A new health and economic model clearly shows why it’s imperative that food manufacturers reduce the amount of added sugar in their products.
Explore This Research Lab
The V-ATPase is an acid pumping protein that controls pH at sub-cellular, cellular, local and systemic levels. It is implicated in rare (e.g. renal distal tubular acidosis, osteopetrosis), as well as more common diseases, such as various types of cancer, osteoporosis, Alzheimer's and Parkinson's neurodegenerative diseases. This enzyme is, therefore, an emerging drug target for treatment of all these diseases. However, the mechanisms that are involved in V-ATPase regulation in both physiological and pathophysiological conditions are poorly understood. To address this question, we performed the first systematic proteome-wide analysis of V-ATPase protein-protein interactions (1). Some previously known as well as several novel V-ATPase interacting proteins were revealed; five of these proteins, called DMXL1, DMXL2, WDR7, NCOA7 and OXR1 were found to regulate V-ATPase activity in mammalian cells. We use a combination of biochemical, molecular biology, structural and bioinformatics methods to study the molecular mechanisms of this regulation, as well as mouse knockout models to study the potential role of these and other V-ATPase interacting proteins in kidney function and acid-base homeostasis. This work is currently supported by Dr. Dennis Brown, director of the Program in Membrane Biology (PMB), affiliated with the MGH interdisciplinary Center for Systems Biology (CSB).
- Merkulova M, Păunescu TG, Azroyan A, Marshansky V, Breton S, Brown D. Mapping the H(+) (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation.Sci. Rep. 2015; 5: 14827.
- Aug | 13 | 2021
In this interview, Kerry Reynolds, MD chats with Meghan Sise, MD, director of onconephrology at Mass General Hospital, to learn more about how immune checkpoint inhibitor (ICI) therapy affects kidney function.
- Press Release
- Jul | 8 | 2021
Las puntuaciones de riesgo genético podrían mejorar la identificación clínica de los pacientes con mayor riesgo de infarto
Un equipo descubrió recientemente que la aplicación de la PRS puede identificar a los pacientes de riesgo que actualmente no se identifican mediante las evaluaciones clínicas estándar.
- Press Release
- Jun | 7 | 2021
Automated emails and letters that provide personalized feedback related to cafeteria purchases at work may help employees make healthier food choices.
- Staff Story
- Nov | 17 | 2020
Winfred W. Williams, MD, has been named a deputy editor of The New England Journal of Medicine. Williams, who is associate chief of the Division of Nephrology, becomes the first African American to serve in that role.
- Press Release
- Sep | 2 | 2020
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients.
About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.