A new health and economic model clearly shows why it’s imperative that food manufacturers reduce the amount of added sugar in their products.
Department of Medicine
Russo Lab: Leileata Russo, PhD
Explore This Research Lab
Since 2008, I have directed my research towards translational applications and have successfully advanced the diagnostic use of urinary exosomes and microvesicles (collectively referred to as extracellular vesicles, or EVs). EVs are vesicles released from all cells, and contain a snapshot of the parent cell cytoplasm. The analysis of EVs in biofluids can be used as a non-invasive biopsy. For example, I have shown that EVs contain intact RNA whose stability is dictated by the precision of isolation and sample handling. This finding has advanced the diagnostic use of EVs and has allowed the development of ‘clinical laboratory friendly’ EV RNA isolation kits, which enable reproducible results - an important cornerstone of any diagnostic. From 2010-2013, I was the Director of Research 13 at Exosome Diagnostics, Inc, a biotechnology company I helped co-found based on our research at Massachusetts General Hospital/Harvard Medical School, Neurology and Nephrology Divisions. During this time I initiated the development of a Prostate Cancer Detection Platform from my work on urinary EVs. I have now returned to academia with the goal of passing on my industry experience and helping to guide others with similar budding translational research interests. In addition, I have initiated new areas of research including the development and testing of much needed novel therapeutics for CKD. This research utilizes my diagnostic EV platform to enable us to follow therapeutic efficacy non-invasively.
- Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.Kidney Int. 2007; 71(6): 504-13.
- Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D. Impaired tubular uptake explains albuminuria in early diabetic nephropathy. J Am Soc Nephrol. 2009; 20(3): 489-94.
- Miranda KC, Bond DT, McKee M, Skog J, Păunescu TG, Da Silva N, Brown D, Russo LM. Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease. Kidney Int. 2010; 78(2): 191-9.
- Russo LM, Srivatsan S, Seaman M, Suleiman H, Shaw AS, Comper WD. Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin. FEBS Lett. 2013; 587: 3738-41.
- Miranda KC, Bond DT, Levin JZ, Adiconis X, Sivachenko A, Russ C, Brown D, Nusbaum C, Russo LM. Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA. PLoS One. 2014; 9(5): e96094.
- Aug | 13 | 2021
In this interview, Kerry Reynolds, MD chats with Meghan Sise, MD, director of onconephrology at Mass General Hospital, to learn more about how immune checkpoint inhibitor (ICI) therapy affects kidney function.
- Press Release
- Jul | 8 | 2021
Las puntuaciones de riesgo genético podrían mejorar la identificación clínica de los pacientes con mayor riesgo de infarto
Un equipo descubrió recientemente que la aplicación de la PRS puede identificar a los pacientes de riesgo que actualmente no se identifican mediante las evaluaciones clínicas estándar.
- Press Release
- Jun | 7 | 2021
Automated emails and letters that provide personalized feedback related to cafeteria purchases at work may help employees make healthier food choices.
- Staff Story
- Nov | 17 | 2020
Winfred W. Williams, MD, has been named a deputy editor of The New England Journal of Medicine. Williams, who is associate chief of the Division of Nephrology, becomes the first African American to serve in that role.
- Press Release
- Sep | 2 | 2020
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients
Mass General study demonstrates that kidneys infected with hepatitis C can be safely transplanted into healthy recipients.
About the Nephrology Division
The Division of Nephrology at Massachusetts General Hospital is a leading provider of services for patients with kidney disease, including diagnosis and management of kidney diseases and medical management of renal transplantation.