With the addition of high-dose cyclophosphamide to graft-versus-host disease prophylaxis, simultaneous stem cell/kidney transplantation is feasible for selected patients who have partially HLA-matched donors.
Explore This Research Lab
In collaboration with the Laboratory of Molecular Medicine (part of Partners Healthcare) we have developed a genetic testing platform that uses a single test to screen for any inherited kidney disease. This test can detect known genetic changes that lead to kidney disease as well as detect novel variation in new genes. The test is ideal for patients in which there are multiple family members affected. We hope to use information from genetic sequencing to guide treatment and to provide new pathways for further research.
Our group also has an interest in Fabry disease. Currently we are looking for novel urine biomarkers that can suggest involvement of the kidney in Fabry disease. Such biomarkers may help to determine when to initiate therapy in individuals with Fabry.
- Isakova T, Xie H, Barchi-Chung A, Vargas G, Sowden N, Houston J, Wahl P, Lundquist A, Epstein M, Smith K, Contreras G, Ortega L, Lenz O, Briones P, Egbert P, Ikizler TA, Jueppner H, Wolf M. Fibroblast growth factor 23 in patients undergoing peritoneal dialysis. Clin J Am Soc Nephrol. 2011; 6(11):2688-95.
- Olsson M, Tintle L, Kierczak M, Perloski M, Tonomura N, Lundquist A, Murén E, Fels M, Tengvall K, Pielberg G, Dufaure de Citres C, Dorso L, Abadie J, Hanson J, Thomas A, Leegwater P, Hedhammar A, Lindblad-Toh K, Meadows JR. Thorough Investigation of a Canine Auto-inflammatory Disease (AID) Confirms One Main Risk Locus and Suggests a Modifier Locus for Amyloidosis. PLoS One 2013; 8(10):e75242.
- Hoeppner MP, Lundquist A, Pirun M, Meadows JR, Zamani N, Johnson J, Sundström G, Cook A, FitzGerald MG, Swofford R, Mauceli E, Moghadam BT, Greka A, Alföldi J, Abouelleil A, Aftuck L, Bessette D, Berlin A, Brown A, Gearin G, Lui A, Macdonald JP, Priest M, Shea T, Turner-Maier J, Zimmer A, Lander ES, di Palma F, Lindblad-Toh K, Grabherr MG. An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts. PLoS One. 2014; 9(3):e91172.
- Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele D, Waikar SS, The Utility of Diagnostic Testing Employed in the Initial Evaluation of Chronic Kidney Disease. JAMA Intern Med. 2015; 175(5):853-6.
- Sise ME, Bloom AK, Wisoky J, Lin MV, Gustafson JL, Lundquist AL, Steele D, Thiim M, Williams WW, Hashemi N, Kin AY, Thadhani R, Chung RT. Treatment of Hepatitis C Virus-Associated Mixed Cryoglobulinemia with Sofosbuvir-Based Direct-Acting Antiviral Agents. Hepatology. 2016; 63 (2): 408-17.
- Mendu ML, Lundquist A, Alzer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. Clinical Predictors of Diagnostic Testing Utility in the Initial Evaluation of Chronic Kidney Disease. Nephrology. 2015 Nov 26 [epub ahead of print].
- Lundquist AL, Nigwekar SU. Optimal management of bone mineral disorders in chronic kidney disease and end stage renal disease.Curr Opin Nephrol Hypertens. 2016 Jan 16. [epub ahead of print]
- Assistant Clinical Director, Nephrology - Department of Medicine
- Press Release
- Jan | 22 | 2020
Researchers have developed a method to design drugs that efficiently block rather than activate critical cell receptors which may help avoid adverse medication outcomes.
- Press Release
- Oct | 16 | 2019
Linemen's rapid weight gain can lead to hardening of heart, arteries, but problems may be offset with increased aerobic training
- Sep | 24 | 2019
Bone health specialists typically spend their time trying to figure how to slow or stop the bone loss that leads to osteoporosis. What if they could find a new way to stimulate the growth of new bone tissue instead?
- Press Release
- Jun | 25 | 2019
A biological pathway previously found to contribute to the impact of stress on the risk of cardiovascular disease also may underlie the increased incidence of such disease experienced by individuals with lower socioeconomic status.
- Press Release
- Jun | 13 | 2019
A study based at the Ragon Institute of MGH, MIT and Harvard has determined how a pregnant woman’s vaccine-induced immunity is transferred to her child, which has implications for the development of more effective maternal vaccines.
About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.