David N. Louis, MD
Benjamin Castleman Professor of Pathology, Harvard Medical School
Pathologist-in-Chief, Massachusetts General Hospital
55 Fruit Street
Boston, MA 2114
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About the Lab
Over the past 30 years, we have demonstrated alterations characteristic of specific glioma subtypes and grades. We originally demonstrated that molecular genetic analysis could be used to define clinicopathologically relevant subsets of glioblastomas, and then showed that molecular genetic alterations are powerful predictors of therapeutic response and survival in patients with anaplastic oligodendrogliomas and in other oligodendroglial tumors. These findings have already led to incorporation of molecular diagnostic testing around the world for these parameters. Work over the past few years has been directed toward incorporating molecular testing into the World Health Organization Classification of Central Nervous System Tumors, a process directed by Dr. Louis, and toward making molecular diagnostics a practical and routine part of brain tumor diagnosis through international efforts led by Dr. Louis (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy [cIMPACT] and the CNS dataset of the International Collaboration on Cancer Reporting [ICCR]). The lab has also demonstrated that glioblastomas treated with the alkylating agent temozolomide (which is now the standard of care for such cases) frequently inactivate mismatched repair genes, leading to more rapid growth during therapy and to therapeutic resistance, and has worked collaboratively on epigenetic and single-cell studies of high-grade gliomas.
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Louis DN et al. cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathol. 2020 Apr 19. doi: 10.1111/bpa.12832. Online ahead of print.
Louis DN et al. Data sets for the reporting of tumors of the central nervous system: recommendations from the International Collaboration on Cancer Reporting. Arch Pathol Lab Med. 2020; 144:196-206, 2020.
Louis DN et al. cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates. Brain Pathol. 2019; 29:469-472.
Louis DN et al. Announcing cIMPACT-NOW: The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy. Acta Neuropathol. 2017; 133:1-3.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds.). World Health Organization Classification of Tumours of the Central Nervous System. Lyon: International Agency for Research on Cancer, 2016.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 WHO classification of tumours of the central nervous system: a summary. Acta Neuropathol. 2016; 131(6):803-820.
Louis DN. Perry A, Burger P, et al. International Society of Neuropathology- Haarlem consensus guidelines for nervous system tumor classification and grading. Brain Pathol. 2014; 24:429-435.
- Pathologist-in-Chief, Massachusetts General Hospital
- Benjamin Castleman Professor of Pathology, Harvard Medical School