F11 synapse rescue with treatment b a hz Courtesy of Tara Spires-Jones and Brad Hyman

Hyman Lab

The Hyman lab focuses on research in neural system failure underlying cognitive loss in Alzheimer’s disease.



Dr. Hyman directs the Alzheimer’s disease research unit at the MassGeneral Institute for Neurodegenerative Disease with the goal of understanding the neuropathophysiologic and genetic factors that underlie dementia. His laboratory studies the anatomical and molecular basis of dementia in Alzheimer’s disease, and dementia with Lewy bodies.

Dr. Hyman’s research includes a collaborative of several labs working on different aspects of neurodegenerative disease and dementia. The following principal investigators have research labs and collaborate with Dr. Hyman’s lab.

Group Members

Brad Hyman seated in front of a microscope

Principal Investigator

Bradley T. Hyman, MD, PhD

  • John B. Penney, Jr. Professor of Neurology 
    Harvard Medical School
  • Associate in Neurology,
    Massachusetts General Hospital
  • Director,
    Massachusetts Alzheimer's Disease Research Center

Affiliated Principal Investigators

  • Mark W. Albers, MD, PhD - Olfactory biomarkers of neurodegeneration, electronic health record mining, Data-driven approaches to repurposing drugs, therapies targeting inflammatory drivers of neuronal death in Alzheimer’s & ALS
  • Steven Arnold, MD – Translational and early phase clinical trials with novel treatments for Alzheimer’s disease and related neurodegenerative dementias; Discovery, validation and implementation of cerebrospinal fluid and blood-based biomarkers; Molecular pathophysiology in aging and dementias.
  • Brian Bacskai, PhD - Multiphoton imaging, functional studies of neural systems
  • Oksana Berezovska, PhD - Biology of presenilin and gamma secretase
  • Matthew Frosch, MD, PhD - Cerebral Amyloid Angiopathy, Alzheimer's, Parkinson's diseases
  • Teresa Gomez-Isla, MD, PhD - Neurobiology of normal aging and early stages of Alzheimer’s disease; studies on disease biomarkers and transgenic animal models
  • Stephen Gomperts, MD, PhD – Neurophysiology and pathophysiology of Alzheimer’s and dementia with Lewy bodies (DLB) animal models; novel therapies targeting Alzheimer’s, Parkinson’s, and DLB; PET molecular imaging in Parkinson’s and DLB patients
  • Eloise Hudry, PhD - Gene transfer to the brain - In vivo imaging - Alzheimer's disease - Apolipoprotein E
  • Brad Hyman, MD, PhD - Clinical pathological correlations and animal models of Alzheimer’s and Lewy body diseases; in vivo imaging; apoE neurobiology
  • Brian Wainger, PhD - Human iPSC and Primary Mouse Models in Amyotrophic Lateral Sclerosis and Pain; Connections Between Neuronal Physiology and Disease Pathology in Pre-Clinical and Clinical Studies

Laboratory Staff - includes all lab members of principal investigator labs

  • Aguero, Cinthya, PhD
  • Anderson, Lauren, PhD
  • Bennett, Rachel, PhD
  • Bruzzese, Morgan
  • Calvo-Rodriguez, Maria, PhD
  • Carlyle, Becky, PhD
  • Commins, Caitlin
  • Dubreuil, Dan, PhD
  • Dujardin, Simon, PhD
  • Fan, Zhanyun, MD
  • Gonzalez-Perez, Paloma, MD, PhD
  • Hou, Steven, PhD
  • Hudry, Eloise, PhD
  • Jackson, Rosemary, PhD
  • Kastanenka, Ksenia, PhD
  • Kelly, Patricia, PhD
  • Lee, Yee Fun (Evelyn)
  • Maesako, Masato, PhD
  • Marques, Christine, PhD
  • Melanson, Sharon
  • Naka, Yasushi, PhD
  • Oakley, Derek, MD, PhD
  • Otterson, Jennifer
  • Perez-Rando, Marta, PhD
  • Rodriguez, Steven, PhD
  • Sahin, Alsi, PhD
  • Serrano-Pozo, Alberto, MD, PhD
  • Silva Amaral, Ana Claudia, PhD
  • Van Veluw, Susanne, PhD
  • Yap, Liang, PhD
  • Yoon, Hyejin, PhD
  • Zhang, Shao-Qing, PhD
  • Zhou, heng, PhD

Research Positions

Read about and apply for residency, fellowship and observership programs at http://www.massgeneral.org/neurology/education/.

All applicants should register with the Mass General Careers Web site at http://www.massgeneral.org/careers/viewall.aspx. Request a list of current open positions at mghneurologyjobs@partners.org.


View All PubMed Publications

  1. Hyman BT, Yuan J. Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology. Nat Rev Neurosci. 2012; 13(6):395-406. View in: PubMed
  2. Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012 May; 71(5):362-81. View in: PubMed
  3. Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct Dendritic Spine and Nuclear Phases of Calcineurin Activation after Exposure to Amyloid-ß Revealed by a Novel Fluorescence Resonance Energy Transfer Assay. J Neurosci. 2012 Apr 11; 32(15):5298-309. View in: PubMed
  4. Pankratz N, Beecham GW, Destefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T. Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2. Ann Neurol. 2012 Mar; 71(3):370-84. View in: PubMed
  5. Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid Beta neurotoxicity in a mouse model of Alzheimer's disease. J Neurosci. 2012 Feb 29; 32(9):3176-92. View in: PubMed


Contact Us

MassGeneral Institute for Neurodegenerative Disease

Building 114, Charlestown Navy Yard

114 16th Street, Room 2003Mailcode: CNY B114-2-2003 Charlestown, MA 02129
  • Near Public Transit
  • Accessible
  • Phone: 617-726-2000
  • Fax: 617-724-1480

How to Apply for Positions

How to apply for jobs: Send an e-mail to mghneurologyjobs@partners.org to receive an automated e-mail with full instructions for all types of positions.

Fundraising Contact

Contact Krista McCabe in the Mass General Development office at 617-726-1392 or KMCCABE@PARTNERS.ORG.


Anne B. Young, MD, PhD
Director, Massgeneral Institute for Neurodegenerative Disease 
Professor of Neurology, Harvard Medical School

Clinical Appointments, Consultations & Clinical Trials

Please visit the main Neurology Service Contact page for all other contact information.

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