Latest News

June 3, 2021: Healey Inspiration Award
The Healey Center is proud to announce that Sandy Morris is the inaugural recipient of the annual Inspiration Award, which honors and acknowledges people with ALS or their caregivers who have offered their time, wisdom, and inspiration in the pursuit to finding cures for ALS.
Learn more.

May 17, 2021: Answering the Call: The Healey ALS Platform Trial
BioSpace highlights some of the patients and experimental study drugs involved in the HEALEY ALS Platform Trial.
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Mar 11, 2021: Advances in Motion: Accelerating Treatments with the HEALEY Center Platform Trial
In this video from Advances in Motion, Merit E. Cudkowicz, MD, MSc, chief of the Department Neurology and director of the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital, discusses the HEALEY ALS Platform Trial, which aims to accelerate the discovery of new drug therapies for people with amyotrophic lateral sclerosis (ALS).
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Patient & Community Webinar Series

We are committed to an ongoing dialogue about the HEALEY ALS Platform Trial with the entire ALS patient community.

We will continue to share enrollment updates as well as new ideas and opportunities. Our team will be available to answer all questions that the community might have about this groundbreaking trial.

In addition to occasional comprehensive updates and our Mechanism of Action & Science series, we host weekly informal Q&A sessions. The idea of weekly interactive sessions came from our Patient Advisory Committee and we absolutely love the opportunity to connect with all who might be interested on a frequent basis. Please join us as often as you would like!

To submit questions prior to the webinars please email healeyalsplatform@mgh.harvard.edu

Upcoming Webinars

  • August 5, 5:00 pm Eastern: Weekly Q&A
  • Aug 12, 5:00 pm Eastern: Weekly Q&A with special guest Michael Weiss, MD, FAAN from the University of Washington
  • August 19, 5:00 pm Eastern: Weekly Q&A with special guest Laura Foster, MD from the University of Colorado
Register for weekly webinars

Webinar Recordings

Science & Mechanism of Action Series

February 25: Zilucoplan Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, research scientists from UCB and regimen co-leads Sabrina Paganoni, MD, PhD and Christina Fournier, MD presented the rationale and science behind Zilucoplan, one of the study drugs currently being tested in the HEALEY ALS Platform Trial, and answered questions from the audience.
Watch recording | Download slides (PDF)

February 18: Verdiperstat Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, research scientists from Biohaven Pharmaceuaticals and regimen co-leads, Jinsy Andrews, MD, MSc and Suma Babu, MD,MPH,MBBS presented the rationale and science behind Verdiperstat, one of the study drugs currently being tested in the HEALEY ALS Platform Trial, and answered questions from the audience.
Watch recording | Download slides (PDF)

February 4: CNM-Au8 Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, Sabrina Paganoni, MD, PhD, research scientists from Clene Nanomedicine and regimen co-leads James Berry, MD, MPH and Nicholas Maragakis, MD presented the rationale and science behind CNM-Au8, one of the study drugs currently being tested in the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

January 21: Pridopidine Mechanism of Action & Science
Merit Cudkowicz, MD, MSc, Sabrina Paganoni, MD, PhD, research scientists from Prilenia Therapeutics and regimen co-leads Jeremy Shefner, MD, PhD and Björn Oskarsson, MD, FAAN presented the rationale and science behind Pridopidine, one of the study drugs currently being tested in the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

Weekly & Monthly Updates

July 29, 2021: Weekly Q&A With Guest Speaker Hristelina Ilieva, MD, PhD 
James Berry MD, MPH presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Hristelina Ilieva, MD, PhD from Thomas Jefferson University.
Watch recording | Download slides (PDF)

July 22, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker Richard Bedlack, MD, PhD, MS from Duke University.
Watch recording | Download slides (PDF)

July 15, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial. They were joined by special guest Shafeeq Ladha, MD of the Barrow Neurological Institute.
Watch recording | Download slides (PDF)

July 8, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

July 1, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Jeffrey Rosenfeld, PhD, MD, FAAN of Loma Linda University.
Watch recording | Download slides (PDF)

June 24, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

June 17, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Lauren Elman, MD from the University of Pennsylvania.
Watch recording | Download slides (PDF)

June 10, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

June 3, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 27, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 20, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 13, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

May 6, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

April 29, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience with guest speaker Eduardo Locatelli, MD from Holy Cross Hospital.
Watch recording | Download slides (PDF)

April 22, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience, with guest speaker Daragh Heitzman, MD, FAAN of Texas Neurology.
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April 15, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial with guest speaker Adam Quick, MD, from The Ohio State University Wexner Medical Center and answered questions from the audience.
Watch recording | Download slides (PDF)

April 8, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial, discussed voice app biomarkers with guest speaker Jeremey Shefner, MD, PhD and answered questions from the audience.
Watch recording | Download slides (PDF)

April 1, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented this week’s updates on the HEALEY ALS Platform Trial, discussed biomarkers with guest speaker James Berry, MD, MPH and answered questions from the audience.
Watch recording | Download slides (PDF)

March 25, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

March 18, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

March 11, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

March 4, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience
Watch recording | Download slides (PDF)

February 11, 2021: Weekly Q&A

Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

January 28, 2021: Weekly Q&A
Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial, discussed the trial design, and answered questions from the audience.
Watch recording | Download slides (PDF)

January 14, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week's updates on the HEALEY ALS Platform Trial, discussed the expanded access program, and answered questions from the audience.
Watch recording | Download slides (PDF)

January 7, 2021: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week's updates on the HEALEY ALS Platform Trial, discussed the expanded access program, and answered questions from the audience.
Watch recording | Download slides (PDF)

December 17, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial, discussed open label extension and COVID impact, and answered questions from the audience.
Watch recording | Download slides (PDF)

December 10, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD presented this week's updates on the HEALEY ALS Platform Trial, discussed the enrollment process and study visits, and answered questions from the audience.
Watch recording | Download slides (PDF)

December 3, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week's updates on the HEALEY ALS Platform Trial and the Expanded Access Program, discussed the relationship between clinical research trials for ALS and clinical care, and answered questions from the audience.
Watch recording | Download slides (PDF)

November 30, 2020: Monthly Update
Merit Cudkowicz, MD, MSc, principal investigator, and Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, provided an update on the progress of the HEALEY ALS Platform Trial. They were joined by Jen DiMartino of ALS One.
Watch recording | Download slides (PDF)

November 19, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

November 12, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD and Merit Cudkowicz, MD, MSc presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

November 5, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD presented the week’s updates on the HEALEY ALS Platform Trial and answered questions from the audience.
Watch recording | Download slides (PDF)

October 29, 2020: Monthly Update
Merit Cudkowicz, MD, MSc, principal investigator, and Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, provided an update on the progress of the HEALEY ALS Platform Trial. They were joined by Troy Green from Tackle ALS and Peter Foss from ALS Finding a Cure.
Watch recording | Download slides (PDF)

October 22, 2020: Weekly Q&A
Enrollment updates, trial sites, and patient questions.
Watch recording | Download slides (PDF)

October 21, 2020: ALS/MND Alliance Clinical Trial Design Webinar
Merit Cudkowicz, MD, MSc joined researchers from Europe and Scotland to discuss new research and clinical trial models, how they will change the landscape going forward and their practical implications for patients and researchers.
Watch recording

October 15, 2020: Weekly Q&A
Sabrina Paganoni, MD, PhD covers newly active trial sites, patient navigator service, and patient questions about the HEALEY ALS Platform Trial.
Watch recording | Download slides (PDF)

October 13, 2020: CTTI Master Protocol Development Webinar for Researchers
Marianne Chase, the Senior Director Clinical Trial Operations at Mass General's Neurological Clinical Research Institute, joined representatives from the FDA, Janssen R&D and Edgewise Therapeutics to discuss the design of master protocol clinical trials, which allow researchers to answer multiple scientific questions within a single trial. Watch recording.

October 8, 2020: Weekly Q&A
Mass General researchers Merit Cudkowicz, MD, MSc and Sabrina Paganoni, MD, PhD are joined by Sandy Morris of I AM ALS.
Watch recording | Download slides (PDF)

September 29, 2020, 2020: Monthly Update
Merit Cudkowicz, MD, MSc, principal investigator, and Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, provided an update on the progress of the HEALEY ALS Platform Trial. They were joined by Kuldip Dave, PhD, of the ALS Association.
Watch recording | Download slides (PDF)

August 27, 2020, 2020: Monthly Update

Sabrina Paganoni, MD, co-principal investigator of the HEALEY ALS Platform Trial, joined Taner Dagdelen, co-founder and CEO of Unite Genomics, for a webinar on August 27 to discuss the latest updates on the trial.
Watch recording

Watch Our Launch Video

Pre-Launch Updates

July 7, 2020: Status Update
Healey Center faculty provide update on the status of the HEALEY ALS Platform Trial.
Watch recording.

March 25, 2020: COVID Updates and April 8th Webinar
As you all are, we too are closely monitoring the impact of COVID-19 on the HEALEY ALS Platform Trial timelines and operations.  The bottom line is this: we are committed to beginning the trial as soon and as safely as we can.

January 22, 2020: Sean M. Healey & AMG Center for ALS at Mass General receives “May Proceed” notice for three drugs in first ALS platform trial
The Sean M. Healey & AMG Center for ALS at Mass General has received approval from the U.S. Food and Drug Administration (FDA) to proceed with administering three proposed drug regimens in the HEALEY ALS Platform Trial – the first trial of its kind for amyotrophic lateral sclerosis (ALS)

Merit Cudkowicz, MD, MSc, Director of the Healey Center for ALS, discusses the impact of the “May Proceed” notice from the FDA for three drugs in first ALS platform trial

January 14, 2020: ALS Association makes multi-year commitment to HEALEY ALS Platform Trial
The ALS Association announced a $3 million commitment to the first platform trial for ALS, taking place at the Sean M. Healey & AMG Center for ALS at Mass General in collaboration with the Barrow Neurological Institute and the Northeast ALS Consortium (NEALS).

September 18, 2019: Sean M. Healey & AMG Center for ALS at Mass General launches first ALS Platform Trial with 5 promising drugs
The Sean M. Healey & AMG Center at Massachusetts General Hospital will launch the first platform trial for amyotrophic lateral sclerosis (ALS) to accelerate the development of effective and breakthrough treatments for people with ALS.