Advanced neuroimaging techniques can identify intact brain networks after traumatic brain injury.

Acute traumatic brain injury (TBI) leads to more than 250,000 hospitalizations each year. Severe TBI leads to a prolonged period of unconsciousness and is associated with several pathologic brain injuries including diffuse axonal injury, brain edema and contusion. Some of the questions our faculty address include:

  • How do patients recover consciousness after a severe TBI?
  • What genetic, neuroimaging, and blood biomarkers can help with prognosis after TBI?
  • Can new treatments prevent additional secondary injury after TBI?

Faculty Studying This Topic

Daniel Rubin Daniel Rubin, MD, PhD
Clinical profile
Research profile

Completed and Ongoing Clinical Trials

  • ASTRAL: A study to evaluate the efficacy and safety of BIIB093 in participants with brain contusion
  • RESPONSE 2: Resting and stimulus-based paradigms to detect organized networks and predict emergence of consciousness
  • STIMPACT: Stimulant therapy targeted to individualized connectivity maps to promote reactivation of consciousness