for reducing costs while improving the quality of care. The ultimate mission of our group is to design and implement coordinated care models for neurological care of high value.
We uncover the genetic basis and molecular mechanisms of microbial recognition and immune regulation in the digestive tract.
Our focus is to better understand inflammatory processes impacting mucosal surfaces, particularly in the lung and digestive tract.
The Multiple Sclerosis (MS) Imaging Laboratory in the Department of Neurology at Massachusetts General Hospital, led by Eric Klawiter, MD, Msc, is focused on developing new imaging techniques to better understand, diagnose and treat multiple sclerosis.
Research topics include: vascular biology, tumor physiology and tissue engineering.
Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.
The Musculoskeletal Genetics and Regenerative Biology Laboratory (MGRBL) is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.
Research topics include: molecular mechanisms of gene regulation; the function of co-activators and co-repressors in mediating the action of transcription regulators
The Natarajan Laboratory uses genomics, biomarkers, bioinformatics, mobile technology, and deep phenotypic learning to discover and understand the causal factors of atherosclerotic cardiovascular disease.
The Natural Orifice Translumenal Endoscopic Surgery (NOTES) Laboratory develops innovative minimally invasive techniques using the body’s natural orifices to perform surgeries.
The Neural Prosthetic Lab seeks to improve the effectiveness of CNS-based neural prosthetics by understanding how and why neurons respond to electric stimulation. We use this knowledge to develop improved methods of stimulation. Projects focus on retinal prosthetics, DBS and other devices.
The Stephen E. and Catherine Pappas Center for Neuro-Oncology is a national leader in clinical research and the development of experimental therapeutics for adult malignant brain tumors.
The Neuroanesthesia Research Laboratory directed by Oluwaseun Johnson-Akeju, MD, MMSc, at Massachusetts General Hospital conducts research that intersects medicine, neuroscience, mathematical modeling and engineering.
The Neurochemistry Laboratory at Massachusetts General Hospital studies novel chemotherapeutic agents for clinical trials in patients with Alzheimer's disease.
Learn more about clinical research in the Neuroendocrine Unit at Massachusetts General Hospital.
The Neuroendocrine Center is one of the premier multidisciplinary clinical and research programs in neuroendocrinology and pituitary tumors in the USA. A recognized international referral center, the Neuroendocrine Center incorporates multidisciplinary expertise from Neuroendocrinology, Neurosurgery, Neurology, Radiation Oncology and Psychiatry.
Learn more about basic research the the Neuroendocrine Unit at Massachusetts General Hospital.
The laboratory is focused upon clinical and translational research in GI Motility and Visceral Pain Syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome.
Dr. Swoboda’s research and clinical activities are dedicated to the diagnosis and treatment of neurologic disorders, especially neuromuscular diseases, movement disorders, and neurodegenerative disorders with childhood-onset.
The Schizophrenia Program Neuroimaging Investigators use MRI and other imaging technologies to conduct cutting-edge research on the neurobiological basis of schizophrenia.
The Neurological Clinical Research Institute (NCRI) at Mass. General is experienced in developing, facilitating, and conducting multicenter clinical trials in Amyotrophic Lateral Sclerosis (ALS) and other neurological diseases.
Drs. Vaina and Buonanno's Neurology of Vision Lab links stroke neurology to neuroscience and multimodal brain imaging, to offer diagnosis and treatment of disorders of the brain affecting visual perception and cognition.
With faculty members from the departments of Neurology, Radiology, Pediatrics, and Anesthesia and Critical Care, the Neuroscience Center works to understand the biology of neurological disorders and develop novel methods of diagnosis and treatment.
The MGH Neurotherapeutics Program encompasses the clinical, research and training activities related to device-based treatments for psychiatric disorders.
The Mass General Nuclear Magnetic Resonance Surgical Laboratory investigates biomedical problems related to mechanisms underlying significant medical paradigms, including neoplasia, injury, inflammation, infection and stroke rehabilitation.
Research Interests: Palliative care, informed decision-making, and racial disparities within the chronic kidney disease population.
Massachusetts General Hospital researchers are spearheading an international effort to study optical coherence tomography (OCT), an imaging technology that could help doctors identify the vulnerable coronary plaques that cause heart attacks or sudden cardiac death.
The Ott laboratory is dedicated to discovering the gene expression control factors that are essential for leukemia and lymphoma cell survival.
The Ott Laboratory is working to develop new tissue engineering strategies for regenerating whole organs and organ grafts as an alternative to donor transplantation.
Research at the Outcomes Research Center at Massachusetts General Hospital focuses on evaluating the impact of cancer and its treatment on patients, helping patients make better, more informed treatment decisions, and assessing and improving patient-centered cancer care.
Research topics include the pathophysiology of tumor-associated lymphatic vessels and lymphatic metastasis.
The focus of the basic and translational laboratory efforts is the molecular mechanisms underlying the initiation, progression, and maintenance of pancreatic disease and cancer, specifically the contribution of developmental genes.
Basic and translational research with an emphasis on cancer biology
Our unit conducts clinical and epidemiologic research related to skin diseases including research on the causes, prevention, evaluation, and management of interventions for skin diseases in human populations.
Patricio Leyton researches how mutations in bone morphogenetic proteins can result in the development of Primary Pulmonary Arterial Hypertension (PAH).
Patrick Purdon develops and applies novel methods in neuroimaging and biomedical signal processing to study the systems neuroscience of general anesthesia and other altered states of consciousness.
The Teodor Paunescu Laboratory studies proton secretion in the kidney and the olfactory epithelium, and its relevance for maintaining body acid-base balance, the sense of smell, and nutrition.
The Pediatric Airway, Swallowing and Voice Center, a collaboration of MassGeneral Hospital for Children and the Massachusetts Eye and Ear Infirmary, specializes in conducting research to treat children with voice disorders and airway management symptoms that affect the ability to eat, breathe or speak.
The Center for Pediatric Hematology and Oncology is actively participating in clinical trials and translational research. A significant number of our clinical trials are through collaborative efforts with the Children's Oncology Group (COG), the Pediatric Brain Tumor Consortium (PBTC), the New England Retinoblastoma Group and the Hodgkin Lymphoma Consortium.
Research within the Pediatric Endocrine-Neuroendocrine-Sports Endocrine Lab aims to further medical knowledge about endocrine, bone, neurocognitive and neuropsychiatric outcomes in athletes, girls with low-weight eating disorders, teenagers and young adults undergoing bariatric surgery, and children with autism spectrum disorders. In particular, we focus on studies whose results allow us to adapt and improve medical care for female athletes and young girls and women with eating disorders.
The goal of our laboratory research is to find ways to generate regulated insulin secretion in cells or tissues for pancreatic b-cell replacement therapy in diabetes.
The Pediatric Epilepsy Research Lab studies how neuronal ion transport and synaptic plasticity alter the spread of epileptic activity in neural networks.
The mission of the Pediatric Psychopharmacology and Adult ADHD Program at Massachusetts General Hospital is to advance the well-being of children and families afflicted with mental illness through research, education and clinical care to identify, prevent and treat those afflicted with mental illness.
The mission of the Pediatric Radiation Oncology Research program is to continuously improve cancer treatment and outcomes in our pediatric patients through innovative and collaborative research that we translate into clinical care.
The Pediatric Surgical Research Laboratories focus on areas of Developmental Biology which hold promise for clinical application for birth defects and cancer prevention and treatment.
We have discovered that the cholesterol biosynthetic pathway is critically important to the hepatitis C viral lifecycle and are examining this relationship further.
Research efforts are focused on developing radiation treatment techniques to optimize physical dose conformation to the tumor target volume and to increase the precision of the dose application.
Research topics include:
B cell Development and Lineage Commitment; A Novel Cell Surface Acetylation/Deacetylation Paradigm for Regulating Humoral Immunity and Development; Characterizing Peripheral Human B cells and B cells in Patients with Chronic Lymphocytic Leukemia
The focus of the Pinello laboratory is to use innovative computational approaches and cutting-edge experimental assays such as genome editing and single cell sequencing to systematically analyze sources of genetic and epigenetic variation and gene expression variability that underlie human traits and diseases.
The Plastic Surgery Research Laboratory conducts investigations into tissue engineering of cartilage, mechanisms of neural injury and regeneration, ischemia/reperfusion injury, and transplantation of vascularized limb tissues.
The Post-traumatic Stress Disorder Research Laboratory at Massachusetts General Hospital performs state-of-the-art psychobiological research into the assessment, pathophysiology, prevention and treatment of post-traumatic stress disorder (PTSD).
“Elucidating the immunophenotype and functional capacity of stem cells capable of developing into various tissue lineages...”
The PSC Registry at Massachusetts General Hospital is a database and tissue repository established to be a resource for clinical and basic science investigators studying primary sclerosing cholangitis.
The MGH Program in Membrane Biology brings together a diverse group of investigators with a common interest in understanding how physiological signals regulate tissue and organ function at the cellular level.
The mission of the Psychiatric & Neurodevelopmental Genetics Unit (PNGU) at Massachusetts General Hospital is to identify and characterize the genetic basis of psychiatric, behavioral and neurodevelopmental disorders and to translate these discoveries to improvements in clinical care and public health.
Epidemiology provides a public health perspective on mental health and mental illness in that it is concerned with psychiatric disorders in the general population.
In a collaboration between the Department of Psychiatry, consistently rated the best program in the US, and the Mass General Cancer Center, ranked among the top ten in the nation, we are able to complement the research on cancer treatments by focusing on the psychological and behavioral aspects of cancer.
The Psychological Evaluation and Research Laboratory (PEaRL) is a clinical assessment, research, and training service at Massachusetts General Hospital directed by Mark A. Blais, PsyD.
The QPID (Queriable Patient Inference Dossier) Informatics group includes physicians and computer scientists who are developing a novel platform capable of extracting useful patterns of electronic health record data from clinical data repositories.
Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system, in part due to the abundance of respiratory diseases of unknown causes and without cures.
Research topics include: multiple myeloma; tumor microenvironment; bone disease and myeloma; novel therapies for multiple myeloma
Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.
Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.
Research at the Center for Cancer Risk Assessment (CCRA) is devoted to advancing all aspects of cancer risk assessment, screening and prevention. The Center has both laboratory and clinical components.
The Behavioral Medicine Program at Massachusetts General Hospital is at the forefront of research focused on developing, validating and disseminating psychosocial interventions to help individuals with a variety of health and medical issues.
My research focuses on research in epidemiology and outcomes of inflammatory bowel diseases and development of personalized medicine approach.
The Rheumatology Clinical Research Unit at Massachusetts General Hospital performs state-of-the-art translational research for patients with immune-mediated and rheumatological conditions.
Riccardo Barbieri analyzes biological systems such as the cardiovascular, central nervous and automatic nervous systems through mathematical modeling, providing a more accurate and noninvasive assessment of these systems.
Richa Saxena studies the genetics of circadian rhythms/sleep disorders and their association with common disease like type 2 diabetes. The lab also investigates the genetics of preeclampsia, and its role in predicting the risk of future cardiovascular disease.
“Using genomics to identify critical pathways in pediatric tumors…”
The Anthony Laboratory at Massachusetts General Hospital investigates the role and regulation of immunoglobulin glycosylation.
The Center for Medical Simulation is a lab that uses highly realistic mannequin simulation to examine communication and cognition in the OR, ER, and ICU. The lab also examine the dilemmas clinicians face in providing effective feedback, conducting interprofessional negotiations in high-stakes clinical decisions, handling disclosure and apology, and learning to debrief clinical simulations.
“To characterize the mechanisms of CD4 cell dysfunction in persons with acute HIV infection...”
A major effort in the laboratory of Bo Rueda, PhD, has been in the identification and functional characterization of gynecological cancer cells.
The Edward T. Ryan, MD Laboratory’s research focuses on host-bacterial pathogen interactions and immune responses, with a particular focus on enteric infections and the development of vaccines protective against enteric infections, and development of diagnostic assays.
Research Interests: Optimizing the care delivered to patients with cancer and their family
The Islam Laboratory investigates mechanisms regulating skin immunity and inflammation, and chemokine and associated pathways in chronic skin inflammation and host immunity
The laboratory focuses on identifying epigenetic alterations that regulate gene expression in brain disorders, and investigates whether these alterations are heritable across multiple generations.
The Salinas Lab is driven by the guiding hypothesis that our social relationships alter the biology of the brain and are crucial to brain health.
The Sarcoma/Oncology Computational Biology Laboratory conducts cancer genomic/bioinformatics studies in order to detect molecular patterns relevant to tumor outcome and response to conventional or novel treatments
The Center for Sarcoma and Connective Tissue Oncology offers a truly multidisciplinary approach to care, including research and clinical trials conducted as part of one of the largest hospital-based programs in the nation.
The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.
I am interested in the structure and function of the cerebellum, and in the cerebral and cerebellar roles in cognition and emotion. We perform neuroanatomical tract tracing studies in monkey; structural and functional MRI and PET in patients and controls; and we treat and study patients with ataxia and/or cognitive disorders.
Research topics include: Cyclin D1
The Schwarzschild lab targets three purines—adenosine, caffeine and urate—in pursuit of improved therapy for Parkinson’s and related neurodegenerative diseases.
The Harris Lab is a multi-disciplinary, inter-departmental group of investigators aiming to advance the understanding of whole-organ physiology and pathophysiology of the human lung through the development and implementation of advanced imaging techniques, sophisticated mathematical and computer modeling and bioengineering. In our studies, we apply rigorous quantitative tools to investigate the complex structure-function relationships of healthy and diseased lungs.
The Sanja Sever Laboratory's research focuses on podocyte structure and function, the large regulatory GTPase dynamin, as well as the intersection of these two areas.
“Understanding the molecular genetic events associated with the pathogenesis of human breast cancer...”
The Bromley Laboratory investigates lymphocyte migration, with an emphasis on the mechanisms that regulate the accumulation of T cells within normal and inflamed non-lymphoid tissues.
The Shi Lab is researching the effects of infections and immune disorders on the intestine and the role of gestational factors in the development of child allergies.
Research topics include: signaling of mammary epithelial cells
The Oottamasathien Laboratory at Massachusetts General Hospital is focused on understanding the inflammatory cascade for better care and treatment of those suffering from IC/PBS.
The Skeletal Biology Research Center (SBRC) applies advances in treatment to the art of reconstruction for congenital and acquired facial deformities.
The Sleep Disorders Clinical Research Program at Massachusetts General Hospital is dedicated to clinical and investigative efforts in sleep disorders, including restless legs syndrome, insomnia and sleep-related eating disorder.
“Investigating the causes of acute and chronic rejection...”
At the Mass General Smoking Cessation Program, people with schizophrenia receive the best in personally tailored behavioral and medication treatment for smoking cessation as well as prevention of relapse to smoking.
The Smoller Laboratory works to understand the genetic basis of psychiatric disorders in order to improve diagnosis and treatment. It is part of the Psychiatric & Neurodevelopmental Genetics Unit (PNGU) at Massachusetts General Hospital.
The overall focus of the Roy Soberman Laboratory is to understand signal integration and macromolecular organization in cells of the immune system, and how these processes are linked to control the amplification of the immune response.
We conduct leading scientific research to better understand concussions in young people and to develop better approaches to assessment, treatment, and rehabilitation.
We study transcriptional regulation of gastrointestinal and hepatobiliary development and its application to regenerative medicine and cancer.
The Stem Cell Therapeutics and Imaging Program focuses on engineering therapeutic and diagnostic stem cells for different pathologies in pre-clinical settings and translating them into clinics.
“Investigating hereditary brain tumor syndromes...”
“Investigating the molecular mechanisms of vascular disease...”
Clinical stroke research is critical to the prevention and treatment of this disabling disease. Our research may take the form of clinical trials, or studies that follow patients over time.
Research topics include: pharmacokinetic studies of new anticancer agents
The focus of the Pulmonary Optical Imaging Laboratory is the development and subsequent translation of novel optical diagnostic tools for evaluating the pulmonary airways and lung.
Research topics include: biology of brain tumors, in particular glioblastoma and oligodendroglioma.
"Genetic and non-genetic determinants of single-cell programs in human gliomas"
Research topics include: leukemia, tumor suppressor gene, cancer genetics, stem cell,
We combine microelectrode and macroelectrode recording and computing techniques to study brain activity, mechanisms for brain machine interface, and the neurophysiology of epilepsy.
Syed Shaukat Husain studies the molecular composition of general anesthesia.
Research topics in the Tanabe Lab include: hepatobiliary cancer, Epidermal Growth Factor and hepatocellular carcinoma.
Bakhos Tannous, PhD – Research focus in molecular Imaging, gene transfer technologies and high throughput screening aiming at finding novel therapeutics against brain tumors.
Research Interests: Breast cancer disparities and end of life care.
“The development and validation of non-invasive, high-resolution optical imaging methods for disease diagnosis...”
The Technology Implementation Research Center (TIRC) conducts translational research relating to orthopedic implants, materials and surgical technologies. Our mission is to dramatically improve the quality of orthopaedic care by leveraging biomechanical and biomaterials research to bring disruptive technology to active clinical use.
The Teratology Program focuses on the study of the causes of congenital malformations.
Research Interests: How women with a history of cancer get their needs met in the face of challenges.
The Ravi Thadhani Laboratory's research efforts are divided into two main areas: Pregnancy and Dialysis. Pregnancy related studies have centered on human studies supporting basic science collaborations in the area of angiogenic factors and preeclampsia. In dialysis, we have conducted studies examining the effect of vitamin D in the survival of chronic hemodialysis patients.
Massachusetts General Hospital has created our nation's first multi-specialty institute dedicated to the prevention and treatment of atrial fibrillation and one of its most devastating complications – stroke.
The mission of the Deborah Kelly Center is to facilitate exemplary obstetrical and gynecologic outcomes-based research in women's health care.
At The Laboratory for Therapeutic 3D Bioprinting at Massachusetts General Hospital, we bioprint live micro-tissues that are comparable to human tissues for therapeutic purposes including tissue regeneration, organ regeneration and anticancer therapy.
The Laboratory for Tissue Engineering and Organ Fabrication is designing and building replacement living tissues and organs to ultimately translate to clinical therapies.
The Program in Nutritional Metabolism at Massachusetts General Hospital was formed under the direction of Dr. Steven Grinspoon, a recognized expert in the nutritional regulation of pituitary function and the metabolic consequences of obesity and fat redistribution.
Research topics include: Circulating tumor cells; microfludics and control of the cell microenvironment; imaging.
The Laboratory for the Study of Childhood Behavior Disorders, directed by Alisha Pollastri, PhD, uses modern research tools to examine the cognitive, biological and social underpinnings of behavioral challenges during childhood, and the factors that are associated with positive treatment outcomes.
Lung cancer is the leading cause of cancer-related mortality in the United States. Despite great advances in the understanding of lung cancer biology, only 15% of patients are alive five years after diagnosis. The research program of the Center for Thoracic Cancers is a multifaceted effort designed to understand thoracic cancer biology, discover novel agents and improve treatment.
The Mempel Laboratory at Massachusetts General Hospital investigates cell migration and intercellular communction in the adaptive immune system through direct dynamic in vivo visualization of immune cell behavior using multiphoton intravital microscopy in mice.
The main focus of the Mass General Thyroid Cancer Research Laboratory, led by Sareh Parangi, MD, is to study certain key genetic and epigenetic changes seen more frequently in those patients who do poorly, and find out how exactly these genetic changes lead to more aggressive cancer behavior in those patients.
Tilo Winkler studies the effect of bronchoconstriction on regional ventilation to determine how ventilation defects emerge, and identify methods of treatment and prevention. The laboratory also develops new methods for pulmonary imaging and image analysis to improve studies in asthma, COPD, ventilator induced lung injury and other diseases.
Research Topics Include: Pancreatic ductal adenocarcinoma (PDAC)
TRANSCEND. Treatment Research and NeuroSCience Evaluation of Neurodevelopmental Disorders.
Research in the Translational Brain Tumor Immunology Lab focuses on the development and evaluation of novel therapies for brain tumors.
The Transplantation Biology Research Center (TBRC) Laboratories in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital comprises two laboratories investigating tolerance induction in transplantation.
Research at the Trauma Research Laboratory targets critical aspects of early trauma care, focusing on clearly defined high-impact goals.
Our laboratory focuses on secondary mechanisms of acute brain injury including trauma and intracerebral hemorrhage.
Anna Mandinova page
Anna Mandinova, M.D., Ph.D.
Anna Mandinova, M.D., Ph.D. Principal Investigator Biologist (Dermatology) Massachusetts General Hospital
The overall goal of my research effort is to better understand the genetic basis of melanoma formation and the clinical realization of these molecular events.
The Turka Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital investigates the cellular and molecular aspects of T cell tolerance, with a particular interest in mechanisms of transplant tolerance.
The Urology Research Lab at Massachusetts General Hospital studies the molecular basis of urologic tumors, including cancers of the prostate, bladder and kidney.
The aim of the Urology Research Lab is to reduce the burden on our patients by studying the basic mechanisms that are responsible for some common urologic diseases.
The Vascular Surgery Research Laboratory is involved in experimental strategies geared towards understanding the pathophysiology of intimal hyperplasia and ischemia reperfusion injury. We are also involved in the development of novel clinically relevant experimental therapies to treat and/or prevent both of these complex problems.
The Vascularized Composite Allotransplantation Laboratory in the Massachusetts General Hospital Center for Transplantation Sciences (CTS)investigates the immunobiology of vascularized composite allografts with a primary focus on developing tolerance induction strategies in preclinical models.
Research topics include: non-coding RNAs, microRNAs, AU-rich elements, Translation, Cytokines, VEGF, oocytes, cell cycle, quiescence
Research Interests: Early integrated outpatient palliative care and palliative care communication education.
The Visual Prosthesis Lab is working to create a means to restore sight to the blind by sending signals from a digital camera directly into the brain.
The Vocal Hyperfunction Clinical Research Center at Massachusetts General Hospital is exploring improved methods and technologies to prevent, diagnose and treat vocal hyperfunction, which is associated with the most frequently occurring types of voice disorders such as vocal cord nodules and muscle tension dysphonia.
Mass General's Voice Center Research Laboratories are designed to develop novel technologies, biomaterials, devices, and surgical tools for advancing the diagnosis, management and treatment of laryngeal diseases and pathologies that affect voice.
The Jatin Vyas, MD, PhD Laboratory at Massachusetts General Hospital focuses on the innate immune response to invasive fungal infections.
The Wainger Lab at Massachusetts General Hospital focuses on how abnormalities of motor and sensory neuron physiology contribute to diseases such as ALS and chronic pain.
The research efforts of the Walker Lab include defining the passive and active protective properties of human breast milk with regard to the protection from disease during the newborn period.
The Walker Laboratory at Massachusetts General Hospital combines genetic, molecular and biochemical approaches to investigate neurofibromatosis type 1 (NF1) and schwannomatosis.
The Wang Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital uses a unique diphtheria toxin-resistant yeast Pichia Pastoris expression system as a platform to develop novel diphtheria toxin-based recombinant immunotoxins/fusion toxins for specific depletion of targeted cell populations in vivo.
The Warren Laboratory researches the pathogenesis and treatment of serious bacterial infections, sepsis, and induced secondary inflammation from any cause.
Wasim Malik researches and develops technology for healthcare applications with a focus on neuroscience and neuroengineering.
The Shreffler Laboratory at Massachusetts General Hospital is interested in the mechanisms regulating both primary sensitization and the subsequent balance between immune progression or regulation that determines either clinical sensitivity or tolerance to mucosal allergens.
The Webster Center is dedicated to improving patient safety and maintaining high quality of care in radiology.
We study muscular dystrophies with the long-term goal of finding new treatments for patients.
Research topics include: histone demethylase; chromatin; C. elegans; transcription; epigenetics; JMJC; HDAC
Dr. Wilbur's lab researches endocervical and endometrial glandular lesions in gynecologic cytopathology, computational pathology and translational molecular medicine.
Research topics include: lung cancer; radiation; EGFR; molecular targeting; DNA repair
The Winfred Williams Laboratory studies the genetic basis of chronic allograft nephropathy.
The David Wojciechowski Laboratory's clinical research is focused on the prevention and treatment of viral infection post-kidney transplant, improving access to transplantation, and the evaluation of immunosuppressive regimens focusing on novel agents and drug combinations in order to maximize patient and graft outcomes and minimize toxicity.
“Studying the molecular basis of human urologic tumors, including cancers of the prostate, bladder and kidney...”
The primary research goal of the Xavier Laboratory is to discover and understand the function of important mediators and effectors involved in the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and pathophysiological contexts of innate immunity. Current themes of the lab include (1) systems biology of innate and adaptive immunity, (2) functional mapping of pathways associated with Crohn's disease, ulcerative colitis and diabetes, and (3) genetics of Crohn's disease, celiac disease and ulcerative colitis.
Research topics include: tumor angiogenesis and metastasis; tumor microenvironment
My research is focused on studying cellular functions (self-renewal, differentiation, proliferation, and chromatin remodeling) and developmental signaling pathways using chemical and genomic tools.
My principal interest is to understand the molecular basis of cancer progression.
The Yeh Laboratory in the Center for Transplantation Sciences (CTS) at Massachusetts General Hospital researches ways to improve access to transplantation and reduce wait list times.
“Understanding the underlying principles of cellular responses to chromosomal insults and their roles in the maintenance of genomic stability...”
We have recently cloned a novel protein, Cables, which maps to human chromosome 18q and inhibits growth of cells in culture and tumor formation in nude mice.
The Array Tomography Core, part of the Neurosciences Center at Massachusetts General Hospital, offers array tomography imaging services and in vivo multiphoton imaging.
The Biostatistics Center maintains a combined research and collaborative program that focuses on the development and application of quantitative methods relevant to cancer.
The Cancer Pharmacology Core provides DF/HCC investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations.
The Cardiovascular Imaging Core Lab at Massachusetts General Hospital is an independent facility dedicated to providing the highest quality services to the cardiovascular imaging community.
Overview of CBRC Cores.
Please follow the link below for the main MGH Cores page
The CCIB DNA Core at Massachusetts General Hospital is dedicated to providing high-quality research services (molecular biology, genomics and laboratory automation) and access to state-of-the-art instrumentation, methodologies and expertise.
The nonprofit Cell Resource Core at Massachusetts General Hospital provides fresh and cryopreserved hepatocytes for use by researchers at Mass General and other research institutions.
The Center for Cancer Systems Discovery (CSD) uses computational, bioinformatic, and statistical approaches to analyze complex biological datasets for basic discovery, translational, and clinical research.
Providing Clinically Actionable Molecular Diagnostics to Accelerate the Adoption of Personalized Medicine
The Center for Molecular Therapeutics is actively investigating better ways to match individual cancer patients with particular targeted drug therapies in order to maximize the likelihood of a clinical response.
The goal of our center is to transform the CTC-Chip into a robust technology that will allow detailed studies across multiple different types of cancer.
The Echocardiography Core Lab at Massachusetts General Hospital provides expert echocardiography readings for public and privately funded clinical trials.
Genome-wide RNAi libraries available at the Broad Institute
The purpose of the human embryonic stem cell (hESC) Core Facility is to provide an institutional resource for hESC research at Massachusetts General Hospital.
The Histopathology Research Core provides standard and customized research specific histology services including routine formalin fixation and paraffin embedding, and sectioning and preparation of frozen sections
Offers custom-built instrumentation for cell sorting and data analysis.
This program investigates HIV pathogenesis and evaluates anti-HIV preventive and therapeutic interventions, in an improved humanized mouse model capable of generating HIV-specific human cellular and humoral immune responses.
The mission of the Immune Monitoring Laboratory is to provide comprehensive immune monitoring that is of high quality, innovative, and enables translational research of immune-based therapies.
The Institute for Health Policy (IHP) is dedicated to conducting world-class research on the leading health issues.
The CIID Intravital Microscopy Lab is dedicated to the dynamic visualization of cellular processes in vivo in small animals using multiphoton excitation fluorescence microscopy.
Includes state-of-the art Nikon upright (80i) and inverted (TE2000-U) microscopes.
The Massachusetts General Hospital Imaging Trials Center is an Academic Research Organization (ARO) that enhances clinical imaging research by providing scientific and informatics expertise to foster, design, conduct, and support clinical trials.
The goal of the Massachusetts General Hospital Tissue Repository is to collect human tumor surgical specimens for distribution to researchers in the Massachusetts General Hospitals scientific community, and to the broader biomedical science community as well. Tumor specimens are now available for distribution to researchers.
The Microfluidics Core, part of the Neurosciences Center at Massachusetts General Hospital, provides know-how and state-of-the-art facilities for investigators of the nervous system to study the cellular microenvironment at the scale comparable to cell size.
The Molecular Profiling Laboratory (MPL) is one of the Cancer Center research centers that provide technological support to Cancer Center investigators.
The Center translates the latest research advances into practical information to help people work with their doctors toward the most accurate diagnosis and best possible treatment results.
The Luster Lab has expertise in mouse models of disease and in the generation of genetically modified knockout, transgenic and reporter mice to study immune cell function in vivo.
The Multiphoton Imaging Core is part of the Neurosciences Center at Massachusetts General Hospital.
The Palliative Care Service, in conjunction with the Harvard Medical School Center for Palliative Care, continues to focus research on innovative projects to promote education in end-of life care for health care professionals.
The Massachusetts General Hospital Pancreatic Islet Isolation Laboratory is a specialized service facility practicing FDA-approved Good Manufacture Procedure (cGMP) standards to manufacture human pancreatic islets.
Testing services provided by the former Pathology Clinical Laboratory Research Core changed effective January 16, 2015. Please refer to the Tests and Prices list for more information.
The Pathology Imaging Research Core provides professional and technical imaging services to researchers at MGH, academic researchers outside the Harvard system, and investigators in Industry
The PET (positron emission tomography) Core Laboratory provides a full range of technical and professional services for the design and execution of programs using PET.
Basic research is necessary to achieve an understanding of the normal and pathological state, but cannot, by itself, put new knowledge to useful applications. The bridge to application is created by the development of diagnostic tests, new drugs or treatment approaches that allow an intervention in patients.
The Quantitative Real Time PCR Core, part of the Neurosciences Center at Massachusetts General Hospital, offers quantitative measurement of nucleic acid (DNA or RNA) levels using real-time PCR.
Our shop specializes in custom design, engineering, and manufacturing. We have a full complement of machine shop equipment ranging from CNC lathes to milling machines and 3D printers.
The Massachusetts General Hospital Department of Radiology's Clinical Trials Program offers contract research organizations, core-imaging labs, biopharmaceutical companies and biotechnology corporations the full spectrum of imaging-related services in support of clinical trials.
Radiology Research Administration supports basic and clinical research in the Massachusetts General Hospital Department of Radiology by fostering communication and providing guidance regarding funding, regulatory issues, and study management.
Tissue analysis is critical to validation and evaluation of animal models of human cancer, and human cancer tissues serve as the "operating system" for translational research.
The Tetramer Resource Lab generates fluorescently labeled peptide:MHC multimers for the purpose of detecting polyclonal populations of antigen-specific T cells.
The Analytical and Quantitative Cytology Core Facility offers services and equipment to perform most flow cytometric assays.
Anti-cancer drugs are screened against a large collection (>1000) cancer cell lines representative of many different malignancies to discover links between genotypes and drug response.
The Tissue MicroArray Core in Mass General Hospital Pathology offers tissue array services and technical support in preparing cores.
A laboratory dedicated to fostering personalized cancer patient care, through development and implementation of innovative tumor genotyping technologies and collaborative clinical and translational research studies.
The Transmission Electron Microscopy Core, part of the Neurosciences Center at Massachusetts General Hospital, aids in elucidating the complex architecture of the nervous system.
The mission of the Tumor Imaging Metrics Core (TIMC) is to provide standardized, consistent, longitudinal, multimodality radiological measurements to evaluate therapeutic response for patients enrolled in DF/HCC clinical trials.
The Tumor Imaging Metrics Core (TIMC) provides standardized, consistent, and efficient radiological measurements to evaluate tumor response for DF/HCC (Dana-Farber /Harvard Cancer Center) clinical trials.
The Neuroscience Center Vector Core was established to meet the increasing need of researchers for recombinant viral vectors capable of achieving efficient and long-lasting genetic modification of cells in primary cultures and living animals.
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