Overview and Ongoing Projects

At the core of the Laboratory for Translational Neurorecovery is a hypothesis-driven and quantitative approach to clinical research informed by both fundamental human neuroscience and neural engineering.

(I) Stroke Motor Rehabilitation and Recovery Study (SMaHRT)

The MGH Stroke Motor reHabilitation and Recovery sTudy (SMaHRT) is an observational, natural history, and interdisciplinary research study of motor recovery after stroke. We collect rehabilitation-focused outcomes starting during the acute stroke hospitalization at Massachusetts General Hospital and continuing over time across the post-acute care continuum. We are closely integrated with the MGH Neurorecovery Clinic. We apply quantitative methods to analyzing outcomes data informed by neuro- and rehab- sciences.

(II) Systems Neuroscience Subserving Stroke Motor Recovery

We apply quantitative analysis of data from neuroimaging, EEG, and Transcranial Magnetic Stimulation (TMS) to understand how neural structure and function contribute to stroke motor recovery. This work is in close collaboration with the Laboratory for Restorative Neurotechnology and the Brain Recovery Lab. To date, work in our lab has established novel and automated methods for quantifying injury to key brain structures responsible for arm motor recovery after stroke.

(III) Novel EEG Brain-Computer Interface to Enhance Arm Motor Recovery after Stroke

We are working with a multidisciplinary team to design a novel EEG-driven Brain-Computer Interface Arm Orthosis System to maximize arm motor neurorehabilitation. We inform our engineering with neuroscientific insights from the natural history of stroke recovery as well as cutting-edge neural decoding strategies. This work is in close collaboration with the Laboratory for Restorative Neurotechnology (BrainGate).

Faculty and Staff

David J. Lin, MD
Principal Investigator
Director, MGH Neurorecovery Clinic | Neuro-intensivist, Mass General
Instructor in Neurology, Harvard Medical School
Kimberly Erler, PhD, OTR/L
Assistant Professor
Department of Occupational Therapy
MGH Institute of Health Professions
Julie A. DiCarlo, MS
Lab Manager
Clinical Research Coordinator II
Iris Wu, BA
Data Analyst
Clinical Research Coordinator II
Taya Hamilton, PT
Physical Therapist/Clinical Neurotechnology Consultant
Clinical Research Coordinator II
Marina Petrilli, BA
Occupational Therapy Student
MGH Institute of Health Professions

Collaborators

Paul A. Maeder Professor of Engineering and Applied Sciences
Harvard School of Engineering and Applied Sciences
 
Professor
Director, Brain Recovery Lab
Department of Physical Therapy
MGH Institute of Health Professions
 
University Distinguished Professor in Biology
Electrical and Computer Engineering, and Physics
Northeastern University

Lab Alumni

Alison Cloutier, MS, Clinical Research Coordinator II
Nicole Lam, BS, Occupational Therapy Student, MGH Institute of Health Professions

Publications

See the latest publications from our laboratory.

Open Research Positions

Postdoctoral Fellow
We are seeking a highly-motivated individual to advance neurophysiological biomarkers of motor recovery after stroke. Experience with EEG acquisition and analysis is preferred, along with an interest in MRI and Transcranial Magnetic Stimulation (TMS). The goal of this study is to identify optimal neurophysiological biomarkers of upper extremity motor recovery that will directly inform the development of new neurotechnologies including Brain Computer Interfaces to improve upper extremity motor recovery.
 
This position is available for two years at Massachusetts General Hospital, under the primary mentorship of David Lin, MD. Additional mentorship will be provided by Leigh Hochberg, MD, PhD, Sydney Cash, MD, PhD, and Catherine Chu, MD.
 
Inquiries should be made directly to Laboratory for Translational Neurorecovery PI, Dr. David Lin, at dlin7@mgh.harvard.edu.

Funding

Work in the Lin Lab is currently supported by the American Academy of Neurology, the Andrew David Heitman Foundation, the American Society of Neurorehabilitation, the Veterans Health Administration, the Mass General Center for Neurotechnology and Neurorecovery, and the Mass General Department of Neurology.
 
Dr. Lin has received past support from the American Heart Association/Northeast Cerebrovascular Consortium and the National Institutes of Health.