Grand Rounds Recordings

This timely and informative seminar series addresses major topics in neurology, including stroke, epilepsy, and the neurological complications of COVID-19. For details about Grand Rounds and Partners Continuing Professional Development, please visit the Neurology Grand Rounds course page. Selected lecture recordings are shared here.

March 25, 2021: Tyler Memorial Neurology Grand Rounds: Immune Mechanisms in Neurologic Diseases
Howard Weiner, MD discusses how the innate and adaptive immune systems contribute to neurologic disease and how they can be used to treat it. Dr. Weiner is the Robert L. Kroc Professor of Neurology at Harvard Medical School, the Director and Founder of the Brigham MS Center and the Co-Director of the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital.

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March 18, 2021: Three Short Stories in Neuroimmunology
Michael Levy, MD, PhD, director of the Mass General Neuromyelitis Optica Clinic & Research Lab, discusses neuromyelitis optica (NMO) and MOG antibody disease, their immunological differences and treatment options.

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February 25, 2021: Dual Genome 'Omics: The Mitochondrial DNA Heteroplasmy Problem
Melissa A. Walker, MD discusses her work on mitochondrial genetics, clinical manifestations of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes, and the influence of cell type on somatic mitochondrial genetics. Dr. Walker is the Director of the Mass General Neuro-Pediatric Mitochondrial Disorders Clinic and a Consortium Co-Investigator with the NIH Undiagnosed Disease Network.

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February 18, 2021: Modeling the Complexity of Migraine: Challenges and Future Directions
Mass General Neurologist Andrea Harriott, MD, PhD, discusses the utility of in-vitro models of migraine in the preclinical setting and of behavioral models of migraine with aura in the preclinical setting.

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Previous Lectures

February 11, 2021: Computable Neurologic Phenotypes in Pediatric Critical Care
University of Washington Professor Mark Wainwright, MD, PhD, FAAN discusses pediatric neurocritical care, including neuromonitoring methods and the potential of electronic health records and streaming physiologic data to identify risks of neurologic injury in the ICU.

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January 28, 2021: Changing the Paradigm for ALS Clinical Trials
Sabrina Paganoni, MD, PhD presents the Krivickas Memorial Grand Rounds Lecture, focusing on the success of new clinical trials for ALS in the past year, including the CENTAUR trial and the HEALEY ALS Platform Trial.
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December 10, 2020: The Role of Pandemics in the Evolution and Destruction of the Human Brain

Virus illustration

Avindra Nath, MD, Chief of the Section of Infections of the Nervous System at NIH, covers neurological complications associated with recent and remote pandemics, the way that pandemics have shaped human evolution and brain development, and how pathogens incorporated in the human genome from remote pandemics can influence the pathophysiology of neurodegenerative diseases.

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November 19, 2020: Neuro-Vascular Interactions in the Brain
Chenghua Gu, DVM, PhD, a Professor of Neurobiology at Harvard Medical School, explains molecular mechanisms underlying the blood-brain barrier and neurovascular coupling.

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May 14, 2020: Case Study: A 60-year-old woman with COVID-19 and altered mental status
Moderator: Meridale Baggett, MD, Associate Editor, New England Journal of Medicine Case Records of the Massachusetts General Hospital
Panel: Aneesh Singhal, MD, Bart Chwalisz, MD, Shibani Mukerji, MD, PhD and Ramon Gonzalez, MD

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April 30, 2020: Neurology & COVID-19 Research Update
Presenters Jonathan Rosand, MD, Mark Albers, MD and Eric Klawiter, MD, MSc share new information about COVID-19 clinical trials and ongoing research.
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April 23, 2020: COVID-19 & Neurology: A Panel Discussion
Presenters Bart Chwalisz, MD, M. Brandon Westover, MD, PhD, Paloma Gonzalez-Perez, MD, PhD and Shibani Mukerji, MD, PhD discuss the neurological impacts of COVID-19.

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Accreditation

Partners HealthCare System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Partners HealthCare System designates this live activity for a maximum of 1 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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