The Hematopathology group, led by Dr Harris since 1980 and by Dr. Ferry since January, 2010, provides diagnostic services for patients at Massachusetts General Hospital (Mass General) and consultation services for US and international pathologists. The group has focused on the careful morphologic, immunophenotypic, and genetic characterization of lymphoid and myeloid neoplasms, in order to develop criteria for diagnosis and to better define clinically relevant hematologic diseases. The group works closely with hematologists and oncologists to provide optimal patient care. A major mission of the group is also to train future leaders in the field of hematopathology.


Clinical Program

Approximately 2,000 tissue specimens procured from patients at Mass General are reviewed primarily by the Hematopathology service. These include bone marrow samples (approximately 1,200 specimens) and other tissues (including lymph nodes, spleen, thymus, and lymphoid infiltrates or suspected lymphoma in gastrointestinal, bone and soft tissue, head and neck, and neuropathology specimens, approximately 800 specimens). The Hematopathology service also provides input on additional cases from other Mass General surgical pathology services when there is a question of a hematologic neoplasm. Approximately 400 peripheral smears per year and 180 body fluids per year (cerebrospinal, pleural, peritoneal, and ascitic) are submitted to the Hematopathology service for pathologist review. In addition, approximately 1,200 consultation cases from outside institutions are reviewed by the Hematopathology service each year.

Academic and Research Accomplishments

The Hematopathology group has been interested in using a combination of morphology, immunophenotype, and genetic features to characterize lymphoid and myeloid disorders, to improve the diagnosis and classification of these diseases. Characterizing small B-cell neoplasms, diffuse large B-cell lymphomas, extranodal lymphomas, reactive proliferations that may mimic lymphomas, acute leukemias, and myelodysplastic syndromes have been particular interests. Dr. Harris is a founding member of the International Lymphoma Study Group, and led the development of the Revised European-American Classification of Lymphoid Neoplasms (REAL classification), published in 1994, and was an editor of the World Health Organization classification of tumors of the hematopoietic and lymphoid tissues, published in 2001 and 2008. Members of the Mass General Hematopathology group have written and edited books and monographs, and have contributed chapters to books on hematologic disorders. The research interests of individual faculty are listed below. Visit faculty research laboratories or select the "Research" and "Publications" tabs on doctor profiles for more details.

Educational Intera.ctions with Other Departments
Hematopathology attendings and fellows participate in a number of weekly, biweekly or monthly multidisciplinary conferences with the Hematology/Oncology service during which pathology of active patient cases is shown and discussed, including Lymphoma Conference, Leukemia Conference, Lymphoma/Myeloma Clinicopathologic Conference, Leukemia/Bone Marrow Transplant Clinicopathologic Conference, and the Hematology Interdisciplinary Seminar.  In addition, the Hematopathology attendings, fellows and current rotating residents meet weekly to review and discuss interesting and challenging cases around the microscope (Interesting Case Conference) or to discuss a relevant article of interest (Journal Club). Residents and fellows present cases with interesting and instructive cytogenetic findings at the monthly Hematopathology/Cytogenetics Conference, which is attended by cytogeneticists from Brigham and Women's Hospital.  Hematology/Oncology fellows from the combined Dana Farber-Massachusetts General Hospiral fellowship with interest in hematology participate in Hematopathology sign-out during a rotation in their second year of training.

Pathology Resident Education at Massachusetts General Hospital
Residents spend two months (AP) or two and one half months (CP or AP/CP) on Hematopathology, where they are primarily responsible for bone marrow, peripheral blood, lymph node, and other specimens involved by hematologic disorders. Daily sign-out occurs as two separate services (Bone Marrow and Lymph Node), each with a faculty member, at multiheaded microscopes. A fellow is usually present at each sign-out, and there are often visitors from other departments or institutions. Residents are responsible for reporting all diagnostic modalities on their cases, for example: bone marrow biopsy, aspirate smear, peripheral blood smear, flow cytometry, and immunohistochemistry are reviewed together by one resident-faculty-fellow team, reinforcing the importance of integrated reporting of hematologic neoplasms. The resident also receives reports of cytogenetics and molecular tests and works with the faculty member to incorporate this information into the final diagnosis. The Hematopathology faculty give didactic lectures to the residents during their Hematopathology rotation, including an intensive series of practically-oriented lectures and slide review sessions during the first week of each rotation.

Education of Hematopathology Fellows
The Mass General Pathology Hematopathology Fellowship is accredited by the ACGME for two positions.  The two fellows supervise the residents in bone marrow and lymph node diagnosis. The fellows also handle the complex consultation cases referred to the Hematopathology faculty. The fellows participate in research projects during the fellowship and have produced a large number of research publications.

Previous and Current Fellows

Fellow Site of Residency Grad Year Current Position
Abner Louissaint Jr., MD, PhD Massachusetts General Hospital 2010 Hematopathologist, Autopsy Service, Massachusetts General Hospital
Ha Nishino, MD Baylor and Massachusetts General Hospital 2010 North Shore Medical Center
Julia Turbiner Geyer, MD Massachusetts General Hospital 2009 Hematopathologist, Cornell-Weill Medical Center
Michael Kluk, MD, PhD Yale University 2009 Molecular Pathology Fellow, Harvard Program
Graham Slack, MD University of Alberta 2008 Hematopathologist, University of British Columbia
Chad Soupir, MD Massachusetts General Hospital 2008 Pathologist, Ridgeview Medical Center, MN
Aliyah R. Sohani, MD Massachusetts General Hospital 2007 Hematopathologist, Massachusetts General Hospital
Rania Seliem, MD Baystate and Massachusetts General Hospital 2006 Hematopathologist, Rashid Hospital, Dubai, UAE
Sa A Wang, MD Yale University 2005 Hematopathologist, MD Anderson Cancer Center
Zoe Tang, MD Massachusetts General Hospital 2004 Hematopathologist, Kaiser Permanente, San Francisco Medical Center
Wen Jing, MD Massachusetts General Hospital 2004 Hematopathologist, Kaiser Permanente, San Francisco Medical Center
Lan Wang, MD Massachusetts General Hospital 2003 Pathologist, Chilton Memorial Hospital, NJ
Souhad Younes, MD Massachusetts General Hospital 2002 Pathologist, Sutter Davis Hospital, CA
Mohammed Mahmoud, MD Maimonides 1999 Hematopathologist Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
Henry Y. Dong, MD Massachusetts General Hospital 1998 Director of Hematopathology and Molecular Diagnostics, Genzyme Genetics/IMPATH, New York, NY

Medical Students
MedMassachusetts General HospitalMedical students from Harvard Medical School (HMS) and other institutions performing elective rotations in pathology are typically assigned to one week of Hematopathology, during which they participate in the sign-outs. Dr. Hasserjian teaches second-year medical students in the HMS Hematology course and Dr. Sohani teaches first-year medical students in the HMS Pathology course. Dr. Sohani and Dr. Hasserjian also participate in didactic case discussions with third-year medical students rotating at Massachusetts General Hospital during their Longitudinal Patient Care clerkship.

Post-Graduate Courses
Drs. Harris, Ferry, Hasserjian, and Sohani lecture on hematopathology topics at the annual MGH Current Concepts in Surgical Pathology course, which routinely draws over 200 participants. The Hematopathology faculty participate in several US and International Postgraduate courses in pathology, including courses sponsored by the American Society of Clinical Pathology, the United States and Canadian Academy of Pathology and Harvard Medical School. Dr. Ferry is a faculty member of the Tutorial on Neoplastic Hematopathology under the direction of Dr. Daniel Knowles (Cornell-Weill Medical Center). 


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