Brain health is essential to the health span. When brain health (neurological and mental health) becomes impaired, we lose our ability to pay attention, solve problems, communicate, be resilient in the face of stress and care for ourselves, our loved ones and others. The impact of the COVID-19 pandemic on global brain health has only just begun to be felt.
COVID-19 victims are at high risk for impaired brain health and wellbeing.
The novel coronavirus appears to have a direct impact on the brain. In COVID-19 severe enough to require admission to the hospital, the ICU and mechanical ventilation, risks to the brain are substantial. These risks include the virus’s direct impact on the cells of the brain and the impact on the brain of the exuberant virus-triggered inflammatory response as well as the effects of prolonged stays in an ICU in a medically induced coma deprived of family contact. There is even some evidence that survivors of COVID-19 may also be at risk for chronic neurodegenerative disease such as Alzheimer's.
Despite these risks, there are currently very limited data on COVID-19 and brain health. Without these data, we cannot discover the treatments that might protect brain health in COVID-19, or help COVID-19 patients recover their brain health.
To make matters even more concerning, COVID-19 critical illness is having a disproportionate impact on communities already affected deeply by disparities in health care and whose health care needs are understudied. For many of them, English is a second language or not spoken at all. This adds even more urgency. The impact of loss of brain health is even more devastating when combined with the effects of poverty and poor access to health care.
The Henry and Allison McCance Center for Brain Health has assembled a multidisciplinary team of world-class investigators to conduct a comprehensive study of the impact of COVID-19 on brain health. The team is led by world-renowned neurologist Dr. Jonathan Rosand, who founded the McCance Center with his colleagues, neuroscientist Dr. Rudy Tanzi and psychiatrist Dr. Greg Fricchione.
The McCance Center’s study team includes neurologists, psychiatrists, pulmonary physicians, nurses, and laboratory investigators who will collect data on COVID-19 patients in the hospital and once they have been discharged. They will perform brain scanning such as MRI and blood testing for genetics, along with a comprehensive assessment of blood markers. They will track COVID-19 patients as they recover, assessing how well they can resume their lives, the challenges they face and the deficits in memory, concentration or language they may have.
In order to make discoveries as rapidly as possible, the McCance Center team has joined a global research consortium devoted to uncovering the effects of COVID-19 on the brain. Working within this large coordinated effort will ensure that we discover life-improving treatments as rapidly as possible.
Philanthropic funding will enable the McCance Center’s COVID-19 team to launch the study immediately.
- American Heart Association. What is brain health? 2020.
- Holmes EA, O'Connor RC, Perry VH, et al. Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. The Lancet Psychiatry 2020.
- Li Y-C, Bai W-Z, Hirano N, Hayashida T, Hashikawa T. Coronavirus infection of rat dorsal root ganglia: Ultrastructural characterization of viral replication, transfer, and the early response of satellite cells. Virus Research 2012; 163(2): 628-35.
- Xu J, Zhong S, Liu J, et al. Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis. Clinical Infectious Diseases 2005; 41(8): 1089-96.
- Li K, Wohlford-Lenane C, Perlman S, et al. Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4. The Journal of Infectious Diseases 2015; 213(5): 712-22.
- LaBuzetta JN, Rosand J, Vranceanu AM. Review: Post-Intensive Care Syndrome: Unique Challenges in the Neurointensive Care Unit. Neurocrit Care 2019; 31(3): 534-45.
- Marra A, Pandharipande PP, Girard TD, et al. Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness. Critical care medicine 2018; 46(9): 1393-401.
- Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A. SARS-CoV-2: at the crossroad between aging and neurodegeneration. Movement Disorders; n/a(n/a).
- Servick K. For survivors of severe COVID-19, beating the virus is just the beginning. Science 2020.
- Johnson CY, Cha AE. The dark side of ventilators: Those hooked up for long periods face difficult recoveries. Washinton Post. 2020 April 6.