Louis Lab
Contact Information
Louis Laboratory
David N. Louis, MD
Benjamin Castleman Professor of Pathology, Harvard Medical School
Pathologist-in-Chief, Massachusetts General Hospital
WRN2
55 Fruit Street
Boston,
MA
2114
Phone: 617-726-2966
Fax: 617-726-7533
Email: dlouis@partners.org
Program Affiliations
Pathology Service, Mass General Hospital
Center for Cancer Research
Explore This Laboratory
About the Lab
Over the past 30 years, we have demonstrated alterations characteristic of specific glioma subtypes and grades. We originally demonstrated that molecular genetic analysis could be used to define clinicopathologically relevant subsets of glioblastomas, and then showed that molecular genetic alterations are powerful predictors of therapeutic response and survival in patients with anaplastic oligodendrogliomas and in other oligodendroglial tumors. These findings have already led to incorporation of molecular diagnostic testing around the world for these parameters. Work over the past few years has been directed toward incorporating molecular testing into the World Health Organization Classification of Central Nervous System Tumors, a process directed by Dr. Louis, and toward making molecular diagnostics a practical and routine part of brain tumor diagnosis through international efforts led by Dr. Louis (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy [cIMPACT] and the CNS dataset of the International Collaboration on Cancer Reporting [ICCR]). The lab has also demonstrated that glioblastomas treated with the alkylating agent temozolomide (which is now the standard of care for such cases) frequently inactivate mismatched repair genes, leading to more rapid growth during therapy and to therapeutic resistance, and has worked collaboratively on epigenetic and single-cell studies of high-grade gliomas.
Read more about the Louis Lab from the Center for Cancer Research Annual Report and the Pathology Basic Science Research Brochure.
Research Positions
Read about and apply for residency, fellowship and observership programs here.
Apply for temporary positions (summer interns) through the Mass General Careers Web site.
All applicants should register with the at Mass General Careers Web site
Selected Publications
Louis DN et al. cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathol. 2020 Apr 19. doi: 10.1111/bpa.12832. Online ahead of print.
Louis DN et al. Data sets for the reporting of tumors of the central nervous system: recommendations from the International Collaboration on Cancer Reporting. Arch Pathol Lab Med. 2020; 144:196-206, 2020.
Louis DN et al. cIMPACT-NOW: a practical summary of diagnostic points from Round 1 updates. Brain Pathol. 2019; 29:469-472.
Louis DN et al. Announcing cIMPACT-NOW: The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy. Acta Neuropathol. 2017; 133:1-3.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds.). World Health Organization Classification of Tumours of the Central Nervous System. Lyon: International Agency for Research on Cancer, 2016.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 WHO classification of tumours of the central nervous system: a summary. Acta Neuropathol. 2016; 131(6):803-820.
Louis DN. Perry A, Burger P, et al. International Society of Neuropathology- Haarlem consensus guidelines for nervous system tumor classification and grading. Brain Pathol. 2014; 24:429-435.
PubMed Article: Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma.
Physician Profile
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- Pathologist-in-Chief, Massachusetts General Hospital
- Benjamin Castleman Professor of Pathology, Harvard Medical School
$19 Million
Pathology Research activities occupy approx. 20,000 sq.ft., with researchers receiving over $19 million in direct costs of annual research support
Pathology Basic Science Research Brochure
The Pathology Basic Science Research Brochure brochure highlights the basic scientific research activities in MGH Pathology.