Below is a selection of research publications from the Healey Center for ALS at Massachusetts General Hospital. Learn more about our research programs or look up our full publication listing at PubMed.
  1. Babu S, Macklin EA, Jackson KE, Simpson E, Mahoney K, Yu H, Walker J, Simmons Z, David WS, Barkhaus PE, Simionescu L, Dimachkie MM, Pestronk A, Salameh JS, Weiss MD, Brooks BR, Schoenfeld D, Shefner J, Aggarwal S, Cudkowicz ME, Atassi N. Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Oct 14:1-9. doi: 10.1080/21678421.2019.1672750. [Epub ahead of print] PMID: 31608711 [PubMed - as supplied by publisher]
  2. Paganoni S, van de Rijn M, Drake K, Burke K, Doyle M, Ellrodt AS, Nicholson K, Atassi N, de Marchi F, Babu S, Estrada J, Schwamm LH, Berry JD. Adjusted cost analysis of video televisits for the care of people with amyotrophic lateral sclerosis. Muscle Nerve. 2019 Aug;60(2):147-154. doi: 10.1002/mus.26606. Epub 2019 Jun 27. PubMed PMID: 31136007.
  3. Brizzi K, Paganoni S, Zehm A, De Marchi F, Berry JD. Integration of a palliative care specialist in an amyotrophic lateral sclerosis clinic: Observations from one center. Muscle Nerve. 2019 Aug;60(2):137-140. doi: 10.1002/mus.26607. Epub 2019 Jun 20. PubMed PMID: 31172537.
  4. Moakley D, Koh J, Pereira JD, DuBreuil DM, Devlin AC, Berezovski E, Zhu K, Wainger BJ. Pharmacological Profiling of Purified Human Stem Cell-Derived and Primary Mouse Motor Neurons. Sci Rep. 2019 Jul 25;9(1):10835. doi: 10.1038/s41598-019-47203-7. PMID: 31346219 [PubMed - in process] Free Article
  5. Schoenfeld DA, Finkelstein DM, Macklin E, Zach N, Ennist DL, Taylor AA, Atassi N. Design and analysis of a clinical trial using previous trials as historical control. Pooled Resource Open-Access ALS Clinical Trials Consortium. Clin Trials. 2019 Jul 1:1740774519858914. doi: 10.1177/1740774519858914. [Epub ahead of print] PMID: 31256630 [PubMed - as supplied by publisher]
  6. Goutman SA, Brown MB, Cudkowicz M, Atassi N, Feldman EL. ALS/SURV: a modification of the CAFS statistic. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Jul 23:1-8. doi: 10.1080/21678421.2019.1643375. [Epub ahead of print] PubMed PMID: 31334681.
  7. Nguyen VT, Zafonte RD, Kponee-Shovein KZ, Paganoni S, Weisskopf MG. All-Cause and Cause-Specific Mortality Among Major League Baseball Players. JAMA Intern Med. 2019 Jul 22. doi: 10.1001/jamainternmed.2019.1218. [Epub ahead of print] PubMed PMID: 31329214; PubMed Central PMCID: PMC6646969.
  8. Dios AM, Babu S, Granucci EJ, Mueller KA, Mills AN, Alshikho MJ, Zürcher NR,Cernasov P, Gilbert TM, Glass JD, Berry JD, Atassi N, Hooker JM, Sadri-Vakili G. Class I and II histone deacetylase expression is not altered in human amyotrophic lateral sclerosis: Neuropathological and positron emission tomography molecular neuroimaging evidence. Muscle Nerve. 2019 Jun 26. doi: 10.1002/mus.26620. [Epub ahead of print] PubMed PMID: 31241177.
  9. Atassi N. When a negative trial in ALS has a positive effect on research. Lancet Neurol. 2018 Aug;17(8):653-655. doi: 10.1016/S1474-4422(18)30210-2. Epub 2018 Jun 19. No abstract available. PMID: 29934197 [PubMed - indexed for MEDLINE]

  10. Wills AM, Garry J, Hubbard J, Mezoian T, Breen CT, Ortiz-Miller C, Nalipinski P, Sullivan S, Berry JD, Cudkowicz M, Paganoni S, Chan J, Macklin EA. Nutritional counseling with or without mobile health technology: a randomized open-label standard-of-care-controlled trial in ALS. BMC Neurol. 2019 May 29;19(1):104. doi: 10.1186/s12883-019-1330-6. PubMed PMID: 31142272; PubMed Central PMCID: PMC6540456.
  11. Shefner JM, Cudkowicz ME, Hardiman O, Cockroft BM, Lee JH, Malik FI, Meng L, Rudnicki SA, Wolff AA, Andrews JA; VITALITY-ALS STUDY GROUP. A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May 13:1-11. doi:10.1080/21678421.2019.1612922. [Epub ahead of print] Erratum in: Amyotroph Lateral Scler Frontotemporal Degener. 2019 Jul 14;:1. PubMed PMID: 31081694.
  12. Pattee GL, Plowman EK, Focht Garand KL, Costello J, Brooks BR, Berry JD, Smith RA, Atassi N, Chapin JL, Yunusova Y, McIlduff CE, Young E, Macklin EA, Locatelli ER, Silani V, Heitzman D, Wymer J, Goutman SA, Gelinas DF, Perry B, Nalipinski P, Stipancic K, O'Brien M, Sullivan SL, Pioro EP, Gargiulo G, Green JR; Contributing Members of the NEALS Bulbar Subcommittee. Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyotrophic lateral sclerosis. Muscle Nerve. 2019 May;59(5):531-536. doi: 10.1002/mus.26408. Epub 2019 Jan 22. PubMed PMID: 30620104.
  13. Berry JD, Paganoni S, Carlson K, Burke K, Weber H, Staples P, Salinas J, Chan J, Green JR, Connaghan K, Barback J, Onnela JP. Design and results of a smartphone-based digital phenotyping study to quantify ALS progression. Ann Clin Transl Neurol. 2019 Apr 3;6(5):873-881. doi: 10.1002/acn3.770. eCollection 2019 May. PMID: 31139685 [PubMed] Free PMC Article

  14. Nussbacher JK, Tabet R, Yeo GW, Lagier-Tourenne C. Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions. Neuron. 2019 Apr 17;102(2):294-320. doi: 10.1016/j.neuron.2019.03.014. Review. PMID: 30998900 [PubMed - in process]

  15. Chew S, Atassi N. Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis. Front Neurol. 2019 Mar 1;10:135. doi: 10.3389/fneur.2019.00135. eCollection 2019. Review. PMID: 30881332 [PubMed] Free Article

  16. Bedlack RS, Wicks P, Vaughan T, Opie A, Blum R, Dios A, Sadri-Vakili G. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Jan 21:1-9. doi: 10.1080/21678421.2018.1556698. [Epub ahead of print] PMID: 30663902 [PubMed - as supplied by publisher]

  17. Karam C, Berry JD. Heterogeneity, urgency, generalizability, and enrollment: The HUGE balance in ALS trials. Neurology. 2019 Jan 9. pii: 10.1212/WNL.0000000000006837. doi: 10.1212/WNL.0000000000006837. [Epub ahead of print] No abstract available. PMID: 30626648 [PubMed - as supplied by publisher]

  18. Paganoni S, Alshikho MJ, Luppino S, Chan J, Pothier L, Schoenfeld D, Andres PL, Babu S, Zürcher NR, Loggia ML, Barry RL, Luotti S, Nardo G, Trolese MC, Pantalone S, Bendotti C, Bonetto V, De Marchi F, Rosen B, Hooker J, Cudkowicz M, Atassi N. A pilot trial of RNS60 in amyotrophic lateral sclerosis. Muscle Nerve. 2019 Mar;59(3):303-308. doi: 10.1002/mus.26385. Epub 2018 Dec 26. PMID: 30458059 [PubMed - indexed for MEDLINE]
  19. Paganoni S, Simmons Z. Telemedicine to innovate amyotrophic lateral sclerosis multidisciplinary care: The time has come. Muscle Nerve. 2019 Jan;59(1):3-5. doi: 10.1002/mus.26311. Epub 2018 Dec 18. No abstract available. PMID: 30066337 [PubMed - indexed for MEDLINE]

  20. Wainger BJ, Lagier-Tourenne C. Taking on the Elephant in the Tissue Culture Room: iPSC Modeling for Sporadic ALS. Cell Stem Cell. 2018 Oct 4;23(4):466-467. doi: 10.1016/j.stem.2018.09.015. PMID: 30290176 [PubMed - indexed for MEDLINE]
  21. Dawson TM, Golde TE, Lagier-Tourenne C. Animal models of neurodegenerative diseases. Nat Neurosci. 2018 Oct;21(10):1370-1379. doi: 10.1038/s41593-018-0236-8. Epub 2018 Sep 24. Review. PMID: 30250265 [PubMed - indexed for MEDLINE]

  22.  Ratai EM, Alshikho MJ, Zürcher NR, Loggia ML, Cebulla CL, Cernasov P, Reynolds B, Fish J, Seth R, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated imaging of [11C]-PBR28 PET, MR diffusion and magnetic resonance spectroscopy 1H-MRS in amyotrophic lateral sclerosis. Neuroimage Clin. 2018 Aug 9;20:357-364. doi: 10.1016/j.nicl.2018.08.007. eCollection 2018. PMID: 30112276 [PubMed - indexed for MEDLINE] Free PMC Article

  23. Alshikho MJ, Zürcher NR, Loggia ML, Cernasov P, Reynolds B, Pijanowski O, Chonde DB, Izquierdo Garcia D, Mainero C, Catana C, Chan J, Babu S, Paganoni S, Hooker JM, Atassi N. Integrated magnetic resonance imaging and [11 C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis. Ann Neurol. 2018 Jun;83(6):1186-1197. doi: 10.1002/ana.25251. PMID: 29740862 [PubMed - indexed for MEDLINE] Free PMC Article
  24. Atassi N. Nonmotor manifestations in ALS patients with tracheostomy and invasive ventilation. Muscle Nerve. 2018 May;57(5):699-700. doi: 10.1002/mus.26068. Epub 2018 Feb 19. No abstract available. PMID: 29342311 [PubMed - indexed for MEDLINE]

  25. Burke K, Ellrodt AS, Levine J, Adams T, Allis R, Macmurdie I, Paganoni S. Exploring the Use of Educational Material About Shoulder Dysfunction: A Quality Improvement Project in People With Amyotrophic Lateral Sclerosis. Am J Phys Med Rehabil. 2018 May;97(5):379-382. doi: 10.1097/PHM.0000000000000885. PMID: 29303793 [PubMed - indexed for MEDLINE] Free PMC Article

  26. Paganoni S, Nicholson K, Chan J, Shui A, Schoenfeld D, Sherman A, Berry J, Cudkowicz M, Atassi N; Urate levels predict survival in amyotrophic lateral sclerosis: Analysis of the expanded Pooled Resource Open-Access ALS clinical trials database. Pooled Resource Open-Access ALS Clinical Trials Consortium. Muscle Nerve. 2018 Mar;57(3):430-434. doi: 10.1002/mus.25950. Epub 2017 Sep 21. PMID: 28857199 [PubMed - indexed for MEDLINE]