Explore This Lab
The Gomez-Isla lab at Massachusetts General Hospital focuses on the development and characterization of transgenic mouse models of Alzheimer's disease and on testing novel therapeutic strategies. Research is also conducted with human brain tissue from individuals who suffered Alzheimer's disease while alive.
Dr. Gomez-Isla’s clinical research focuses on cognitively intact individuals across the age spectrum to search for molecular mechanisms responsible for individual vulnerability or resilience to this type of dementia.
In this work, we investigated for the first time, APOE and PRNP genotypes simultaneously in 474 AD and 175 sporadic CJD (sCJD) patients compared to a common control population of 335 subjects. Differences in genotype distribution between patients and control subjects were studied by logistic regression analysis using age and gender as covariates.
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Our Research Team
- Department of Neurology