Explore This Lab


The Family Center for Neurofibromatosis and Schwannomatosis advances our understanding of these rare, genetic disorders through innovative basic science, clinical, and population level research. Our research program spans all types of neurofibromatosis (NF), including neurofibromatosis 1 (NF1), NF2-related schwannomatosis (NF2-SWN, formerly known as neurofibromatosis type 2 or NF2), and other forms of schwannomatosis (SWN). We are committed to identifying new medical treatments for all types of NF by designing and running innovative clinical trials. We also collaborate with a multidisciplinary team of researchers across Massachusetts General Hospital and Mass Eye and Ear to advance our understanding of NF. Current research explores all aspects of NF, from the molecular biology of tumors to the psychological aspects of having these disorders.

Research Projects

Ongoing clinical trials and research projects led by our team include:

This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with NF2-associated schwannomatosis (formerly called neurofibromatosis type 2) with associated progressive tumors of vestibular schwannomas, non-vestibular schwannomas, meningiomas, and ependymomas.

This is a placebo-controlled, multi-arm phase II platform screening trial designed to test the safety, pain responses, and pharmacodynamic activity of multiple experimental therapies simultaneously in participants with moderate-to-severe pain due to schwannomatosis.

This clinical trial will compare two ways to increase guideline-recommended health surveillance for children and adults with NF1 who speak English or Spanish and do not currently receive care at a specialty NF clinic.


Meet Our Research Team



Faculty in our research center help lead multiple national and international research efforts to improve care for people with NF, including:

We also partner with many NF patient advocacy groups, including: