Assistant Professor of Pathology, Harvard Medical School Assistant Molecular Pathologist and Co-Director, Translational Research Laboratory, Massachusetts General Hospital Contact email: email@example.com
Targeted cancer therapies require the rapid and accurate identification of genetic abnormalities predictive of therapeutic response. Our lab developed the first high-throughput clinical genotyping platform designed to detect specific mutations in a broad range of human malignancies and enable prospective patient selection to the most appropriate targeted treatments. To obtain a more complete tumor genetic fingerprint and expand the scope of therapeutic options available to each patient, we improved upon our original platform by the development of next generation sequencing technologies. Our clinical molecular panels identify somatic mutations, genetic rearrangements and copy number alterations in a wide range of solid tumors and hematopoietic malignancies.
Our research efforts have focused on the molecular characterization of rare tumor types and led to the identification of clinically relevant genetic alterations in Merkel cell carcinoma, pleomorphic xanthoastrocytoma and salivary duct carcinoma. We have developed research collaborations with the MGH Thoracic Oncology, the Endocrine Unit and the Gastrointestinal Cancer teams, to uncover novel genetic drivers of malignancy, monitor disease progression, and identify mechanism of acquired resistance to therapy.
Dias-Santagata D, Selim MA, Su Y, Peng Y, Vollmer R, Chłopik A, Tell-Marti G, Paral KM, Shalin SC, Shea CR, Puig S, Fernandez-Figueras MT, Biernat W, Ryś J, Marszalek A, Hoang MP. KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas. Br J Der- matol. 2017;177(5):1376-1384.