Neuroimmunology Clinic and Research Laboratory


Contact Information
The NMO Clinic & Research Laboratory
Wang Ambulatory Care Center
15 Parkman Street, 8th Floor, Suite 835
Boston,
MA
02114
Neuroimmunology phone: 617-726-7565
Find Us on Social Media
Research Publications at PubMedExplore This Treatment Program
About Us
The Neuroimmunology Clinic and Research Laboratory at Mass General is the first home in New England for patients with NMOSD (Neuromyelitis optica spectrum disorder), MOGAD (Myelin oligodendrocyte glycoprotein antibody disease), transverse myelitis and other rare autoimmune disorders of the central nervous system. Here, we specialize in these rare conditions – they are not an afterthought.
In our clinic, you can expect to see physicians who work at the vanguard of their fields. You might participate in a clinical trial. You could join us in increasing awareness about your particular disease. And you may find community with others who suffer from similar ailments.
– Neuroimmunology Clinic PatientDr. Levy was very responsive, very compassionate and also very easy to talk with. He made me and my husband both feel very welcome and open to any questions that we have.
Diseases We Treat
- Neuromyelitis Optica Spectrum Disorder (NMOSD)
- MOG Antibody Disease (MOGAD)
- Transverse Myelitis (TM)
- Acute Disseminated Encephalomyelitis (ADEM)
Research and Clinical Trials

The Neuroimmunology Lab is actively involved in research to advance knowledge, improve care, unearth new treatments, and ultimately find cures for NMO and MOG spectrum disorders.
We conduct research and clinical studies in our state-of-the-art neuroimmunology laboratory in Charlestown, and participate with industry in clinical trials of new and repurposed drugs to treat these rare neuroimmunological disorders.
Current Research
- New biomarkers of neuroimmunological disorders: Just as aquaporin-4 and MOG antibodies have transformed the field for patients with NMOSD, we are looking for new antibodies and specific immune cells that could identify patients with other autoimmune diseases of the nervous system
- Genetic studies in familial transverse myelitis: We found the first genetic mutation in patients with familial transverse myelitis. We are actively recruiting more TM patients for testing and we have developed mouse models of these mutations to understand the role they play in this disease
- Mouse models of NMOSD and MOGAD: Mouse models of NMOSD and MOG antibody disease are critical in our work to develop tolerization therapy. Tolerization therapy re-educates the immune system to stop attacking its own spinal cord and optic nerve. This therapy carries the promise of a durable cure that will not require long term immune-suppressive medications
- Does diet affect disease course in MOGAD? To enroll, contact Lexi Marta at amarta1@jhu.edu
Patient blood samples are critical for the success of this research. We were pleased to be a site for the CIRCLES biorepository sponsored by the Guthy Jackson Research Foundation, and are continuing to collect blood from our own patients and the Mass General Brigham BioBank.
Active Clinical Trials
The Neuroimmunology Laboratory is a site for several sponsored studies, including:
- Eculizumab in children with AQP4+ NMO (Alexion) – Now enrolling
To enroll, contact Dr. Levy at mlevy11@mgh.harvard.edu or call 617-724-3627 - Inebulizumab in children with AQP4+ NMO (Horizon) – Now enrolling
To enroll, contact Dr. Levy at mlevy11@mgh.harvard.edu or call 617-724-3627 - Rozanolixizumab for adults with MOGAD – Now enrolling
To enroll, contact Ozden Ozkur Akinci, oozkurakinci@mgh.harvard.edu - SPHERES (With Guthy Jackson Charitable Foundation and CorEvitas) – a registry for patients with NMOSD to ascertain treatment efficacy and safety – Now enrolling
To enroll, please ask your neurologist at time of visit - Satralizumab for adults with AQP4+ NMO who have never been on immune suppressants or who relapsed on Rituximab or a biosimilar – Now enrolling. To enroll, contact Santiago Pardo at spardo1@mgh.harvard.edu or 410-926-6248
- Satralizumab for adults with MOGAD – Now enrolling
To enroll, contact Alexis Marta at amarta@mgh.harvard.edu
- Ravulizumab in adults (Alexion) – No longer enrolling
- Point-of-care dry blood spot diagnostic test for AQP4+ patients – No longer enrolling
- TENS for pain in AQP4+ NMO –No longer enrolling
We plan to launch additional clinical trials for MOG antibody disease soon.
Please ask your doctor if you can participate in any of the trials for which we are now recruiting patients.
We look forward to hosting additional trials in the future, and will announce the research as it becomes available to our patients.
Education and Outreach

The Neuroimmunology Clinic and Research Laboratory is a center for education about NMOSD, MOGAD and related disorders.
For professionals, we house fellowship programs, host medical residents and offer educational programming. We are working to raise awareness among physicians around the world about these often-unknown diseases.
For patients and the public at large, we are raising the profile of NMOSD and MOGAD, increasing name recognition and promoting understanding about living with invisible chronic illness. The Clinic will provide its own educational programs and also partner with other institutions to offer learning opportunities for patients and their communities, including an annual “patient day”, sponsored by the Guthy Jackson Charitable Foundation and hosted by Brigham & Women’s Hospital.
Recent Events
Dr. Levy regularly appears on podcasts and webinars about neuroimmune disorders. Visit our YouTube playlists to find recordings.
May 7, 2021: Dr. Levy discusses Covid-19 and rare neuroimmune disorders with GG deFiebre of SRNA in a podcast here.
February 28, 2021: In this continuing medical education (CME) course for physicians, Dr. Levy and Dr. Prem Subramanian, ophthalmologist from the University of Colorado Hospital, discuss optic neuritis in NMOSD.
February 16, 2021: Dr. Levy summarizes his lab’s current research in this podcast from the Siegel Rare Neuroimmune Association.
Earlier Events
October 19, 2020: Dr. Levy joins Dr. Leslie Benson from Boston Children's Hospital for a discussion about adult and pediatric presentations of MOG Antibody Disease in this Siegel Rare Neuroimmune Association podcast.
May 13, 2020: The Siegel Rare Neuroimmune Association "Ask the Expert" podcast series presents Dr. Levy and Dr. Benjamin Greenberg from UT Southwestern in Dallas, TX, discussing COVID-19 and rare neuroimmune disorders
February 29, 2020: The McCourt Foundation Educational Update – Drs. Levy and Matiello shared current thinking and the latest research in NMO and MOG spectrum disorders at this educational event about neurological conditions in Newton, Massachusetts.
October 5, 2019: The NMO Clinic and Research Lab at Mass General cohosted a day with Neurology at Brigham & Women’s for NMOSD patients at a conference sponsored by the Guthy Jackson Foundation at Brigham & Women’s. Experts from both hospitals as well as Dr. Vanda Lennon from the Mayo Clinic shared updates in treatments and research, and answered patient questions.
October 4, 2019: The NMO Clinic and Research Lab hosted a CME course covering progress in the understanding of and research in Neuromyelitis optica.
Other Patient Resources
Direct manufacturer assistance, including financial support, care coordination and educational resources is available for patients using medications from Alexion, Genentech/Roche and Horizon Therapeutics. In addition, we can recommend the following patient support and advocacy organizations:
- Guthy Jackson Foundation - Funding research on the pathophysiology and biochemistry of NMO
- Sumaira Foundation for NMO - A nonprofit organization dedicated to generating global awareness of NMO
- The MOG Project - Devoted to raising awareness and advancing research to support those suffering from MOG-AD
- Siegel Rare Neuroimmune Association (SRNA) - An international nonprofit supporting patients with rare neuroimmune diseases
- National Organization for Rare Disorders - A patient advocacy organization dedicated to individuals with rare diseases
- Patients Like Me - A patient-led community where you can share your experiences and learn from others
Financial assistance organizations for patients include:
- Victoria's Victory - Small grants for in-home nursing services, home & mobility equipment, vehicle/driver assistance
- The Assistance Fund - Financial support for eligible patients including travel costs and copays
- NeedyMeds - Connecting patients with programs offering help with healthcare costs
- PAN Foundation - The Patient Access Network helps patients with out-of-pocket medical costs
- RxAssist - Comprehensive directory of patient assistance programs
- 180 Medical Scholarships - College scholarships for people with TM and other conditions
Our Doctors
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- Attending Neurologist, Massachusetts General Hospital
- Instructor in Neurology, Harvard Medical School
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- Instructor of Neurology, Harvard Medical School
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- Director, Multiple Sclerosis and Neuromyelitis Optica Unit
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- Associate Professor, Harvard Medical School
- Research Director, Division of Neuroimmunology & Neuroinfectious Disease
- Director, Neuroimmunology Clinic and Research Laboratory
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- Associate Professor, Harvard Medical School
- Director, Global Health, Department of Neurology
- Associate Director, Multiple Sclerosis & Neuromyelitis Optica Unit
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- Associate Professor of Neurology, Harvard Medical School
- Vice-Chair of Clinical Affairs, Mass General Hospital Department of Neurology
- Senior Clinical Neurologist, Division of NeuroImmunology/NeuroInfectious Diseases; Division of Comprehensive Neurology
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- Chief, Division of Neuroimmunology and Neuro-Infectious Diseases
- Director, Advanced General and Autoimmune Neurology Fellowship Program
- Director, Master Clinician-Educator Program
Pediatric Clinic
Tanuja Chitnis, MD
- Professor of Neurology, Harvard Medical School
- Director, Mass General Brigham Pediatric Multiple Sclerosis Center, Massachusetts General Hospital
- Director, Translational Neuroimmunology Research Center, Brigham and Women’s Hospital
- Director, CLIMB Study, Mass General Brigham Multiple Sclerosis Center, Brigham and Women’s Hospital
Pediatric Research
- Director, NMO Clinic and Research Laboratory
- Research Director, Division of Neuroimmunology & Neuroinfectious Disease
Other Team Members
- Administrator for Community Relations, Clinical Research Coordinator (Mon - Thurs)
- Practice Manager
Clinical Research Coordinators
Rebecca Salky
William Coffey
Alexis Marta
Support Our Work
Make a donation to support NMO and MOG research today. We are committed to finding new, safe and effective treatments for these rare disorders, and we know that finding the key to NMO and MOG can help open doors to other autoimmune diseases.