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In 2020, the Mass General Neurology faculty published more than 1,000 papers in journals like Neurology, Stroke, and JAMA Neurology, and we are on track to surpass that record for 2021. Our research efforts advance our mission to rapidly discover new treatments to reduce and eliminate the devastating impact of neurological disorders.

Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation.
Badr CE, da Hora CC, Kirov AB, Tabet E, Amante R, Maksoud S, Nibbs AE, Fitzsimons E, Boukhali M, Chen JW, Chiu NHL, Nakano I, Haas W, Mazitschek R, Tannous BA. ACS Chem Biol. 2020 Jun 19;15(6):1445-1454. doi: 10.1021/acschembio.0c00104.


Motor tract reorganization after acute central nervous system injury: a translational perspective.
Takase H, Regenhardt RW. Neural Regen Res. 2021 Jun;16(6):1144-1149. doi: 10.4103/1673-5374.300330.   


Aneurysmal Subarachnoid Hemorrhage.
Chung DY, Abdalkader M, Nguyen TN. Neurol Clin. 2021 May;39(2):419-442. doi: 10.1016/j.ncl.2021.02.006.


Video Telehealth Occupational Therapy Services for Older Veterans: National Survey Study.
Gately ME, Tickle-Degnen L, Voydetich DJ, Ward N, Ladin K, Moo LR. JMIR Rehabil Assist Technol. 2021 Apr 27;8(2):e24299. doi: 10.2196/24299.


COVID-19 in a patient treated with eculizumab for aquaporin-4 neuromyelitis optica.
Cabal-Herrera AM, Mateen FJ. J Neurol. 2021 Apr 27:1-4. doi: 10.1007/s00415-021-10578-7. 


Teaching NeuroImages: Increasing SPECTations for Ictal SPECT in Epilepsy Surgical Evaluation.
Nascimento FA, Cochran RL, Chow DZ, Scott JA, Chu CJ. Neurology. 2021 Apr 26:10.1212/WNL.0000000000012097. doi: 10.1212/WNL.0000000000012097. 


Risk Factors With Neurotoxicity After Chimeric Antigen Receptor T-Cell Therapy-Reply.
Rubin DB, Jacobson C, Vaitkevicius H. JAMA Neurol. 2021 Apr 26. doi: 10.1001/jamaneurol.2021.0893.


Overlapping and dissociable brain activations for fluid intelligence and executive functions.
Santarnecchi E, Momi D, Mencarelli L, Plessow F, Saxena S, Rossi S, Rossi A, Mathan S, Pascual-Leone A. Cogn Affect Behav Neurosci. 2021 Apr 26. doi: 10.3758/s13415-021-00870-4.


Identifying Medicare beneficiaries with dementia.
Moura LMVR, Festa N, Price M, Volya M, Benson NM, Zafar S, Weiss M, Blacker D, Normand SL, Newhouse JP, Hsu J. J Am Geriatr Soc. 2021 Apr 26. doi: 10.1111/jgs.17183.


Unique actions of GABA arising from cytoplasmic chloride microdomains.
Rahmati N, Normoyle KP, Glykys J, Dzhala VI, Lillis KP, Kahle KT, Raiyyani R, Jacob T, Staley KJ. J Neurosci. 2021 Apr 26:JN-RM-3175-20. doi: 10.1523/JNEUROSCI.3175-20.2021.


Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study.
Yaghi S, Henninger N, Giles JA, Leon Guerrero C, Mistry E, Liberman AL, Asad D, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Furie KL, Keyrouz SG, Nouh A, de Havenon A, Khan M, Smith EE, Gurol ME. J Neurol Neurosurg Psychiatry. 2021 Apr 26:jnnp-2021-326166. doi: 10.1136/jnnp-2021-326166.


CNS demyelination with TNFα inhibitor exposure: A retrospective cohort study
Hutto SK, Rice DR, Mateen FJ. J. Neuroim. 2021 Apr 25. doi: 10.1016/j.jneuroim.2021.577587


Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.
Dawson J, Liu CY, Francisco GE, Cramer SC, Wolf SL, Dixit A, Alexander J, Ali R, Brown BL, Feng W, DeMark L, Hochberg LR, Kautz SA, Majid A, O'Dell MW, Pierce D, Prudente CN, Redgrave J, Turner DL, Engineer ND, Kimberley TJ. Lancet. 2021 Apr 24;397(10284):1545-1553. doi: 10.1016/S0140-6736(21)00475-X.


Meningeal Multipotent Cells: A Hidden Target for CNS Repair?
Hayakawa K, Snyder EY, Lo EH. Neuromolecular Med. 2021 Apr 24. doi: 10.1007/s12017-021-08663-1.


Off-Label Promotion of Transcranial Magnetic Stimulation on Provider Websites.
Wexler A, Nagappan A, Kopyto D, Santarnecchi E, Pascual-Leone A. Brain Stimul. 2021 Apr 23:S1935-861X(21)00083-8. doi: 10.1016/j.brs.2021.04.013.


Covid-19: a call for mobilizing geriatric expertise.
O'Hanlon S, Dhesi J, Aronson L, Inouye SK. Eur Geriatr Med. 2021 Apr 23:1-4. doi: 10.1007/s41999-021-00500-9.


Contribution of Racial and Ethnic Differences in Cerebral Small Vessel Disease Subtype and Burden to Risk of Cerebral Hemorrhage Recurrence.
Castello JP, Pasi M, Abramson JR, Rodriguez-Torres A, Marini S, Demel S, Gilkerson L, Kubiszewski P, Charidimou A, Kourkoulis C, DiPucchio Z, Schwab K, Gurol ME, Viswanathan A, Anderson CD, Langefeld CD, Flaherty ML, Towfighi A, Greenberg SM, Woo D, Rosand J, Biffi A. Neurology. 2021 Apr 21:10.1212/WNL.0000000000011932. doi: 10.1212/WNL.0000000000011932.


Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons.
Oakley DH, Klickstein N, Commins C, Chung M, Dujardin S, Bennett RE, Hyman BT, Frosch MP. J Neurosci. 2021 Apr 20:JN-RM-2590-20. doi: 10.1523/JNEUROSCI.2590-20.2021.


Restrictive diet in a patient with irritable bowel syndrome leading to Wernicke encephalopathy.
Wang Q, Charmchi Z, George IC. BMC Gastroenterol. 2021 Apr 20;21(1):179. doi: 10.1186/s12876-021-01758-w.


To reduce the risk of dementia focus on the patient.
Pascual-Leone A. Ann Neurol. 2021 Apr 18. doi: 10.1002/ana.26086.  


A Novel Method to Measure Venular Perivascular Spaces in Patients with MS on 7T MRI.
George IC, Arrighi-Allisan A, Delman BN, Balchandani P, Horng S, Feldman R. AJNR Am J Neuroradiol. 2021 Apr 15. doi: 10.3174/ajnr.A7144.


Cognitive Demands Influence Upper Extremity Motor Performance During Recovery From Acute Stroke.
Lin DJ, Erler KS, Snider SB, Bonkhoff AK, DiCarlo JA, Lam N, Ranford J, Parlman K, Cohen A, Freeburn J, Finklestein SP, Schwamm LH, Hochberg LR, Cramer SC. Neurology. 2021 Apr 15:10.1212/WNL.0000000000011992. doi: 10.1212/WNL.0000000000011992. 


Ibudilast (MN-166) In Amyotrophic Lateral Sclerosis - an Open Label, Safety and Pharmacodynamic Trial
Babu S, Hightower BG, Chan J,  Zürcher NR,  Kivisäkk P, Tseng CJ, Sanders DL, Robichaud A,  Banno H, Evora A,  Ashokkumar A,  Pothier L,  Paganoni S,  Chew S,  Dojillo J,  Matsuda K,  Gudesblatt M, Berry JD,  Cudkowicz ME,  Hooker JM, Atassi N. NeuroImage: Clinical. 2021 April 15. doi: 10.1016/j.nicl.2021.102672


Brain insulin signaling and cerebrovascular disease in human postmortem brain.
Arvanitakis Z, Capuano AW, Wang HY, Schneider JA, Kapasi A, Bennett DA, Ahima RS, Arnold SE. Acta Neuropathol Commun. 2021 Apr 15;9(1):71. doi: 10.1186/s40478-021-01176-9.


Spreading depression as an innate antiseizure mechanism.
Tamim I, Chung DY, de Morais AL, Loonen ICM, Qin T, Misra A, Schlunk F, Endres M, Schiff SJ, Ayata C. Nat Commun. 2021 Apr 13;12(1):2206. doi: 10.1038/s41467-021-22464-x.


Algorithm for automatic detection of self-similarity and prediction of residual central respiratory events during continuous positive airway pressure.
Oppersma E, Ganglberger W, Sun H, Thomas RJ, Westover MB. Sleep. 2021 Apr 9;44(4):zsaa215. doi: 10.1093/sleep/zsaa215.


Evidence-Based Medicine Training in US-based Physiatry Residency Programs.
Annaswamy TM, Rizzo JR, Schnappinger A, Morgenroth DC, Engkasan JP, Ilieva E, Arnold WD, Boninger M, Bean AC, Cirstea CM, Dicianno BE, Fredericson M, Jayabalan P, Raghavan P, Sawaki L, Suri P, Suskauer SJ, Wang QM, Hosseini M, Case C, Whyte J, Paganoni S. Am J Phys Med Rehabil. 2021 Apr 8. doi: 10.1097/PHM.0000000000001752.


A simple method for implanting free-floating microdevices into the nervous tissue.
Khalifa A, Eisape A, Coughlin B, Cash SS. J Neural Eng. 2021 Apr 7. doi: 10.1088/1741-2552/abf590. 


Prolonged Intubation in Patients With Prior Cerebrovascular Disease and COVID-19.
Mukerji SS, Das S, Alabsi H, Brenner LN, Jain A, Magdamo C, Collens SI, Ye E, Keller K, Boutros CL, Leone MJ, Newhouse A, Foy B, Li MD, Lang M, Anahtar MN, Shao YP, Ge W, Sun H, Triant VA, Kalpathy-Cramer J, Higgins J, Rosand J, Robbins GK, Westover MB. Front Neurol. 2021 Apr 9;12:642912. doi: 10.3389/fneur.2021.642912.


Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation.
Louis EKS, Videnovic A. Neurotherapeutics. 2021 Apr 5:1-5. doi: 10.1007/s13311-021-01032-7.


Connecting TDP-43 Pathology with Neuropathy.
Klim JR, Pintacuda G, Nash LA, Guerra San Juan I, Eggan K. Trends Neurosci. 2021 Apr 5:S0166-2236(21)00040-0. doi: 10.1016/j.tins.2021.02.008.


MCOLN1 gene therapy corrects neurologic dysfunction in the mouse model of mucolipidosis IV.
De Rosa S, Salani M, Smith S, Sangster M, Miller-Browne V, Wassmer S, Xiao R, Vandenberghe L, Slaugenhaupt S, Misko A, Grishchuk Y. Hum Mol Genet. 2021 Apr 5:ddab093. doi: 10.1093/hmg/ddab093.


Identification of Personalized Transcranial Magnetic Stimulation Targets Based on Subgenual Cingulate Connectivity: An Independent Replication.
Siddiqi SH, Weigand A, Pascual-Leone A, Fox MD. Biol Psychiatry. 2021 Apr 2:S0006-3223(21)00119-0. doi: 10.1016/j.biopsych.2021.02.015. 


Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.
Prokopenko D, Morgan SL, Mullin K, Hofmann O, Chapman B, Kirchner R; Alzheimer's Disease Neuroimaging Initiative (ADNI), Amberkar S, Wohlers I, Lange C, Hide W, Bertram L, Tanzi RE. Alzheimers Dement. 2021 Apr 2. doi: 10.1002/alz.12319.


Stress, resilience, and coping strategies in a sample of community-dwelling older adults during COVID-19.
Vannini P, Gagliardi GP, Kuppe M, Dossett ML, Donovan NJ, Gatchel JR, Quiroz YT, Premnath PY, Amariglio R, Sperling RA, Marshall GA. J Psychiatr Res. 2021 Apr 2;138:176-185. doi: 10.1016/j.jpsychires.2021.03.050.


Editorial: Understanding factors that, beyond plaques and tangles, contribute to the heterogeneity of Alzheimer disease and implications for the development of biomarkers and design of interventions.
Gomez-Isla T. Curr Opin Neurol. 2021 Apr 1;34(2):226-227. doi: 10.1097/WCO.0000000000000915.


Arm Motor Recovery After Ischemic Stroke: A Focus on Clinically Distinct Trajectory Groups.
Kline DK, Lin DJ, Cloutier A, Sloane K, Parlman K, Ranford J, Picard-Fraser M, Fox AB, Hochberg LR, Kimberley TJ. J Neurol Phys Ther. 2021 Apr 1;45(2):70-78. doi: 10.1097/NPT.0000000000000350.


Regional Changes in Patterns of Stroke Presentation During the COVID-19 Pandemic.
Etherton MR, Zachrison KS, Yan Z, Sveikata L, Bretzner M, Estrada J, Viswanathan A, Singhal AB, Schwamm LH. Stroke. 2021 Apr;52(4):1398-1406. doi: 10.1161/STROKEAHA.120.031300.


The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches.
Tsintou M, Dalamagkas K, Moore TL, Rathi Y, Kubicki M, Rosene DL, Makris N. Neural Regen Res. 2021 Apr;16(4):605-613. doi: 10.4103/1673-5374.295269.


Cerebral microbleeds and prediction of intracranial haemorrhage.
Greenberg SM. Lancet Neurol. 2021 Apr;20(4):252-254. doi: 10.1016/S1474-4422(21)00065-X.


Case 292.
Douglas VP, Douglas KAA, Reinshagen KL, Chwalisz BK. Radiology. 2021 Apr;299(1):234-236. doi: 10.1148/radiol.2021201712.    


Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis: a pilot study.
Barry RL, Babu S, Anteraper SA, Triantafyllou C, Keil B, Rowe OE, Rangaprakash D, Paganoni S, Lawson R, Dheel C, Cernasov PM, Rosen BR, Ratai EM, Atassi N. Neuroimage Clin. 2021 Mar 30;30:102648. doi: 10.1016/j.nicl.2021.102648.


HIV Increases Sleep-based Brain Age Despite Antiretroviral Therapy.
Leone MJ, Sun H, Boutros CL, Liu L, Ye E, Sullivan L, Thomas RJ, Robbins GK, Mukerji SS, Westover MB. Sleep. 2021 Mar 30:zsab058. doi: 10.1093/sleep/zsab058.


Home Use of a Percutaneous Wireless Intracortical Brain-Computer Interface by Individuals With Tetraplegia.
Simeral JD, Hosman T, Saab J, Flesher SN, Vilela M, Franco B, Kelemen J, Brandman DM, Ciancibello JG, Rezaii PG, Eskandar EN, Rosler DM, Shenoy KV, Henderson JM, Nurmikko AV, Hochberg LR. IEEE Trans Biomed Eng. 2021 Mar 30;PP. doi: 10.1109/TBME.2021.3069119. 


Injustice in Health: Now Is the Time to Change the Story.
Ogedegbe G, Inouye SK. Ann Intern Med. 2021 Mar 30. doi: 10.7326/M21-1279. 


Intracranial foreign body granuloma mimicking brain tumor recurrence: a case series.
Winter SF, Forst DA, Oakley DH, Batchelor TT, Dietrich J. Oncologist. 2021 Mar 29. doi: 10.1002/onco.13766. 


Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
Ding Y, Li Y, Chhetri G, Peng X, Wu J, Wang Z, Zhao B, Zhao W, Li X. Cells. 2021 Mar 28;10(4):746. doi: 10.3390/cells10040746. 


Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
Ding Y, Li Y, Chhetri G, Peng X, Wu J, Wang Z, Zhao B, Zhao W, Li X. Cells. 2021 Mar 28;10(4):746. doi: 10.3390/cells10040746.


The neurology of IGG4-related disease.
Saitakis G, Chwalisz BK. J Neurol Sci. 2021 Mar 27:117420. doi: 10.1016/j.jns.2021.117420.


Cerebral amyloid angiopathy and related inflammatory disorders.
Chwalisz BK. J Neurol Sci. 2021 Mar 27:117425. doi: 10.1016/j.jns.2021.117425.

Re: Predictors and outcomes of hemorrhagic stroke in reversible cerebral vasoconstriction syndrome (Garg et al., Volume 421, 117312, February 15, 2021).
Singhal AB. J Neurol Sci. 2021 Mar 27:117427. doi: 10.1016/j.jns.2021.117427.


Expectations and blind spots for structural variation detection from long-read assemblies and short-read genome sequencing technologies.
Zhao X, Collins RL, Lee WP, Weber AM, Jun Y, Zhu Q, Weisburd B, Huang Y, Audano PA, Wang H, Walker M, Lowther C, Fu J; Human Genome Structural Variation Consortium, Gerstein MB, Devine SE, Marschall T, Korbel JO, Eichler EE, Chaisson MJP, Lee C, Mills RE, Brand H, Talkowski ME. Am J Hum Genet. 2021 Mar 26:S0002-9297(21)00098-7. doi: 10.1016/j.ajhg.2021.03.014.  


Patient reported outcomes in ALS: characteristics of the self-entry ALS Functional Rating Scale-revised and the Activities-specific Balance Confidence Scale.
Chew S, Burke KM, Collins E, Church R, Paganoni S, Nicholson K, Babu S, Scalia JB, De Marchi F, Ellrodt AL, Moura LMVR, Chan J, Berry JD. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Mar 26:1-11. doi: 10.1080/21678421.2021.1900259.


Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease.
Qian J, Betensky RA, Hyman BT, Serrano-Pozo A. Neurology. 2021 Mar 26:10.1212/WNL.0000000000011883. doi: 10.1212/WNL.0000000000011883. 


A Phase 2 Proof-of-Concept, Randomized, Placebo-Controlled Trial of CX-8998 in Essential Tremor.
Papapetropoulos S, Lee MS, Versavel S, Newbold E, Jinnah HA, Pahwa R, Lyons KE, Elble R, Ondo W, Zesiewicz T, Hedera P, Handforth A, Elder J, Versavel M. Mov Disord. 2021 Mar 25. doi: 10.1002/mds.28584.


Utilization of Advanced Imaging for Acute Ischemic Stroke: The Ongoing Quest for Optimized Stroke Systems of Care.
Turner AC, Zachrison KS. Circ Cardiovasc Qual Outcomes. 2021 Mar 24:CIRCOUTCOMES121007845. doi: 10.1161/CIRCOUTCOMES.121.007845.  


Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology.
Popescu M, Feldman TB, Chitnis T. Front Pharmacol. 2021 Mar 23;12:626107. doi: 10.3389/fphar.2021.626107. eCollection 2021.


Microscale Physiological Events on the Human Cortical Surface.
Paulk AC, Yang JC, Cleary DR, Soper DJ, Halgren M, O'Donnell AR, Lee SH, Ganji M, Ro YG, Oh H, Hossain L, Lee J, Tchoe Y, Rogers N, Kiliç K, Ryu SB, Lee SW, Hermiz J, Gilja V, Ulbert I, Fabó D, Thesen T, Doyle WK, Devinsky O, Madsen JR, Schomer DL, Eskandar EN, Lee JW, Maus D, Devor A, Fried SI, Jones PS, Nahed BV, Ben-Haim S, Bick SK, Richardson RM, Raslan AM, Siler DA, Cahill DP, Williams ZM, Cosgrove GR, Dayeh SA, Cash SS. Cereb Cortex. 2021 Mar 22:bhab040. doi: 10.1093/cercor/bhab040.


Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection.
Roy JCL, Vitalo A, Andrew MA, Mota-Silva E, Kovalenko M, Burch Z, Nhu AM, Cohen PE, Grabczyk E, Wheeler VC, Mouro Pinto R. Nucleic Acids Res. 2021 Mar 22:gkab152. doi: 10.1093/nar/gkab152.   


Impairment of visual cortical plasticity by amyloid-beta species.
William CM, Stern MA, Pei X, Saqran L, Ramani M, Frosch MP, Hyman BT. Neurobiol Dis. 2021 Mar 22;154:105344. doi: 10.1016/j.nbd.2021.105344.  


Obesity is associated with the Optic Neuritis severity in Male patients with Multiple Sclerosis.
Chu DT, Rosso M, Gonzalez CT, Saxena S, Healy BC, Weiner HL, Chitnis T. Mult Scler Relat Disord. 2021 Mar 21;51:102910. doi: 10.1016/j.msard.2021.102910.


Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum.
Iuliano M, Seeley C, Sapp E, Jones EL, Martin C, Li X, DiFiglia M, Kegel-Gleason KB. Front Synaptic Neurosci. 2021 Mar 18;13:618391. doi: 10.3389/fnsyn.2021.618391.


Low-field portable brain MRI in CNS demyelinating disease.
Mateen FJ, Cooley CZ, Stockmann JP, Rice DR, Vogel AC, Wald LL. Mult Scler Relat Disord. 2021 Mar 18;51:102903. doi: 10.1016/j.msard.2021.102903.


Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults.
Fong TG, Vasunilashorn SM, Gou Y, Libermann TA, Dillon S, Schmitt E, Arnold SE, Kivisäkk P, Carlyle B, Oh ES, Vlassakov K, Kunze L, Hshieh T, Jones RN, Marcantonio ER, Inouye SK; RISE Study Group. Alzheimers Dement (N Y). 2021 Mar 17;7(1):e12125. doi: 10.1002/trc2.12125. eCollection 2021.  


Cerebral microbleeds and prediction of intracranial haemorrhage.
Greenberg SM. Lancet Neurol. 2021 Apr;20(4):252-254. doi: 10.1016/S1474-4422(21)00065-X. Epub 2021 Mar 17. 


Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids.
Lathuiliere A, Hyman BT. Front Neurosci. 2021 Mar 19;15:654176. doi: 10.3389/fnins.2021.654176. eCollection 2021.


Brain-Computer Interfaces in Neurorecovery and Neurorehabilitation.
Young MJ, Lin DJ, Hochberg LR. Semin Neurol. 2021 Mar 19. doi: 10.1055/s-0041-1725137. 


Persistent repression of tau in the brain using engineered zinc finger protein transcription factors.
Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, Zhang L, Goodwin A, Ledeboer A, Lam S, Ankoudinova I, Tran H, Scarlott N, Amora R, Surosky R, Miller JC, Robbins AB, Rebar EJ, Urnov FD, Holmes MC, Pooler AM, Riley B, Zhang HS, Hyman BT. Sci Adv. 2021 Mar 19;7(12):eabe1611. doi: 10.1126/sciadv.abe1611.  


Amyloid PET Imaging in Self-Identified Non-Hispanic Black Participants of the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study.
Deters KD, Napolioni V, Sperling RA, Greicius MD, Mayeux R, Hohman T, Mormino EC. Neurology. 2021 Mar 16;96(11):e1491-e1500. doi: 10.1212/WNL.0000000000011599.


Contextual MEG and EEG Source Estimates Using Spatiotemporal LSTM Networks.
Dinh C, Samuelsson JG, Hunold A, Hämäläinen MS, Khan S. Front Neurosci. 2021 Mar 9;15:552666. doi: 10.3389/fnins.2021.552666. eCollection 2021.


Neurological complications of cancer immunotherapy (CAR T cells).
Rubin DB, Vaitkevicius H. J Neurol Sci. 2021 Mar 18:117405. doi: 10.1016/j.jns.2021.117405


Functional dystonia: A case-control study and risk prediction algorithm.
Stephen CD, Perez DL, Chibnik LB, Sharma N. Ann Clin Transl Neurol. 2021 Mar 16. doi: 10.1002/acn3.51307.    


The Importance of Delirium and Delirium Prevention in Older Adults During Lockdowns.
Inouye SK. JAMA. 2021 Mar 15. doi: 10.1001/jama.2021.2211.


Degeneration Versus Development: Hunting-Out the D-Unit of Huntington's Disease.
Lu S, Lu B. Neurosci Bull. 2021 Mar 15.


Autoimmune encephalitis: new hammers in the toolbox.
Linnoila J. J Neurol Neurosurg Psychiatry. 2021 Mar 15:jnnp-2021-326096. doi: 10.1136/jnnp-2021-326096.


Teaching Video NeuroImages: Shedding Light on Sunflower Syndrome.
Nascimento FA, Thiele EA. Neurology. 2021 Mar 15:10.1212/WNL.0000000000011776. doi: 10.1212/WNL.0000000000011776.  


Closed-Eye Visual Hallucinations Associated With Clarithromycin.
Young MJ, Caplan RA, Connolly I, Matiello M, Mateen FJ. J Neuropsychiatry Clin Neurosci. 2021 Mar 12:appineuropsych20100253. doi: 10.1176/appi.neuropsych.20100253.


Children with autism spectrum disorder show altered functional connectivity and abnormal maturation trajectories in response to inverted faces.
Mamashli F, Kozhemiako N, Khan S, Nunes AS, McGuiggan NM, Losh A, Joseph RM, Ahveninen J, Doesburg SM, Hämäläinen MS, Kenet T. Autism Res. 2021 Mar 11. doi: 10.1002/aur.2497. 


IGF2R circular RNA hsa_circ_0131235 expression in the middle temporal cortex is associated with AD pathology.
Bigarré IM, Trombetta BA, Guo YJ, Arnold SE, Carlyle BC. Brain Behav. 2021 Mar 11:e02048. doi: 10.1002/brb3.2048.   


Blood-Based Detection of BRAF V600E in Gliomas and Brain Tumor Metastasis.
Kang KM, Muralidharan K, Yekula A, Small JL, Rosh ZS, Jones PS, Carter BS, Balaj L. Cancers (Basel). 2021 Mar 11;13(6):1227. doi: 10.3390/cancers13061227.


High epileptiform discharge burden predicts delayed cerebral ischemia after subarachnoid hemorrhage.
Kim JA, Zheng WL, Elmer J, Jing J, Zafar SF, Ghanta M, Moura V Junior, Gilmore EJ, Hirsch LJ, Patel A, Rosenthal E, Westover MB. Clin Neurophysiol. 2021 Mar 10:S1388-2457(21)00063-8. doi: 10.1016/j.clinph.2021.01.022.


Behavioral and Neurodynamic Effects of Word Learning on Phonotactic Repair.
Gow DW, Schoenhaut A, Avcu E, Ahlfors SP. Front Psychol. 2021 Mar 10;12:590155. doi: 10.3389/fpsyg.2021.590155. eCollection 2021.


Atrophy in Distinct Corticolimbic Networks Subserving Socioaffective Behavior in Semantic Variant Primary Progressive Aphasia.
Eldaief MC, Perez DL, Quimby M, Hochberg D, Touroutoglou A, Feldman Barrett L, Dickerson BC. Dement Geriatr Cogn Disord. 2021 Mar 10:1-9. doi: 10.1159/000511341.  


Reply: Shouldn't Patients With Paradoxical Emboli and Thrombophilia Be Given Anticoagulant Agents?
Liu K, Song B, Palacios IF, Inglessis-Azuaje I, Lo EH, Xu Y, Buonanno FS, Ning M. JACC Cardiovasc Interv. 2021 Mar 8;14(5):583-584. doi: 10.1016/j.jcin.2021.01.002.


Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease.
Tommasi NS, Gonzalez C, Briggs D, Properzi MJ, Gatchel JR, Marshall GA; Alzheimer’s Disease Neuroimaging Initiative**. Int J Geriatr Psychiatry. 2021 Mar 8. doi: 10.1002/gps.5530. 


Individualized prediction of COVID-19 adverse outcomes with MLHO.
Estiri H, Strasser ZH, Murphy SN. Sci Rep. 2021 Mar 5;11(1):5322. doi: 10.1038/s41598-021-84781-x.


In vivo brain imaging of mitochondrial Ca2+ in neurodegenerative diseases with multiphoton microscopy. Calvo-Rodriguez M, Kharitonova EK, Bacskai BJ. Biochim Biophys Acta Mol Cell Res. 2021 Mar 5:118998. doi: 10.1016/j.bbamcr.2021.118998.  


Hereditary Myelopathies.
Walker MA. Semin Neurol. 2021 Mar 4. doi: 10.1055/s-0041-1725153. 


Principles of Neural Repair and Their Application to Stroke Recovery Trials.
Lin DJ, Cramer SC. Semin Neurol. 2021 Mar 4. doi: 10.1055/s-0041-1725140. 


Xenopus models suggest convergence of gene signatures on neurogenesis in autism.
Brennand KJ, Talkowski ME. Neuron. 2021 Mar 3;109(5):743-745. doi: 10.1016/j.neuron.2021.02.017.


Decomposition of Reaching Movements Enables Detection and Measurement of Ataxia.
Oubre B, Daneault JF, Whritenour K, Khan NC, Stephen CD, Schmahmann JD, Lee SI, Gupta AS. Cerebellum. 2021 Mar 2. doi: 10.1007/s12311-021-01247-6.


Abnormal dynamic functional connectivity is linked to recovery after acute ischemic stroke.
Bonkhoff AK, Schirmer MD, Bretzner M, Etherton M, Donahue K, Tuozzo C, Nardin M, Giese AK, Wu O, D Calhoun V, Grefkes C, Rost NS. Hum Brain Mapp. 2021 Mar 2. doi: 10.1002/hbm.25366.


The Quest for Covert Consciousness: Bringing Neuroethics to the Bedside.
Young MJ, Edlow BL. Neurology. 2021 Mar 2:10.1212/WNL.0000000000011734. doi: 10.1212/WNL.0000000000011734.


High-Density EEG in Current Clinical Practice and Opportunities for the Future.
Stoyell SM, Wilmskoetter J, Dobrota MA, Chinappen DM, Bonilha L, Mintz M, Brinkmann BH, Herman ST, Peters JM, Vulliemoz S, Seeck M, Hämäläinen MS, Chu CJ. J Clin Neurophysiol. 2021 Mar 1;38(2):112-123. doi: 10.1097/WNP.0000000000000807. 


Therapeutic Neuromodulation for Bipolar Disorder-The Case for Biomarker-Driven Treatment Development.
Camprodon JA. JAMA Netw Open. 2021 Mar 1;4(3):e211055. doi: 10.1001/jamanetworkopen.2021.1055.


Clinical, radiological and genomic features and targeted therapy in BRAF V600E mutant adult glioblastoma.
Lim-Fat MJ, Song KW, Iorgulescu JB, Andersen BM, Forst DA, Jordan JT, Gerstner ER, Reardon DA, Wen PY, Arrillaga-Romany I. J Neurooncol. 2021 Mar 1. doi: 10.1007/s11060-021-03719-5. 


Holding Out Hope After Traumatic Brain Injury.
Kim JA, Sheth KN. JAMA Neurol. 2021 Mar 1. doi: 10.1001/jamaneurol.2020.5328. 


Clinical and electrophysiological evaluation of myasthenic features in an alpha-dystroglycanopathy cohort (FKRP-predominant).
Gonzalez-Perez P, Smith C, Sebetka WL, Gedlinske A, Perlman S, Mathews KD. Neuromuscul Disord. 2020 Mar;30(3):213-218. doi: 10.1016/j.nmd.2020.01.002.


Stroke in Pregnancy: A Multidisciplinary Approach.
Camargo EC, Singhal AB. Obstet Gynecol Clin North Am. 2021 Mar;48(1):75-96. doi: 10.1016/j.ogc.2020.11.004. 


Neuro-ophthalmic Complications of Immune-Checkpoint Inhibitors.
Mukharesh L, Chwalisz BK. Semin Ophthalmol. 2021 Feb 27:1-9. doi: 10.1080/08820538.2021.1890796.  


Bright spotty lesions as an imaging marker for neuromyelitis optica spectrum disorder.
Salama S, Levy M. Mult Scler. 2021 Feb 26:1352458521994259. doi: 10.1177/1352458521994259.


Teleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury.
Matiello M, Turner AC, Estrada J, Whitney CM, Kitch BT, Lee PT, Girkar U, Palacios R, Singla P, Schwamm L. Neurology. 2021 Feb 26:10.1212/WNL.0000000000011751. doi: 10.1212/WNL.0000000000011751. 


The combined use of steroids and immune checkpoint inhibitors in brain metastasis patients: a systematic review and meta-analysis.
Jessurun CAC, Hulsbergen AFC, de Wit AE, Tewarie IA, Snijders TJ, Verhoeff J, Phillips J, Reardon DA, Mekary RA, Broekman MLD. Neuro Oncol. 2021 Feb 25:noab046. doi: 10.1093/neuonc/noab046. 


Hippocampal sharp wave ripples during invasive monitoring: A physiologic finding.
McLaren JR, Shi W, Misko AL, Emerton BC, Chu CJ. Clin Neurophysiol. 2021 Feb 24;132(5):1077-1079. doi: 10.1016/j.clinph.2021.02.003.


Machine and deep learning in MS research are just powerful statistics - No.
Healy BC. Mult Scler. 2021 Feb 24:1352458520978648. doi: 10.1177/1352458520978648.


One-Year Medicare Costs Associated With Delirium in Older Patients Undergoing Major Elective Surgery.
Gou RY, Hshieh TT, Marcantonio ER, Cooper Z, Jones RN, Travison TG, Fong TG, Abdeen A, Lange J, Earp B, Schmitt EM, Leslie DL, Inouye SK; SAGES Study Group. JAMA Surg. 2021 Feb 24. doi: 10.1001/jamasurg.2020.7260.


Understanding Sunflower syndrome: Results of an online questionnaire.
Barnett JR, Fleming BM, Doshi SP, Freedman J, Ambrosio NR, Geenen KR, Bruno PL, Thiele EA. Epilepsy Behav. 2021 Feb 24;117:107856. doi: 10.1016/j.yebeh.2021.107856.  


Association of Memory Impairment with Concomitant Tau Pathology in Patients with Cerebral Amyloid Angiopathy.
Schoemaker D, Charidimou A, Zanon Zotin MC, Raposo N, Johnson KA, Sanchez JS, Greenberg SM, Viswanathan A. Neurology. 2021 Feb 24:10.1212/WNL.0000000000011745. doi: 10.1212/WNL.0000000000011745. 


Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases.
McEntire CRS, Song KW, McInnis RP, Rhee JY, Young M, Williams E, Wibecan LL, Nolan N, Nagy AM, Gluckstein J, Mukerji SS, Mateen FJ. Front Neurol. 2021 Feb 22;12:634827. doi: 10.3389/fneur.2021.634827.


Ptosis as Clinical Presentation in a Patient With Emery-Dreifuss Muscular Dystrophy Type 5.
Douglas KAA, Douglas VP, Gaier ED, Chwalisz BK. J Neuroophthalmol. 2021 Feb 19. doi: 10.1097/WNO.0000000000001187.


A high proportion of novel ACAN mutations and their prevalence in a large cohort of Chinese short stature children.
Lin L, Li M, Luo J, Li P, Zhou S, Yang Y, Chen K, Weng Y, Ge X, Mireguli M, Wei H, Yang H, Li G, Sun Y, Cui L, Zhang S, Chen J, Zeng G, Xu L, Luo X, Shen Y. J Clin Endocrinol Metab. 2021 Feb 19:dgab088. doi: 10.1210/clinem/dgab088.  


Serum NFL levels predict progression of motor impairment and reduction in putamen dopamine transporter binding ratios in de novo Parkinson's disease: An 8-year longitudinal study.
Ye R, Locascio JJ, Goodheart AE, Quan M, Zhang B, Gomperts SN. Parkinsonism Relat Disord. 2021 Feb 17;85:11-16. doi: 10.1016/j.parkreldis.2021.02.008.


Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations.
Anzabi M, Li B, Wang H, Kura S, Sakadžić S, Boas D, Østergaard L, Ayata C. J Cereb Blood Flow Metab. 2021 Feb 16:271678X21994013. doi: 10.1177/0271678X21994013.


Is the COVID-19 pandemic magnifying disparities in stroke treatment?
Regenhardt RW, Young MJ, Leslie-Mazwi TM. J Neurointerv Surg. 2021 Feb 16:neurintsurg-2021-017292. doi: 10.1136/neurintsurg-2021-017292.   


Regional Changes in Patterns of Stroke Presentation During the COVID-19 Pandemic.
Etherton MR, Zachrison KS, Yan Z, Sveikata L, Bretzner M, Estrada J, Viswanathan A, Singhal AB, Schwamm LH. Stroke. 2021 Feb 16:STROKEAHA120031300. doi: 10.1161/STROKEAHA.120.031300.


Association of Digital Clock Drawing with PET Amyloid and Tau Pathology in Normal Older Adults.
Rentz DM, Papp KV, Mayblyum DV, Sanchez JS, Klein H, Souillard-Mandar W, Sperling RA, Johnson KA. Neurology. 2021 Feb 15:10.1212/WNL.0000000000011697. doi: 10.1212/WNL.0000000000011697. 


Regional prefrontal cortical atrophy predicts specific cognitive-behavioral symptoms in ALS-FTD.
Ratti E, Domoto-Reilly K, Caso C, Murphy A, Brickhouse M, Hochberg D, Makris N, Cudkowicz ME, Dickerson BC. Brain Imaging Behav. 2021 Feb 15. doi: 10.1007/s11682-021-00456-1.


Machine learning identifies candidates for drug repurposing in Alzheimer's disease.
Rodriguez S, Hug C, Todorov P, Moret N, Boswell SA, Evans K, Zhou G, Johnson NT, Hyman BT, Sorger PK, Albers MW, Sokolov A. Nat Commun. 2021 Feb 15;12(1):1033. doi: 10.1038/s41467-021-21330-0. 


Workshop report. Circadian rhythm sleep-wake disorders: gaps and opportunities.
Duffy JF, Abbott SM, Burgess HJ, Crowley SJ, Emens JS, Epstein LJ, Gamble KL, Hasler BP, Kristo DA, Malkani RG, Rahman SA, Thomas SJ, Wyatt JK, Zee PC, Klerman EB. Sleep. 2021 Feb 14:zsaa281. doi: 10.1093/sleep/zsaa281.


Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer's Disease.
Shoup TM, Griciuc A, Normandin MD, Quinti L, Walsh LV, Dhaynaut M, Moon SH, Guehl NJ, Brugarolas P, Elmaleh DR, Fakhri GE, Tanzi RE. J Alzheimers Dis. 2021 Feb 12. doi: 10.3233/JAD-201419.


A Virtual, Randomized, Control Trial of a Digital Therapeutic for Speech, Language, and Cognitive Intervention in Post-stroke Persons With Aphasia.
Braley M, Pierce JS, Saxena S, De Oliveira E, Taraboanta L, Anantha V, Lakhan SE, Kiran S. Front Neurol. 2021 Feb 12;12:626780. doi: 10.3389/fneur.2021.626780.


Comparison of Two Clinical Upper Motor Neuron Burden Rating Scales in ALS Using Quantitative Brain Imaging.
Makary MM, Weerasekara A, Rodham H, Hightower BG, Tseng CJ, Chan J, Chew S, Paganoni S, Ratai EM, Zürcher NR, Hooker JM, Atassi N, Babu S. ACS Chem Neurosci. 2021 Feb 12. doi: 10.1021/acschemneuro.0c00772.


18F-AV-1451 positron emission tomography in neuropathological substrates of corticobasal syndrome.
Goodheart AE, Locascio JJ, Samore WR, Collins JA, Brickhouse M, Schultz A, Touroutoglou A, Johnson KA, Frosch MP, Growdon JH, Dickerson BC, Gomperts SN. Brain. 2021 Feb 12;144(1):266-277. doi: 10.1093/brain/awaa383.  


Differential gene expression data from the human central nervous system across Alzheimer's disease, Lewy body diseases, and the amyotrophic lateral sclerosis and frontotemporal dementia spectrum.
Noori A, Mezlini AM, Hyman BT, Serrano-Pozo A, Das S. Data Brief. 2021 Feb 11;35:106863. doi: 10.1016/j.dib.2021.106863.


Amyloid PET imaging in self-identified non-Hispanic Blacks from the Anti-Amyloid in Asymptomatic Alzheimer's Disease (A4) Study.
Deters K, Napolioni V, Sperling RA, Greicius MD, Mayeux R, Hohman T, Mormino EC. Neurology. 2021 Feb 10:10.1212/WNL.0000000000011599. doi: 10.1212/WNL.0000000000011599.


Validation of an Internationally Derived Patient Severity Phenotype to Support COVID-19 Analytics from Electronic Health Record Data.
Klann JG, Weber GM, Estiri H, Moal B, Avillach P, Hong C, Castro V, Maulhardt T, Tan ALM, Geva A, Beaulieu-Jones BK, Malovini A, South AM, Visweswaran S, Omenn GS, Ngiam KY, Mandl KD, Boeker M, Olson KL, Mowery DL, Morris M, Follett RW, Hanauer DA, Bellazzi R, Moore JH, Loh NW, Bell DS, Wagholikar KB, Chiovato L, Tibollo V, Rieg S, Li ALLJ, Jouhet V, Schriver E, Samayamuthu MJ, Xia Z, Hutch M, Luo Y; Consortium for Clinical Characterization of COVID-19 by EHR (4CE) (CONSORTIA AUTHOR), Kohane IS, Brat GA, Murphy SN. J Am Med Inform Assoc. 2021 Feb 10:ocab018. doi: 10.1093/jamia/ocab018. 


Implementation of high-cadence cycling for Parkinson's disease in the community setting: A pragmatic feasibility study.
McKee KE, Johnson RK, Chan J, Wills AM. Brain Behav. 2021 Feb 9:e02053. doi: 10.1002/brb3.2053.


Is MRI in the Angiographic Suite a New Frontier?
Lev MH, Leslie-Mazwi TM. Radiology. 2021 Feb 9:204563. doi: 10.1148/radiol.2021204563.  


Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets.
Pintacuda G, Martín JM, Eggan KC. Mol Autism. 2021 Feb 8;12(1):10. doi: 10.1186/s13229-021-00417-x.  


Neuropsychiatric symptoms in a occipito-temporal infarction with remarkable long-term functional recovery.
Tanev KS, Federico LE, Sydnor VJ, Leveroni CL, Hassan K, Biffi A. Cortex. 2021 Feb 6;137:205-214. doi: 10.1016/j.cortex.2021.01.013.


Reimagining Stroke Rehabilitation and Recovery Across the Care Continuum: Results from a Design-Thinking Workshop to Identify Challenges and Propose Solutions.
DiCarlo JA, Gheihman G, Lin DJ; 2019 Northeast Cerebrovascular Consortium Conference Stroke Recovery Workshop Participants. Arch Phys Med Rehabil. 2021 Feb 5:S0003-9993(21)00142-8. doi: 10.1016/j.apmr.2021.01.074.


Predicting COVID-19 mortality with electronic medical records.
Estiri H, Strasser ZH, Klann JG, Naseri P, Wagholikar KB, Murphy SN. NPJ Digit Med. 2021 Feb 4;4(1):15. doi: 10.1038/s41746-021-00383-x.


Functional Dystonia: Differentiation From Primary Dystonia and Multidisciplinary Treatments.
Frucht L, Perez DL, Callahan J, MacLean J, Song PC, Sharma N, Stephen CD. Front Neurol. 2021 Feb 4;11:605262. doi: 10.3389/fneur.2020.605262. eCollection 2020.


CTA Protocols in a Telestroke Network Improve Efficiency for Both Spoke and Hub Hospitals.
Yu AT, Regenhardt RW, Whitney C, Schwamm LH, Patel AB, Stapleton CJ, Viswanathan A, Hirsch JA, Lev M, Leslie-Mazwi TM. AJNR Am J Neuroradiol. 2021 Feb 4. doi: 10.3174/ajnr.A6950.


The role of innate immune genes in Alzheimer's disease.
Griciuc A, Tanzi RE. Curr Opin Neurol. 2021 Feb 3. doi: 10.1097/WCO.0000000000000911. 


Lacunes, Microinfarcts and Vascular Dysfunction in Cerebral Amyloid Angiopathy.
Gokcal E, Horn MJ, van Veluw SJ, Frau-Pascual A, Das AS, Pasi M, Fotiadis P, Warren AD, Schwab K, Rosand J, Viswanathan A, Polimeni JR, Greenberg SM, Gurol ME. Neurology. 2021 Feb 3:10.1212/WNL.0000000000011631. doi: 10.1212/WNL.0000000000011631.


Challenges and Opportunities in Multimodal Monitoring and Data Analytics in Traumatic Brain Injury.
Foreman B, Lissak IA, Kamireddi N, Moberg D, Rosenthal ES. Curr Neurol Neurosci Rep. 2021 Feb 2;21(3):6. doi: 10.1007/s11910-021-01098-y.


Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors.
Etherton MR, Shah S, Haolin X, Xian Y, Maisch L, Hannah D, Lindholm B, Lytle B, Thomas L, Smith EE, Fonarow GC, Schwamm LH, Bhatt DL, Hernandez AF, O'Brien EC. Stroke Vasc Neurol. 2021 Feb 1:svn-2020-000691. doi: 10.1136/svn-2020-000691


Clinical Characteristics and Outcomes Associated With Oral Anticoagulant Use Among Patients Hospitalized With Intracerebral Hemorrhage.
Xian Y, Zhang S, Inohara T, Grau-Sepulveda M, Matsouaka RA, Peterson ED, Piccini JP, Smith EE, Sheth KN, Bhatt DL, Fonarow GC, Schwamm LH. JAMA Netw Open. 2021 Feb 1;4(2):e2037438. doi: 10.1001/jamanetworkopen.2020.37438.


Robust Stability of Melatonin Circadian Phase, Sleep Metrics, and Chronotype Across Months in Young Adults Living in Real-World Settings.
McHill AW, Sano A, Hilditch CJ, Barger LK, Czeisler CA, Picard R, Klerman EB. J Pineal Res. 2021 Feb 1:e12720. doi: 10.1111/jpi.12720.


Language preference does not influence stroke patients' symptom recognition or emergency care time metrics.
Zachrison KS, Natsui S, Luan Erfe BM, Mejia NI, Schwamm LH. Am J Emerg Med. 2021 Feb;40:177-180. doi: 10.1016/j.ajem.2020.10.064.


The best matrix for the brain: advances in secondary CNS lymphoma.Dietrich J. Lancet Haematol. 2021 Feb;8(2):e96-e97. doi: 10.1016/S2352-3026(20)30431-2.  


Inequities in neurology amplified by the COVID-19 pandemic.
Nolen L, Mejia NI. Nat Rev Neurol. 2021 Feb;17(2):67-68. doi: 10.1038/s41582-020-00452-x. 


Telemedicine Can Support Measurable and High-Quality Epilepsy Care During the COVID-19 Pandemic.
Moura LMVR, Donahue MA, Smith JR, Dass D, Sanches PR, Ayub N, McGraw C, Zafar SF, Cash SS, Hoch DB. Am J Med Qual. 2021 Jan-Feb 01;36(1):5-16. doi: 10.1097/01.JMQ.0000733444.71245.6c.


Author Correction: Evaluating drug targets through human loss-of-function genetic variation.
Minikel EV, Karczewski KJ, Martin HC, Cummings BB, Whiffin N, Rhodes D, Alföldi J, Trembath RC, van Heel DA, Daly MJ; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Schreiber SL, MacArthur DG. Nature. 2021 Feb;590(7846):E56. doi: 10.1038/s41586-020-03177-5.


Author Correction: A structural variation reference for medical and population genetics.
Collins RL, Brand H, Karczewski KJ, Zhao X, Alföldi J, Francioli LC, Khera AV, Lowther C, Gauthier LD, Wang H, Watts NA, Solomonson M, O'Donnell-Luria A, Baumann A, Munshi R, Walker M, Whelan CW, Huang Y, Brookings T, Sharpe T, Stone MR, Valkanas E, Fu J, Tiao G, Laricchia KM, Ruano-Rubio V, Stevens C, Gupta N, Cusick C, Margolin L; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium, Taylor KD, Lin HJ, Rich SS, Post WS, Chen YI, Rotter JI, Nusbaum C, Philippakis A, Lander E, Gabriel S, Neale BM, Kathiresan S, Daly MJ, Banks E, MacArthur DG, Talkowski ME. Nature. 2021 Feb;590(7846):E55. doi: 10.1038/s41586-020-03176-6.


Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, Jean-Gilles D, Clark R, Atchison K, Moore R, Chibnik LB, Tanzi RE, Frosch MP, Serrano-Pozo A, Elwood F, Steen JA, Kennedy ME, Hyman BT. Nat Med. 2021 Jan 29. doi: 10.1038/s41591-021-01251-7.


Uridine-responsive epileptic encephalopathy due to inherited variants in CAD: A Tale of Two Siblings.
McGraw CM, Mahida S, Jayakar P, Koh HY, Taylor A, Resnick T, Rodan L, Schwartz MA, Ejaz A, Sankaran VG, Berry G, Poduri A. Ann Clin Transl Neurol. 2021 Jan 26. doi: 10.1002/acn3.51272.  


Case Report: Deep Brain Stimulation to the Ventral Internal Capsule/Ventral Striatum Induces Repeated Transient Episodes of Voltage-Dependent Tourette-Like Behaviors.
Camprodon JA, Chou T, Testo AA, Deckersbach T, Scharf JM, Dougherty DD. Front Hum Neurosci. 2021 Jan 25;14:590379. doi: 10.3389/fnhum.2020.590379.


Serum neurofilament levels and patient-reported outcomes in multiple sclerosis.
Galetta K, Deshpande C, Healy BC, Glanz B, Ziehn M, Saxena S, Paul A, Saleh F, Collins M, Gaitan-Walsh P, Castro-Mendoza P, Weiner HL, Chitnis T. Ann Clin Transl Neurol. 2021 Jan 25. doi: 10.1002/acn3.51305. 


A transdiagnostic and biopsychosocial-informed perspective across functional seizures and functional movement disorder.
Saxena A, Perez DL. Epilepsy Behav. 2021 Jan 25:107749. doi: 10.1016/j.yebeh.2020.107749.


Unmasking Covert Language Processing in the Intensive Care Unit with EEG.
Edlow BL, Naccache L. Ann Neurol. 2021 Jan 25. doi: 10.1002/ana.26030.


Child Neurology: Intractable Epilepsy and Transient Deficits in a Patient with a History of HSV Encephalitis.
Manzano GS, Danish HH, Chu CJ, Kimchi EY. Neurology. 2021 Jan 25:10.1212/WNL.0000000000011606. doi: 10.1212/WNL.0000000000011606. 


Electroencephalography, Hospital Complications, and Longitudinal Outcomes After Subarachnoid Hemorrhage.
Lissak IA, Locascio JJ, Zafar SF, Schleicher RL, Patel AB, Leslie-Mazwi T, Stapleton CJ, Koch MJ, Kim JA, Anderson K, Rosand J, Westover MB, Kimberly WT, Rosenthal ES. Neurocrit Care. 2021 Jan 22. doi: 10.1007/s12028-020-01177-x. 


MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols.
Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, Rosenberg G, Sagare A, Satizabal CL, Schneider J, Seshadri S, Sur S, Tracy RP, Yasar S, Williams V, Singh H, Mazina L, Helmer KG, Corriveau RA, Schwab K, Kivisäkk P, Greenberg SM; MarkVCID Consortium. Alzheimers Dement. 2021 Jan 21. doi: 10.1002/alz.12215. 


Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models.
Eyme KM, Carvalho L, Badr CE. STAR Protoc. 2021 Jan 21;2(1):100290. doi: 10.1016/j.xpro.2020.100290. eCollection 2021 Mar 19.


MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.
Lu H, Kashani AH, Arfanakis K, Caprihan A, DeCarli C, Gold BT, Li Y, Maillard P, Satizabal CL, Stables L, Wang DJJ, Corriveau RA, Singh H, Smith EE, Fischl B, van der Kouwe A, Schwab K, Helmer KG, Greenberg SM; MarkVCID Consortium. Alzheimers Dement. 2021 Jan 21. doi: 10.1002/alz.12216. 


MRI Lesion State Modulates the Relationship Between Serum Neurofilament Light and Age in Multiple Sclerosis.
Rosso M, Healy BC, Saxena S, Paul A, Bjornevik K, Kuhle J, Benkert P, Leppert D, Guttmann C, Bakshi R, Weiner HL, Chitnis T. J Neuroimaging. 2021 Jan 21. doi: 10.1111/jon.12826.


Should neurosurgeons continue to work in the absence of personal protective equipment during the COVID-19 era?
Eijkholt M, Hulsbergen A, Muskens I, Mathiesen TI, Bolger C, Feldman Z, Kitchen N, Samprón N, Sandvik U, Tisell M, Broekman M. Acta Neurochir (Wien). 2021 Jan 20. doi: 10.1007/s00701-021-04703-8


The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography.
Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, Gómez-Isla T, Quiroz YT, Rentz DM, Sperling RA, Seshadri S, Augustinack J, Price JC, Johnson KA. Sci Transl Med. 2021 Jan 20;13(577):eabc0655. doi: 10.1126/scitranslmed.abc0655.


Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia.
Gallée J, Cordella C, Fedorenko E, Hochberg D, Touroutoglou A, Quimby M, Dickerson BC. Brain Sci. 2021 Jan 20;11(2):E130. doi: 10.3390/brainsci11020130.


Machine Learning-Driven Metabolomic Evaluation of Cerebrospinal Fluid: Insights Into Poor Outcomes After Aneurysmal Subarachnoid Hemorrhage.
Koch M, Acharjee A, Ament Z, Schleicher R, Bevers M, Stapleton C, Patel A, Kimberly WT. Neurosurgery. 2021 Jan 19:nyaa557. doi: 10.1093/neuros/nyaa557. 


Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2.
Thomas R, Moloney EB, Macbain ZK, Hallett PJ, Isacson O. Mol Brain. 2021 Jan 19;14(1):16. doi: 10.1186/s13041-020-00712-3.  


Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update.
Fifel K, Videnovic A. Front Neurosci. 2021 Jan 18;14:627330. doi: 10.3389/fnins.2020.627330.


Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19.
Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. J Neurol Sci. 2021 Jan 15;421:117308. doi: 10.1016/j.jns.2021.117308.


Focal sleep spindle deficits reveal focal thalamocortical dysfunction and predict cognitive deficits in childhood epilepsy with centrotemporal spikes.
Kramer MA, Stoyell SM, Chinappen D, Ostrowski LM, Spencer ER, Morgan AK, Emerton BC, Jing J, Westover MB, Eden UT, Stickgold R, Manoach DS, Chu CJ. J Neurosci. 2021 Jan 14:JN-RM-2009-20. doi: 10.1523/JNEUROSCI.2009-20.2020.  


Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation.
Amaral AC, Perez-Nievas BG, Siao Tick Chong M, Gonzalez-Martinez A, Argente-Escrig H, Rubio-Guerra S, Commins C, Muftu S, Eftekharzadeh B, Hudry E, Fan Z, Ramanan P, Takeda S, Frosch MP, Wegmann S, Gomez-Isla T. iScience. 2021 Jan 13;24(2):102058. doi: 10.1016/j.isci.2021.102058.


Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion.
Igarashi T, Sastre C, Wolcott Z, Kimberly WT. J Stroke Cerebrovasc Dis. 2021 Jan 12;30(3):105595. doi: 10.1016/j.jstrokecerebrovasdis.2020.105595. 


Implications of COVID-19 sequelae for health-care personnel.
Praschan N, Josephy-Hernandez S, Kim DD, Kritzer MD, Mukerji S, Newhouse A, Pasinski M, Chemali Z. Lancet Respir Med. 2021 Jan 11:S2213-2600(20)30575-0. doi: 10.1016/S2213-2600(20)30575-0.


Auditory cues reveal intended movement information in middle frontal gyrus neuronal ensemble activity of a person with tetraplegia.
Hosman T, Hynes JB, Saab J, Wilcoxen KG, Buchbinder BR, Schmansky N, Cash SS, Eskandar EN, Simeral JD, Franco B, Kelemen J, Vargas-Irwin CE, Hochberg LR. Sci Rep. 2021 Jan 11;11(1):98. doi: 10.1038/s41598-020-77616-8.


The paradoxical effect of COVID-19 outbreak on loneliness.
Bartrés-Faz D, Macià D, Cattaneo G, Borràs R, Tarrero C, Solana J, Tormos JM, Pascual-Leone A. BJPsych Open. 2021 Jan 11;7(1):e30. doi: 10.1192/bjo.2020.163.


Beware of Optimism Bias in the Context of the COVID-19 Pandemic.
Pascual-Leone A, Cattaneo G, Macià D, Solana J, Tormos JM, Bartrés-Faz D. Ann Neurol. 2021 Jan 11. doi: 10.1002/ana.26001.


Mutations causing Lopes-Maciel-Rodan Syndrome are huntingtin hypomorphs.
Jung R, Lee Y, Barker D, Correia K, Shin B, Loupe J, Collins RL, Lucente D, Ruliera J, Gillis T, Mysore JS, Rodan L, Picker J, Lee JM, Howland D, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS. Hum Mol Genet. 2021 Jan 11:ddaa283. doi: 10.1093/hmg/ddaa283.


Considerations on clinical biomarkers analyses using immunoassays.
Moscovitch-Lopatin M. J Immunoassay Immunochem. 2021 Jan 11:1-3. doi: 10.1080/15321819.2021.1872358.


Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration.
Patnaik D, Pao PC, Zhao WN, Silva MC, Hylton NK, Chindavong PS, Pan L, Tsai LH, Haggarty SJ. ACS Chem Neurosci. 2021 Jan 8. doi: 10.1021/acschemneuro.0c00308.


Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin.
Cheah PS, Prabhakar S, Yellen D, Beauchamp RL, Zhang X, Kasamatsu S, Bronson RT, Thiele EA, Kwiatkowski DJ, Stemmer-Rachamimov A, György B, Ling KH, Kaneki M, Tannous BA, Ramesh V, Maguire CA, Breakefield XO. Sci Adv. 2021 Jan 8;7(2):eabb1703. doi: 10.1126/sciadv.abb1703.


Inequities in neurology amplified by the COVID-19 pandemic.
Nolen L, Mejia NI. Nat Rev Neurol. 2021 Jan 7:1-2. doi: 10.1038/s41582-020-00452-x.


Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study.
Nolan AL, Petersen C, Iacono D, Mac Donald CL, Mukherjee P, van der Kouwe A, Jain S, Stevens A, Diamond B, Wang R, Markowitz AJ, Fischl B, Perl D, Manley GT, Keene CD, Diaz-Arrastia R, Edlow BL. J Neurotrauma. 2021 Jan 7. doi: 10.1089/neu.2020.7373.


Case 26-2020: A Woman with Altered Mental Status and Left-Sided Weakness. Reply.
Singhal AB, Mukerji SS, Chwalisz BK. N Engl J Med. 2021 Jan 7;384(1):92. doi: 10.1056/NEJMc2030849.


Association of CSF Biomarkers with Hippocampal-dependent Memory in Preclinical Alzheimer Disease.
Trelle AN, Carr VA, Wilson EN, Swarovski MS, Hunt MP, Toueg TN, Tran TT, Channappa D, Corso NK, Thieu MK, Jayakumar M, Nadiadwala A, Guo W, Tanner NJ, Bernstein JD, Litovsky CP, Guerin SA, Khazenzon AM, Harrison MB, Rutt BK, Deutsch GK, Chin FT, Davidzon GA, Hall JN, Sha SJ, Fredericks CA, Andreasson KI, Kerchner GA, Wagner AD, Mormino EC. Neurology. 2021 Jan 6:10.1212/WNL.0000000000011477. doi: 10.1212/WNL.0000000000011477.


Beyond gait and balance: urinary and bowel dysfunction in X-linked adrenoleukodystrophy.
Corre CS, Grant N, Sadjadi R, Hayden D, Becker C, Gomery P, Eichler FS. Orphanet J Rare Dis. 2021 Jan 6;16(1):14. doi: 10.1186/s13023-020-01596-1.


Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease.
Samaroo A, Amariglio RE, Burnham S, Sparks P, Properzi M, Schultz AP, Buckley R, Johnson KA, Sperling RA, Rentz DM, Papp KV. Alzheimers Dement (Amst). 2021 Jan 5;12(1):e12132. doi: 10.1002/dad2.12132. eCollection 2020.


MRI Characteristics of NMO, MOG and MS Related Optic Neuritis.
Winter A, Chwalisz B. Semin Ophthalmol. 2021 Jan 4:1-10. doi: 10.1080/08820538.2020.1866027.  


Common and distinct neural substrates of sentence production and comprehension.
Lukic S, Thompson CK, Barbieri E, Chiappetta B, Bonakdarpour B, Kiran S, Rapp B, Parrish TB, Caplan D. Neuroimage. 2021 Jan 1;224:117374. doi: 10.1016/j.neuroimage.2020.117374.


Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility.
Dev SI, Dickerson BC, Touroutoglou A. Adv Exp Med Biol. 2021;1281:93-112. doi: 10.1007/978-3-030-51140-1_7.


APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches.
Serrano-Pozo A, Das S, Hyman BT. Lancet Neurol. 2021 Jan;20(1):68-80. doi: 10.1016/S1474-4422(20)30412-9.


A Synergistic Engineering Approach to Build Human Brain Spheroids.
von Maydell D, Jorfi M. Methods Mol Biol. 2021;2258:151-169. doi: 10.1007/978-1-0716-1174-6_11. 


Huntington's Disease Pathogenesis: Two Sequential Components.
Hong EP, MacDonald ME, Wheeler VC, Jones L, Holmans P, Orth M, Monckton DG, Long JD, Kwak S, Gusella JF, Lee JM. J Huntingtons Dis. 2021;10(1):35-51. doi: 10.3233/JHD-200427.  


The role of biomarkers and neuroimaging in ischemic/hemorrhagic risk assessment for cardiovascular/cerebrovascular disease prevention.
Gokcal E, Horn MJ, Gurol ME. Handb Clin Neurol. 2021;177:345-357. doi: 10.1016/B978-0-12-819814-8.00021-4.


Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models.
Wheeler VC, Dion V. J Huntingtons Dis. 2021;10(1):123-148. doi: 10.3233/JHD-200426.


Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility.
Dev SI, Dickerson BC, Touroutoglou A. Adv Exp Med Biol. 2021;1281:93-112. doi: 10.1007/978-3-030-51140-1_7.


The Computerized Cognitive Composite (C3) in an Alzheimer's Disease Secondary Prevention Trial.
Papp KV, Rentz DM, Maruff P, Sun CK, Raman R, Donohue MC, Schembri A, Stark C, Yassa MA, Wessels AM, Yaari R, Holdridge KC, Aisen PS, Sperling RA. J Prev Alzheimers Dis. 2021;8(1):59-67. doi: 10.14283/jpad.2020.38.

 Earlier Publications