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In 2019, the Mass General Neurology faculty published more than 1,000 papers in journals like Neurology, Stroke, and JAMA Neurology, and we are on track to surpass that record for 2020. Our research efforts advance our mission to rapidly discover new treatments to reduce and eliminate the devastating impact of neurological disorders.

Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates.
Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. J Exp Med. 2020 Dec 7;217(12):e20182266. doi: 10.1084/jem.20182266


Rapid hematoma growth triggers spreading depolarizations in experimental intracortical hemorrhage.
Fischer P, Sugimoto K, Chung DY, Tamim I, Morais A, Takizawa T, Qin T, Gomez CA, Schlunk F, Endres M, Yaseen MA, Sakadzic S, Ayata C. J Cereb Blood Flow Metab. 2020 Sep 16:271678X20951993. doi: 10.1177/0271678X20951993.


Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice.
Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan SA, Qin T, Iii WJE, Lee H, Yaseen MA, Sakadžić S, Boas DA, Whalen MJ, Ayata C. J Cereb Blood Flow Metab. 2020 Sep 16:271678X20940152. doi: 10.1177/0271678X20940152.


Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy.
Charidimou A, Perosa V, Frosch MP, Scherlek AA, Greenberg SM, van Veluw SJ. Brain. 2020 Sep 16:awaa266. doi: 10.1093/brain/awaa266.


Home Video Visits: 2-D View of the Geriatric 5-Ms.
Moo LR. J Am Geriatr Soc. 2020 Sep 15. doi: 10.1111/jgs.16843.


MRI-visible Enlarged perivascular spaces: Beyond microbleeds to predict intracerebral hemorrhage.
Raposo N, Viswanathan A. Neurology. 2020 Sep 15:10.1212/WNL.0000000000010790. doi: 10.1212/WNL.0000000000010790. 


Long-term follow-up results of the SMART coil in the endovascular treatment of intracranial aneurysms.
McAvoy MB, Cappuzzo JM, Stapleton CJ, Koch MJ, Raymond SB, Torok CM, Patel AB. Interv Neuroradiol. 2020 Sep 15:1591019920956890. doi: 10.1177/1591019920956890.

MGMT promoter methylation and hypermutant recurrence in IDH mutant lower-grade glioma.
Miller JJ, Cahill DP. Neuro Oncol. 2020 Sep 14:noaa212. doi: 10.1093/neuonc/noaa212.


White Matter Hyperintensities Predict Response to Language Treatment in Poststroke Aphasia.
Varkanitsa M, Peñaloza C, Charidimou A, Caplan D, Kiran S. Neurorehabil Neural Repair. 2020 Sep 13:1545968320952809. doi: 10.1177/1545968320952809. 


The NEALS primary lateral sclerosis registry.
Paganoni S, De Marchi F, Chan J, Thrower SK, Staff NP, Datta N, Kisanuki YY, Drory V, Fournier C, Pioro EP, Goutman SA, Atassi N; NEALS PLS Registry Study Group. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Sep 11:1-8. doi: 10.1080/21678421.2020.1804591.


Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms.
Yanagisawa T, Zhang H, Suzuki T, Kamio Y, Takizawa T, Morais A, Chung DY, Qin T, Murayama Y, Faber JE, Patel AB, Ayata C. Stroke. 2020 Sep 11:STROKEAHA120029651. doi: 10.1161/STROKEAHA.120.029651.


Clinical Reasoning: A 33-year-old with left sided hemiparesis and anarthria.
Schowalter S, Katz DI, Lin DJ. Neurology. 2020 Sep 10:10.1212/WNL.0000000000010809. doi: 10.1212/WNL.0000000000010809.


Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients.
Sheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. JAMA Neurol. 2020 Sep 8. doi: 10.1001/jamaneurol.2020.3263.


Huntington's Disease: Les Jeux Sont Faits?
Pfister EL, Aronin N. Trends Mol Med. 2020 Sep 4:S1471-4914(20)30206-9. doi: 10.1016/j.molmed.2020.08.004.


Preoperative Depressive Symptoms Associated with Poor Functional Recovery after Surgery.
Tang VL, Cenzer I, McCulloch CE, Finlayson E, Cooper Z, Silvestrini M, Ngo S, Schmitt EM, Inouye SK. J Am Geriatr Soc. 2020 Sep 8. doi: 10.1111/jgs.16781.


Update on neuromyelitis optica spectrum disorder.
Holroyd KB, Manzano GS, Levy M. Curr Opin Ophthalmol. 2020 Sep 3. doi: 10.1097/ICU.0000000000000703.  


Association of Plasma Neurofilament Light with Postoperative Delirium.
Fong TG, Vasunilashorn SM, Ngo L, Libermann T, Dillon S, Schmitt E, Pascual-Leone A, Arnold SE, Jones R, Marcantonio ER, Inouye SK; SAGES Study Group. Ann Neurol. 2020 Sep 3. doi: 10.1002/ana.25889.


Small but Fierce: Tracking the Role of Extracellular Vesicles in Glioblastoma Progression and Therapeutic Resistance.
Schweiger MW, Tannous BA. Adv Biosyst. 2020 Sep 3:e2000035. doi: 10.1002/adbi.202000035. Online ahead of print. PMID: 32881418


Telemedicine in Behavioral Neurology-Neuropsychiatry: Opportunities and Challenges Catalyzed by COVID-19.
Perez DL, Biffi A, Camprodon JA, Caplan DN, Chemali Z, Kritzer MD, Moo LR, Newhouse AL, Ramirez-Gomez L, Razafsha M, Tanev KS, Schmahmann JD. Cogn Behav Neurol. 2020 Sep;33(3):226-229. doi: 10.1097/WNN.0000000000000239.


A Theoretical Paradigm for Evaluating Risk-Benefit of Status Epilepticus Treatment.
Amorim E, McGraw CM, Westover MB. J Clin Neurophysiol. 2020 Sep;37(5):385-392. doi: 10.1097/WNP.0000000000000753.


CLoSES: A platform for closed-loop intracranial stimulation in humans.
Zelmann R, Paulk AC, Basu I, Sarma A, Yousefi A, Crocker B, Eskandar E, Williams Z, Cosgrove GR, Weisholtz DS, Dougherty DD, Truccolo W, Widge AS, Cash SS. Neuroimage. 2020 Aug 31:117314. doi: 10.1016/j.neuroimage.2020.117314.


Neighborhood-Level Social Disadvantage and Risk of Delirium Following Major Surgery.
Arias F, Chen F, Fong TG, Shiff H, Alegria M, Marcantonio ER, Gou Y, Jones RN, Travison TG, Schmitt EM, Kind AJH, Inouye SK. J Am Geriatr Soc. 2020 Aug 31. doi: 10.1111/jgs.16782.


Association of Selective Serotonin Reuptake Inhibitor Use After Intracerebral Hemorrhage With Hemorrhage Recurrence and Depression Severity.
Kubiszewski P, Sugita L, Kourkoulis C, DiPucchio Z, Schwab K, Anderson CD, Gurol ME, Greenberg SM, Viswanathan A, Rosand J, Biffi A. JAMA Neurol. 2020 Aug 31. doi: 10.1001/jamaneurol.2020.3142.


Anterior Insular Resting-State Functional Connectivity is Related to Cognitive Reserve in Multiple Sclerosis.
Bizzo BC, Arruda-Sanchez T, Tobyne SM, Bireley JD, Lev MH, Gasparetto EL, Klawiter EC. J Neuroimaging. 2020 Aug 28. doi: 10.1111/jon.12779.


Mapping mania symptoms based on focal brain damage.
Cotovio G, Talmasov D, Barahona-Corrêa JB, Hsu J, Senova S, Ribeiro R, Soussand L, Velosa A, Silva VCE, Rost N, Wu O, Cohen AL, Oliveira-Maia AJ, Fox MD. J Clin Invest. 2020 Aug 24:136096. doi: 10.1172/JCI136096.


Engaging ALS patients and caregivers (the ALS research ambassadors) to help design the REFINE-ALS biomarker study.
Berry JD, Bedlack R, Mathews D, Agnese W, Apple S.
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug 24:1-4. doi: 10.1080/21678421.2020.1804939.


New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders.
Moyses-Oliveira M, Yadav R, Erdin S, Talkowski ME. Curr Opin Genet Dev. 2020 Aug 23;65:195-206. doi: 10.1016/j.gde.2020.07.001.


Case 26-2020: A 60-Year-Old Woman with Altered Mental Status and Weakness on the Left Side.
Singhal AB, Gonzalez RG, Chwalisz BK, Mukerji SS. N Engl J Med. 2020 Aug 20;383(8):764-773. doi: 10.1056/NEJMcpc2004976.


Tau reduction in aged mice does not impact Microangiopathy.
Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT. Acta Neuropathol Commun. 2020 Aug 18;8(1):137. doi: 10.1186/s40478-020-01014-4.


Discovery of ACE2 receptors for SARS-CoV-2 (COVID-19) on peripheral small-fiber sensory neurons of uncertain clinical significance.
Oaklander AL.
Pain. 2020 Aug 18. doi: 10.1097/j.pain.0000000000002050.


Improved relapse recovery in paediatric compared to adult multiple sclerosis.
Chitnis T, Aaen G, Belman A, Benson L, Gorman M, Goyal MS, Graves JS, Harris Y, Krupp L, Lotze T, Mar S, Ness J, Rensel M, Schreiner T, Tillema JM, Waubant E, Weinstock-Guttman B, Roalstad S, Rose J, Weiner HL, Casper TC, Rodriguez M. Brain. 2020 Aug 18:awaa199. doi: 10.1093/brain/awaa199.


Gene therapy for Alzheimer's Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
Griciuc A, Federico AN, Natasan J, Forte AM, McGinty D, Nguyen H, Volak A, LeRoy S, Gandhi S, Lerner EP, Hudry E, Tanzi RE, Maguire CA. Hum Mol Genet. 2020 Aug 17:ddaa179. doi: 10.1093/hmg/ddaa179.


Sex mediates relationships between regional tau pathology and cognitive decline.
Buckley RF, Scott MR, Jacobs HI, Schultz AP, Properzi MJ, Amarglio RE, Hohman TJ, Mayblyum DV, Rubinstein ZB, Manning L, Hanseeuw BJ, Mormino EC, Rentz DM, Johnson KA, Sperling RA. Ann Neurol. 2020 Aug 16. doi: 10.1002/ana.25878.


An early start to Huntington's disease.
DiFiglia M. Science. 2020 Aug 14;369(6505):771-772. doi: 10.1126/science.abd6215.


Epidermal Neurite Density in Skin Biopsies from Patients with Juvenile Fibromyalgia.
Boneparth A, Chen S, Horton DB, Moorthy LN, Farquhar I, Downs HM, Lee H, Oaklander AL. J Rheumatol. 2020 Aug 15:jrheum.200378. doi: 10.3899/jrheum.200378.


Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit.
Edlow BL, Barra ME, Zhou DW, Foulkes AS, Snider SB, Threlkeld ZD, Chakravarty S, Kirsch JE, Chan ST, Meisler SL, Bleck TP, Fins JJ, Giacino JT, Hochberg LR, Solt K, Brown EN, Bodien YG. Neurocrit Care. 2020 Aug 13. doi: 10.1007/s12028-020-01062-7.


Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells.
Walker MA, Lareau CA, Ludwig LS, Karaa A, Sankaran VG, Regev A, Mootha VK. N Engl J Med. 2020 Aug 12. doi: 10.1056/NEJMoa2001265.


Stronger together: Diagnostic testing for ocular myasthenia gravis.
Doughty CT, Guidon AC. Neurology. 2020 Aug 11:10.1212/WNL.0000000000010616. doi: 10.1212/WNL.0000000000010616.


Synergy between amyloid-β and tau in Alzheimer's disease.
Busche MA, Hyman BT. Nat Neurosci. 2020 Aug 10. doi: 10.1038/s41593-020-0687-6.

Rubin DB, Al Jarrah A, Li K, LaRose S, Monk AD, Ali AB, Spendley LN, Nikiforow S, Jacobson C, Vaitkevicius H. JAMA Neurol. 2020 Aug 10. doi: 10.1001/jamaneurol.2020.2703. 

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints.
Minikel EV, Zhao HT, Le J, O'Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-Ura K, Beck M, O'Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. Nucleic Acids Res. 2020 Aug 10:gkaa616. doi: 10.1093/nar/gkaa616.


Opposing and potentially antagonistic effects of BMP and TGF-β in multiple sclerosis: The "Yin and Yang" of neuro-immune Signaling.
Sotiropoulos MG, Chitnis T. J Neuroimmunol. 2020 Aug 7;347:577358. doi: 10.1016/j.jneuroim.2020.577358.


Accurate detection of spontaneous seizures using a generalized linear model with external validation.
Fumeaux NF, Ebrahim S, Coughlin BF, Kadambi A, Azmi A, Xu JX, Abou Jaoude M, Nagaraj SB, Thomson KE, Newell TG, Metcalf CS, Wilcox KS, Kimchi EY, Moraes MFD, Cash SS. Epilepsia. 2020 Aug 6. doi: 10.1111/epi.16628.


Association of epileptiform abnormalities and seizures in Alzheimer disease.
Lam AD, Sarkis RA, Pellerin KR, Jing J, Dworetzky BA, Hoch DB, Jacobs CS, Lee JW, Weisholtz DS, Zepeda R, Westover MB, Cole AJ, Cash SS. Neurology. 2020 Aug 6:10.1212/WNL.0000000000010612. doi: 10.1212/WNL.0000000000010612. 


Mobility Action Group: Using Quality Improvement Methods to Create a Culture of Hospital Mobility.
Lorgunpai SJ, Finke B, Burrows I, Brown CJ, Rubin FH, Wierman HR, Heisey SJ, Gartaganis S, Ling SM, Press M, Inouye SK. J Am Geriatr Soc. 2020 Aug 5. doi: 10.1111/jgs.16699.


Author response: Disruption of the ascending arousal network in acute traumatic disorders of consciousness.
Edlow BL, Snider SB. Neurology. 2020 Aug 4;95(5):234. doi: 10.1212/WNL.0000000000010099.


Periodic Oscillations in Daily Reported Infections and Deaths for Coronavirus Disease 2019.
Bukhari Q, Jameel Y, Massaro JM, D'Agostino RB Sr, Khan S. JAMA Netw Open. 2020 Aug 3;3(8):e2017521. doi: 10.1001/jamanetworkopen.2020.17521.


Short-term Palliative Care for Advanced Neurologic Disease.
Brizzi KT. JAMA Netw Open. 2020 Aug 3;3(8):e2015247. doi: 10.1001/jamanetworkopen.2020.15247. PMID: 32857143


CRMP-5-IgG Associated Paraneoplastic Chorea.
Vaswani PA, Kimchi EY, Hung AY. Mov Disord Clin Pract. 2020 Aug 3;7(6):713-715. doi: 10.1002/mdc3.13019.


Exploring the use of educational materials for increasing participation in a stretching program: a quality improvement project in people with motor neuron disease.
Burke K, De Marchi F, Ellrodt AS, Doyle M, Koul M, Comeau O, Adelson E, Walter R, Kusy M, Amaya F, Anderson C, Honda J, Chan J, Berry J, Paganoni S. Eur J Phys Rehabil Med. 2020 Aug 3. doi: 10.23736/S1973-9087.20.06245-0. Online ahead of print.


Amyotrophic Lateral Sclerosis: Fuel for the Corticofugal Feud.
Wainger BJ, Brown RH Jr. Ann Neurol. 2020 Aug 2. doi: 10.1002/ana.25861. Online ahead of print.


Clinical Trial Readiness Study of Distal Myopathy and Dysphagia in Nephropathic Cystinosis.
Sadjadi R, Sullivan S, Grant N, Thomas SE, Doyle M, Hammond C, Corre C, Mello N, David WS, Eichler F. Muscle Nerve. 2020 Aug 1. doi: 10.1002/mus.27039. Online ahead of print.


Editorial: Advances in rare movement disorders.
Sharma N. Curr Opin Neurol. 2020 Aug;33(4):498-499. doi: 10.1097/WCO.0000000000000830.


Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration.
Das S, Li Z, Noori A, Hyman BT, Serrano-Pozo A. J Neuroinflammation. 2020 Jul 31;17(1):227. doi: 10.1186/s12974-020-01898-y.
PMID: 32736565


Lower extremity entrapment neuropathies.
Madani S, Doughty C. Best Pract Res Clin Rheumatol. 2020 Jul 31:101565. doi: 10.1016/j.berh.2020.101565. Online ahead of print. PMID: 32747188


Neuroinflammation and histone H3 citrullination are increased in X-linked Dystonia Parkinsonism post-mortem prefrontal cortex.
Petrozziello T, Mills AN, Vaine CA, Penney EB, Fernandez-Cerado C, Legarda GPA, Velasco-Andrada MS, Acuña PJ, Ang MA, Muñoz EL, Diesta CCE, Macalintal-Canlas R, Acuña-Sunshine G, Ozelius LJ, Sharma N, Bragg DC, Sadri-Vakili G. Neurobiol Dis. 2020 Jul 30:105032. doi: 10.1016/j.nbd.2020.105032. Online ahead of print.
PMID: 32739252


Detecting Seizures and Epileptiform Abnormalities in Acute Brain Injury.
Singla S, Garcia GE, Rovenolt GE, Soto AL, Gilmore EJ, Hirsch LJ, Blumenfeld H, Sheth KN, Omay SB, Struck AF, Westover MB, Kim JA. Curr Neurol Neurosci Rep. 2020 Jul 27;20(9):42. doi: 10.1007/s11910-020-01060-4.
PMID: 32715371


Sirtuin activation targets IDH-mutant tumors.
Miller JJ, Fink A, Banagis JA, Nagashima H, Subramanian M, Lee CK, Melamed L, Tummala SS, Tateishi K, Wakimoto H, Cahill DP. Neuro Oncol. 2020 Jul 26:noaa180. doi: 10.1093/neuonc/noaa180. Online ahead of print.
PMID: 32710757


Hospital Elder Life Program in Long-Term Care (HELP-LTC): A Cluster Randomized Controlled Trial.
Boockvar KS, Judon KM, Eimicke JP, Teresi JA, Inouye SK. J Am Geriatr Soc. 2020 Jul 25. doi: 10.1111/jgs.16695.


The Consequences of Coronavirus-Induced Cytokine Storm Are Associated With Neurological Diseases, Which May Be Preventable.
Isacson O.
Front Neurol. 2020 Jul 24;11:745. doi: 10.3389/fneur.2020.00745. eCollection 2020.


Cerebral Microvascular Injury in Severe COVID-19.
Conklin J, Frosch MP, Mukerji S, Rapalino O, Maher M, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux J, Sabeti P, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. medRxiv. 2020 Jul 24:2020.07.21.20159376. doi: 10.1101/2020.07.21.20159376. Preprint.


Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases.
Saxena S, Lokhande H, Gombolay G, Raheja R, Rooney T, Chitnis T. Sci Rep. 2020 Jul 24;10(1):12405. doi: 10.1038/s41598-020-69182-w.


Dementia Unspecified: A Multidisciplinary Approach.
Newhouse A, Buch K, Chemali Z. Prim Care Companion CNS Disord. 2020 Jul 23;22(4):19nr02570. doi: 10.4088/PCC.19nr02570.


Clinical Outcomes and Selection Criteria for Prodromal Huntington's Disease Trials.
Langbehn DR, Hersch S. Mov Disord. 2020 Jul 20. doi: 10.1002/mds.28222.


Opportunities of Connectomic Neuromodulation.
Horn A, Fox MD. Neuroimage. 2020 Jul 20:117180. doi: 10.1016/j.neuroimage.2020.117180.


Brain edema takes center stage.
Sheth KN, Kimberly WT. Neurosci Lett. 2020 Jul 20;736:135266. doi: 10.1016/j.neulet.2020.135266.


Pediatric Multiple Sclerosis Severity Score in a Large U.S. Cohort.
Santoro JD, Waltz M, Aaen G, Belman A, Benson L, Gorman M, Goyal MS, Graves JS, Harris Y, Krupp L, Lotze T, Mar S, Moodley M, Ness J, Rensel M, Rodriguez M, Schreiner T, Tillema JM, Waubant E, Weinstock-Guttman B, Hurtubise BF, Roalstad S, Rose J, Casper TC, Chitnis T; U.S. Network of Pediatric MS Centers. Neurology. 2020 Jul 20:10.1212/WNL.0000000000010414. doi: 10.1212/WNL.0000000000010414.


Clinical Electroencephalography Findings and Considerations in Hospitalized Patients with Coronavirus SARS-CoV-2.
Ayub N, Cohen J, Jing J, Jain A, Tesh R, Mukerji SS, Zafar SF, Westover MB, Kimchi EY. medRxiv. 2020 Jul 15:2020.07.13.20152207. doi: 10.1101/2020.07.13.20152207. Preprint.


Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?
Young MJ, O'Hare M, Matiello M, Schmahmann JD. Brain Behav Immun. 2020 Jul 15:S0889-1591(20)31522-1. doi: 10.1016/j.bbi.2020.07.007.


Safety Considerations for Cerebellar Theta Burst Stimulation.
Hurtado-Puerto AM, Nestor K, Eldaief M, Camprodon JA. Clin Ther. 2020 Jul 14:S0149-2918(20)30279-4. doi: 10.1016/j.clinthera.2020.06.001.


Corrigendum: Interhemispheric and Intrahemispheric Connectivity From the Left Pars Opercularis Within the Language Network Is Modulated by Transcranial Stimulation in Healthy Subjects.
Yoo WK, Vernet M, Kim JH, Brem AK, Bashir S, Ifert-Miller F, Im CH, Eldaief M, Pascual-Leone A. Front Hum Neurosci. 2020 Jul 14;14:249. doi: 10.3389/fnhum.2020.00249.

The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium.
Katsumi Y, Racine AM, Torrado-Carvajal A, Loggia ML, Hooker JM, Greve DN, Hightower BG, Catana C, Cavallari M, Arnold SE, Fong TG, Vasunilashorn SM, Marcantonio ER, Schmitt EM, Xu G, Libermann TA, Barrett LF, Inouye SK, Dickerson BC, Touroutoglou A, Collins JA; RISE Study Group. Neuroimage Clin. 2020 Jul 14;27:102346. doi: 10.1016/j.nicl.2020.102346. 


Delineating the phenotypic spectrum of sulfite oxidase and molybdenum cofactor deficiency.
Misko AL, Liang Y, Kohl JB, Eichler F. Neurol Genet. 2020 Jul 14;6(4):e486. doi: 10.1212/NXG.0000000000000486. eCollection 2020 Aug.


Cost-effectiveness analysis of multimodal prognostication in cardiac arrest with EEG monitoring.
Amorim E, Mo SS, Palacios S, Ghassemi MM, Weng WH, Cash SS, Bianchi MT, Westover MB. Neurology. 2020 Jul 13:10.1212/WNL.0000000000009916. doi: 10.1212/WNL.0000000000009916.

Genomic Mechanisms in Alzheimer's Disease.
Bertram L, Tanzi RE. Brain Pathol. 2020 Jul 13. doi: 10.1111/bpa.12882.


Accuracy of ICD-10-CM claims-based definitions for epilepsy and seizure type.
Smith JR, Jones FJS, Fureman BE, Buchhalter JR, Herman ST, Ayub N, McGraw C, Cash SS, Hoch DB, Moura LMVR. Epilepsy Res. 2020 Jul 11;166:106414. doi: 10.1016/j.eplepsyres.2020.106414.


Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists.
Rezaei SJ, Vogel AC, Gazdag B, Alakel N, Kumar AR, Mateen FJ. J Neuroimmunol. 2020 Jul 11;346:577320. doi: 10.1016/j.jneuroim.2020.577320


Optimizing the accuracy of cortical volumetric analysis in traumatic brain injury.
Diamond BR, Donald CLM, Frau-Pascual A, Snider SB, Fischl B, Dams-O'Connor K, Edlow BL. MethodsX. 2020 Jul 11;7:100994. doi: 10.1016/j.mex.2020.100994. eCollection 2020.


Transitive Sequencing Medical Records for Mining Predictive and Interpretable Temporal Representations.
Estiri H, Strasser ZH, Klann JG, McCoy TH Jr, Wagholikar KB, Vasey S, Castro VM, Murphy ME, Murphy SN. Patterns (N Y). 2020 Jul 10;1(4):100051. doi: 10.1016/j.patter.2020.100051. Epub 2020 Jun 18.


Experimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson's disease genetic risk.
Thomas R, Hallett PJ, Isacson O. Int Rev Neurobiol. 2020;154:279-302. doi: 10.1016/bs.irn.2020.02.004. Epub 2020 Jul 10.
PMID: 32739007


Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations.
Sugimoto K, Chung DY, Böhm M, Fischer P, Takizawa T, Aslihan Aykan S, Qin T, Yanagisawa T, Harriott A, Oka F, Yaseen MA, Sakadžić S, Ayata C. Stroke. 2020 Jul 9:STROKEAHA120029618. doi: 10.1161/STROKEAHA.120.029618. Online ahead of print.
PMID: 32640946


National Geriatric Network Rapidly Addresses Trainee Telehealth Needs in Response to COVID-19.
Nearing KA, Lum HD, Dang S, Powers B, McLaren J, Gately M, Hung W, Moo L. J Am Geriatr Soc. 2020 Jul 8. doi: 10.1111/jgs.16704. [Epub ahead of print] PMID: 32639578


Impact of COVID-19 on U.S. and Canadian neurologists' therapeutic approach to multiple sclerosis: a survey of knowledge, attitudes, and practices.
Mateen FJ, Rezaei S, Alakel N, Gazdag B, Kumar AR, Vogel A. J Neurol. 2020 Jul 7. doi: 10.1007/s00415-020-10045-9. [Epub ahead of print]
PMID: 32638107


Advances toward precision medicine for bipolar disorder: mechanisms & molecules.
Haggarty SJ, Karmacharya R, Perlis RH. Mol Psychiatry. 2020 Jul 7. doi: 10.1038/s41380-020-0831-4. [Epub ahead of print] Review.
PMID: 32636474


Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1.
Mouro Pinto R, Arning L, Giordano JV, Razghandi P, Andrew MA, Gillis T, Correia K, Mysore JS, Grote Urtubey DM, Parwez CR, Hein von SM, Clark HB, Nguyen HP, Förster E, Beller A, Jayadaev S, Keene CD, Bird TD, Lucente D, Vonsattel JP, Orr H, Saft C, Petrasch-Parwez E, Wheeler VC. Hum Mol Genet. 2020 Jul 7:ddaa139. doi: 10.1093/hmg/ddaa139.


Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy in paediatric patients with multiple sclerosis: Results from the PARADIGMS study.
Chitnis T, Banwell B, Krupp L, Arnold DL, Bar-Or A, Brück W, Giovannoni G, Greenberg B, Ghezzi A, Waubant E, Rostasy K, Deiva K, Huppke P, Wolinsky JS, Zhang Y, Azmon A, K-Laflamme A, Karan R, Gärtner J. Mult Scler. 2020 Jul 7:1352458520936934. doi: 10.1177/1352458520936934. [Epub ahead of print]
PMID: 32633694


Intact Brain Network Function in an Unresponsive Patient with COVID-19.
Fischer D, Threlkeld ZD, Bodien YG, Kirsch JE, Huang SY, Schaefer PW, Rapalino O, Hochberg LR, Rosen BR, Edlow BL. Ann Neurol. 2020 Jul 1. doi: 10.1002/ana.25838. [Epub ahead of print]
PMID: 32613682


White Matter Atrophy in Cerebral Amyloid Angiopathy.
Fotiadis P, Reijmer YD, Van Veluw SJ, Martinez-Ramirez S, Karahanoglu FI, Gokcal E, Schwab KM; Alzheimer’s Disease Neuroimaging Initiative study group, Goldstein JN, Rosand J, Viswanathan A, Greenberg SM, Gurol ME. Neurology. 2020 Jul 1. pii: 10.1212/WNL.0000000000010017. doi: 10.1212/WNL.0000000000010017. [Epub ahead of print]
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Zika Virus: Learning from the Past as We Prepare for the Future.
Mochida GH. J Pediatr. 2020 Jul;222:15-16. doi: 10.1016/j.jpeds.2020.04.006.
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Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease.
Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Front Neurosci. 2020 Jun 30;14:705. doi: 10.3389/fnins.2020.00705. eCollection 2020.
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Thrombolysis beyond 4.5 h in Acute Ischemic Stroke.
Etherton MR, Gadhia RR, Schwamm LH. Curr Neurol Neurosci Rep. 2020 Jun 30;20(8):35. doi: 10.1007/s11910-020-01055-1. Review.
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Evaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study.
Vespa PM, Olson DM, John S, Hobbs KS, Gururangan K, Nie K, Desai MJ, Markert M, Parvizi J, Bleck TP, Hirsch LJ, Westover MB. Crit Care Med. 2020 Jun 29. doi: 10.1097/CCM.0000000000004428. [Epub ahead of print]
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Leaky memories: Impact of APOE4 on blood-brain barrier and dementia.
Li W, Lo EH. J Cereb Blood Flow Metab. 2020 Jun 29:271678X20938146. doi: 10.1177/0271678X20938146. [Epub ahead of print]
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Disease of the Year: COVID-19 and Its Neuro-ophthalmic Complications.
Chwalisz BK, Dinkin MJ. J Neuroophthalmol. 2020 Jun 26. doi: 10.1097/WNO.0000000000001046. [Epub ahead of print] PMID: 32604246 


Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.
Silva MC, Nandi GA, Tentarelli S, Gurrell IK, Jamier T, Lucente D, Dickerson BC, Brown DG, Brandon NJ, Haggarty SJ. Nat Commun. 2020 Jun 26;11(1):3258. doi: 10.1038/s41467-020-16984-1.
PMID: 32591533


A standardized nomenclature for spectrogram EEG patterns: Inter-rater agreement and correspondence with common intensive care unit EEG patterns.
Zafar SF, Amorim E, Williamsom CA, Jing J, Gilmore EJ, Haider HA, Swisher C, Struck A, Rosenthal ES, Ng M, Schmitt S, Lee JW, Brandon Westover M. Clin Neurophysiol. 2020 Jun 24:S1388-2457(20)30369-2. doi: 10.1016/j.clinph.2020.05.032. Online ahead of print.
PMID: 32660817


Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo.
Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. J Alzheimers Dis. 2020 Jun 24. doi: 10.3233/JAD-200128. [Epub ahead of print]
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Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases.
Mormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, Fredericks CA, Koran ME, Zeineh M, Poston K, Greicius MD, Khalighi M, Davidzon GA, Shen B, Zaharchuk G, Wagner AD, Chin FT. Eur J Nucl Med Mol Imaging. 2020 Jun 23. doi: 10.1007/s00259-020-04923-7. [Epub ahead of print]
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COVID-19 Outpatient Screening: a Prediction Score for Adverse Events.
Sun H, Jain A, Leone MJ, Alabsi HS, Brenner LN, Ye E, Ge W, Shao YP, Boutros CL, Wang R, Tesh RA, Magdamo C, Collens SI, Ganglberger W, Bassett IV, Meigs JB, Kalpathy-Cramer J, Li MD, Chu JT, Dougan M, Stratton L, Rosand J, Fischl B, Das S, Mukerji SS, Robbins GK, Westover MB. medRxiv. 2020 Jun 22. pii: 2020.06.17.20134262. doi: 10.1101/2020.06.17.20134262.
PMID: 32607523


Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, Jean-Gilles D, Clark R, Atchison K, Moore R, Chibnik LB, Tanzi RE, Frosch MP, Serrano-Pozo A, Elwood F, Steen JA, Kennedy ME, Hyman BT.
Nat Med. 2020 Jun 22. doi: 10.1038/s41591-020-0938-9. [Epub ahead of print]
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Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy-Related Inflammation.
Regenhardt RW, Thon JM, Das AS, Thon OR, Charidimou A, Viswanathan A, Gurol ME, Chwalisz BK, Frosch MP, Cho TA, Greenberg SM. JAMA Neurol. 2020 Jun 22. doi: 10.1001/jamaneurol.2020.1782. [Epub ahead of print]
PMID: 32568365


Chasing Protection in Parkinson's Disease: Does Exercise Reduce Risk and Progression?
Crotty GF, Schwarzschild MA. Front Aging Neurosci. 2020 Jun 19;12:186. doi: 10.3389/fnagi.2020.00186. eCollection 2020. Review.
PMID: 32636740


Commentary in response to 'Impact of the COVID-19 pandemic on the process and outcome of thrombectomy for acute ischemic stroke'.
Leslie-Mazwi TM, Chandra RV, Hirsch JA. J Neurointerv Surg. 2020 Jun 19. pii: neurintsurg-2020-016426. doi: 10.1136/neurintsurg-2020-016426. [Epub ahead of print]
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Determining the Need for Thrombectomy-Capable Stroke Centers Based on Travel Time to the Nearest Comprehensive Stroke Center.
Baker DW, Tschurtz BA, Aliaga AE, Williams SC, Jauch EC, Schwamm LH. Jt Comm J Qual Patient Saf. 2020 Jun 18:S1553-7250(20)30157-4. doi: 10.1016/j.jcjq.2020.06.005. Online ahead of print.
PMID: 32736996


Brain insulin signaling, Alzheimer's disease pathology, and cognitive function.
Arvanitakis Z, Wang HY, Capuano AW, Khan A, Taïb B, Anokye-Danso F, Schneider JA, Bennett DA, Ahima RS, Arnold SE. Ann Neurol. 2020 Jun 18. doi: 10.1002/ana.25826. [Epub ahead of print]
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Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion disease.
Vallabh SM, Minikel EV, Williams VJ, Carlyle BC, McManus AJ, Wennick CD, Bolling A, Trombetta BA, Urick D, Nobuhara CK, Gerber J, Duddy H, Lachmann I, Stehmann C, Collins SJ, Blennow K, Zetterberg H, Arnold SE. BMC Med. 2020 Jun 18;18(1):140. doi: 10.1186/s12916-020-01608-8.
PMID: 32552681


High mitochondrial calcium levels precede neuronal death in vivo in Alzheimer's disease.
Calvo-Rodriguez M, Bacskai BJ. Cell Stress. 2020 Jun 18;4(7):187-190. doi: 10.15698/cst2020.07.226.
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Whole-blood dysregulation of actin-cytoskeleton pathway in adult spinal muscular atrophy patients.
Siranosian JJ, Nery FC, Alves CRR, Siranosian BA, Lyons NJ, Eichelberger EJ, Garner R, Da Silva Duarte Lepez S, Johnstone AJ, Subramanian A, Swoboda KJ. Ann Clin Transl Neurol. 2020 Jun 17. doi: 10.1002/acn3.51092. [Epub ahead of print]
PMID: 32558393


Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects.
Kim KH, Hong EP, Shin JW, Chao MJ, Loupe J, Gillis T, Mysore JS, Holmans P, Jones L, Orth M, Monckton DG, Long JD, Kwak S, Lee R, Gusella JF, MacDonald ME, Lee JM. Am J Hum Genet. 2020 Jun 16. pii: S0002-9297(20)30159-2. doi: 10.1016/j.ajhg.2020.05.012. [Epub ahead of print]
PMID: 32589923


Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients.
Rodriguez S, Cao L, Rickenbacher GT, Benz EG, Magdamo C, Ramirez Gomez LA, Holbrook E, Dhilla Albers A, Gallagher R, Westover MB, Evans KE, Tatar D, Mukerji S, Zafonte R, Boyer EW, Yu CR, Albers MW. medRxiv. 2020 Jun 16. pii: 2020.06.14.20131128. doi: 10.1101/2020.06.14.20131128.
PMID: 32587994


Implementing standardized provider documentation in a tertiary epilepsy clinic.
Jones FJS, Smith JR, Ayub N, Herman ST, Buchhalter JR, Fureman BE, Cash SS, Hoch DB, Moura LMVR. Neurology. 2020 Jun 16. pii: 10.1212/WNL.0000000000009778. doi: 10.1212/WNL.0000000000009778. [Epub ahead of print]
PMID: 32546650


Stander Use in Spinal Muscular Atrophy: Results From a Large Natural History Database.
Townsend EL, Simeone SD, Krosschell KJ, Zhang RZ, Swoboda KJ; Project Cure SMA Investigatorʼs Network. Pediatr Phys Ther. 2020 Jun 16. doi: 10.1097/PEP.0000000000000713. [Epub ahead of print]
PMID: 32569095


Characterizing Sunflower syndrome: a clinical series.
Barnett JR, Fleming BM, Geenen KR, Sourbron J, Freedman JH, Bruno PL, Thiele EA. Epileptic Disord. 2020 Jun 15. doi: 10.1684/epd.2020.1161. [Epub ahead of print]
PMID: 32554362


β-Glucocerebrosidase Activity in GBA-linked Parkinson's Disease: The Type of Mutation Matters.
Huh YE, Ruby Chiang MS, Locascio JJ, Liao Z, Liu G, Choudhury K, Kuras YI, Tuncali I, Videnovic A, Hunt AL, Schwarzschild MA, Hung AY, Herrington TM, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Sardi SP, Scherzer CR. Neurology. 2020 Jun 15. pii: 10.1212/WNL.0000000000009989. doi: 10.1212/WNL.0000000000009989. [Epub ahead of print]
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Author Correction: Potential circadian effects on translational failure for neuroprotection.
Esposito E, Li W, Mandeville ET, Park JH, Şencan I, Guo S, Shi J, Lan J, Lee J, Hayakawa K, Sakadžić S, Ji X, Lo EH. Nature. 2020 Jun 13. doi: 10.1038/s41586-020-2427-1. [Epub ahead of print]
PMID: 32533095


A computational paradigm for real-time MEG neurofeedback for dynamic allocation of spatial attention.
Rana KD, Khan S, Hämäläinen MS, Vaina LM. Biomed Eng Online. 2020 Jun 12;19(1):45. doi: 10.1186/s12938-020-00787-y.
PMID: 32532277


Neurological Manifestation of COVID-19 and the Enhanced Role of Physiatrists.
Iaccarino MA, Tenforde AS, Zafonte RD, Silver JK, Hefner J, Paganoni S. Am J Phys Med Rehabil. 2020 Jun 10. doi: 10.1097/PHM.0000000000001502. [Epub ahead of print]
PMID: 32541351


Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage.
Biffi A, Urday S, Kubiszewski P, Gilkerson L, Sekar P, Rodriguez-Torres A, Bettin M, Charidimou A, Pasi M, Kourkoulis C, Schwab K, DiPucchio Z, Behymer T, Osborne J, Morgan M, Moomaw CJ, James ML, Greenberg SM, Viswanathan A, Gurol ME, Worrall BB, Testai FD, McCauley JL, Falcone GJ, Langefeld CD, Anderson CD, Kamel H, Woo D, Sheth KN, Rosand J. Stroke. 2020 Jun 10:STROKEAHA120028310. doi: 10.1161/STROKEAHA.120.028310. [Epub ahead of print]
PMID: 32517581


Pemetrexed in Recurrent or Progressive Central Nervous System Lymphoma: A Phase I Multicenter Clinical Trial.
Dietrich J, Versmee L, Drappatz J, Eichler AF, Nayak L, Norden A, Wong E, Pisapia MR, Jones SS, Gordon AB, Chabner BA, Hochberg F, Batchelor TT. Oncologist. 2020 Jun 10. doi: 10.1634/theoncologist.2020-0489. [Epub ahead of print]
PMID: 32520407 


Longitudinal biomarkers in amyotrophic lateral sclerosis.
Huang F, Zhu Y, Hsiao-Nakamoto J, Tang X, Dugas JC, Moscovitch-Lopatin M, Glass JD, Brown RH Jr, Ladha SS, Lacomis D, Harris JM, Scearce-Levie K, Ho C, Bowser R, Berry JD. Ann Clin Transl Neurol. 2020 Jun 9. doi: 10.1002/acn3.51078. [Epub ahead of print]
PMID: 32515902


Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-κB/STAT3 Signaling.
Schweiger MW, Li M, Giovanazzi A, Fleming RL, Tabet EI, Nakano I, Würdinger T, Chiocca EA, Tian T, Tannous BA.
Adv Biosyst. 2020 Jun 9:e1900312. doi: 10.1002/adbi.201900312. [Epub ahead of print]
PMID: 32519463 


Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
Yang HS, White CC, Klein HU, Yu L, Gaiteri C, Ma Y, Felsky D, Mostafavi S, Petyuk VA, Sperling RA, Ertekin-Taner N, Schneider JA, Bennett DA, De Jager PL. Neuron. 2020 Jun 8. pii: S0896-6273(20)30356-1. doi: 10.1016/j.neuron.2020.05.010. [Epub ahead of print]
PMID: 32526197


FastSurfer - A fast and accurate deep learning based neuroimaging pipeline.
Henschel L, Conjeti S, Estrada S, Diers K, Fischl B, Reuter M. Neuroimage. 2020 Jun 8:117012. doi: 10.1016/j.neuroimage.2020.117012. [Epub ahead of print]
PMID: 32526386


Advances in rare movement disorders.
Sharma N. Curr Opin Neurol. 2020 Jun 8. doi: 10.1097/WCO.0000000000000830. [Epub ahead of print]
PMID: 32520806


Whole Blood SMN Protein Levels Correlate with Severity of Denervation in Spinal Muscular Atrophy.
Alves CRR, Zhang R, Johnstone AJ, Garner R, Eichelberger EJ, Da Silva Duarte Lepez S, Yi V, Stevens V, Poxson R, Schwartz R, Zaworski P, Swoboda KJ. Muscle Nerve. 2020 Jun 8. doi: 10.1002/mus.26995. [Epub ahead of print]
PMID: 32511765