Explore the Chordoma Treatment Program


The Massachusetts General Hospital Cancer Center’s Center for Sarcoma and Connective Tissue Oncology provides patients with expert chordoma care. We bring a unified focus to the evaluation, treatment, and support of chordoma patients, and to research advancing understanding of the causes of and treatments for this rare cancer.

Innovative Approaches

Massachusetts General Hospital Cancer Center is home to the Stephan L. Harris Center for Chordoma Care, a comprehensive treatment and research center. In addition, the availability of proton beam therapy, as well as expertise in surgical management of spinal tumors, attract chordoma patients from around the world. Collaboration with specialists from the Center for Head and Neck Cancers, the Cranial Base Program, and the Massachusetts Eye and Ear Infirmary ensures expert, coordinated care for the widely varying manifestations of chordoma.

Expertise in Diagnosing and Staging Cancers

Our musculoskeletal pathologists specializing in cancer of the bones and soft tissues consult on chordoma cases from around the world. Every biopsy is carefully evaluated to ensure an accurate diagnosis and to exclude other tumors that can mimic chordomas.

During surgery, the pathologist works closely with the surgeon and radiation oncologist to make sure that the resection is as effective as possible. The archiving of tissue collected at the time of biopsy and resection is enabling our pathologists to study chordomas on a molecular level. Their research is aimed at discovering the pathogenesis of chordomas and uncovering tumor markers to guide future therapies.

Advanced imaging technologies help to define the size and shape of the tumor, identify important normal tissue nearby, and aid in removal of the tumor and protection of normal tissue. These include:

  • MRI to pinpoint the location, size and shape of the tumor
  • High-resolution CT to pinpoint the location, size and shape of the tumor

Personalized Therapy

The Stephan L. Harris Center for Chordoma Care at Mass General provides extraordinary, compassionate care while advancing the art and science of evaluating, diagnosing, treating and supporting patients with chordoma. Treatment is tailored to address the unique needs of each patient, and usually involves advanced surgical or radiation techniques, or a combination of these approaches.

Multidisciplinary Patient Care

Your care team may include a wide variety of experts:

  • Pathologists evaluate all tumor samples to provide precise diagnostic and staging information
  • Radiologists offer advanced imaging to evaluate tumors, assist in surgical planning and monitor the results of treatment
  • Surgeons provide the most advanced surgical techniques to maximize tumor removal and maintain function. Depending on the location of the tumor, neurosurgeons, otolaryngologists, ophthalmologists, oculoplastic surgeons, surgical oncologists, orthopaedic oncology surgeons, and spine surgeons may be part of the team
  • Radiation oncologists offer innovative radiation therapy techniques customized to your individual needs and designed to deliver the most therapeutic radiation to the cancer while preserving adjacent healthy tissue
  • Medical and/or pediatric oncologists provide access to innovative systemic treatments for chordoma
  • Oncology nurses and nurse practitioners bring special expertise in cancer care
  • Oncology psychiatrists, social workers, and chaplains provide family, spiritual, emotional and mental health support
  • Oncology nutritionists help with dietary issues to enhance your health and well-being during treatment
  • Palliative care providers work with your team to address pain and quality-of-life concerns

Mass General Cancer Center's Adolescent and Young Adult (AYA) Cancer Program provides specialized resources and support for our AYA patients. Patients can access supportive care resources including social work, psychology, psychiatry, sexual health and fertility, lifestyle medicine, integrative therapies, and parenting guidance. Dedicated AYA clinicians and program manager are available to connect patients to these resources and answer any questions.

Excellence in Surgical Care

Our surgeons have extensive experience treating chordoma while minimizing damage to surrounding structures. Advanced surgical techniques include:

  • Endoscopic cranial base surgery is a noninvasive way to remove tumors through natural openings such as the nasal passages
  • Microsurgery, often used for cranial base tumors, involves operating on tiny structures through a microscope • Image-guided neurosurgery that allows the surgeon to navigate to the tumor without disrupting normal tissue and to operate through smaller incisions
  • Complex spinal operations, including “en bloc” resections – wide excisions of tumor in difficult anatomic location – and innovative reconstruction techniques

Pioneering Radiation Therapies

Our radiation oncologists offer a range of therapies designed to shrink or destroy tumors while protecting normal tissue. Advanced technologies include:

  • Proton beam therapy, a highly focused form of radiation that delivers precise radiation to the tumor while helping to spare surrounding healthy tissue
  • Intraoperative radiation therapy (IORT), a novel technique to deliver additional radiation during surgery to sites where the proximity of critical normal tissue prevents surgeons from removing as much tissue around the tumor as they would like
  • Intraoperative dural brachytherapy was developed by Cancer Center specialists. This new technique uses a custom-designed applicator imbued with a radioactive element to safely deliver radiation to areas of the spine close to the protective sac around the spinal cord

Learn more about radiation therapy.

Developing Better Therapies through Research

Physician-scientists in the Sarcoma Molecular Biology laboratory are pursuing research to identify the genetic abnormalities associated with chordoma. We have the largest archive in the world of chordoma tissue, which we study to uncover the mechanisms that drive chordoma and to search for a cure.

Learn more about chordoma research under way at Mass General's Harris Center.

Clinical Trials

The Cancer Center is a site for trials of new targeted agents as well as a National Institutes of Health-sponsored study of familial chordoma. We can offer participation in this study to families in which two or more relatives have chordoma. Our goal is to search for genetic or hereditary factors that may help us to better understand the disease and suggest new therapies.

Find Clinical Trials for Chordoma.

Sarcoma and Chordoma: Compassionate, Team-Based & Personalized Care

The Center for Sarcoma and Connective Tissue Oncology is one of the largest and most experienced sarcoma and chordoma treatment groups in the country. Our team specializes in the diagnosis and treatment of bone and soft tissue tumors, and provides the latest and most innovative treatments matched with compassionate care. Learn more from our team in this video.

Patient Education Resources

Chordoma is a rare, slow-growing malignant tumor believed to arise from cellular remnants of the notochord.

Harris Center

Harris Center

Learn about the The Stephan L. Harris Center for Chordoma Care.

Adolescent and Young Adult Cancer Program

Adolescent and Young Adult Cancer Program

This program addresses the unique needs of patients with cancer ages 15-39.

Cancer Rehabilitation Program

Cancer Rehabilitation Program

This program helps patients regain physical abilities and maintain independence.

Bone & Spine Metastasis Program

Bone & Spine Metastasis Program

Personalized, team-oriented care for patients whose cancer has spread to their bones.

Preparing for Your Visit

Preparing for Your Visit

A checklist of items to bring with you for your first visit and helpful information.

Supportive Care

Supportive Care

We offer a variety of education and support resources to help you and your family.

Workshops & Support Groups

Workshops & Support Groups

We offer a wide range of integrative therapies, workshops and support groups.