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Dr. Gomperts's basic and clinical research focuses on Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. In human studies, he is working to understand the causes of cognitive impairment that can arise in these diseases with PET imaging of pathogenic processes, such as the accumulation of beta-amyloid and tau and the loss of dopamine neurons projecting to brain regions that subserve cognition. In animal models, he uses large scale, multi-electrode recordings of brain cell activity together with optogenetic tools to investigate normal brain function and develop treatments to restore brain function in these diseases.
Stephen N. Gomperts, MD, PhD
In this clinical study we sought to confirm the hypothesis that brain amyloid deposition, an early feature of Dementia with Lewy Bodies, may account, in part, for its early dementia.We also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases. Many patients with Parkinson's disease develop PD with dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies; PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism.
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MassGeneral Institute for Neurodegenerative Disease
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Anne B. Young, MD, PhDDirector, Massgeneral Institute for Neurodegenerative Disease Professor of Neurology, Harvard Medical School
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